Motif ID: Foxp1_Foxj2

Z-value: 1.083

Transcription factors associated with Foxp1_Foxj2:

Gene SymbolEntrez IDGene Name
Foxj2 ENSMUSG00000003154.9 Foxj2
Foxp1 ENSMUSG00000030067.11 Foxp1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxp1mm10_v2_chr6_-_99028874_990289420.724.6e-07Click!
Foxj2mm10_v2_chr6_+_122819888_1228199380.554.0e-04Click!


Activity profile for motif Foxp1_Foxj2.

activity profile for motif Foxp1_Foxj2


Sorted Z-values histogram for motif Foxp1_Foxj2

Sorted Z-values for motif Foxp1_Foxj2



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxp1_Foxj2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_22439719 12.831 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr6_-_148444336 9.984 ENSMUST00000060095.8
ENSMUST00000100772.3
 Tmtc1

transmembrane and tetratricopeptide repeat containing 1

chr16_-_22439570 7.705 ENSMUST00000170393.1
 Etv5
ets variant gene 5
chr8_-_84773381 7.356 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr8_+_36457548 6.943 ENSMUST00000135373.1
ENSMUST00000147525.1
 6430573F11Rik

RIKEN cDNA 6430573F11 gene

chr3_+_68584154 6.410 ENSMUST00000182997.1
 Schip1
schwannomin interacting protein 1
chr15_-_60824942 6.311 ENSMUST00000100635.3
 Fam84b
family with sequence similarity 84, member B
chr15_-_66969616 5.692 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr6_-_58907120 5.417 ENSMUST00000059539.3
 Nap1l5
nucleosome assembly protein 1-like 5
chr16_-_43979050 5.106 ENSMUST00000165648.1
ENSMUST00000036321.7
 Zdhhc23

zinc finger, DHHC domain containing 23

chr15_+_3270767 4.935 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr13_+_16014457 4.678 ENSMUST00000164993.1
 Inhba
inhibin beta-A
chr10_+_60106452 4.596 ENSMUST00000165024.2
 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr8_+_66386292 4.484 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr18_+_51117754 4.462 ENSMUST00000116639.2
 Prr16
proline rich 16
chr4_-_15149755 4.413 ENSMUST00000108273.1
 Necab1
N-terminal EF-hand calcium binding protein 1
chr7_+_82175156 4.231 ENSMUST00000180243.1
 Sh3gl3
SH3-domain GRB2-like 3
chr18_+_36952621 4.110 ENSMUST00000115661.2
 Pcdha2
protocadherin alpha 2
chr19_+_26750939 4.068 ENSMUST00000175953.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr4_-_14621805 3.974 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 372 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.3 21.4 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.9 11.8 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.7 10.5 GO:0001553 luteinization(GO:0001553)
0.1 9.9 GO:0007416 synapse assembly(GO:0007416)
0.7 8.5 GO:0070842 aggresome assembly(GO:0070842)
0.8 8.1 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
1.0 8.0 GO:0060137 maternal process involved in parturition(GO:0060137)
0.2 7.4 GO:0006376 mRNA splice site selection(GO:0006376)
1.0 7.2 GO:0019532 oxalate transport(GO:0019532)
0.2 7.2 GO:0018345 protein palmitoylation(GO:0018345)
0.6 7.1 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.1 7.1 GO:0071805 potassium ion transmembrane transport(GO:0071805)
1.5 5.9 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.6 5.7 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.3 5.2 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.5 5.0 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.2 4.9 GO:0045793 positive regulation of cell size(GO:0045793)
0.2 4.9 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
1.6 4.7 GO:0043379 memory T cell differentiation(GO:0043379)
0.9 4.7 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 179 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.9 GO:0014069 postsynaptic density(GO:0014069)
0.0 14.7 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 9.3 GO:0097060 synaptic membrane(GO:0097060)
0.1 8.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 8.2 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 7.3 GO:0000139 Golgi membrane(GO:0000139)
0.2 6.5 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 5.9 GO:0031012 extracellular matrix(GO:0031012)
0.0 5.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.3 5.4 GO:0071564 npBAF complex(GO:0071564)
0.2 5.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 4.8 GO:0009925 basal plasma membrane(GO:0009925)
1.6 4.7 GO:0043512 inhibin A complex(GO:0043512)
0.2 4.5 GO:0031430 M band(GO:0031430)
0.0 4.5 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 4.3 GO:0005903 brush border(GO:0005903)
0.2 3.9 GO:0032433 filopodium tip(GO:0032433)
0.1 3.7 GO:0031941 filamentous actin(GO:0031941)
0.3 3.6 GO:0043203 axon hillock(GO:0043203)
0.0 3.6 GO:0005789 endoplasmic reticulum membrane(GO:0005789)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 247 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.5 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.2 8.6 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 8.1 GO:0017124 SH3 domain binding(GO:0017124)
0.7 7.2 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
1.2 7.0 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.2 6.6 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 6.5 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.2 6.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.2 6.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 5.7 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 5.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.5 5.3 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 5.1 GO:0044325 ion channel binding(GO:0044325)
0.2 4.9 GO:0042287 MHC protein binding(GO:0042287)
1.2 4.7 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.8 4.7 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 4.6 GO:0005509 calcium ion binding(GO:0005509)
0.1 4.5 GO:0015459 potassium channel regulator activity(GO:0015459)
0.2 4.3 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.4 4.2 GO:0008140 cAMP response element binding protein binding(GO:0008140)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 21.0 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 8.7 PID_LKB1_PATHWAY LKB1 signaling events
0.3 8.1 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.2 7.3 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 6.4 PID_ENDOTHELIN_PATHWAY Endothelins
0.1 5.4 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 5.4 PID_FOXO_PATHWAY FoxO family signaling
0.1 5.3 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 4.9 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 4.8 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 4.6 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.1 4.4 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.2 3.7 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 3.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 3.4 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 2.9 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.1 2.8 PID_SHP2_PATHWAY SHP2 signaling
0.1 2.7 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 2.4 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 2.4 PID_ALK1_PATHWAY ALK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.9 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 6.6 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.2 5.7 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.3 5.1 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.4 5.0 REACTOME_ACTIVATED_POINT_MUTANTS_OF_FGFR2 Genes involved in Activated point mutants of FGFR2
1.2 4.7 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 4.5 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.2 4.4 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.2 4.1 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.3 3.4 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.2 3.4 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 3.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 3.2 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 3.0 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.1 3.0 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.2 2.7 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.1 2.7 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.1 2.7 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.2 2.6 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.1 2.5 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling