Motif ID: Foxi1_Foxo1

Z-value: 2.951

Transcription factors associated with Foxi1_Foxo1:

Gene SymbolEntrez IDGene Name
Foxi1 ENSMUSG00000047861.2 Foxi1
Foxo1 ENSMUSG00000044167.5 Foxo1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo1mm10_v2_chr3_+_52268337_522683880.076.7e-01Click!


Activity profile for motif Foxi1_Foxo1.

activity profile for motif Foxi1_Foxo1


Sorted Z-values histogram for motif Foxi1_Foxo1

Sorted Z-values for motif Foxi1_Foxo1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxi1_Foxo1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 52.431 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr3_-_52104891 34.737 ENSMUST00000121440.1
 Maml3
mastermind like 3 (Drosophila)
chr2_+_181767283 26.576 ENSMUST00000108757.2
 Myt1
myelin transcription factor 1
chr2_+_181767040 26.306 ENSMUST00000108756.1
 Myt1
myelin transcription factor 1
chr8_+_34807287 25.737 ENSMUST00000033930.4
 Dusp4
dual specificity phosphatase 4
chr17_-_70851710 23.014 ENSMUST00000166395.2
 Tgif1
TGFB-induced factor homeobox 1
chr10_-_92165159 22.170 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
 Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr15_+_25752860 21.290 ENSMUST00000022882.5
ENSMUST00000135173.1
 Myo10

myosin X

chr3_-_27153861 20.346 ENSMUST00000108300.1
ENSMUST00000108298.2
 Ect2

ect2 oncogene

chr3_-_27153844 19.637 ENSMUST00000176242.2
ENSMUST00000176780.1
 Ect2

ect2 oncogene

chr14_+_73237891 19.551 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr7_-_37773555 19.249 ENSMUST00000176534.1
 Zfp536
zinc finger protein 536
chr1_+_6487231 19.170 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr7_-_115824699 19.132 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr11_-_101551837 17.535 ENSMUST00000017290.4
 Brca1
breast cancer 1
chr3_-_27153782 16.743 ENSMUST00000175857.1
ENSMUST00000177055.1
ENSMUST00000176535.1
 Ect2


ect2 oncogene


chr4_-_97584612 16.730 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr18_+_5593566 16.656 ENSMUST00000160910.1
 Zeb1
zinc finger E-box binding homeobox 1
chr4_-_97584605 16.650 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr2_-_69206146 16.541 ENSMUST00000127243.1
ENSMUST00000149643.1
ENSMUST00000167875.2
ENSMUST00000005365.8
 Spc25



SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 478 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.6 64.9 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
3.9 62.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
4.8 52.9 GO:0060539 diaphragm development(GO:0060539)
8.7 52.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
3.5 38.6 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
2.2 33.1 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
2.6 31.1 GO:0060013 righting reflex(GO:0060013)
2.4 31.1 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
2.4 26.9 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
3.0 26.7 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
2.4 26.0 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
1.2 25.9 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.8 24.7 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.7 24.4 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.5 24.2 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
4.5 22.6 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
1.2 21.2 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.2 19.6 GO:0043488 regulation of mRNA stability(GO:0043488)
1.1 19.2 GO:0070102 interleukin-6-mediated signaling pathway(GO:0070102)
3.7 18.5 GO:0015671 oxygen transport(GO:0015671)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 196 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 154.5 GO:0005654 nucleoplasm(GO:0005654)
0.0 119.1 GO:0005634 nucleus(GO:0005634)
12.5 62.4 GO:0097149 centralspindlin complex(GO:0097149)
0.2 61.3 GO:0016607 nuclear speck(GO:0016607)
4.0 36.0 GO:0030478 actin cap(GO:0030478)
0.2 35.2 GO:0044798 nuclear transcription factor complex(GO:0044798)
4.7 28.1 GO:0031262 Ndc80 complex(GO:0031262)
0.4 26.5 GO:0016459 myosin complex(GO:0016459)
0.2 26.2 GO:0032993 protein-DNA complex(GO:0032993)
7.7 23.0 GO:0070557 PCNA-p21 complex(GO:0070557)
2.1 22.6 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.3 22.2 GO:0005902 microvillus(GO:0005902)
0.6 21.9 GO:0035371 microtubule plus-end(GO:0035371)
0.8 21.8 GO:0051233 spindle midzone(GO:0051233)
0.2 20.0 GO:0000776 kinetochore(GO:0000776)
0.3 19.5 GO:0005844 polysome(GO:0005844)
0.1 18.4 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 18.2 GO:0005814 centriole(GO:0005814)
3.0 17.7 GO:0070531 BRCA1-A complex(GO:0070531)
0.1 14.1 GO:0005681 spliceosomal complex(GO:0005681)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 313 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 126.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.5 70.6 GO:0017048 Rho GTPase binding(GO:0017048)
2.4 35.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.3 35.1 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.2 34.3 GO:0003714 transcription corepressor activity(GO:0003714)
0.4 33.0 GO:0003774 motor activity(GO:0003774)
0.9 29.3 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
3.7 25.9 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.8 25.0 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
8.1 24.4 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
7.7 23.0 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
1.2 23.0 GO:0070410 co-SMAD binding(GO:0070410)
1.3 22.6 GO:0051010 microtubule plus-end binding(GO:0051010)
1.2 21.4 GO:0045295 gamma-catenin binding(GO:0045295)
1.1 21.2 GO:0030215 semaphorin receptor binding(GO:0030215)
2.4 19.2 GO:0050693 LBD domain binding(GO:0050693)
0.3 19.0 GO:0003684 damaged DNA binding(GO:0003684)
3.7 18.5 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 18.1 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.1 17.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 70.8 PID_AR_PATHWAY Coregulation of Androgen receptor activity
1.2 63.1 PID_PLK1_PATHWAY PLK1 signaling events
1.2 55.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.6 32.7 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.7 30.0 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.6 29.9 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
2.0 28.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.7 26.0 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
2.6 23.0 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.6 18.6 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.4 15.8 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.3 14.0 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.3 11.5 PID_RAC1_PATHWAY RAC1 signaling pathway
0.2 10.1 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 9.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.5 9.3 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.2 8.8 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.2 8.7 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.4 8.6 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.2 8.1 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 93.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.7 58.2 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
2.4 40.5 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
1.5 39.2 REACTOME_KINESINS Genes involved in Kinesins
1.1 38.1 REACTOME_G1_PHASE Genes involved in G1 Phase
1.0 38.1 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
1.1 29.4 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
1.6 24.3 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.8 24.2 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
1.1 23.4 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
2.5 22.6 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.4 21.2 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.4 19.0 REACTOME_PI3K_AKT_ACTIVATION Genes involved in PI3K/AKT activation
0.6 14.0 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.3 13.7 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.8 12.7 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.4 12.6 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.7 11.7 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.7 10.8 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.6 10.3 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation