Motif ID: Foxo3

Z-value: 0.774


Transcription factors associated with Foxo3:

Gene SymbolEntrez IDGene Name
Foxo3 ENSMUSG00000048756.5 Foxo3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo3mm10_v2_chr10_-_42276744_422767630.572.6e-04Click!


Activity profile for motif Foxo3.

activity profile for motif Foxo3


Sorted Z-values histogram for motif Foxo3

Sorted Z-values for motif Foxo3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_84773381 9.678 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr16_-_22439719 4.678 ENSMUST00000079601.6
Etv5
ets variant gene 5
chr14_-_51913393 4.117 ENSMUST00000004673.7
ENSMUST00000111632.3
Ndrg2

N-myc downstream regulated gene 2

chr7_-_103813913 3.582 ENSMUST00000098192.3
Hbb-bt
hemoglobin, beta adult t chain
chr16_-_43979050 3.434 ENSMUST00000165648.1
ENSMUST00000036321.7
Zdhhc23

zinc finger, DHHC domain containing 23

chr11_+_3332426 3.158 ENSMUST00000136474.1
Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr11_-_101785252 3.045 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr10_+_112271123 3.034 ENSMUST00000092175.2
Kcnc2
potassium voltage gated channel, Shaw-related subfamily, member 2
chr6_+_55836878 2.477 ENSMUST00000044729.6
Ccdc129
coiled-coil domain containing 129
chr7_+_141476374 2.440 ENSMUST00000117634.1
Tspan4
tetraspanin 4
chr5_+_66968416 2.295 ENSMUST00000038188.7
Limch1
LIM and calponin homology domains 1
chr2_-_120245157 2.265 ENSMUST00000090071.4
Pla2g4e
phospholipase A2, group IVE
chr5_+_66968559 2.222 ENSMUST00000127184.1
Limch1
LIM and calponin homology domains 1
chr4_-_116405986 2.213 ENSMUST00000123072.1
ENSMUST00000144281.1
Mast2

microtubule associated serine/threonine kinase 2

chr10_+_40349265 2.083 ENSMUST00000044672.4
ENSMUST00000095743.2
Cdk19

cyclin-dependent kinase 19

chr3_-_145649970 1.896 ENSMUST00000029846.3
Cyr61
cysteine rich protein 61
chr2_-_51972990 1.876 ENSMUST00000145481.1
ENSMUST00000112705.2
Nmi

N-myc (and STAT) interactor

chr5_+_65131184 1.729 ENSMUST00000031089.5
ENSMUST00000101191.3
Klhl5

kelch-like 5

chr17_+_43389436 1.715 ENSMUST00000113599.1
Gpr116
G protein-coupled receptor 116
chr7_+_82175156 1.692 ENSMUST00000180243.1
Sh3gl3
SH3-domain GRB2-like 3
chr3_+_53488677 1.686 ENSMUST00000029307.3
Stoml3
stomatin (Epb7.2)-like 3
chr3_+_63295815 1.630 ENSMUST00000029400.1
Mme
membrane metallo endopeptidase
chr14_-_121698417 1.623 ENSMUST00000040700.7
Dock9
dedicator of cytokinesis 9
chr4_-_87806296 1.587 ENSMUST00000126353.1
ENSMUST00000149357.1
Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr4_-_87806276 1.575 ENSMUST00000148059.1
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr7_-_90129339 1.562 ENSMUST00000181189.1
2310010J17Rik
RIKEN cDNA 2310010J17 gene
chr1_-_140183404 1.461 ENSMUST00000066859.6
ENSMUST00000111976.2
Cfh

complement component factor h

chr2_-_51973219 1.398 ENSMUST00000028314.2
Nmi
N-myc (and STAT) interactor
chr16_+_93683184 1.393 ENSMUST00000039620.6
Cbr3
carbonyl reductase 3
chr11_+_19924403 1.365 ENSMUST00000093298.5
Spred2
sprouty-related, EVH1 domain containing 2
chr10_-_93310963 1.290 ENSMUST00000151153.1
Elk3
ELK3, member of ETS oncogene family
chr4_+_94739276 1.278 ENSMUST00000073939.6
ENSMUST00000102798.1
Tek

endothelial-specific receptor tyrosine kinase

chr14_-_57133585 1.274 ENSMUST00000039380.8
Gjb6
gap junction protein, beta 6
chrX_+_159697308 1.220 ENSMUST00000123433.1
Sh3kbp1
SH3-domain kinase binding protein 1
chr11_-_60352869 1.210 ENSMUST00000095254.5
ENSMUST00000102683.4
ENSMUST00000093048.6
ENSMUST00000093046.6
ENSMUST00000064019.8
ENSMUST00000102682.4
Tom1l2





target of myb1-like 2 (chicken)





chr8_+_71568866 1.201 ENSMUST00000034267.4
Slc27a1
solute carrier family 27 (fatty acid transporter), member 1
chr1_+_36511867 1.197 ENSMUST00000001166.7
ENSMUST00000097776.3
Cnnm3

cyclin M3

chr2_+_4718145 1.154 ENSMUST00000056914.6
Bend7
BEN domain containing 7
chr18_-_74961252 1.092 ENSMUST00000066532.4
Lipg
lipase, endothelial
chr11_+_19924354 1.089 ENSMUST00000093299.6
Spred2
sprouty-related, EVH1 domain containing 2
chr12_-_84698769 1.065 ENSMUST00000095550.2
Syndig1l
synapse differentiation inducing 1 like
chr5_-_123140135 1.014 ENSMUST00000160099.1
AI480526
expressed sequence AI480526
chr3_-_146770218 1.012 ENSMUST00000106137.1
Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr1_-_140183283 0.942 ENSMUST00000111977.1
Cfh
complement component factor h
chr7_+_30291941 0.913 ENSMUST00000144508.1
Clip3
CAP-GLY domain containing linker protein 3
chr11_+_85353156 0.851 ENSMUST00000108061.1
ENSMUST00000108062.1
ENSMUST00000108056.1
ENSMUST00000138423.1
ENSMUST00000074875.4
ENSMUST00000092821.3
Bcas3





breast carcinoma amplified sequence 3





chr10_-_53647080 0.849 ENSMUST00000169866.1
Fam184a
family with sequence similarity 184, member A
chr7_-_109616548 0.792 ENSMUST00000077909.1
ENSMUST00000084738.3
St5

suppression of tumorigenicity 5

chr10_-_93311073 0.787 ENSMUST00000008542.5
Elk3
ELK3, member of ETS oncogene family
chrX_+_85574018 0.762 ENSMUST00000048250.3
ENSMUST00000137438.1
ENSMUST00000146063.1
Tab3


TGF-beta activated kinase 1/MAP3K7 binding protein 3


chr18_+_37513652 0.739 ENSMUST00000061405.4
Pcdhb21
protocadherin beta 21
chr1_+_75142775 0.735 ENSMUST00000097694.4
Fam134a
family with sequence similarity 134, member A
chr7_+_30291659 0.716 ENSMUST00000014065.8
ENSMUST00000150892.1
ENSMUST00000126216.1
Clip3


CAP-GLY domain containing linker protein 3


chr3_+_84925476 0.678 ENSMUST00000107675.1
Fbxw7
F-box and WD-40 domain protein 7
chr19_-_42086338 0.674 ENSMUST00000051772.8
Morn4
MORN repeat containing 4
chr17_+_40811089 0.642 ENSMUST00000024721.7
Rhag
Rhesus blood group-associated A glycoprotein
chr1_+_12718496 0.640 ENSMUST00000088585.3
Sulf1
sulfatase 1
chr6_-_83831736 0.638 ENSMUST00000058383.8
Paip2b
poly(A) binding protein interacting protein 2B
chr17_+_24840108 0.595 ENSMUST00000164251.1
Hagh
hydroxyacyl glutathione hydrolase
chr2_+_3513035 0.582 ENSMUST00000036350.2
Cdnf
cerebral dopamine neurotrophic factor
chr7_+_130692532 0.548 ENSMUST00000033141.6
Tacc2
transforming, acidic coiled-coil containing protein 2
chr15_+_79347534 0.544 ENSMUST00000096350.3
Maff
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)
chr4_-_155345696 0.542 ENSMUST00000103178.4
Prkcz
protein kinase C, zeta
chr18_-_62756275 0.534 ENSMUST00000067450.1
ENSMUST00000048109.5
2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr18_-_39489776 0.522 ENSMUST00000025300.6
Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr9_+_114731177 0.520 ENSMUST00000035007.8
Cmtm6
CKLF-like MARVEL transmembrane domain containing 6
chr7_+_24907618 0.497 ENSMUST00000151121.1
Arhgef1
Rho guanine nucleotide exchange factor (GEF) 1
chr8_-_64205970 0.494 ENSMUST00000066166.4
Tll1
tolloid-like
chr11_-_68386974 0.470 ENSMUST00000135141.1
Ntn1
netrin 1
chr10_+_128303322 0.464 ENSMUST00000005825.6
Pan2
PAN2 polyA specific ribonuclease subunit homolog (S. cerevisiae)
chr2_-_104493690 0.464 ENSMUST00000111124.1
Hipk3
homeodomain interacting protein kinase 3
chr10_+_97565436 0.450 ENSMUST00000038160.4
Lum
lumican
chr8_-_41016295 0.412 ENSMUST00000131965.1
Mtus1
mitochondrial tumor suppressor 1
chr7_-_65371210 0.402 ENSMUST00000102592.3
Tjp1
tight junction protein 1
chr14_+_30879257 0.387 ENSMUST00000040715.6
Mustn1
musculoskeletal, embryonic nuclear protein 1
chr8_-_41016749 0.380 ENSMUST00000117735.1
Mtus1
mitochondrial tumor suppressor 1
chr8_-_122476036 0.349 ENSMUST00000014614.3
Rnf166
ring finger protein 166
chr3_+_5218516 0.348 ENSMUST00000175866.1
Zfhx4
zinc finger homeodomain 4
chr2_-_91710519 0.336 ENSMUST00000028678.8
ENSMUST00000076803.5
Atg13

autophagy related 13

chr11_-_26591729 0.316 ENSMUST00000109504.1
Vrk2
vaccinia related kinase 2
chr4_-_134915010 0.304 ENSMUST00000105863.1
ENSMUST00000030626.5
Tmem50a

transmembrane protein 50A

chr3_+_5218589 0.291 ENSMUST00000177488.1
Zfhx4
zinc finger homeodomain 4
chr3_+_5218546 0.272 ENSMUST00000026284.6
Zfhx4
zinc finger homeodomain 4
chr12_-_85270564 0.238 ENSMUST00000019378.6
ENSMUST00000166821.1
Mlh3

mutL homolog 3 (E coli)

chr8_-_25785154 0.228 ENSMUST00000038498.8
Bag4
BCL2-associated athanogene 4
chr15_-_89379246 0.223 ENSMUST00000049968.7
Odf3b
outer dense fiber of sperm tails 3B
chr2_-_7081256 0.212 ENSMUST00000183209.1
Celf2
CUGBP, Elav-like family member 2
chr5_-_137531204 0.210 ENSMUST00000150063.2
Gnb2
guanine nucleotide binding protein (G protein), beta 2
chrX_+_7878298 0.188 ENSMUST00000033495.8
Pim2
proviral integration site 2
chr1_+_17601893 0.186 ENSMUST00000088476.2
Pi15
peptidase inhibitor 15
chr6_-_39725193 0.183 ENSMUST00000101497.3
Braf
Braf transforming gene
chr11_-_68386821 0.154 ENSMUST00000021284.3
Ntn1
netrin 1
chr9_-_108649349 0.147 ENSMUST00000013338.8
Arih2
ariadne homolog 2 (Drosophila)
chr15_+_79348061 0.143 ENSMUST00000163691.1
Maff
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)
chr18_-_39489880 0.121 ENSMUST00000152853.1
Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr19_-_19111181 0.119 ENSMUST00000112832.1
Rorb
RAR-related orphan receptor beta
chr1_-_75142360 0.113 ENSMUST00000041213.5
Cnppd1
cyclin Pas1/PHO80 domain containing 1
chr10_+_96616998 0.089 ENSMUST00000038377.7
Btg1
B cell translocation gene 1, anti-proliferative
chr10_-_5069044 0.080 ENSMUST00000095899.3
Syne1
spectrin repeat containing, nuclear envelope 1
chr6_+_125009665 0.048 ENSMUST00000046064.10
ENSMUST00000152752.1
ENSMUST00000088308.3
ENSMUST00000112425.1
ENSMUST00000084275.5
Zfp384




zinc finger protein 384




chr13_+_60602182 0.040 ENSMUST00000044083.7
Dapk1
death associated protein kinase 1
chr18_-_66022580 0.031 ENSMUST00000143990.1
Lman1
lectin, mannose-binding, 1
chr2_+_136713444 0.031 ENSMUST00000028727.4
ENSMUST00000110098.3
Snap25

synaptosomal-associated protein 25

chr11_-_48946148 0.029 ENSMUST00000104958.1
Psme2b
protease (prosome, macropain) activator subunit 2B
chr2_-_164389095 0.024 ENSMUST00000167427.1
Slpi
secretory leukocyte peptidase inhibitor
chr5_-_151190154 0.014 ENSMUST00000062015.8
ENSMUST00000110483.2
Stard13

StAR-related lipid transfer (START) domain containing 13

chr2_-_148046896 0.013 ENSMUST00000172928.1
ENSMUST00000047315.3
Foxa2

forkhead box A2

chr1_-_163403627 0.006 ENSMUST00000045138.4
Gorab
golgin, RAB6-interacting

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 7.7 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
1.1 3.3 GO:1902524 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.5 1.6 GO:0071492 cellular response to UV-A(GO:0071492)
0.5 9.7 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.5 3.2 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.4 1.3 GO:0048014 Tie signaling pathway(GO:0048014)
0.4 2.4 GO:0045919 complement activation, alternative pathway(GO:0006957) positive regulation of cytolysis(GO:0045919)
0.4 1.9 GO:0060591 chondroblast differentiation(GO:0060591)
0.4 1.1 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.3 1.2 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.3 2.2 GO:0045075 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.3 3.0 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.2 0.6 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.2 1.6 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.2 3.2 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.2 4.8 GO:0010574 regulation of vascular endothelial growth factor production(GO:0010574)
0.2 2.5 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.2 0.3 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.2 2.0 GO:0042182 ketone catabolic process(GO:0042182)
0.1 0.7 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.1 0.5 GO:2000551 positive regulation of T-helper 2 cell differentiation(GO:0045630) regulation of T-helper 2 cell cytokine production(GO:2000551) positive regulation of T-helper 2 cell cytokine production(GO:2000553)
0.1 1.7 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.1 0.6 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.1 0.5 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.1 1.0 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.1 2.2 GO:0018345 protein palmitoylation(GO:0018345)
0.1 0.6 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.1 0.4 GO:1902732 positive regulation of chondrocyte proliferation(GO:1902732)
0.1 2.3 GO:0009395 phospholipid catabolic process(GO:0009395)
0.1 0.2 GO:0090365 regulation of mRNA modification(GO:0090365)
0.1 0.9 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.6 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.4 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.6 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.2 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.8 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 0.2 GO:0007144 female meiosis I(GO:0007144)
0.0 2.1 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.0 0.5 GO:0030953 astral microtubule organization(GO:0030953)
0.0 0.5 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.5 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291)
0.0 4.5 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 1.2 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.0 0.1 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.1 GO:0046549 retinal cone cell development(GO:0046549)
0.0 0.1 GO:0090292 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.7 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.0 0.3 GO:0098780 response to mitochondrial depolarisation(GO:0098780)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.6 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 0.7 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.2 0.5 GO:0031251 PAN complex(GO:0031251)
0.1 1.3 GO:0005922 connexon complex(GO:0005922)
0.1 0.5 GO:0045179 apical cortex(GO:0045179)
0.1 1.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 3.0 GO:0030673 axolemma(GO:0030673)
0.1 0.7 GO:0032426 stereocilium tip(GO:0032426)
0.1 3.2 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 0.9 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 1.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.4 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.5 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.3 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.1 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.2 GO:0032300 mismatch repair complex(GO:0032300)
0.0 2.4 GO:0072562 blood microparticle(GO:0072562)
0.0 1.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.3 GO:0009925 basal plasma membrane(GO:0009925)
0.0 1.2 GO:0030139 endocytic vesicle(GO:0030139)
0.0 1.2 GO:0005901 caveola(GO:0005901)
0.0 2.8 GO:0005769 early endosome(GO:0005769)
0.0 2.4 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 1.5 GO:0005903 brush border(GO:0005903)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.9 3.6 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.6 2.4 GO:0001851 complement component C3b binding(GO:0001851)
0.5 2.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.5 1.4 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.4 2.5 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.3 0.9 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.3 1.1 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.3 1.6 GO:0097001 ceramide binding(GO:0097001)
0.2 3.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.2 0.6 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 0.7 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 0.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 2.3 GO:0004623 phospholipase A2 activity(GO:0004623)
0.1 1.2 GO:0031957 fatty acid transporter activity(GO:0015245) very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 1.0 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 1.9 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 2.2 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 0.6 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.1 0.2 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 0.6 GO:0022842 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
0.0 2.1 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.4 GO:0071253 connexin binding(GO:0071253)
0.0 0.6 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.1 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 2.4 GO:0003823 antigen binding(GO:0003823)
0.0 0.5 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 2.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 12.1 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.5 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 2.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.3 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 1.2 GO:0030276 clathrin binding(GO:0030276)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.7 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 1.9 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 4.1 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.0 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 2.5 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.5 PID_IGF1_PATHWAY IGF1 pathway
0.0 1.6 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.3 PID_SHP2_PATHWAY SHP2 signaling
0.0 1.2 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.7 PID_MYC_PATHWAY C-MYC pathway
0.0 1.4 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.2 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.4 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.6 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 0.5 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.4 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.1 1.3 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.1 0.8 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 3.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 0.6 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 0.4 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.5 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 1.0 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.6 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.6 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 1.2 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.6 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 1.2 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.5 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 2.3 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.9 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.7 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.2 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling