Motif ID: Foxq1
Z-value: 0.975
Transcription factors associated with Foxq1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Foxq1 | ENSMUSG00000038415.8 | Foxq1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Foxq1 | mm10_v2_chr13_+_31558157_31558176 | 0.09 | 6.2e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 6.8 | GO:0060708 | spongiotrophoblast differentiation(GO:0060708) |
| 1.5 | 6.2 | GO:0086046 | membrane depolarization during SA node cell action potential(GO:0086046) |
| 1.2 | 3.7 | GO:0032650 | regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) interleukin-1 alpha secretion(GO:0050703) regulation of bleb assembly(GO:1904170) |
| 1.1 | 3.3 | GO:0070343 | white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) |
| 1.0 | 2.0 | GO:0014877 | response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 0.9 | 2.6 | GO:0030827 | negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283) |
| 0.6 | 1.9 | GO:0014826 | vein smooth muscle contraction(GO:0014826) |
| 0.5 | 4.8 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.4 | 2.5 | GO:0010968 | regulation of microtubule nucleation(GO:0010968) |
| 0.3 | 2.4 | GO:0090091 | positive regulation of extracellular matrix disassembly(GO:0090091) |
| 0.3 | 3.0 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.3 | 1.3 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.3 | 1.8 | GO:0032264 | IMP salvage(GO:0032264) |
| 0.3 | 3.8 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
| 0.2 | 0.7 | GO:1903244 | positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203) |
| 0.2 | 3.8 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.2 | 8.5 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.2 | 5.9 | GO:0095500 | acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145) |
| 0.2 | 0.8 | GO:0046368 | GDP-L-fucose metabolic process(GO:0046368) |
| 0.2 | 4.1 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.2 | 0.9 | GO:0044314 | protein K27-linked ubiquitination(GO:0044314) |
| 0.2 | 1.8 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.2 | 1.7 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033) |
| 0.1 | 3.3 | GO:0007614 | short-term memory(GO:0007614) |
| 0.1 | 1.1 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
| 0.1 | 1.4 | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
| 0.1 | 0.9 | GO:2000258 | negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258) |
| 0.1 | 0.8 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
| 0.1 | 0.6 | GO:0071476 | cellular hypotonic response(GO:0071476) |
| 0.1 | 0.6 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 0.1 | 2.3 | GO:0008210 | estrogen metabolic process(GO:0008210) |
| 0.1 | 1.0 | GO:0070574 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
| 0.1 | 0.5 | GO:0036438 | maintenance of lens transparency(GO:0036438) |
| 0.1 | 0.4 | GO:0002188 | translation reinitiation(GO:0002188) |
| 0.1 | 0.4 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 0.1 | 14.4 | GO:0007416 | synapse assembly(GO:0007416) |
| 0.1 | 0.9 | GO:0019368 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.1 | 0.4 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
| 0.1 | 0.5 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.1 | 0.6 | GO:0033625 | positive regulation of integrin activation(GO:0033625) |
| 0.1 | 0.4 | GO:0035234 | ectopic germ cell programmed cell death(GO:0035234) |
| 0.1 | 1.6 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.1 | 7.3 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332) |
| 0.1 | 0.3 | GO:0002175 | protein localization to paranode region of axon(GO:0002175) |
| 0.1 | 0.3 | GO:0008655 | pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097) |
| 0.1 | 0.5 | GO:0006560 | proline metabolic process(GO:0006560) |
| 0.1 | 1.9 | GO:0006826 | iron ion transport(GO:0006826) |
| 0.1 | 0.6 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.0 | 0.5 | GO:0035520 | monoubiquitinated protein deubiquitination(GO:0035520) |
| 0.0 | 0.5 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.0 | 1.7 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.0 | 0.9 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.0 | 0.3 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.0 | 0.2 | GO:0097501 | stress response to metal ion(GO:0097501) |
| 0.0 | 1.3 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.0 | 0.2 | GO:0010587 | miRNA catabolic process(GO:0010587) |
| 0.0 | 0.1 | GO:0019065 | receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509) |
| 0.0 | 0.7 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
| 0.0 | 0.2 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.0 | 4.6 | GO:0006869 | lipid transport(GO:0006869) |
| 0.0 | 0.1 | GO:0018243 | protein O-linked glycosylation via threonine(GO:0018243) |
| 0.0 | 0.7 | GO:0051591 | response to cAMP(GO:0051591) |
| 0.0 | 0.2 | GO:0031571 | mitotic G1 DNA damage checkpoint(GO:0031571) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 6.8 | GO:0000805 | X chromosome(GO:0000805) |
| 0.6 | 6.2 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.2 | 3.7 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.2 | 2.6 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.2 | 3.0 | GO:0098644 | complex of collagen trimers(GO:0098644) |
| 0.2 | 4.2 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.1 | 0.7 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.1 | 4.8 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.1 | 1.4 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.1 | 0.5 | GO:0033263 | CORVET complex(GO:0033263) |
| 0.1 | 3.8 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.1 | 0.8 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.1 | 0.3 | GO:0097454 | Schwann cell microvillus(GO:0097454) |
| 0.1 | 0.8 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 6.9 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 0.9 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.0 | 0.5 | GO:0042405 | nuclear inclusion body(GO:0042405) |
| 0.0 | 0.4 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 2.5 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.0 | 2.0 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 0.3 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 3.0 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 0.6 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 16.9 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 0.7 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 3.5 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 5.2 | GO:0030549 | acetylcholine receptor activator activity(GO:0030549) |
| 0.8 | 6.2 | GO:0086007 | voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007) |
| 0.8 | 3.0 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.6 | 1.9 | GO:0004962 | endothelin receptor activity(GO:0004962) |
| 0.6 | 3.7 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.3 | 2.4 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.3 | 1.8 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.3 | 1.5 | GO:0004920 | interleukin-10 receptor activity(GO:0004920) |
| 0.2 | 0.5 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.2 | 1.9 | GO:0015093 | ferrous iron transmembrane transporter activity(GO:0015093) |
| 0.2 | 0.5 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
| 0.1 | 1.4 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 0.7 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
| 0.1 | 0.7 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.1 | 1.6 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.1 | 1.8 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
| 0.1 | 0.6 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.1 | 0.7 | GO:0051429 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 0.1 | 0.4 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
| 0.1 | 0.8 | GO:0008417 | fucosyltransferase activity(GO:0008417) |
| 0.1 | 1.3 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.1 | 0.6 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.1 | 4.8 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 0.9 | GO:0009922 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.1 | 0.5 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.1 | 6.6 | GO:0002039 | p53 binding(GO:0002039) |
| 0.1 | 0.8 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.1 | 0.9 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
| 0.1 | 11.9 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 0.3 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.1 | 1.2 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.1 | 0.3 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.0 | 0.3 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.0 | 0.9 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
| 0.0 | 0.2 | GO:0050265 | RNA uridylyltransferase activity(GO:0050265) |
| 0.0 | 6.7 | GO:0043021 | ribonucleoprotein complex binding(GO:0043021) |
| 0.0 | 0.4 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.0 | 1.1 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
| 0.0 | 1.7 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.0 | 0.8 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 1.4 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.9 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 1.8 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 0.5 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
| 0.0 | 0.4 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 0.6 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.0 | 0.5 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.0 | 0.2 | GO:0070064 | proline-rich region binding(GO:0070064) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.8 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 0.8 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 1.8 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 3.9 | PID_ENDOTHELIN_PATHWAY | Endothelins |
| 0.0 | 1.4 | PID_INTEGRIN_A4B1_PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 2.0 | PID_FOXO_PATHWAY | FoxO family signaling |
| 0.0 | 2.2 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 0.5 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.9 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.7 | REACTOME_THE_NLRP3_INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.2 | 2.6 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 1.8 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
| 0.1 | 3.0 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 1.2 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 1.4 | REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.1 | 0.6 | REACTOME_METAL_ION_SLC_TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.1 | 0.7 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.0 | 0.9 | REACTOME_RNA_POL_III_CHAIN_ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.0 | 0.8 | REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING | Genes involved in Spry regulation of FGF signaling |
| 0.0 | 0.9 | REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 0.8 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |
| 0.0 | 0.7 | REACTOME_PLC_BETA_MEDIATED_EVENTS | Genes involved in PLC beta mediated events |
| 0.0 | 1.3 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.4 | REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 0.4 | REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.0 | 0.7 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 0.6 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 0.3 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
| 0.0 | 0.4 | REACTOME_NOD1_2_SIGNALING_PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 0.9 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
