Motif ID: Foxl1

Z-value: 0.479


Transcription factors associated with Foxl1:

Gene SymbolEntrez IDGene Name
Foxl1 ENSMUSG00000097084.1 Foxl1
Foxl1 ENSMUSG00000043867.5 Foxl1



Activity profile for motif Foxl1.

activity profile for motif Foxl1


Sorted Z-values histogram for motif Foxl1

Sorted Z-values for motif Foxl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxl1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_102490418 2.421 ENSMUST00000020040.3
 Nts
neurotensin
chr7_+_122289297 1.576 ENSMUST00000064989.5
ENSMUST00000064921.4
 Prkcb

protein kinase C, beta

chr13_-_23622502 1.568 ENSMUST00000062045.2
 Hist1h1e
histone cluster 1, H1e
chr10_+_26229707 1.369 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr2_+_119325784 1.204 ENSMUST00000102517.3
 Dll4
delta-like 4 (Drosophila)
chr13_+_23763660 1.170 ENSMUST00000055770.1
 Hist1h1a
histone cluster 1, H1a
chr4_+_11191726 1.147 ENSMUST00000029866.9
ENSMUST00000108324.3
 Ccne2

cyclin E2

chr6_-_147264124 1.123 ENSMUST00000052296.6
 Pthlh
parathyroid hormone-like peptide
chr1_-_172057573 1.068 ENSMUST00000059794.3
 Nhlh1
nescient helix loop helix 1
chr6_-_23248264 1.047 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr17_-_91092715 0.690 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
 Nrxn1


neurexin I


chr18_-_25753852 0.647 ENSMUST00000025117.6
ENSMUST00000115816.2
 Celf4

CUGBP, Elav-like family member 4

chrX_+_112604274 0.641 ENSMUST00000071814.6
 Zfp711
zinc finger protein 711
chrM_+_2743 0.628 ENSMUST00000082392.1
 mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr2_-_59948155 0.598 ENSMUST00000153136.1
 Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr16_+_43508118 0.548 ENSMUST00000114690.1
 Zbtb20
zinc finger and BTB domain containing 20
chr13_+_23575753 0.489 ENSMUST00000105105.1
 Hist1h3d
histone cluster 1, H3d
chr2_-_94264713 0.474 ENSMUST00000129661.1
 E530001K10Rik
RIKEN cDNA E530001K10 gene
chr13_+_23555023 0.454 ENSMUST00000045301.6
 Hist1h1d
histone cluster 1, H1d
chrX_+_18162575 0.376 ENSMUST00000044484.6
ENSMUST00000052368.8
 Kdm6a

lysine (K)-specific demethylase 6A

chr2_+_18055203 0.350 ENSMUST00000028076.8
 Mllt10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr15_+_43477213 0.334 ENSMUST00000022962.6
 Emc2
ER membrane protein complex subunit 2
chr16_+_45093611 0.327 ENSMUST00000099498.2
 Ccdc80
coiled-coil domain containing 80
chr18_+_34409415 0.318 ENSMUST00000166156.1
ENSMUST00000014647.7
 Pkd2l2

polycystic kidney disease 2-like 2

chr2_-_94264745 0.317 ENSMUST00000134563.1
 E530001K10Rik
RIKEN cDNA E530001K10 gene
chr1_-_170110491 0.316 ENSMUST00000027985.2
 Ddr2
discoidin domain receptor family, member 2
chr17_+_40811089 0.314 ENSMUST00000024721.7
 Rhag
Rhesus blood group-associated A glycoprotein
chr9_-_101198999 0.288 ENSMUST00000066773.7
 Ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr2_-_147186389 0.288 ENSMUST00000109970.3
ENSMUST00000067075.5
 Nkx2-2

NK2 homeobox 2

chr9_+_71215779 0.254 ENSMUST00000034723.5
 Aldh1a2
aldehyde dehydrogenase family 1, subfamily A2
chr2_+_91255954 0.227 ENSMUST00000134699.1
 Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr9_+_44069421 0.217 ENSMUST00000114830.2
 Usp2
ubiquitin specific peptidase 2
chr10_+_88091070 0.215 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chr18_-_15151427 0.203 ENSMUST00000025992.6
 Kctd1
potassium channel tetramerisation domain containing 1
chr11_+_31872100 0.203 ENSMUST00000020543.6
ENSMUST00000109412.2
 Cpeb4

cytoplasmic polyadenylation element binding protein 4

chr6_+_42286676 0.194 ENSMUST00000031894.6
 Clcn1
chloride channel 1
chrX_-_94123087 0.187 ENSMUST00000113925.1
 Zfx
zinc finger protein X-linked
chr2_+_91256144 0.161 ENSMUST00000154959.1
ENSMUST00000059566.4
 Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr12_+_69963452 0.120 ENSMUST00000110560.1
 Gm3086
predicted gene 3086
chr16_+_30065333 0.088 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr2_-_91255995 0.004 ENSMUST00000180732.1
 Gm17281
predicted gene, 17281

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0072554 blood vessel lumenization(GO:0072554) negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.3 1.6 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.2 1.7 GO:0016584 nucleosome positioning(GO:0016584)
0.2 1.1 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.2 1.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 0.7 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.1 0.6 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.1 0.3 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.1 0.3 GO:0007525 somatic muscle development(GO:0007525)
0.1 0.3 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 0.3 GO:0035799 ureter maturation(GO:0035799)
0.1 0.2 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.0 0.4 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.0 0.3 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.3 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 2.4 GO:0008542 visual learning(GO:0008542)
0.0 1.1 GO:0007129 synapsis(GO:0007129)
0.0 0.1 GO:0021557 oculomotor nerve development(GO:0021557) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.0 0.6 GO:0033194 response to hydroperoxide(GO:0033194)
0.0 0.2 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.2 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.4 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.5 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 1.2 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.2 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.1 0.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 2.1 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.3 GO:0000786 nucleosome(GO:0000786)
0.0 0.4 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.3 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 1.6 GO:0031526 brush border membrane(GO:0031526)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 2.4 GO:0043679 axon terminus(GO:0043679)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0035184 histone threonine kinase activity(GO:0035184)
0.2 1.6 GO:0032564 dATP binding(GO:0032564)
0.1 2.4 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 1.1 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 0.7 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 0.4 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 0.3 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 0.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 1.2 GO:0005112 Notch binding(GO:0005112)
0.0 1.1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.4 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.2 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.3 GO:0022842 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
0.0 0.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.3 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.6 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.2 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 1.1 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 1.6 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.1 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 2.3 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.2 PID_NOTCH_PATHWAY Notch signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.8 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 1.2 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 1.6 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 1.1 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 2.6 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.3 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 1.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.3 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.1 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development