Motif ID: Foxf2

Z-value: 1.265


Transcription factors associated with Foxf2:

Gene SymbolEntrez IDGene Name
Foxf2 ENSMUSG00000038402.2 Foxf2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxf2mm10_v2_chr13_+_31625802_316258160.173.2e-01Click!


Activity profile for motif Foxf2.

activity profile for motif Foxf2


Sorted Z-values histogram for motif Foxf2

Sorted Z-values for motif Foxf2



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxf2

PNG image of the network

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Top targets:


Showing 1 to 20 of 111 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66969616 20.709 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr6_-_148444336 16.378 ENSMUST00000060095.8
ENSMUST00000100772.3
 Tmtc1

transmembrane and tetratricopeptide repeat containing 1

chr16_-_22439719 8.416 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr16_-_22439570 8.355 ENSMUST00000170393.1
 Etv5
ets variant gene 5
chr16_+_91269759 8.202 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr15_+_3270767 7.917 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr8_-_84773381 7.221 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr10_+_60106452 6.698 ENSMUST00000165024.2
 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr7_+_82175156 6.510 ENSMUST00000180243.1
 Sh3gl3
SH3-domain GRB2-like 3
chr1_-_87573825 4.961 ENSMUST00000068681.5
 Ngef
neuronal guanine nucleotide exchange factor
chr7_-_4844665 4.220 ENSMUST00000066041.5
ENSMUST00000172377.1
 Shisa7

shisa homolog 7 (Xenopus laevis)

chr4_+_5724304 4.093 ENSMUST00000108380.1
 Fam110b
family with sequence similarity 110, member B
chr4_+_101507947 3.997 ENSMUST00000149047.1
ENSMUST00000106929.3
 Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr12_-_112511136 3.992 ENSMUST00000066791.5
 Tmem179
transmembrane protein 179
chr3_-_144202300 3.922 ENSMUST00000121796.1
ENSMUST00000121112.1
 Lmo4

LIM domain only 4

chr16_-_4880284 3.668 ENSMUST00000037843.6
 Ubald1
UBA-like domain containing 1
chr4_+_101507855 3.601 ENSMUST00000038207.5
 Dnajc6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr3_+_53488677 3.525 ENSMUST00000029307.3
 Stoml3
stomatin (Epb7.2)-like 3
chr8_+_93810832 3.521 ENSMUST00000034198.8
ENSMUST00000125716.1
 Gnao1

guanine nucleotide binding protein, alpha O

chr19_-_17837620 3.484 ENSMUST00000025618.8
ENSMUST00000050715.8
 Pcsk5

proprotein convertase subtilisin/kexin type 5


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 20.7 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
3.7 18.3 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0 15.6 GO:0006396 RNA processing(GO:0006396)
0.1 8.2 GO:0048663 neuron fate commitment(GO:0048663)
1.3 7.6 GO:0072318 clathrin coat disassembly(GO:0072318)
0.4 7.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.7 6.7 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.7 6.5 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.1 6.0 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.4 5.6 GO:0070842 aggresome assembly(GO:0070842)
0.5 5.0 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.5 4.0 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.3 3.9 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.4 3.5 GO:0033625 positive regulation of integrin activation(GO:0033625)
0.1 3.5 GO:0051926 dopamine receptor signaling pathway(GO:0007212) negative regulation of calcium ion transport(GO:0051926)
0.7 3.3 GO:0070305 response to cGMP(GO:0070305) cellular response to cGMP(GO:0071321)
1.0 2.9 GO:0009826 unidimensional cell growth(GO:0009826) susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1 2.5 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.6 2.3 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.4 2.3 GO:0007258 JUN phosphorylation(GO:0007258)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 24.8 GO:0005739 mitochondrion(GO:0005739)
0.6 21.1 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 17.0 GO:0014069 postsynaptic density(GO:0014069)
0.0 7.3 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 6.5 GO:0005769 early endosome(GO:0005769)
0.0 6.3 GO:0005667 transcription factor complex(GO:0005667)
0.1 4.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.2 3.5 GO:1990635 proximal dendrite(GO:1990635)
0.1 3.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 3.5 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
1.1 3.3 GO:0098855 HCN channel complex(GO:0098855)
0.2 2.9 GO:0070852 cell body fiber(GO:0070852)
0.1 2.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 1.8 GO:0031931 TORC1 complex(GO:0031931)
0.2 1.6 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.5 1.5 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 1.5 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.3 1.3 GO:0031673 H zone(GO:0031673)
0.3 1.3 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 1.3 GO:0071437 invadopodium(GO:0071437)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 22.4 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.5 20.7 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 12.0 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.1 7.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 6.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 5.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 4.0 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.6 3.5 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 3.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.8 3.3 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.2 3.1 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.6 2.3 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 2.3 GO:0019213 deacetylase activity(GO:0019213)
0.4 2.2 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 2.1 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.4 2.0 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.6 1.8 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.5 1.8 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.1 1.6 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 1.6 GO:0045294 alpha-catenin binding(GO:0045294)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 20.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.5 16.8 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.2 6.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 5.0 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 4.5 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.2 4.0 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.1 3.9 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.2 3.5 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 3.3 PID_LKB1_PATHWAY LKB1 signaling events
0.1 2.3 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 2.0 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.0 1.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.6 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.1 1.3 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 1.1 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.6 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.6 PID_FGF_PATHWAY FGF signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 7.0 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 4.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 4.3 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2 4.2 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 3.5 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.0 3.3 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.1 2.8 REACTOME_SIGNALLING_BY_NGF Genes involved in Signalling by NGF
0.0 2.8 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 2.5 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.3 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 1.8 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 1.5 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.5 REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
0.1 1.3 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 1.2 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 1.2 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 1.1 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 1.1 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.8 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1