Motif ID: Foxo4

Z-value: 0.718


Transcription factors associated with Foxo4:

Gene SymbolEntrez IDGene Name
Foxo4 ENSMUSG00000042903.7 Foxo4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo4mm10_v2_chrX_+_101254528_1012545740.677.1e-06Click!


Activity profile for motif Foxo4.

activity profile for motif Foxo4


Sorted Z-values histogram for motif Foxo4

Sorted Z-values for motif Foxo4



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_181767283 2.896 ENSMUST00000108757.2
 Myt1
myelin transcription factor 1
chr4_-_97778042 2.855 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr2_+_181767040 2.741 ENSMUST00000108756.1
 Myt1
myelin transcription factor 1
chr4_+_8690399 2.558 ENSMUST00000127476.1
 Chd7
chromodomain helicase DNA binding protein 7
chr17_-_51831884 2.235 ENSMUST00000124222.1
 Satb1
special AT-rich sequence binding protein 1
chr4_-_32950813 2.091 ENSMUST00000084750.1
ENSMUST00000084748.2
 Ankrd6

ankyrin repeat domain 6

chr17_+_78508063 1.971 ENSMUST00000024880.9
 Vit
vitrin
chr4_+_97777606 1.807 ENSMUST00000075448.6
ENSMUST00000092532.6
 Nfia

nuclear factor I/A

chr2_-_175931051 1.781 ENSMUST00000108949.2
ENSMUST00000109018.2
 Gm8898

predicted gene 8898

chr19_-_5796924 1.625 ENSMUST00000174808.1
 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr17_+_80944611 1.539 ENSMUST00000025092.4
 Tmem178
transmembrane protein 178
chr2_+_176521056 1.499 ENSMUST00000108997.2
ENSMUST00000178443.1
 Gm14431

predicted gene 14431

chr1_+_6487231 1.493 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr2_-_175338197 1.488 ENSMUST00000121393.2
 Gm4631
predicted gene 4631
chr14_-_98169542 1.466 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr2_+_175469985 1.401 ENSMUST00000109042.3
ENSMUST00000109002.2
ENSMUST00000109043.2
ENSMUST00000143490.1
 Gm8923



predicted gene 8923



chr7_-_103813913 1.378 ENSMUST00000098192.3
 Hbb-bt
hemoglobin, beta adult t chain
chr2_-_175703646 1.314 ENSMUST00000109027.2
ENSMUST00000179061.1
ENSMUST00000131041.1
 Gm4245


predicted gene 4245


chr2_+_175372436 1.290 ENSMUST00000131676.1
ENSMUST00000109048.2
ENSMUST00000109047.2
 Gm4723


predicted gene 4723


chr2_-_175141999 1.266 ENSMUST00000109062.1
ENSMUST00000109059.1
ENSMUST00000109060.1
 Gm14399


predicted gene 14399


chr2_+_178023284 1.138 ENSMUST00000108925.3
ENSMUST00000108926.2
 Etohi1

ethanol induced 1

chr2_+_176670522 1.125 ENSMUST00000121956.1
ENSMUST00000108985.2
 Gm14306

predicted gene 14306

chr2_-_177957239 1.114 ENSMUST00000108928.1
ENSMUST00000108932.1
ENSMUST00000108930.2
 Gm14326


predicted gene 14326


chr14_+_32028989 1.059 ENSMUST00000022460.4
 Galnt15
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
chr11_-_77078404 1.027 ENSMUST00000102494.1
 Ccdc55
coiled-coil domain containing 55
chr11_-_102579461 0.996 ENSMUST00000107081.1
 Gm11627
predicted gene 11627
chr2_-_177840318 0.946 ENSMUST00000108939.2
ENSMUST00000150650.1
 Gm14325

predicted gene 14325

chr6_+_56714891 0.929 ENSMUST00000031805.8
 Avl9
AVL9 homolog (S. cerevisiase)
chr2_+_176226569 0.837 ENSMUST00000099009.2
ENSMUST00000136719.1
 2210418O10Rik

RIKEN cDNA 2210418O10 gene

chr2_+_175965331 0.793 ENSMUST00000109007.1
ENSMUST00000174416.1
 Gm2026

predicted gene 2026

chr2_-_176927809 0.721 ENSMUST00000099007.2
 Gm14296
predicted gene 14296
chr6_+_42286676 0.718 ENSMUST00000031894.6
 Clcn1
chloride channel 1
chr8_-_47352348 0.673 ENSMUST00000110367.2
 Stox2
storkhead box 2
chr8_+_79639618 0.659 ENSMUST00000173078.1
ENSMUST00000173286.1
 Otud4

OTU domain containing 4

chr7_-_4778141 0.658 ENSMUST00000094892.5
 Il11
interleukin 11
chr3_+_107895916 0.656 ENSMUST00000172247.1
ENSMUST00000167387.1
 Gstm5

glutathione S-transferase, mu 5

chr2_-_178078425 0.652 ENSMUST00000108924.2
ENSMUST00000131702.1
ENSMUST00000108923.1
 Zfp931


zinc finger protein 931


chr18_-_38918642 0.633 ENSMUST00000040647.4
 Fgf1
fibroblast growth factor 1
chr7_-_27355944 0.632 ENSMUST00000003857.6
 Shkbp1
Sh3kbp1 binding protein 1
chr2_-_175206899 0.621 ENSMUST00000109055.1
ENSMUST00000099028.3
ENSMUST00000109056.1
ENSMUST00000109058.2
 Gm14391



predicted gene 14391



chr5_-_70842617 0.620 ENSMUST00000031119.1
 Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr2_+_176708328 0.599 ENSMUST00000108981.2
ENSMUST00000108980.2
 Gm14305

predicted gene 14305

chr8_+_26119361 0.591 ENSMUST00000014022.8
ENSMUST00000153528.1
ENSMUST00000131138.1
ENSMUST00000110575.1
 Rnf170



ring finger protein 170



chr9_+_109096659 0.549 ENSMUST00000130366.1
 Plxnb1
plexin B1
chr11_-_102365111 0.542 ENSMUST00000006749.9
 Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr2_-_176636318 0.539 ENSMUST00000108990.2
ENSMUST00000119149.1
ENSMUST00000117267.1
 Gm14308


predicted gene 14308


chr2_-_175435782 0.526 ENSMUST00000152941.1
ENSMUST00000109045.2
 Gm4724

predicted gene 4724

chr2_+_177000956 0.526 ENSMUST00000108975.2
ENSMUST00000156844.1
 Gm14419

predicted gene 14419

chr9_+_57076395 0.521 ENSMUST00000168177.1
 Sin3a
transcriptional regulator, SIN3A (yeast)
chr2_+_176798612 0.500 ENSMUST00000118012.2
 Gm14295
predicted gene 14295
chr2_+_175869219 0.482 ENSMUST00000109011.1
 Gm6710
predicted gene 6710
chr2_-_176486773 0.478 ENSMUST00000120959.1
ENSMUST00000120521.1
 Gm14434

predicted gene 14434

chr2_-_177206421 0.461 ENSMUST00000108964.1
 Gm14410
predicted gene 14410
chr15_-_102625436 0.452 ENSMUST00000184485.1
ENSMUST00000185070.1
ENSMUST00000184616.1
ENSMUST00000108828.2
 ATF7



Cyclic AMP-dependent transcription factor ATF-7



chr15_-_97767798 0.450 ENSMUST00000129223.2
ENSMUST00000126854.2
ENSMUST00000135080.1
 Rapgef3


Rap guanine nucleotide exchange factor (GEF) 3


chr16_-_64771146 0.395 ENSMUST00000076991.6
 4930453N24Rik
RIKEN cDNA 4930453N24 gene
chr6_+_42286709 0.379 ENSMUST00000163936.1
 Clcn1
chloride channel 1
chr9_+_57076343 0.345 ENSMUST00000168678.1
 Sin3a
transcriptional regulator, SIN3A (yeast)
chr7_-_133123770 0.341 ENSMUST00000164896.1
ENSMUST00000171968.1
 Ctbp2

C-terminal binding protein 2

chr18_-_6490808 0.340 ENSMUST00000028100.6
ENSMUST00000050542.5
 Epc1

enhancer of polycomb homolog 1 (Drosophila)

chr4_-_6454262 0.314 ENSMUST00000029910.5
 Nsmaf
neutral sphingomyelinase (N-SMase) activation associated factor
chrX_-_134600976 0.313 ENSMUST00000033621.6
 Gla
galactosidase, alpha
chr8_-_45410539 0.301 ENSMUST00000034056.4
ENSMUST00000167106.1
 Tlr3

toll-like receptor 3

chr9_-_119322421 0.264 ENSMUST00000040853.4
 Oxsr1
oxidative-stress responsive 1
chr14_-_25903100 0.254 ENSMUST00000052286.8
 Plac9a
placenta specific 9a
chr19_-_50030735 0.251 ENSMUST00000071866.1
 Rpl13a-ps1
ribosomal protein 13A, pseudogene 1
chr12_+_75308308 0.247 ENSMUST00000118602.1
ENSMUST00000118966.1
ENSMUST00000055390.5
 Rhoj


ras homolog gene family, member J


chr17_-_23745829 0.247 ENSMUST00000046525.8
 Kremen2
kringle containing transmembrane protein 2
chr14_-_32085595 0.238 ENSMUST00000022461.4
ENSMUST00000067955.5
ENSMUST00000124303.1
ENSMUST00000112000.1
 Dph3



diphthamine biosynthesis 3



chr11_+_3290300 0.227 ENSMUST00000057089.6
ENSMUST00000093402.5
 Patz1

POZ (BTB) and AT hook containing zinc finger 1

chr14_-_26182480 0.206 ENSMUST00000184142.1
 Plac9b
placenta specific 9b
chr10_-_40257648 0.206 ENSMUST00000019982.7
 Gtf3c6
general transcription factor IIIC, polypeptide 6, alpha
chr15_-_102625061 0.202 ENSMUST00000184077.1
ENSMUST00000184906.1
ENSMUST00000169033.1
 ATF7


Cyclic AMP-dependent transcription factor ATF-7


chr7_-_89517576 0.189 ENSMUST00000041761.5
 Prss23
protease, serine, 23
chr11_+_101246960 0.175 ENSMUST00000107282.3
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr2_-_144011202 0.171 ENSMUST00000016072.5
ENSMUST00000037875.5
 Rrbp1

ribosome binding protein 1

chr5_-_24445166 0.148 ENSMUST00000115043.1
ENSMUST00000115041.1
 Fastk

Fas-activated serine/threonine kinase

chr5_-_24445254 0.141 ENSMUST00000030800.6
 Fastk
Fas-activated serine/threonine kinase
chr15_-_35938009 0.098 ENSMUST00000156915.1
 Cox6c
cytochrome c oxidase subunit VIc
chr8_+_26119611 0.090 ENSMUST00000140819.1
 Rnf170
ring finger protein 170
chr12_-_69892989 0.090 ENSMUST00000110567.1
ENSMUST00000171211.1
 Map4k5

mitogen-activated protein kinase kinase kinase kinase 5

chr6_-_128424883 0.050 ENSMUST00000001559.8
 Itfg2
integrin alpha FG-GAP repeat containing 2
chrX_+_7579666 0.049 ENSMUST00000115740.1
ENSMUST00000115739.1
 Foxp3

forkhead box P3

chr1_+_171213969 0.043 ENSMUST00000005820.4
ENSMUST00000075469.5
ENSMUST00000155126.1
 Nr1i3


nuclear receptor subfamily 1, group I, member 3


chr5_-_90366176 0.041 ENSMUST00000014421.8
ENSMUST00000081914.6
ENSMUST00000168058.2
 Ankrd17


ankyrin repeat domain 17


chr15_-_102624922 0.029 ENSMUST00000183765.1
 ATF7
Cyclic AMP-dependent transcription factor ATF-7
chr12_+_69893105 0.026 ENSMUST00000021466.8
 Atl1
atlastin GTPase 1
chr7_+_3629985 0.007 ENSMUST00000008517.6
ENSMUST00000179769.1
 Prpf31

PRP31 pre-mRNA processing factor 31 homolog (yeast)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.5 5.6 GO:0060539 diaphragm development(GO:0060539)
0.5 1.5 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.3 1.6 GO:0035063 nuclear speck organization(GO:0035063)
0.3 0.9 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.2 0.6 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.1 0.5 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.1 2.2 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 2.1 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 1.5 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.1 1.8 GO:0072189 ureter development(GO:0072189)
0.1 0.5 GO:1904451 regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453)
0.1 1.1 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.3 GO:0045349 regulation of dendritic cell cytokine production(GO:0002730) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.1 0.7 GO:0070458 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.1 0.3 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.1 1.5 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.0 0.3 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.0 0.3 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.5 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.2 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0 0.7 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.2 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.3 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.0 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.0 0.0 GO:0032829 positive regulation of T cell anergy(GO:0002669) negative regulation of chronic inflammatory response(GO:0002677) negative regulation of T cell cytokine production(GO:0002725) positive regulation of lymphocyte anergy(GO:0002913) regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of immature T cell proliferation in thymus(GO:0033092) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.0 0.0 GO:0039533 regulation of MDA-5 signaling pathway(GO:0039533)
0.0 0.3 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 2.0 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.5 GO:0097574 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.1 0.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.9 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.2 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0 2.2 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.3 GO:0097470 ribbon synapse(GO:0097470)
0.0 1.2 GO:0072562 blood microparticle(GO:0072562)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.2 1.5 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.1 0.3 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.1 2.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.1 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 1.1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 0.5 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 0.3 GO:0016936 galactoside binding(GO:0016936)
0.0 0.6 GO:0044548 S100 protein binding(GO:0044548)
0.0 5.6 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 0.3 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.5 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.2 GO:0097643 amylin receptor activity(GO:0097643)
0.0 0.6 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.7 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 0.0 GO:0051525 NFAT protein binding(GO:0051525)
0.0 2.0 GO:0005539 glycosaminoglycan binding(GO:0005539)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.6 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 1.6 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 2.2 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.5 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.9 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 2.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 2.2 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.3 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.7 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.5 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.5 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling