Motif ID: Foxp2_Foxp3

Z-value: 0.613

Transcription factors associated with Foxp2_Foxp3:

Gene SymbolEntrez IDGene Name
Foxp2 ENSMUSG00000029563.10 Foxp2
Foxp3 ENSMUSG00000039521.6 Foxp3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxp2mm10_v2_chr6_+_15185456_15185563-0.231.7e-01Click!
Foxp3mm10_v2_chrX_+_7579666_75796930.115.2e-01Click!


Activity profile for motif Foxp2_Foxp3.

activity profile for motif Foxp2_Foxp3


Sorted Z-values histogram for motif Foxp2_Foxp3

Sorted Z-values for motif Foxp2_Foxp3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxp2_Foxp3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_66386292 4.690 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr4_+_144892813 4.629 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr4_+_144893077 3.731 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_144893127 3.164 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr6_+_141524379 2.943 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr16_-_22439719 2.906 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr15_+_3270767 2.828 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr6_+_30541582 2.790 ENSMUST00000096066.4
 Cpa2
carboxypeptidase A2, pancreatic
chr18_+_69344503 2.368 ENSMUST00000114985.3
 Tcf4
transcription factor 4
chr3_+_5218546 2.192 ENSMUST00000026284.6
 Zfhx4
zinc finger homeodomain 4
chr3_+_5218516 2.064 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr8_-_46294592 1.917 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr7_+_141476374 1.839 ENSMUST00000117634.1
 Tspan4
tetraspanin 4
chr14_-_51913393 1.820 ENSMUST00000004673.7
ENSMUST00000111632.3
 Ndrg2

N-myc downstream regulated gene 2

chr3_+_52268337 1.812 ENSMUST00000053764.5
 Foxo1
forkhead box O1
chr3_+_5218589 1.632 ENSMUST00000177488.1
 Zfhx4
zinc finger homeodomain 4
chr16_-_22439570 1.627 ENSMUST00000170393.1
 Etv5
ets variant gene 5
chr1_-_128592284 1.610 ENSMUST00000052172.6
ENSMUST00000142893.1
 Cxcr4

chemokine (C-X-C motif) receptor 4

chr1_-_190170178 1.548 ENSMUST00000177288.1
 Prox1
prospero-related homeobox 1
chr18_+_5593566 1.490 ENSMUST00000160910.1
 Zeb1
zinc finger E-box binding homeobox 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 198 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 11.5 GO:0042572 retinol metabolic process(GO:0042572)
0.2 4.7 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.9 4.5 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.3 3.1 GO:0042118 endothelial cell activation(GO:0042118)
0.3 3.0 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.3 2.1 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.3 1.8 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.2 1.8 GO:0071455 cellular response to hyperoxia(GO:0071455)
0.1 1.8 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 1.7 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.4 1.6 GO:0035470 positive regulation of vascular wound healing(GO:0035470)
0.1 1.6 GO:0070842 aggresome assembly(GO:0070842)
0.5 1.5 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.5 1.5 GO:0099547 regulation of translation at synapse, modulating synaptic transmission(GO:0099547) regulation of translation at postsynapse, modulating synaptic transmission(GO:0099578) positive regulation of intracellular transport of viral material(GO:1901254)
0.1 1.5 GO:0010574 regulation of vascular endothelial growth factor production(GO:0010574)
0.2 1.4 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.1 1.4 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.4 1.3 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.3 1.3 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.1 1.3 GO:0030538 embryonic genitalia morphogenesis(GO:0030538) embryonic hindgut morphogenesis(GO:0048619)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.8 GO:0005667 transcription factor complex(GO:0005667)
0.2 4.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 3.7 GO:0016605 PML body(GO:0016605)
0.0 1.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.4 1.5 GO:1902737 viral replication complex(GO:0019034) dendritic filopodium(GO:1902737)
0.3 1.5 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 1.5 GO:0009925 basal plasma membrane(GO:0009925)
0.1 1.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 1.4 GO:0045171 intercellular bridge(GO:0045171)
0.1 1.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 1.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 1.2 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.4 1.1 GO:0098855 HCN channel complex(GO:0098855)
0.1 1.1 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 1.1 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.2 1.0 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 1.0 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 0.9 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 0.8 GO:0033391 chromatoid body(GO:0033391)
0.1 0.8 GO:0030478 actin cap(GO:0030478)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 134 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 11.5 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 4.3 GO:0042287 MHC protein binding(GO:0042287)
0.8 3.1 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.7 2.9 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.2 2.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.6 1.8 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 1.8 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 1.8 GO:0003823 antigen binding(GO:0003823)
0.5 1.6 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.2 1.5 GO:0033592 RNA strand annealing activity(GO:0033592)
0.1 1.5 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 1.4 GO:0050693 LBD domain binding(GO:0050693)
0.1 1.3 GO:0070888 E-box binding(GO:0070888)
0.1 1.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.4 1.1 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.3 1.1 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.0 1.1 GO:0070840 dynein complex binding(GO:0070840)
0.0 1.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.3 1.0 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.2 1.0 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.7 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 4.6 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 4.6 PID_FOXO_PATHWAY FoxO family signaling
0.1 2.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 1.7 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 1.6 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 1.5 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.4 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 1.2 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 1.1 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.9 PID_TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 0.8 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.8 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.8 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 0.7 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.7 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.7 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.0 0.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.6 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.6 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.9 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.1 2.5 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 1.7 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.6 REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Early Phase of HIV Life Cycle
0.1 1.4 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.2 1.1 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 1.1 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 1.1 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 1.0 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.0 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 0.9 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.9 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.8 REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH Genes involved in NCAM signaling for neurite out-growth
0.0 0.8 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.0 0.7 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.7 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 0.6 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.6 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 0.5 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.5 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex