Motif ID: Foxo4

Z-value: 0.718


Transcription factors associated with Foxo4:

Gene SymbolEntrez IDGene Name
Foxo4 ENSMUSG00000042903.7 Foxo4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo4mm10_v2_chrX_+_101254528_1012545740.677.1e-06Click!


Activity profile for motif Foxo4.

activity profile for motif Foxo4


Sorted Z-values histogram for motif Foxo4

Sorted Z-values for motif Foxo4



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo4

PNG image of the network

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Top targets:


Showing 1 to 20 of 88 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_181767283 2.896 ENSMUST00000108757.2
 Myt1
myelin transcription factor 1
chr4_-_97778042 2.855 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr2_+_181767040 2.741 ENSMUST00000108756.1
 Myt1
myelin transcription factor 1
chr4_+_8690399 2.558 ENSMUST00000127476.1
 Chd7
chromodomain helicase DNA binding protein 7
chr17_-_51831884 2.235 ENSMUST00000124222.1
 Satb1
special AT-rich sequence binding protein 1
chr4_-_32950813 2.091 ENSMUST00000084750.1
ENSMUST00000084748.2
 Ankrd6

ankyrin repeat domain 6

chr17_+_78508063 1.971 ENSMUST00000024880.9
 Vit
vitrin
chr4_+_97777606 1.807 ENSMUST00000075448.6
ENSMUST00000092532.6
 Nfia

nuclear factor I/A

chr2_-_175931051 1.781 ENSMUST00000108949.2
ENSMUST00000109018.2
 Gm8898

predicted gene 8898

chr19_-_5796924 1.625 ENSMUST00000174808.1
 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr17_+_80944611 1.539 ENSMUST00000025092.4
 Tmem178
transmembrane protein 178
chr2_+_176521056 1.499 ENSMUST00000108997.2
ENSMUST00000178443.1
 Gm14431

predicted gene 14431

chr1_+_6487231 1.493 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr2_-_175338197 1.488 ENSMUST00000121393.2
 Gm4631
predicted gene 4631
chr14_-_98169542 1.466 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr2_+_175469985 1.401 ENSMUST00000109042.3
ENSMUST00000109002.2
ENSMUST00000109043.2
ENSMUST00000143490.1
 Gm8923



predicted gene 8923



chr7_-_103813913 1.378 ENSMUST00000098192.3
 Hbb-bt
hemoglobin, beta adult t chain
chr2_-_175703646 1.314 ENSMUST00000109027.2
ENSMUST00000179061.1
ENSMUST00000131041.1
 Gm4245


predicted gene 4245


chr2_+_175372436 1.290 ENSMUST00000131676.1
ENSMUST00000109048.2
ENSMUST00000109047.2
 Gm4723


predicted gene 4723


chr2_-_175141999 1.266 ENSMUST00000109062.1
ENSMUST00000109059.1
ENSMUST00000109060.1
 Gm14399


predicted gene 14399



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 5.6 GO:0060539 diaphragm development(GO:0060539)
0.9 2.6 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.1 2.2 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 2.1 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 1.8 GO:0072189 ureter development(GO:0072189)
0.3 1.6 GO:0035063 nuclear speck organization(GO:0035063)
0.5 1.5 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.1 1.5 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.1 1.5 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.1 1.1 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.3 0.9 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.1 0.7 GO:0070458 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.0 0.7 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.2 0.6 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.1 0.5 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.1 0.5 GO:1904451 regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453)
0.0 0.5 GO:0015701 bicarbonate transport(GO:0015701)
0.1 0.3 GO:0045349 regulation of dendritic cell cytokine production(GO:0002730) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.1 0.3 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.0 0.3 GO:0046477 glycosylceramide catabolic process(GO:0046477)

Gene overrepresentation in cellular_component category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 GO:0005720 nuclear heterochromatin(GO:0005720)
0.1 2.0 GO:0005614 interstitial matrix(GO:0005614)
0.3 1.4 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 1.2 GO:0072562 blood microparticle(GO:0072562)
0.0 0.9 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 0.5 GO:0097574 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.1 0.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.3 GO:0097470 ribbon synapse(GO:0097470)
0.0 0.2 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0 0.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)

Gene overrepresentation in molecular_function category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.6 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 2.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 2.0 GO:0005539 glycosaminoglycan binding(GO:0005539)
0.2 1.5 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.3 1.4 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.1 1.1 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 1.1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.7 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 0.6 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.6 GO:0050811 GABA receptor binding(GO:0050811)
0.1 0.5 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.5 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 0.3 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.1 0.3 GO:0016936 galactoside binding(GO:0016936)
0.0 0.3 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.2 GO:0097643 amylin receptor activity(GO:0097643)
0.0 0.0 GO:0051525 NFAT protein binding(GO:0051525)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 2.2 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 2.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.6 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.9 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.5 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.7 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 0.6 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.5 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.5 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 0.3 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR