Motif ID: Foxo6

Z-value: 0.298


Transcription factors associated with Foxo6:

Gene SymbolEntrez IDGene Name
Foxo6 ENSMUSG00000052135.8 Foxo6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo6mm10_v2_chr4_-_120287349_1202873490.231.7e-01Click!


Activity profile for motif Foxo6.

activity profile for motif Foxo6


Sorted Z-values histogram for motif Foxo6

Sorted Z-values for motif Foxo6



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo6

PNG image of the network

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Top targets:


Showing 1 to 20 of 78 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_88724667 0.573 ENSMUST00000163271.1
 Mgll
monoglyceride lipase
chr1_-_184883218 0.556 ENSMUST00000048308.5
 C130074G19Rik
RIKEN cDNA C130074G19 gene
chr10_-_93310963 0.478 ENSMUST00000151153.1
 Elk3
ELK3, member of ETS oncogene family
chr10_-_93311073 0.376 ENSMUST00000008542.5
 Elk3
ELK3, member of ETS oncogene family
chr4_+_102570065 0.334 ENSMUST00000097950.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr8_+_25911670 0.327 ENSMUST00000120653.1
ENSMUST00000126226.1
 Kcnu1

potassium channel, subfamily U, member 1

chr1_+_74391479 0.292 ENSMUST00000027367.7
 Ctdsp1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr16_+_10812915 0.287 ENSMUST00000115822.1
 Gm11172
predicted gene 11172
chr11_-_12027958 0.285 ENSMUST00000109654.1
 Grb10
growth factor receptor bound protein 10
chr1_-_180245927 0.253 ENSMUST00000010753.7
 Psen2
presenilin 2
chr4_+_134510999 0.219 ENSMUST00000105866.2
 Aunip
aurora kinase A and ninein interacting protein
chrX_-_163761323 0.199 ENSMUST00000059320.2
 Rnf138rt1
ring finger protein 138, retrogene 1
chr1_-_180245757 0.195 ENSMUST00000111104.1
 Psen2
presenilin 2
chr15_-_75111684 0.194 ENSMUST00000100542.3
 Ly6c2
lymphocyte antigen 6 complex, locus C2
chr12_-_102423741 0.188 ENSMUST00000110020.1
 Lgmn
legumain
chr9_-_22071345 0.181 ENSMUST00000179605.1
ENSMUST00000043922.6
 Zfp653

zinc finger protein 653

chr7_+_62476306 0.173 ENSMUST00000097132.3
 Atp5l-ps1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g, pseudogene 1
chr6_-_23248264 0.161 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr5_-_65391380 0.158 ENSMUST00000120094.1
ENSMUST00000118543.1
ENSMUST00000127874.1
 Rpl9


ribosomal protein L9


chr5_-_65391408 0.152 ENSMUST00000057885.6
 Rpl9
ribosomal protein L9

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.6 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.0 0.4 GO:0043589 skin morphogenesis(GO:0043589)
0.0 0.3 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.3 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.2 GO:0006624 vacuolar protein processing(GO:0006624)
0.0 0.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.1 GO:0045004 DNA replication proofreading(GO:0045004)
0.0 0.1 GO:0098886 modification of dendritic spine(GO:0098886)
0.0 0.1 GO:0007521 muscle cell fate determination(GO:0007521) mammary placode formation(GO:0060596)
0.0 0.1 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
0.0 0.1 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0 0.1 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.1 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.1 GO:0016561 protein import into peroxisome matrix, translocation(GO:0016561)
0.0 0.1 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 0.1 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.1 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.1 GO:0061009 common bile duct development(GO:0061009)
0.0 0.1 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)

Gene overrepresentation in cellular_component category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 GO:0043196 varicosity(GO:0043196)
0.0 0.4 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.1 GO:0097444 spine apparatus(GO:0097444)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.1 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.0 0.1 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.1 GO:0097443 sorting endosome(GO:0097443)

Gene overrepresentation in molecular_function category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 0.9 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.6 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.4 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 0.3 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.0 0.3 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.1 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.1 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 0.1 GO:0003945 N-acetyllactosamine synthase activity(GO:0003945)
0.0 0.1 GO:0034235 GPI anchor binding(GO:0034235)
0.0 0.1 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.0 0.1 GO:0061711 N(6)-L-threonylcarbamoyladenine synthase(GO:0061711)
0.0 0.1 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.1 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.1 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.0 GO:0016979 lipoate-protein ligase activity(GO:0016979)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.3 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.4 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.3 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.3 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 0.2 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.1 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.1 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.1 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.1 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions