Motif ID: Gata2_Gata1

Z-value: 0.618

Transcription factors associated with Gata2_Gata1:

Gene SymbolEntrez IDGene Name
Gata1 ENSMUSG00000031162.8 Gata1
Gata2 ENSMUSG00000015053.8 Gata2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gata2mm10_v2_chr6_+_88198656_881986750.732.4e-07Click!
Gata1mm10_v2_chrX_-_7967817_79679100.144.0e-01Click!


Activity profile for motif Gata2_Gata1.

activity profile for motif Gata2_Gata1


Sorted Z-values histogram for motif Gata2_Gata1

Sorted Z-values for motif Gata2_Gata1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gata2_Gata1

PNG image of the network

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Top targets:


Showing 1 to 20 of 167 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_84701430 3.931 ENSMUST00000037165.4
 Lyl1
lymphoblastomic leukemia 1
chr6_+_30541582 3.184 ENSMUST00000096066.4
 Cpa2
carboxypeptidase A2, pancreatic
chr1_-_162866502 2.928 ENSMUST00000046049.7
 Fmo1
flavin containing monooxygenase 1
chr16_-_95459245 2.473 ENSMUST00000176345.1
ENSMUST00000121809.2
ENSMUST00000118113.1
ENSMUST00000122199.1
 Erg



avian erythroblastosis virus E-26 (v-ets) oncogene related



chr16_+_45093611 2.347 ENSMUST00000099498.2
 Ccdc80
coiled-coil domain containing 80
chr3_+_135825788 2.337 ENSMUST00000167390.1
 Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr6_+_125552948 2.221 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
 Vwf


Von Willebrand factor homolog


chr16_+_45094036 2.135 ENSMUST00000061050.5
 Ccdc80
coiled-coil domain containing 80
chr7_-_4522427 2.125 ENSMUST00000098859.3
 Tnni3
troponin I, cardiac 3
chr11_+_90030295 1.878 ENSMUST00000092788.3
 Tmem100
transmembrane protein 100
chrX_-_107403295 1.747 ENSMUST00000033591.5
 Itm2a
integral membrane protein 2A
chr9_-_32541589 1.659 ENSMUST00000016231.7
 Fli1
Friend leukemia integration 1
chr13_+_38345716 1.651 ENSMUST00000171970.1
 Bmp6
bone morphogenetic protein 6
chr7_+_28833975 1.649 ENSMUST00000066723.8
 Lgals4
lectin, galactose binding, soluble 4
chr4_-_14621805 1.627 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr17_-_45593626 1.508 ENSMUST00000163905.1
ENSMUST00000167692.1
 Slc29a1

solute carrier family 29 (nucleoside transporters), member 1

chr3_+_7366598 1.507 ENSMUST00000028999.6
 Pkia
protein kinase inhibitor, alpha
chr13_-_116309639 1.440 ENSMUST00000036060.6
 Isl1
ISL1 transcription factor, LIM/homeodomain
chr10_-_115185015 1.428 ENSMUST00000006949.8
 Tph2
tryptophan hydroxylase 2
chr9_-_77251829 1.379 ENSMUST00000184322.1
ENSMUST00000184316.1
 Mlip

muscular LMNA-interacting protein


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.1 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.6 3.9 GO:0001955 blood vessel maturation(GO:0001955)
0.4 3.7 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.6 3.4 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.0 3.1 GO:0030168 platelet activation(GO:0030168)
0.2 2.9 GO:0070995 toxin metabolic process(GO:0009404) NADPH oxidation(GO:0070995)
0.4 2.7 GO:0019532 oxalate transport(GO:0019532)
0.5 2.5 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504)
0.1 2.3 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.3 1.9 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.3 1.7 GO:0002317 plasma cell differentiation(GO:0002317) negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.3 1.7 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.1 1.7 GO:0035855 megakaryocyte development(GO:0035855)
0.1 1.7 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.3 1.6 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.2 1.5 GO:0015862 uridine transport(GO:0015862)
0.1 1.5 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.5 1.4 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913)
0.2 1.4 GO:0006586 tryptophan metabolic process(GO:0006568) indolalkylamine metabolic process(GO:0006586)
0.2 1.4 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.9 3.4 GO:1990584 cardiac Troponin complex(GO:1990584)
0.2 3.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 2.3 GO:0016605 PML body(GO:0016605)
0.4 2.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 1.9 GO:0043204 perikaryon(GO:0043204)
0.1 1.6 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 1.3 GO:0097228 sperm principal piece(GO:0097228)
0.4 1.2 GO:0043512 inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512)
0.1 1.2 GO:0097449 astrocyte projection(GO:0097449)
0.0 0.9 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 0.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.8 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.8 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1 0.7 GO:0097441 basilar dendrite(GO:0097441)
0.1 0.5 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 0.5 GO:1990393 3M complex(GO:1990393)
0.0 0.4 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.3 GO:0001674 female germ cell nucleus(GO:0001674)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.5 GO:0001968 fibronectin binding(GO:0001968)
0.2 4.0 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 3.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
1.1 3.4 GO:0030172 troponin C binding(GO:0030172)
0.6 2.9 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.2 2.7 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.0 2.3 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.0 2.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 2.2 GO:0019865 immunoglobulin binding(GO:0019865)
0.2 1.7 GO:0070700 BMP receptor binding(GO:0070700)
0.0 1.7 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 1.7 GO:0035591 signaling adaptor activity(GO:0035591)
0.0 1.7 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.3 1.6 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.3 1.6 GO:0016936 galactoside binding(GO:0016936)
0.1 1.5 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 1.5 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.5 1.4 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.0 1.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.4 GO:0046875 ephrin receptor binding(GO:0046875)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 3.1 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.9 PID_EPO_PATHWAY EPO signaling pathway
0.1 1.6 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 1.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.8 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 0.7 PID_VEGFR1_PATHWAY VEGFR1 specific signals
0.0 0.7 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.7 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.0 0.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.3 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.7 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 3.2 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.9 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.2 2.2 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 2.2 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 2.2 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.1 1.6 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 1.5 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 1.4 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 1.4 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 1.3 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.3 1.2 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 1.1 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 1.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.0 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.9 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 0.8 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.8 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.7 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling