Motif ID: Foxk1_Foxj1
Z-value: 0.632
Transcription factors associated with Foxk1_Foxj1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Foxj1 | ENSMUSG00000034227.7 | Foxj1 |
Foxk1 | ENSMUSG00000056493.8 | Foxk1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Foxj1 | mm10_v2_chr11_-_116335384_116335399 | 0.39 | 1.8e-02 | Click! |
Foxk1 | mm10_v2_chr5_+_142401484_142401532 | -0.37 | 2.3e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.0 | 5.1 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
0.7 | 2.0 | GO:0002191 | cap-dependent translational initiation(GO:0002191) |
0.6 | 3.2 | GO:0042891 | antibiotic transport(GO:0042891) dipeptide transport(GO:0042938) |
0.5 | 2.0 | GO:0021698 | cerebellar cortex structural organization(GO:0021698) |
0.4 | 1.2 | GO:0032696 | negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899) |
0.4 | 3.5 | GO:0010745 | negative regulation of macrophage derived foam cell differentiation(GO:0010745) |
0.4 | 1.1 | GO:0072139 | glomerular parietal epithelial cell differentiation(GO:0072139) |
0.3 | 3.6 | GO:0009404 | toxin metabolic process(GO:0009404) |
0.3 | 3.8 | GO:0035881 | amacrine cell differentiation(GO:0035881) |
0.3 | 1.1 | GO:0046368 | GDP-L-fucose metabolic process(GO:0046368) |
0.3 | 1.4 | GO:0010637 | negative regulation of mitochondrial fusion(GO:0010637) |
0.3 | 0.8 | GO:1903070 | negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070) |
0.3 | 1.1 | GO:0030043 | actin filament fragmentation(GO:0030043) |
0.3 | 2.6 | GO:0071763 | nuclear membrane organization(GO:0071763) |
0.2 | 0.7 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) |
0.2 | 1.3 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368) |
0.2 | 3.6 | GO:0071459 | protein localization to chromosome, centromeric region(GO:0071459) |
0.2 | 1.9 | GO:0046602 | regulation of mitotic centrosome separation(GO:0046602) |
0.2 | 0.5 | GO:0006566 | threonine metabolic process(GO:0006566) |
0.2 | 0.7 | GO:1901894 | regulation of calcium-transporting ATPase activity(GO:1901894) |
0.2 | 0.7 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
0.2 | 0.9 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
0.2 | 0.5 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
0.1 | 0.4 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
0.1 | 0.6 | GO:0055071 | cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071) |
0.1 | 2.7 | GO:0006353 | DNA-templated transcription, termination(GO:0006353) |
0.1 | 0.4 | GO:0006545 | glycine biosynthetic process(GO:0006545) |
0.1 | 0.5 | GO:0051311 | meiotic metaphase plate congression(GO:0051311) attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation(GO:0051316) |
0.1 | 0.7 | GO:0036151 | phosphatidylcholine acyl-chain remodeling(GO:0036151) |
0.1 | 0.8 | GO:0035234 | ectopic germ cell programmed cell death(GO:0035234) |
0.1 | 0.6 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
0.1 | 1.2 | GO:1901386 | negative regulation of voltage-gated calcium channel activity(GO:1901386) |
0.1 | 0.6 | GO:1902732 | positive regulation of chondrocyte proliferation(GO:1902732) |
0.1 | 0.5 | GO:0033326 | cerebrospinal fluid secretion(GO:0033326) |
0.1 | 1.0 | GO:0050957 | equilibrioception(GO:0050957) |
0.1 | 0.4 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
0.1 | 0.7 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
0.1 | 0.3 | GO:0045004 | DNA replication proofreading(GO:0045004) |
0.1 | 0.3 | GO:0044028 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
0.1 | 0.3 | GO:0032918 | polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918) |
0.1 | 2.2 | GO:0030033 | microvillus assembly(GO:0030033) |
0.1 | 0.5 | GO:0008655 | pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097) |
0.1 | 0.3 | GO:0021972 | corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260) |
0.1 | 0.3 | GO:1900108 | negative regulation of nodal signaling pathway(GO:1900108) |
0.1 | 3.6 | GO:0006182 | cGMP biosynthetic process(GO:0006182) |
0.1 | 0.4 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
0.1 | 0.4 | GO:0006447 | regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994) |
0.1 | 0.4 | GO:0010990 | regulation of SMAD protein complex assembly(GO:0010990) |
0.1 | 1.2 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
0.1 | 2.5 | GO:0042462 | eye photoreceptor cell development(GO:0042462) |
0.1 | 0.4 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
0.1 | 0.2 | GO:0097309 | cap1 mRNA methylation(GO:0097309) |
0.1 | 0.7 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
0.1 | 0.3 | GO:0035616 | histone H2B conserved C-terminal lysine deubiquitination(GO:0035616) |
0.1 | 0.2 | GO:0042117 | monocyte activation(GO:0042117) |
0.1 | 0.2 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
0.1 | 0.5 | GO:0048251 | elastic fiber assembly(GO:0048251) |
0.1 | 0.5 | GO:0002318 | myeloid progenitor cell differentiation(GO:0002318) |
0.1 | 1.2 | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482) |
0.1 | 0.3 | GO:0090521 | glomerular visceral epithelial cell migration(GO:0090521) |
0.1 | 0.2 | GO:0006547 | histidine metabolic process(GO:0006547) imidazole-containing compound catabolic process(GO:0052805) |
0.1 | 0.9 | GO:2001275 | positive regulation of glucose import in response to insulin stimulus(GO:2001275) |
0.1 | 0.5 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
0.1 | 0.3 | GO:0034587 | piRNA metabolic process(GO:0034587) |
0.1 | 0.1 | GO:1902071 | regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071) |
0.1 | 0.3 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
0.1 | 0.1 | GO:0051541 | elastin metabolic process(GO:0051541) |
0.1 | 0.2 | GO:1903774 | positive regulation of viral budding via host ESCRT complex(GO:1903774) |
0.0 | 0.2 | GO:0018242 | protein O-linked glycosylation via serine(GO:0018242) |
0.0 | 0.7 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
0.0 | 0.9 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
0.0 | 0.1 | GO:2000836 | luteinizing hormone secretion(GO:0032275) positive regulation of androgen secretion(GO:2000836) positive regulation of testosterone secretion(GO:2000845) |
0.0 | 0.4 | GO:0097475 | motor neuron migration(GO:0097475) |
0.0 | 0.2 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
0.0 | 0.1 | GO:0003032 | detection of oxygen(GO:0003032) |
0.0 | 0.2 | GO:0033762 | response to glucagon(GO:0033762) |
0.0 | 0.1 | GO:1904719 | excitatory chemical synaptic transmission(GO:0098976) positive regulation of AMPA glutamate receptor clustering(GO:1904719) |
0.0 | 0.1 | GO:0019732 | antifungal humoral response(GO:0019732) antifungal innate immune response(GO:0061760) regulation of antifungal innate immune response(GO:1905034) negative regulation of antifungal innate immune response(GO:1905035) |
0.0 | 0.8 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
0.0 | 0.2 | GO:0031022 | nuclear migration along microfilament(GO:0031022) |
0.0 | 1.0 | GO:0051084 | 'de novo' posttranslational protein folding(GO:0051084) |
0.0 | 0.1 | GO:0021933 | radial glia guided migration of cerebellar granule cell(GO:0021933) |
0.0 | 0.2 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
0.0 | 0.5 | GO:0061072 | embryonic retina morphogenesis in camera-type eye(GO:0060059) iris morphogenesis(GO:0061072) |
0.0 | 0.2 | GO:0034393 | positive regulation of smooth muscle cell apoptotic process(GO:0034393) |
0.0 | 1.7 | GO:0006284 | base-excision repair(GO:0006284) |
0.0 | 2.0 | GO:0030071 | regulation of mitotic metaphase/anaphase transition(GO:0030071) regulation of metaphase/anaphase transition of cell cycle(GO:1902099) |
0.0 | 0.1 | GO:0048859 | formation of anatomical boundary(GO:0048859) |
0.0 | 0.3 | GO:0009162 | deoxyribonucleoside monophosphate metabolic process(GO:0009162) |
0.0 | 0.4 | GO:0031119 | tRNA pseudouridine synthesis(GO:0031119) |
0.0 | 0.6 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
0.0 | 0.8 | GO:0008340 | determination of adult lifespan(GO:0008340) |
0.0 | 0.6 | GO:0046597 | negative regulation of viral entry into host cell(GO:0046597) |
0.0 | 0.3 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
0.0 | 0.2 | GO:1990564 | protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592) |
0.0 | 0.2 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
0.0 | 0.1 | GO:0097089 | methyl-branched fatty acid metabolic process(GO:0097089) |
0.0 | 1.6 | GO:0045744 | negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744) |
0.0 | 0.1 | GO:2000189 | positive regulation of cholesterol homeostasis(GO:2000189) |
0.0 | 0.3 | GO:0098789 | pre-mRNA cleavage required for polyadenylation(GO:0098789) |
0.0 | 0.3 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
0.0 | 0.2 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
0.0 | 0.3 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
0.0 | 1.5 | GO:0002066 | columnar/cuboidal epithelial cell development(GO:0002066) |
0.0 | 0.9 | GO:0006270 | DNA replication initiation(GO:0006270) |
0.0 | 0.4 | GO:0021670 | lateral ventricle development(GO:0021670) |
0.0 | 0.0 | GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987) |
0.0 | 0.1 | GO:0015744 | succinate transport(GO:0015744) |
0.0 | 0.1 | GO:0098706 | ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) |
0.0 | 0.4 | GO:0051457 | maintenance of protein location in nucleus(GO:0051457) |
0.0 | 0.1 | GO:0035720 | intraciliary anterograde transport(GO:0035720) |
0.0 | 0.2 | GO:0030382 | sperm mitochondrion organization(GO:0030382) |
0.0 | 0.1 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) |
0.0 | 0.8 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
0.0 | 0.1 | GO:0030210 | heparin biosynthetic process(GO:0030210) |
0.0 | 0.2 | GO:1900262 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
0.0 | 0.1 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
0.0 | 0.1 | GO:0006741 | NADP biosynthetic process(GO:0006741) |
0.0 | 0.5 | GO:0010866 | regulation of triglyceride biosynthetic process(GO:0010866) |
0.0 | 0.1 | GO:2000569 | T-helper 2 cell activation(GO:0035712) regulation of T-helper 2 cell activation(GO:2000569) positive regulation of T-helper 2 cell activation(GO:2000570) |
0.0 | 0.2 | GO:0045579 | positive regulation of B cell differentiation(GO:0045579) |
0.0 | 0.1 | GO:0035902 | response to immobilization stress(GO:0035902) |
0.0 | 0.6 | GO:0006303 | double-strand break repair via nonhomologous end joining(GO:0006303) |
0.0 | 0.2 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
0.0 | 0.1 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
0.0 | 0.1 | GO:0032049 | cardiolipin biosynthetic process(GO:0032049) |
0.0 | 0.1 | GO:0002339 | B cell selection(GO:0002339) |
0.0 | 0.0 | GO:0010616 | negative regulation of cardiac muscle adaptation(GO:0010616) |
0.0 | 0.0 | GO:1903061 | regulation of protein lipidation(GO:1903059) positive regulation of protein lipidation(GO:1903061) |
0.0 | 0.1 | GO:0090043 | regulation of tubulin deacetylation(GO:0090043) |
0.0 | 0.1 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
0.0 | 0.1 | GO:1901668 | regulation of superoxide dismutase activity(GO:1901668) |
0.0 | 0.5 | GO:1901998 | toxin transport(GO:1901998) |
0.0 | 0.2 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
0.0 | 0.9 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
0.0 | 0.1 | GO:0016093 | polyprenol metabolic process(GO:0016093) |
0.0 | 0.2 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
0.0 | 0.1 | GO:0035520 | monoubiquitinated protein deubiquitination(GO:0035520) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 3.0 | GO:0000939 | condensed chromosome inner kinetochore(GO:0000939) |
0.4 | 1.1 | GO:0071914 | prominosome(GO:0071914) |
0.3 | 0.3 | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) |
0.3 | 0.8 | GO:0097135 | cyclin E2-CDK2 complex(GO:0097135) |
0.2 | 0.6 | GO:0042585 | germinal vesicle(GO:0042585) |
0.2 | 3.6 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
0.2 | 2.0 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
0.2 | 2.0 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
0.2 | 0.5 | GO:0005588 | collagen type V trimer(GO:0005588) |
0.1 | 8.5 | GO:0005871 | kinesin complex(GO:0005871) |
0.1 | 2.3 | GO:0035102 | PRC1 complex(GO:0035102) |
0.1 | 1.2 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
0.1 | 0.3 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
0.1 | 0.4 | GO:0070552 | BRISC complex(GO:0070552) |
0.1 | 0.6 | GO:0032807 | DNA ligase IV complex(GO:0032807) |
0.1 | 0.7 | GO:0032591 | dendritic spine membrane(GO:0032591) |
0.1 | 0.3 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
0.1 | 0.9 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
0.1 | 0.8 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
0.1 | 0.3 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
0.0 | 3.5 | GO:0030667 | secretory granule membrane(GO:0030667) |
0.0 | 1.2 | GO:0051233 | spindle midzone(GO:0051233) |
0.0 | 0.5 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
0.0 | 0.5 | GO:0016589 | NURF complex(GO:0016589) |
0.0 | 2.4 | GO:0016459 | myosin complex(GO:0016459) |
0.0 | 4.0 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
0.0 | 0.1 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
0.0 | 0.2 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
0.0 | 0.7 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
0.0 | 0.2 | GO:0060293 | P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293) |
0.0 | 1.2 | GO:0097546 | ciliary base(GO:0097546) |
0.0 | 0.4 | GO:0005922 | connexon complex(GO:0005922) |
0.0 | 0.2 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
0.0 | 0.3 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
0.0 | 0.3 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) |
0.0 | 0.5 | GO:0000800 | lateral element(GO:0000800) |
0.0 | 0.3 | GO:0035253 | ciliary rootlet(GO:0035253) |
0.0 | 0.2 | GO:0031415 | NatA complex(GO:0031415) |
0.0 | 0.7 | GO:0032420 | stereocilium(GO:0032420) |
0.0 | 0.2 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
0.0 | 0.2 | GO:0070822 | Sin3-type complex(GO:0070822) |
0.0 | 1.4 | GO:0005902 | microvillus(GO:0005902) |
0.0 | 0.2 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
0.0 | 0.8 | GO:0002102 | podosome(GO:0002102) |
0.0 | 0.1 | GO:0001652 | granular component(GO:0001652) |
0.0 | 0.2 | GO:0097227 | sperm annulus(GO:0097227) |
0.0 | 0.4 | GO:0000242 | pericentriolar material(GO:0000242) |
0.0 | 0.4 | GO:0030914 | STAGA complex(GO:0030914) |
0.0 | 0.2 | GO:0000813 | ESCRT I complex(GO:0000813) |
0.0 | 2.2 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
0.0 | 0.6 | GO:0030673 | axolemma(GO:0030673) |
0.0 | 1.1 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
0.0 | 0.0 | GO:0034272 | phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272) |
0.0 | 0.6 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
0.0 | 1.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.0 | 0.2 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
0.0 | 0.6 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
0.0 | 0.2 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
0.0 | 0.1 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
0.0 | 0.1 | GO:1990130 | Iml1 complex(GO:1990130) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.2 | 3.6 | GO:0016715 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715) |
1.1 | 3.2 | GO:0042936 | dipeptide transporter activity(GO:0042936) |
0.4 | 1.2 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
0.3 | 1.7 | GO:0000405 | bubble DNA binding(GO:0000405) |
0.3 | 2.0 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
0.3 | 1.8 | GO:0030284 | estrogen receptor activity(GO:0030284) |
0.3 | 4.9 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
0.3 | 1.1 | GO:0043515 | kinetochore binding(GO:0043515) |
0.2 | 0.7 | GO:0030156 | benzodiazepine receptor binding(GO:0030156) |
0.2 | 1.0 | GO:0004382 | guanosine-diphosphatase activity(GO:0004382) |
0.2 | 0.4 | GO:0008732 | threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
0.2 | 3.6 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
0.2 | 0.5 | GO:0070905 | serine binding(GO:0070905) |
0.2 | 1.2 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
0.2 | 0.7 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
0.1 | 0.6 | GO:0015410 | manganese-transporting ATPase activity(GO:0015410) |
0.1 | 0.5 | GO:0010484 | H3 histone acetyltransferase activity(GO:0010484) |
0.1 | 0.4 | GO:0005118 | sevenless binding(GO:0005118) |
0.1 | 3.7 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
0.1 | 0.8 | GO:0015616 | DNA translocase activity(GO:0015616) |
0.1 | 0.5 | GO:0003681 | bent DNA binding(GO:0003681) |
0.1 | 0.6 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
0.1 | 0.4 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
0.1 | 0.3 | GO:0008310 | single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310) |
0.1 | 0.3 | GO:0030171 | voltage-gated proton channel activity(GO:0030171) |
0.1 | 0.3 | GO:0004145 | diamine N-acetyltransferase activity(GO:0004145) |
0.1 | 0.6 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
0.1 | 0.5 | GO:0004849 | uridine kinase activity(GO:0004849) |
0.1 | 0.3 | GO:0016015 | morphogen activity(GO:0016015) |
0.1 | 0.3 | GO:0004677 | DNA-dependent protein kinase activity(GO:0004677) |
0.1 | 0.6 | GO:1901612 | phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612) |
0.1 | 0.3 | GO:0003953 | NAD+ nucleosidase activity(GO:0003953) |
0.1 | 1.9 | GO:0005521 | lamin binding(GO:0005521) |
0.1 | 0.2 | GO:0030158 | protein xylosyltransferase activity(GO:0030158) |
0.1 | 0.4 | GO:0070644 | vitamin D response element binding(GO:0070644) |
0.1 | 0.9 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
0.1 | 0.8 | GO:0008430 | selenium binding(GO:0008430) |
0.1 | 0.5 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
0.1 | 1.5 | GO:0001222 | transcription corepressor binding(GO:0001222) |
0.1 | 0.2 | GO:0071568 | UFM1 transferase activity(GO:0071568) |
0.1 | 0.4 | GO:0001758 | retinal dehydrogenase activity(GO:0001758) |
0.1 | 0.2 | GO:0030549 | acetylcholine receptor activator activity(GO:0030549) |
0.1 | 2.6 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
0.1 | 0.5 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
0.1 | 0.2 | GO:0004483 | mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483) |
0.1 | 0.3 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
0.0 | 0.7 | GO:0003688 | DNA replication origin binding(GO:0003688) |
0.0 | 0.1 | GO:0017153 | sodium:dicarboxylate symporter activity(GO:0017153) |
0.0 | 0.2 | GO:0016841 | ammonia-lyase activity(GO:0016841) |
0.0 | 0.3 | GO:0017040 | ceramidase activity(GO:0017040) |
0.0 | 0.7 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
0.0 | 0.3 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813) |
0.0 | 0.1 | GO:0008823 | cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851) |
0.0 | 0.6 | GO:0016805 | dipeptidase activity(GO:0016805) |
0.0 | 2.7 | GO:0035064 | methylated histone binding(GO:0035064) |
0.0 | 0.3 | GO:0048495 | GTPase inhibitor activity(GO:0005095) Roundabout binding(GO:0048495) |
0.0 | 0.1 | GO:0004605 | phosphatidate cytidylyltransferase activity(GO:0004605) |
0.0 | 1.1 | GO:0042805 | actinin binding(GO:0042805) |
0.0 | 0.1 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
0.0 | 0.2 | GO:0003910 | DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910) |
0.0 | 0.9 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
0.0 | 6.2 | GO:0051015 | actin filament binding(GO:0051015) |
0.0 | 0.2 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
0.0 | 0.5 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
0.0 | 0.6 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
0.0 | 0.2 | GO:0070697 | activin receptor binding(GO:0070697) |
0.0 | 0.1 | GO:0004035 | alkaline phosphatase activity(GO:0004035) |
0.0 | 1.0 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
0.0 | 0.8 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
0.0 | 4.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.0 | 0.4 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
0.0 | 0.5 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
0.0 | 0.2 | GO:0046790 | virion binding(GO:0046790) |
0.0 | 1.2 | GO:0019003 | GDP binding(GO:0019003) |
0.0 | 0.2 | GO:0043142 | single-stranded DNA-dependent ATPase activity(GO:0043142) |
0.0 | 0.3 | GO:0031489 | myosin V binding(GO:0031489) |
0.0 | 0.1 | GO:0004980 | melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980) |
0.0 | 2.8 | GO:0004386 | helicase activity(GO:0004386) |
0.0 | 1.0 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
0.0 | 0.1 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
0.0 | 0.4 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
0.0 | 0.3 | GO:0016799 | hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799) |
0.0 | 0.3 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
0.0 | 0.7 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
0.0 | 0.5 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
0.0 | 0.3 | GO:0008094 | DNA-dependent ATPase activity(GO:0008094) |
0.0 | 0.2 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
0.0 | 0.2 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
0.0 | 0.7 | GO:0005179 | hormone activity(GO:0005179) |
0.0 | 0.2 | GO:0004033 | aldo-keto reductase (NADP) activity(GO:0004033) |
0.0 | 0.1 | GO:0005523 | tropomyosin binding(GO:0005523) |
0.0 | 0.2 | GO:0017025 | TBP-class protein binding(GO:0017025) |
0.0 | 0.1 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
0.0 | 0.1 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
0.0 | 0.2 | GO:0003746 | translation elongation factor activity(GO:0003746) |
0.0 | 0.0 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 7.6 | PID_AURORA_B_PATHWAY | Aurora B signaling |
0.1 | 3.5 | PID_MYC_PATHWAY | C-MYC pathway |
0.1 | 4.2 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
0.1 | 0.8 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
0.0 | 1.3 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
0.0 | 0.8 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
0.0 | 1.6 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
0.0 | 0.5 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
0.0 | 0.5 | PID_HIV_NEF_PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
0.0 | 0.2 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
0.0 | 0.1 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
0.0 | 0.5 | PID_RETINOIC_ACID_PATHWAY | Retinoic acid receptors-mediated signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 7.0 | REACTOME_KINESINS | Genes involved in Kinesins |
0.1 | 2.3 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
0.1 | 4.8 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
0.1 | 1.2 | REACTOME_ERKS_ARE_INACTIVATED | Genes involved in ERKs are inactivated |
0.1 | 0.6 | REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
0.1 | 3.6 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
0.0 | 0.5 | REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
0.0 | 0.6 | REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
0.0 | 0.5 | REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
0.0 | 0.3 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
0.0 | 0.8 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
0.0 | 0.5 | REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
0.0 | 0.7 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
0.0 | 1.4 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
0.0 | 0.3 | REACTOME_DOUBLE_STRAND_BREAK_REPAIR | Genes involved in Double-Strand Break Repair |
0.0 | 0.8 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
0.0 | 0.2 | REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
0.0 | 0.3 | REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
0.0 | 0.6 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
0.0 | 0.4 | REACTOME_DOWNSTREAM_TCR_SIGNALING | Genes involved in Downstream TCR signaling |
0.0 | 0.5 | REACTOME_NOD1_2_SIGNALING_PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
0.0 | 0.3 | REACTOME_SIGNALING_BY_NODAL | Genes involved in Signaling by NODAL |
0.0 | 0.2 | REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
0.0 | 0.3 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
0.0 | 0.4 | REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
0.0 | 0.1 | REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
0.0 | 0.1 | REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING | Genes involved in Spry regulation of FGF signaling |
0.0 | 0.3 | REACTOME_ENOS_ACTIVATION_AND_REGULATION | Genes involved in eNOS activation and regulation |
0.0 | 0.2 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
0.0 | 0.2 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
0.0 | 0.1 | REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
0.0 | 0.2 | REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS | Genes involved in Amine compound SLC transporters |