Motif ID: Foxk1_Foxj1

Z-value: 0.632

Transcription factors associated with Foxk1_Foxj1:

Gene SymbolEntrez IDGene Name
Foxj1 ENSMUSG00000034227.7 Foxj1
Foxk1 ENSMUSG00000056493.8 Foxk1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxj1mm10_v2_chr11_-_116335384_1163353990.391.8e-02Click!
Foxk1mm10_v2_chr5_+_142401484_142401532-0.372.3e-02Click!


Activity profile for motif Foxk1_Foxj1.

activity profile for motif Foxk1_Foxj1


Sorted Z-values histogram for motif Foxk1_Foxj1

Sorted Z-values for motif Foxk1_Foxj1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxk1_Foxj1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_117178726 5.079 ENSMUST00000153953.1
ENSMUST00000106436.1
 Kif2c

kinesin family member 2C

chr10_-_130280218 3.751 ENSMUST00000061571.3
 Neurod4
neurogenic differentiation 4
chr10_-_92165159 3.671 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
 Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr1_-_97977233 3.564 ENSMUST00000161567.1
 Pam
peptidylglycine alpha-amidating monooxygenase
chr13_-_103920295 3.238 ENSMUST00000169083.1
 Erbb2ip
Erbb2 interacting protein
chr3_-_100969644 2.740 ENSMUST00000076941.5
 Ttf2
transcription termination factor, RNA polymerase II
chr3_+_159495408 2.729 ENSMUST00000120272.1
ENSMUST00000029825.7
ENSMUST00000106041.2
 Depdc1a


DEP domain containing 1a


chr5_+_30666886 2.570 ENSMUST00000144742.1
 Cenpa
centromere protein A
chr14_-_62456286 2.515 ENSMUST00000165651.1
ENSMUST00000022501.3
 Gucy1b2

guanylate cyclase 1, soluble, beta 2

chr11_+_119022962 2.309 ENSMUST00000026662.7
 Cbx2
chromobox 2
chr4_-_43499608 2.189 ENSMUST00000136005.1
ENSMUST00000054538.6
 Arhgef39

Rho guanine nucleotide exchange factor (GEF) 39

chr10_+_127705170 2.175 ENSMUST00000079590.5
 Myo1a
myosin IA
chr18_-_62756275 2.086 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr1_+_136467958 2.028 ENSMUST00000047817.6
 Kif14
kinesin family member 14
chr9_-_100506844 1.980 ENSMUST00000112874.3
 Nck1
non-catalytic region of tyrosine kinase adaptor protein 1
chr10_-_92164666 1.947 ENSMUST00000183123.1
ENSMUST00000182033.1
 Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr14_+_46832127 1.889 ENSMUST00000068532.8
 Cgrrf1
cell growth regulator with ring finger domain 1
chr19_+_37376359 1.889 ENSMUST00000012587.3
 Kif11
kinesin family member 11
chr15_+_57912199 1.779 ENSMUST00000022992.6
 Tbc1d31
TBC1 domain family, member 31
chr8_-_53638945 1.711 ENSMUST00000047768.4
 Neil3
nei like 3 (E. coli)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 138 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 5.1 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.3 3.8 GO:0035881 amacrine cell differentiation(GO:0035881)
0.3 3.6 GO:0009404 toxin metabolic process(GO:0009404)
0.2 3.6 GO:0071459 protein localization to chromosome, centromeric region(GO:0071459)
0.1 3.6 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.4 3.5 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.6 3.2 GO:0042891 antibiotic transport(GO:0042891) dipeptide transport(GO:0042938)
0.1 2.7 GO:0006353 DNA-templated transcription, termination(GO:0006353)
0.3 2.6 GO:0071763 nuclear membrane organization(GO:0071763)
0.1 2.5 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.1 2.2 GO:0030033 microvillus assembly(GO:0030033)
0.7 2.0 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.5 2.0 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.0 2.0 GO:0030071 regulation of mitotic metaphase/anaphase transition(GO:0030071) regulation of metaphase/anaphase transition of cell cycle(GO:1902099)
0.2 1.9 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.0 1.7 GO:0006284 base-excision repair(GO:0006284)
0.0 1.6 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 1.5 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.3 1.4 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.2 1.3 GO:0034773 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.5 GO:0005871 kinesin complex(GO:0005871)
0.0 4.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 3.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 3.5 GO:0030667 secretory granule membrane(GO:0030667)
0.8 3.0 GO:0000939 condensed chromosome inner kinetochore(GO:0000939)
0.0 2.4 GO:0016459 myosin complex(GO:0016459)
0.1 2.3 GO:0035102 PRC1 complex(GO:0035102)
0.0 2.2 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.2 2.0 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.2 2.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 1.6 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.4 GO:0005902 microvillus(GO:0005902)
0.1 1.2 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 1.2 GO:0051233 spindle midzone(GO:0051233)
0.0 1.2 GO:0097546 ciliary base(GO:0097546)
0.4 1.1 GO:0071914 prominosome(GO:0071914)
0.0 1.1 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 0.9 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.3 0.8 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.1 0.8 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.2 GO:0051015 actin filament binding(GO:0051015)
0.3 4.9 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 4.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 3.7 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
1.2 3.6 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.2 3.6 GO:0004383 guanylate cyclase activity(GO:0004383)
1.1 3.2 GO:0042936 dipeptide transporter activity(GO:0042936)
0.0 2.8 GO:0004386 helicase activity(GO:0004386)
0.0 2.7 GO:0035064 methylated histone binding(GO:0035064)
0.1 2.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.3 2.0 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.1 1.9 GO:0005521 lamin binding(GO:0005521)
0.3 1.8 GO:0030284 estrogen receptor activity(GO:0030284)
0.3 1.7 GO:0000405 bubble DNA binding(GO:0000405)
0.1 1.5 GO:0001222 transcription corepressor binding(GO:0001222)
0.4 1.2 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.2 1.2 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 1.2 GO:0019003 GDP binding(GO:0019003)
0.3 1.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 1.1 GO:0042805 actinin binding(GO:0042805)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 4.2 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 3.5 PID_MYC_PATHWAY C-MYC pathway
0.0 1.6 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.3 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 0.8 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.8 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.5 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.5 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.2 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.1 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.0 REACTOME_KINESINS Genes involved in Kinesins
0.1 4.8 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 3.6 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 2.3 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 1.4 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.2 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.8 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 0.8 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.7 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 0.6 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.6 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.5 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.5 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.5 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.5 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.4 REACTOME_DOWNSTREAM_TCR_SIGNALING Genes involved in Downstream TCR signaling
0.0 0.4 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.3 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.3 REACTOME_DOUBLE_STRAND_BREAK_REPAIR Genes involved in Double-Strand Break Repair