Motif ID: Foxo6

Z-value: 0.298


Transcription factors associated with Foxo6:

Gene SymbolEntrez IDGene Name
Foxo6 ENSMUSG00000052135.8 Foxo6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo6mm10_v2_chr4_-_120287349_1202873490.231.7e-01Click!


Activity profile for motif Foxo6.

activity profile for motif Foxo6


Sorted Z-values histogram for motif Foxo6

Sorted Z-values for motif Foxo6



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_88724667 0.573 ENSMUST00000163271.1
 Mgll
monoglyceride lipase
chr1_-_184883218 0.556 ENSMUST00000048308.5
 C130074G19Rik
RIKEN cDNA C130074G19 gene
chr10_-_93310963 0.478 ENSMUST00000151153.1
 Elk3
ELK3, member of ETS oncogene family
chr10_-_93311073 0.376 ENSMUST00000008542.5
 Elk3
ELK3, member of ETS oncogene family
chr4_+_102570065 0.334 ENSMUST00000097950.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr8_+_25911670 0.327 ENSMUST00000120653.1
ENSMUST00000126226.1
 Kcnu1

potassium channel, subfamily U, member 1

chr1_+_74391479 0.292 ENSMUST00000027367.7
 Ctdsp1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr16_+_10812915 0.287 ENSMUST00000115822.1
 Gm11172
predicted gene 11172
chr11_-_12027958 0.285 ENSMUST00000109654.1
 Grb10
growth factor receptor bound protein 10
chr1_-_180245927 0.253 ENSMUST00000010753.7
 Psen2
presenilin 2
chr4_+_134510999 0.219 ENSMUST00000105866.2
 Aunip
aurora kinase A and ninein interacting protein
chrX_-_163761323 0.199 ENSMUST00000059320.2
 Rnf138rt1
ring finger protein 138, retrogene 1
chr1_-_180245757 0.195 ENSMUST00000111104.1
 Psen2
presenilin 2
chr15_-_75111684 0.194 ENSMUST00000100542.3
 Ly6c2
lymphocyte antigen 6 complex, locus C2
chr12_-_102423741 0.188 ENSMUST00000110020.1
 Lgmn
legumain
chr9_-_22071345 0.181 ENSMUST00000179605.1
ENSMUST00000043922.6
 Zfp653

zinc finger protein 653

chr7_+_62476306 0.173 ENSMUST00000097132.3
 Atp5l-ps1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g, pseudogene 1
chr6_-_23248264 0.161 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr5_-_65391380 0.158 ENSMUST00000120094.1
ENSMUST00000118543.1
ENSMUST00000127874.1
 Rpl9


ribosomal protein L9


chr5_-_65391408 0.152 ENSMUST00000057885.6
 Rpl9
ribosomal protein L9
chr17_-_57839233 0.151 ENSMUST00000095218.3
 Rpl7a-ps5
ribosomal protein L7A, pseudogene 5
chr11_+_29463735 0.147 ENSMUST00000155854.1
 Ccdc88a
coiled coil domain containing 88A
chr5_+_110330697 0.144 ENSMUST00000112481.1
 Pole
polymerase (DNA directed), epsilon
chr18_-_60648290 0.143 ENSMUST00000143275.2
 Synpo
synaptopodin
chr5_-_117389029 0.140 ENSMUST00000111953.1
ENSMUST00000086461.6
 Rfc5

replication factor C (activator 1) 5

chr4_-_139131058 0.139 ENSMUST00000143971.1
 Minos1
mitochondrial inner membrane organizing system 1
chr12_-_98577940 0.138 ENSMUST00000110113.1
 Kcnk10
potassium channel, subfamily K, member 10
chr1_+_171270321 0.136 ENSMUST00000064272.3
ENSMUST00000141999.1
ENSMUST00000111313.3
 B4galt3


UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3


chr2_-_155357392 0.135 ENSMUST00000165234.1
ENSMUST00000077626.6
 Pigu

phosphatidylinositol glycan anchor biosynthesis, class U

chr3_-_51408925 0.134 ENSMUST00000038108.6
 Ndufc1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1
chrX_+_134585644 0.134 ENSMUST00000113211.1
 Rpl36a
ribosomal protein L36A
chr7_+_19368498 0.130 ENSMUST00000132655.1
 Ppp1r13l
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
chr8_+_46986913 0.126 ENSMUST00000039840.7
ENSMUST00000119686.1
 Enpp6

ectonucleotide pyrophosphatase/phosphodiesterase 6

chr11_+_85832551 0.122 ENSMUST00000000095.6
 Tbx2
T-box 2
chr10_+_79879614 0.121 ENSMUST00000006679.8
 Prtn3
proteinase 3
chr11_+_87853207 0.121 ENSMUST00000038196.6
 Mks1
Meckel syndrome, type 1
chr15_-_81843699 0.115 ENSMUST00000092020.2
 Gm8444
predicted gene 8444
chr14_+_34170640 0.114 ENSMUST00000104925.3
 Rpl23a-ps3
ribosomal protein L23A, pseudogene 3
chr17_-_24696147 0.112 ENSMUST00000046839.8
 Gfer
growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)
chr3_+_103968110 0.101 ENSMUST00000117150.1
ENSMUST00000063717.7
ENSMUST00000055425.8
ENSMUST00000123611.1
ENSMUST00000090685.4
 Phtf1




putative homeodomain transcription factor 1




chr3_-_106167564 0.099 ENSMUST00000063062.8
 Chi3l3
chitinase 3-like 3
chr2_+_120977017 0.097 ENSMUST00000067582.7
 Tmem62
transmembrane protein 62
chr2_-_30194112 0.097 ENSMUST00000113659.1
ENSMUST00000113660.1
 Ccbl1

cysteine conjugate-beta lyase 1

chr5_+_21186267 0.097 ENSMUST00000036031.8
 Gsap
gamma-secretase activating protein
chr19_-_45742873 0.096 ENSMUST00000026241.5
ENSMUST00000026240.7
ENSMUST00000111928.1
 Fgf8


fibroblast growth factor 8


chr19_+_8892987 0.087 ENSMUST00000096249.5
 Ints5
integrator complex subunit 5
chr2_+_129593195 0.081 ENSMUST00000099113.3
ENSMUST00000103202.3
 Sirpa

signal-regulatory protein alpha

chr7_+_28440927 0.081 ENSMUST00000078845.6
 Gmfg
glia maturation factor, gamma
chr5_+_115279666 0.080 ENSMUST00000040421.4
 Coq5
coenzyme Q5 homolog, methyltransferase (yeast)
chr5_+_115605642 0.079 ENSMUST00000094427.3
 Gcn1l1
GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
chr5_+_7179299 0.069 ENSMUST00000179460.1
 Tubb4b-ps1
tubulin, beta 4B class IVB, pseudogene 1
chr7_+_28808795 0.068 ENSMUST00000172529.1
 Hnrnpl
heterogeneous nuclear ribonucleoprotein L
chr7_+_143052739 0.066 ENSMUST00000037941.9
 Cd81
CD81 antigen
chr15_+_3270767 0.065 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr2_+_91650169 0.064 ENSMUST00000090614.4
 Arhgap1
Rho GTPase activating protein 1
chr12_-_84617326 0.064 ENSMUST00000021666.4
 Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chrX_-_8193387 0.063 ENSMUST00000143223.1
ENSMUST00000033509.8
 Ebp

phenylalkylamine Ca2+ antagonist (emopamil) binding protein

chr8_+_83566671 0.062 ENSMUST00000036996.5
 Ndufb7
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7
chrX_+_106920618 0.060 ENSMUST00000060576.7
 Lpar4
lysophosphatidic acid receptor 4
chr7_+_140881898 0.059 ENSMUST00000026560.7
 Psmd13
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr3_-_34351685 0.059 ENSMUST00000174114.1
 Gm20514
predicted gene 20514
chr4_+_62286441 0.057 ENSMUST00000084530.2
 Slc31a2
solute carrier family 31, member 2
chr14_-_50924626 0.054 ENSMUST00000160375.1
ENSMUST00000162177.1
ENSMUST00000159292.1
 Osgep


O-sialoglycoprotein endopeptidase


chr4_-_149099802 0.052 ENSMUST00000103217.4
 Pex14
peroxisomal biogenesis factor 14
chr2_+_129592914 0.050 ENSMUST00000103203.1
 Sirpa
signal-regulatory protein alpha
chr2_-_84425258 0.045 ENSMUST00000074262.2
 Calcrl
calcitonin receptor-like
chr5_+_65391497 0.043 ENSMUST00000031101.3
ENSMUST00000122026.1
 Lias

lipoic acid synthetase

chr11_-_89639631 0.034 ENSMUST00000128717.1
 Ankfn1
ankyrin-repeat and fibronectin type III domain containing 1
chr14_-_47418407 0.033 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr7_-_123369870 0.026 ENSMUST00000106442.2
ENSMUST00000098060.3
ENSMUST00000167309.1
 Arhgap17


Rho GTPase activating protein 17


chr18_-_31911903 0.025 ENSMUST00000054984.6
 Sft2d3
SFT2 domain containing 3
chr13_-_71963713 0.023 ENSMUST00000077337.8
 Irx1
Iroquois related homeobox 1 (Drosophila)
chr9_+_6168638 0.020 ENSMUST00000058692.7
 Pdgfd
platelet-derived growth factor, D polypeptide
chr8_+_36489191 0.019 ENSMUST00000171777.1
 6430573F11Rik
RIKEN cDNA 6430573F11 gene
chr12_-_113260217 0.017 ENSMUST00000178282.1
 Igha
immunoglobulin heavy constant alpha
chr5_-_99037035 0.015 ENSMUST00000031277.6
 Prkg2
protein kinase, cGMP-dependent, type II
chr12_-_91384403 0.001 ENSMUST00000141429.1
 Cep128
centrosomal protein 128
chr4_-_46196298 0.000 ENSMUST00000142380.1
ENSMUST00000058232.4
ENSMUST00000030013.5
 Xpa


xeroderma pigmentosum, complementation group A



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.0 0.1 GO:0045004 DNA replication proofreading(GO:0045004)
0.0 0.1 GO:0098886 modification of dendritic spine(GO:0098886)
0.0 0.2 GO:0006624 vacuolar protein processing(GO:0006624)
0.0 0.1 GO:0007521 muscle cell fate determination(GO:0007521) mammary placode formation(GO:0060596)
0.0 0.1 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
0.0 0.4 GO:0043589 skin morphogenesis(GO:0043589)
0.0 0.1 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0 0.3 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.1 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 0.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.3 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.1 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.1 GO:0016561 protein import into peroxisome matrix, translocation(GO:0016561)
0.0 0.1 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 0.1 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.0 GO:0009106 lipoate metabolic process(GO:0009106)
0.0 0.1 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.1 GO:0061009 common bile duct development(GO:0061009)
0.0 0.1 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.0 0.1 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0 0.1 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) negative regulation of vacuolar transport(GO:1903336)
0.0 0.1 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0 0.0 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.0 0.1 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 0.1 GO:0097421 liver regeneration(GO:0097421)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 GO:0043196 varicosity(GO:0043196)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.1 GO:0097444 spine apparatus(GO:0097444)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.4 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.1 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.0 0.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.1 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.1 GO:0097443 sorting endosome(GO:0097443)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 0.3 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.1 0.4 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.1 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.0 0.6 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.3 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.1 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 0.1 GO:0003945 N-acetyllactosamine synthase activity(GO:0003945)
0.0 0.1 GO:0034235 GPI anchor binding(GO:0034235)
0.0 0.1 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.0 0.1 GO:0061711 N(6)-L-threonylcarbamoyladenine synthase(GO:0061711)
0.0 0.1 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.0 GO:0016979 lipoate-protein ligase activity(GO:0016979)
0.0 0.1 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.1 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.6 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.2 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.1 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.3 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.3 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 0.1 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.1 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.1 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions