Motif ID: Foxd3

Z-value: 0.521


Transcription factors associated with Foxd3:

Gene SymbolEntrez IDGene Name
Foxd3 ENSMUSG00000067261.3 Foxd3



Activity profile for motif Foxd3.

activity profile for motif Foxd3


Sorted Z-values histogram for motif Foxd3

Sorted Z-values for motif Foxd3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxd3

PNG image of the network

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Top targets:


Showing 1 to 20 of 64 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_70630149 2.214 ENSMUST00000022694.9
 Dmtn
dematin actin binding protein
chr17_+_93199348 2.037 ENSMUST00000064775.6
 Adcyap1
adenylate cyclase activating polypeptide 1
chr17_+_29090969 2.004 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr1_+_6734827 1.988 ENSMUST00000139838.1
 St18
suppression of tumorigenicity 18
chr5_+_148265202 1.941 ENSMUST00000110515.2
 Mtus2
microtubule associated tumor suppressor candidate 2
chr6_-_144209471 1.830 ENSMUST00000038815.7
 Sox5
SRY-box containing gene 5
chr6_-_144209558 1.794 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr5_+_148265265 1.725 ENSMUST00000071878.5
 Mtus2
microtubule associated tumor suppressor candidate 2
chr5_+_148265307 1.680 ENSMUST00000110514.1
 Mtus2
microtubule associated tumor suppressor candidate 2
chr14_-_93888732 1.521 ENSMUST00000068992.2
 Pcdh9
protocadherin 9
chr1_-_126830632 1.458 ENSMUST00000112583.1
ENSMUST00000094609.3
 Nckap5

NCK-associated protein 5

chr10_-_11080956 1.383 ENSMUST00000105560.1
 Grm1
glutamate receptor, metabotropic 1
chr4_-_36056726 1.369 ENSMUST00000108124.3
 Lingo2
leucine rich repeat and Ig domain containing 2
chr1_-_126830786 1.339 ENSMUST00000162646.1
 Nckap5
NCK-associated protein 5
chr16_+_13986596 1.236 ENSMUST00000056521.5
ENSMUST00000118412.1
ENSMUST00000131608.1
 2900011O08Rik


RIKEN cDNA 2900011O08 gene


chr11_+_98798653 0.945 ENSMUST00000037930.6
 Msl1
male-specific lethal 1 homolog (Drosophila)
chr6_+_77242644 0.809 ENSMUST00000159616.1
 Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr6_+_77242715 0.800 ENSMUST00000161677.1
 Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr12_+_38783455 0.785 ENSMUST00000161980.1
ENSMUST00000160701.1
 Etv1

ets variant gene 1

chr8_-_87959560 0.766 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.6 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.7 2.2 GO:0035585 calcium-mediated signaling using extracellular calcium source(GO:0035585)
0.7 2.0 GO:0071649 negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865) regulation of chemokine (C-C motif) ligand 5 production(GO:0071649) positive regulation of somatostatin secretion(GO:0090274)
0.2 2.0 GO:0071493 cellular response to UV-B(GO:0071493)
0.2 2.0 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.1 1.6 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.3 1.4 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.0 1.4 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 1.3 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.4 1.2 GO:1903976 negative regulation of glial cell migration(GO:1903976)
0.0 0.9 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.8 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.1 0.5 GO:0034587 piRNA metabolic process(GO:0034587)
0.1 0.5 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.0 0.5 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.1 0.4 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.1 0.4 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.1 0.4 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 0.4 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.0 0.4 GO:0035095 behavioral response to nicotine(GO:0035095)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.3 GO:0045171 intercellular bridge(GO:0045171)
0.0 2.9 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.6 2.2 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.7 2.0 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 2.0 GO:0043195 terminal bouton(GO:0043195)
0.0 2.0 GO:0032993 protein-DNA complex(GO:0032993)
0.0 1.5 GO:0044291 cell-cell contact zone(GO:0044291)
0.1 1.4 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.2 0.9 GO:0072487 MSL complex(GO:0072487)
0.1 0.5 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0 0.5 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.5 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.4 GO:0043512 inhibin A complex(GO:0043512)
0.1 0.4 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 0.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.1 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)

Gene overrepresentation in molecular_function category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.3 GO:0008017 microtubule binding(GO:0008017)
0.0 2.2 GO:0030507 spectrin binding(GO:0030507)
0.7 2.0 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.1 2.0 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 1.6 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.3 1.4 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.1 0.5 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 0.4 GO:0051525 NFAT protein binding(GO:0051525)
0.1 0.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.4 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.4 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.4 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.3 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.2 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.0 0.2 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.2 GO:0016841 ammonia-lyase activity(GO:0016841)
0.0 0.2 GO:0070700 BMP receptor binding(GO:0070700)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.0 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.8 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 0.7 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.4 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.2 PID_ALK2_PATHWAY ALK2 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.0 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 2.0 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.1 1.4 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 0.7 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.5 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 0.4 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 0.4 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.4 REACTOME_ADP_SIGNALLING_THROUGH_P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.0 0.3 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.0 0.3 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway