Motif ID: Foxj3_Tbl1xr1

Z-value: 1.264

Transcription factors associated with Foxj3_Tbl1xr1:

Gene SymbolEntrez IDGene Name
Foxj3 ENSMUSG00000032998.10 Foxj3
Tbl1xr1 ENSMUSG00000027630.8 Tbl1xr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxj3mm10_v2_chr4_+_119539652_1195396980.124.8e-01Click!
Tbl1xr1mm10_v2_chr3_+_22076644_22076681-0.057.8e-01Click!


Activity profile for motif Foxj3_Tbl1xr1.

activity profile for motif Foxj3_Tbl1xr1


Sorted Z-values histogram for motif Foxj3_Tbl1xr1

Sorted Z-values for motif Foxj3_Tbl1xr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxj3_Tbl1xr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_144893127 4.884 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_144893077 4.516 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_144892813 4.066 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr4_+_128846163 4.005 ENSMUST00000138291.1
 Gm12968
predicted gene 12968
chr8_-_53638945 3.839 ENSMUST00000047768.4
 Neil3
nei like 3 (E. coli)
chr15_+_57694651 3.732 ENSMUST00000096430.4
 Zhx2
zinc fingers and homeoboxes 2
chr4_+_11704439 3.695 ENSMUST00000108304.2
 Gem
GTP binding protein (gene overexpressed in skeletal muscle)
chr10_-_130280218 3.544 ENSMUST00000061571.3
 Neurod4
neurogenic differentiation 4
chr19_-_28963863 3.503 ENSMUST00000161813.1
 4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr6_+_138140298 3.445 ENSMUST00000008684.4
 Mgst1
microsomal glutathione S-transferase 1
chr1_-_55226768 3.442 ENSMUST00000027121.8
ENSMUST00000114428.2
 Rftn2

raftlin family member 2

chr5_-_99252839 3.078 ENSMUST00000168092.1
ENSMUST00000031276.8
 Rasgef1b

RasGEF domain family, member 1B

chr5_+_134932351 2.973 ENSMUST00000047196.7
ENSMUST00000111221.2
ENSMUST00000111219.1
ENSMUST00000068617.5
ENSMUST00000111218.1
ENSMUST00000136246.1
 Wbscr27





Williams Beuren syndrome chromosome region 27 (human)





chr4_-_110290884 2.959 ENSMUST00000142722.1
 Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr4_+_97777606 2.938 ENSMUST00000075448.6
ENSMUST00000092532.6
 Nfia

nuclear factor I/A

chr9_-_58313189 2.857 ENSMUST00000061799.8
 Loxl1
lysyl oxidase-like 1
chr14_-_98169542 2.717 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr2_-_33942111 2.699 ENSMUST00000130988.1
ENSMUST00000127936.1
ENSMUST00000134271.1
 Gm13403


predicted gene 13403


chr13_-_23430826 2.697 ENSMUST00000153753.1
ENSMUST00000141543.1
 C230035I16Rik

RIKEN cDNA C230035I16 gene

chr17_-_35704000 2.684 ENSMUST00000097333.3
ENSMUST00000003628.6
 Ddr1

discoidin domain receptor family, member 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 954 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 18.8 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.3 10.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
1.2 7.2 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.6 6.8 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.4 6.7 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.8 6.2 GO:0048625 myoblast fate commitment(GO:0048625)
1.5 6.0 GO:0006982 response to lipid hydroperoxide(GO:0006982) cellular response to lipid hydroperoxide(GO:0071449)
0.4 5.8 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.2 5.4 GO:0010842 retina layer formation(GO:0010842)
0.4 5.3 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
1.6 4.9 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.9 4.7 GO:0060809 mesodermal to mesenchymal transition involved in gastrulation(GO:0060809)
0.3 4.6 GO:0072189 ureter development(GO:0072189)
0.1 4.3 GO:0043488 regulation of mRNA stability(GO:0043488)
0.2 4.2 GO:0070207 protein homotrimerization(GO:0070207)
0.7 4.1 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.1 4.1 GO:0006284 base-excision repair(GO:0006284)
0.4 4.0 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.6 3.9 GO:0036089 cleavage furrow formation(GO:0036089)
0.2 3.9 GO:0070102 interleukin-6-mediated signaling pathway(GO:0070102)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 324 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.3 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 8.9 GO:0032993 protein-DNA complex(GO:0032993)
0.2 8.6 GO:0016459 myosin complex(GO:0016459)
0.6 7.7 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.3 7.6 GO:0051233 spindle midzone(GO:0051233)
0.1 7.5 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 7.4 GO:0005667 transcription factor complex(GO:0005667)
0.8 6.8 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
1.1 6.3 GO:0031262 Ndc80 complex(GO:0031262)
0.4 6.0 GO:0042788 polysomal ribosome(GO:0042788)
0.1 6.0 GO:0005814 centriole(GO:0005814)
0.0 5.6 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.5 4.9 GO:0030478 actin cap(GO:0030478)
0.2 4.7 GO:0035371 microtubule plus-end(GO:0035371)
0.1 4.6 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 4.1 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 4.0 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 3.7 GO:0005871 kinesin complex(GO:0005871)
0.3 3.5 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.2 3.5 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 508 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 27.7 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 27.0 GO:0003677 DNA binding(GO:0003677)
0.1 20.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
2.3 15.8 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 11.4 GO:0003774 motor activity(GO:0003774)
0.4 9.0 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.4 8.4 GO:0070016 armadillo repeat domain binding(GO:0070016)
1.8 7.2 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.2 6.4 GO:0017091 AU-rich element binding(GO:0017091)
0.7 6.0 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.5 5.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.4 5.1 GO:0050693 LBD domain binding(GO:0050693)
0.2 5.0 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.2 4.7 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.7 4.4 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.2 4.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
1.4 4.2 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.3 4.2 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 4.2 GO:0042393 histone binding(GO:0042393)
0.8 4.1 GO:0000405 bubble DNA binding(GO:0000405)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 18.0 PID_PLK1_PATHWAY PLK1 signaling events
0.2 14.7 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 9.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 9.4 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 9.3 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 7.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 5.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 5.8 PID_IL12_2PATHWAY IL12-mediated signaling events
0.2 4.9 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 4.5 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 4.4 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 4.0 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.2 3.5 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 3.5 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.1 3.0 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 2.6 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 2.6 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 2.5 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.5 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 2.1 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 132 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 30.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 6.4 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.2 6.4 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.3 5.1 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2 4.9 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 4.7 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 4.6 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.3 4.3 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 4.1 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.2 4.0 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 3.5 REACTOME_DOUBLE_STRAND_BREAK_REPAIR Genes involved in Double-Strand Break Repair
0.1 3.4 REACTOME_KINESINS Genes involved in Kinesins
0.2 3.3 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 3.2 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.0 2.9 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.5 2.8 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.3 2.8 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.2 2.7 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 2.6 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 2.6 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes