Motif ID: Gata2_Gata1

Z-value: 0.618

Transcription factors associated with Gata2_Gata1:

Gene SymbolEntrez IDGene Name
Gata1 ENSMUSG00000031162.8 Gata1
Gata2 ENSMUSG00000015053.8 Gata2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gata2mm10_v2_chr6_+_88198656_881986750.732.4e-07Click!
Gata1mm10_v2_chrX_-_7967817_79679100.144.0e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Gata2_Gata1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_84701430 3.931 ENSMUST00000037165.4
Lyl1
lymphoblastomic leukemia 1
chr6_+_30541582 3.184 ENSMUST00000096066.4
Cpa2
carboxypeptidase A2, pancreatic
chr1_-_162866502 2.928 ENSMUST00000046049.7
Fmo1
flavin containing monooxygenase 1
chr16_-_95459245 2.473 ENSMUST00000176345.1
ENSMUST00000121809.2
ENSMUST00000118113.1
ENSMUST00000122199.1
Erg



avian erythroblastosis virus E-26 (v-ets) oncogene related



chr16_+_45093611 2.347 ENSMUST00000099498.2
Ccdc80
coiled-coil domain containing 80
chr3_+_135825788 2.337 ENSMUST00000167390.1
Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr6_+_125552948 2.221 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
Vwf


Von Willebrand factor homolog


chr16_+_45094036 2.135 ENSMUST00000061050.5
Ccdc80
coiled-coil domain containing 80
chr7_-_4522427 2.125 ENSMUST00000098859.3
Tnni3
troponin I, cardiac 3
chr11_+_90030295 1.878 ENSMUST00000092788.3
Tmem100
transmembrane protein 100
chrX_-_107403295 1.747 ENSMUST00000033591.5
Itm2a
integral membrane protein 2A
chr9_-_32541589 1.659 ENSMUST00000016231.7
Fli1
Friend leukemia integration 1
chr13_+_38345716 1.651 ENSMUST00000171970.1
Bmp6
bone morphogenetic protein 6
chr7_+_28833975 1.649 ENSMUST00000066723.8
Lgals4
lectin, galactose binding, soluble 4
chr4_-_14621805 1.627 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr17_-_45593626 1.508 ENSMUST00000163905.1
ENSMUST00000167692.1
Slc29a1

solute carrier family 29 (nucleoside transporters), member 1

chr3_+_7366598 1.507 ENSMUST00000028999.6
Pkia
protein kinase inhibitor, alpha
chr13_-_116309639 1.440 ENSMUST00000036060.6
Isl1
ISL1 transcription factor, LIM/homeodomain
chr10_-_115185015 1.428 ENSMUST00000006949.8
Tph2
tryptophan hydroxylase 2
chr9_-_77251829 1.379 ENSMUST00000184322.1
ENSMUST00000184316.1
Mlip

muscular LMNA-interacting protein

chr7_-_139582790 1.368 ENSMUST00000106095.2
Nkx6-2
NK6 homeobox 2
chr3_+_135826075 1.318 ENSMUST00000029810.5
Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr7_+_110627650 1.312 ENSMUST00000033054.8
Adm
adrenomedullin
chr13_-_91388079 1.288 ENSMUST00000181054.1
A830009L08Rik
RIKEN cDNA A830009L08 gene
chr7_-_4522794 1.280 ENSMUST00000140424.1
Tnni3
troponin I, cardiac 3
chr2_+_169633517 1.278 ENSMUST00000109157.1
Tshz2
teashirt zinc finger family member 2
chr6_+_17306335 1.210 ENSMUST00000007799.6
ENSMUST00000115456.1
ENSMUST00000115455.2
ENSMUST00000130505.1
Cav1



caveolin 1, caveolae protein



chr1_+_75507077 1.167 ENSMUST00000037330.4
Inha
inhibin alpha
chr10_-_62342674 1.117 ENSMUST00000143179.1
ENSMUST00000130422.1
Hk1

hexokinase 1

chr3_-_88000350 1.056 ENSMUST00000090971.5
Bcan
brevican
chr5_-_125294107 1.011 ENSMUST00000127148.1
Scarb1
scavenger receptor class B, member 1
chr14_-_52279238 0.982 ENSMUST00000167116.1
ENSMUST00000100631.4
Rab2b

RAB2B, member RAS oncogene family

chr2_+_70474923 0.975 ENSMUST00000100043.2
Sp5
trans-acting transcription factor 5
chr2_-_33087169 0.975 ENSMUST00000102810.3
Garnl3
GTPase activating RANGAP domain-like 3
chr2_-_33086366 0.955 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr3_-_84479418 0.929 ENSMUST00000091002.1
Fhdc1
FH2 domain containing 1
chrX_+_150547375 0.917 ENSMUST00000066337.6
ENSMUST00000112715.1
Alas2

aminolevulinic acid synthase 2, erythroid

chrX_+_73757069 0.912 ENSMUST00000002079.6
Plxnb3
plexin B3
chr2_+_26583858 0.880 ENSMUST00000100290.5
ENSMUST00000102907.5
Egfl7

EGF-like domain 7

chr9_-_77251871 0.879 ENSMUST00000183955.1
Mlip
muscular LMNA-interacting protein
chr5_-_121836810 0.865 ENSMUST00000118580.1
ENSMUST00000040308.7
Sh2b3

SH2B adaptor protein 3

chr3_-_20242173 0.860 ENSMUST00000001921.1
Cpa3
carboxypeptidase A3, mast cell
chr5_-_121836852 0.841 ENSMUST00000086310.1
Sh2b3
SH2B adaptor protein 3
chr16_-_64786321 0.801 ENSMUST00000052588.4
Zfp654
zinc finger protein 654
chr2_-_77170592 0.799 ENSMUST00000164114.2
ENSMUST00000049544.7
Ccdc141

coiled-coil domain containing 141

chr1_+_45311538 0.778 ENSMUST00000087883.6
Col3a1
collagen, type III, alpha 1
chr11_-_102469839 0.765 ENSMUST00000103086.3
Itga2b
integrin alpha 2b
chr1_+_172341197 0.763 ENSMUST00000056136.3
Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr6_+_17463927 0.717 ENSMUST00000115442.1
Met
met proto-oncogene
chr4_-_59438633 0.715 ENSMUST00000040166.7
ENSMUST00000107544.1
Susd1

sushi domain containing 1

chr7_+_119900099 0.689 ENSMUST00000106516.1
Lyrm1
LYR motif containing 1
chr6_+_17743582 0.679 ENSMUST00000000674.6
ENSMUST00000077080.2
St7

suppression of tumorigenicity 7

chr5_+_24364804 0.667 ENSMUST00000030834.4
ENSMUST00000115090.1
Nos3

nitric oxide synthase 3, endothelial cell

chr2_-_36104060 0.666 ENSMUST00000112961.3
ENSMUST00000112966.3
Lhx6

LIM homeobox protein 6

chrX_+_10485121 0.661 ENSMUST00000076354.6
ENSMUST00000115526.1
Tspan7

tetraspanin 7

chr2_+_169632996 0.653 ENSMUST00000109159.2
Tshz2
teashirt zinc finger family member 2
chr14_-_64455903 0.651 ENSMUST00000067927.7
Msra
methionine sulfoxide reductase A
chr6_-_122856151 0.612 ENSMUST00000042081.8
C3ar1
complement component 3a receptor 1
chr14_-_55560340 0.588 ENSMUST00000066106.3
A730061H03Rik
RIKEN cDNA A730061H03 gene
chr11_+_87760533 0.569 ENSMUST00000039627.5
ENSMUST00000100644.3
Bzrap1

benzodiazepine receptor associated protein 1

chr3_-_59262825 0.566 ENSMUST00000050360.7
P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr13_-_18031616 0.560 ENSMUST00000099736.2
Vdac3-ps1
voltage-dependent anion channel 3, pseudogene 1
chr4_-_14621669 0.543 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chrX_+_99975570 0.540 ENSMUST00000113779.1
ENSMUST00000113776.1
ENSMUST00000113775.1
ENSMUST00000113780.1
ENSMUST00000113778.1
ENSMUST00000113781.1
ENSMUST00000113783.1
ENSMUST00000071453.2
ENSMUST00000113777.1
Eda








ectodysplasin-A








chr1_-_132367879 0.540 ENSMUST00000142609.1
Tmcc2
transmembrane and coiled-coil domains 2
chr4_-_14621494 0.495 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr6_+_15185203 0.455 ENSMUST00000154448.1
Foxp2
forkhead box P2
chr16_-_44016387 0.452 ENSMUST00000036174.3
Gramd1c
GRAM domain containing 1C
chr4_-_138326234 0.434 ENSMUST00000105817.3
ENSMUST00000030536.6
Pink1

PTEN induced putative kinase 1

chr10_+_80019621 0.432 ENSMUST00000043311.6
Hmha1
histocompatibility (minor) HA-1
chr12_-_25096080 0.432 ENSMUST00000020974.6
Id2
inhibitor of DNA binding 2
chr10_-_83648631 0.430 ENSMUST00000146876.2
ENSMUST00000176294.1
Appl2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

chr16_+_43503607 0.425 ENSMUST00000126100.1
ENSMUST00000123047.1
ENSMUST00000156981.1
Zbtb20


zinc finger and BTB domain containing 20


chr2_+_62046623 0.424 ENSMUST00000112480.2
Slc4a10
solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
chr4_+_11579647 0.423 ENSMUST00000180239.1
Fsbp
fibrinogen silencer binding protein
chrX_-_60403947 0.418 ENSMUST00000033480.6
ENSMUST00000101527.2
Atp11c

ATPase, class VI, type 11C

chr2_+_103957976 0.414 ENSMUST00000156813.1
ENSMUST00000170926.1
Lmo2

LIM domain only 2

chr18_+_76059458 0.403 ENSMUST00000167921.1
Zbtb7c
zinc finger and BTB domain containing 7C
chr8_+_46490968 0.399 ENSMUST00000110372.1
ENSMUST00000130563.1
Acsl1

acyl-CoA synthetase long-chain family member 1

chr6_-_136941887 0.390 ENSMUST00000111891.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr2_-_20968881 0.366 ENSMUST00000114594.1
Arhgap21
Rho GTPase activating protein 21
chr6_+_17306415 0.365 ENSMUST00000150901.1
Cav1
caveolin 1, caveolae protein
chr2_+_32621750 0.365 ENSMUST00000113278.2
Ak1
adenylate kinase 1
chr11_-_61453992 0.353 ENSMUST00000060255.7
ENSMUST00000054927.7
ENSMUST00000102661.3
Rnf112


ring finger protein 112


chr14_+_55560904 0.338 ENSMUST00000072530.4
ENSMUST00000128490.1
Dcaf11

DDB1 and CUL4 associated factor 11

chr14_+_55561060 0.333 ENSMUST00000117701.1
Dcaf11
DDB1 and CUL4 associated factor 11
chr3_+_106113229 0.331 ENSMUST00000079132.5
ENSMUST00000139086.1
Chia

chitinase, acidic

chr19_-_7019423 0.329 ENSMUST00000040772.8
Fermt3
fermitin family homolog 3 (Drosophila)
chr10_+_90576708 0.328 ENSMUST00000182430.1
ENSMUST00000182960.1
ENSMUST00000182045.1
ENSMUST00000182083.1
Anks1b



ankyrin repeat and sterile alpha motif domain containing 1B



chr7_-_100662315 0.326 ENSMUST00000151123.1
ENSMUST00000107047.2
Plekhb1

pleckstrin homology domain containing, family B (evectins) member 1

chr6_-_122609964 0.320 ENSMUST00000032211.4
Gdf3
growth differentiation factor 3
chr1_+_75549581 0.307 ENSMUST00000154101.1
Slc4a3
solute carrier family 4 (anion exchanger), member 3
chr4_-_32923455 0.290 ENSMUST00000035719.4
ENSMUST00000084749.1
Ankrd6

ankyrin repeat domain 6

chr10_+_90576570 0.287 ENSMUST00000182786.1
ENSMUST00000182600.1
Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr13_+_42709482 0.284 ENSMUST00000066928.5
ENSMUST00000148891.1
Phactr1

phosphatase and actin regulator 1

chr1_+_165788681 0.279 ENSMUST00000161971.1
ENSMUST00000178336.1
ENSMUST00000005907.5
ENSMUST00000027849.4
Cd247



CD247 antigen



chr6_-_136941494 0.275 ENSMUST00000111892.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr6_-_136941694 0.267 ENSMUST00000032344.5
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr3_-_154330543 0.263 ENSMUST00000184966.1
ENSMUST00000177846.2
Lhx8

LIM homeobox protein 8

chr10_+_90576777 0.258 ENSMUST00000183136.1
ENSMUST00000182595.1
Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr4_+_43493345 0.252 ENSMUST00000030181.5
ENSMUST00000107922.2
Ccdc107

coiled-coil domain containing 107

chr9_-_21963568 0.246 ENSMUST00000006397.5
Epor
erythropoietin receptor
chr2_+_62046580 0.244 ENSMUST00000054484.8
Slc4a10
solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
chr10_+_90576252 0.240 ENSMUST00000182427.1
ENSMUST00000182053.1
ENSMUST00000182113.1
Anks1b


ankyrin repeat and sterile alpha motif domain containing 1B


chr2_+_112284561 0.237 ENSMUST00000053666.7
Slc12a6
solute carrier family 12, member 6
chr13_+_98263242 0.237 ENSMUST00000022164.8
ENSMUST00000150352.1
Ankra2

ankyrin repeat, family A (RFXANK-like), 2

chr2_+_72476159 0.229 ENSMUST00000102691.4
Cdca7
cell division cycle associated 7
chrX_-_18461371 0.229 ENSMUST00000044188.4
4930578C19Rik
RIKEN cDNA 4930578C19 gene
chr1_+_165788746 0.228 ENSMUST00000161559.2
Cd247
CD247 antigen
chr17_+_46650328 0.226 ENSMUST00000043464.7
Cul7
cullin 7
chr14_+_55560480 0.225 ENSMUST00000121622.1
ENSMUST00000143431.1
ENSMUST00000150481.1
Dcaf11


DDB1 and CUL4 associated factor 11


chr4_-_46404224 0.224 ENSMUST00000107764.2
Hemgn
hemogen
chrX_-_134111852 0.218 ENSMUST00000033610.6
Nox1
NADPH oxidase 1
chr1_-_14310198 0.212 ENSMUST00000168081.2
ENSMUST00000027066.6
Eya1

eyes absent 1 homolog (Drosophila)

chr19_+_58670358 0.208 ENSMUST00000057270.7
Pnlip
pancreatic lipase
chr5_+_42067960 0.205 ENSMUST00000087332.4
Gm16223
predicted gene 16223
chr2_-_52558539 0.193 ENSMUST00000102760.3
ENSMUST00000102761.2
Cacnb4

calcium channel, voltage-dependent, beta 4 subunit

chrM_+_14138 0.193 ENSMUST00000082421.1
mt-Cytb
mitochondrially encoded cytochrome b
chr11_-_53707269 0.190 ENSMUST00000124352.1
ENSMUST00000020649.7
Rad50

RAD50 homolog (S. cerevisiae)

chr3_+_133338936 0.188 ENSMUST00000150386.1
ENSMUST00000125858.1
Ppa2

pyrophosphatase (inorganic) 2

chr13_+_42681513 0.186 ENSMUST00000149235.1
Phactr1
phosphatase and actin regulator 1
chr10_+_90576678 0.185 ENSMUST00000182284.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr10_+_53337686 0.184 ENSMUST00000046221.6
ENSMUST00000163319.1
Pln

phospholamban

chr18_+_7869159 0.169 ENSMUST00000170932.1
ENSMUST00000167020.1
Wac

WW domain containing adaptor with coiled-coil

chr10_-_62327757 0.167 ENSMUST00000139228.1
Hk1
hexokinase 1
chr2_+_69670100 0.164 ENSMUST00000100050.3
Klhl41
kelch-like 41
chr11_+_70639118 0.159 ENSMUST00000055184.6
ENSMUST00000108551.2
Gp1ba

glycoprotein 1b, alpha polypeptide

chr10_+_5593718 0.156 ENSMUST00000051809.8
Myct1
myc target 1
chr11_+_67586520 0.147 ENSMUST00000108682.2
Gas7
growth arrest specific 7
chr17_-_85688252 0.146 ENSMUST00000024947.7
ENSMUST00000163568.2
Six2

sine oculis-related homeobox 2

chr19_-_42202150 0.134 ENSMUST00000018966.7
Sfrp5
secreted frizzled-related sequence protein 5
chr2_-_25224653 0.134 ENSMUST00000043584.4
Tubb4b
tubulin, beta 4B class IVB
chrX_+_166238901 0.133 ENSMUST00000112235.1
Gpm6b
glycoprotein m6b
chr7_-_99238564 0.133 ENSMUST00000064231.7
Mogat2
monoacylglycerol O-acyltransferase 2
chr3_+_79885930 0.129 ENSMUST00000029567.8
Fam198b
family with sequence similarity 198, member B
chr18_-_78123324 0.128 ENSMUST00000160292.1
ENSMUST00000091813.5
Slc14a1

solute carrier family 14 (urea transporter), member 1

chr8_+_84908731 0.127 ENSMUST00000134569.1
Dnase2a
deoxyribonuclease II alpha
chr10_+_90576872 0.126 ENSMUST00000182550.1
ENSMUST00000099364.5
Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr7_-_100662414 0.122 ENSMUST00000079176.6
Plekhb1
pleckstrin homology domain containing, family B (evectins) member 1
chr10_+_116177351 0.115 ENSMUST00000155606.1
ENSMUST00000128399.1
Ptprr

protein tyrosine phosphatase, receptor type, R

chr3_+_79884496 0.114 ENSMUST00000118853.1
Fam198b
family with sequence similarity 198, member B
chr8_+_84908560 0.114 ENSMUST00000003910.6
ENSMUST00000109744.1
Dnase2a

deoxyribonuclease II alpha

chr11_-_94242701 0.107 ENSMUST00000061469.3
Wfikkn2
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr7_-_80403315 0.103 ENSMUST00000147150.1
Furin
furin (paired basic amino acid cleaving enzyme)
chr1_+_75450699 0.098 ENSMUST00000037708.9
Asic4
acid-sensing (proton-gated) ion channel family member 4
chr11_+_118428493 0.096 ENSMUST00000017590.2
C1qtnf1
C1q and tumor necrosis factor related protein 1
chr2_+_72476225 0.093 ENSMUST00000157019.1
Cdca7
cell division cycle associated 7
chr2_+_3704787 0.092 ENSMUST00000115054.2
Fam107b
family with sequence similarity 107, member B
chrM_+_5319 0.085 ENSMUST00000082402.1
mt-Co1
mitochondrially encoded cytochrome c oxidase I
chr11_+_4986824 0.076 ENSMUST00000009234.9
ENSMUST00000109897.1
Ap1b1

adaptor protein complex AP-1, beta 1 subunit

chr8_+_105636509 0.073 ENSMUST00000005841.9
Ctcf
CCCTC-binding factor
chr9_-_44713196 0.059 ENSMUST00000144251.1
ENSMUST00000156918.1
Phldb1

pleckstrin homology-like domain, family B, member 1

chr7_-_44892358 0.056 ENSMUST00000003049.6
Med25
mediator of RNA polymerase II transcription, subunit 25 homolog (yeast)
chr19_-_37176055 0.056 ENSMUST00000142973.1
ENSMUST00000154376.1
Cpeb3

cytoplasmic polyadenylation element binding protein 3

chr9_+_44069421 0.055 ENSMUST00000114830.2
Usp2
ubiquitin specific peptidase 2
chr15_-_50890396 0.052 ENSMUST00000185183.1
Trps1
trichorhinophalangeal syndrome I (human)
chr15_-_77153772 0.038 ENSMUST00000166610.1
ENSMUST00000111581.2
Rbfox2

RNA binding protein, fox-1 homolog (C. elegans) 2

chr9_+_110052016 0.030 ENSMUST00000164930.1
ENSMUST00000163979.1
Map4

microtubule-associated protein 4

chr7_+_110773658 0.030 ENSMUST00000143786.1
Ampd3
adenosine monophosphate deaminase 3
chr9_-_44342332 0.028 ENSMUST00000097558.3
Hmbs
hydroxymethylbilane synthase
chr3_+_79884576 0.023 ENSMUST00000145992.1
Fam198b
family with sequence similarity 198, member B
chr18_-_43477764 0.016 ENSMUST00000057110.9
Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr10_-_14718191 0.014 ENSMUST00000020016.4
Gje1
gap junction protein, epsilon 1
chrX_-_7572843 0.010 ENSMUST00000132788.1
Ppp1r3f
protein phosphatase 1, regulatory (inhibitor) subunit 3F
chr10_-_13388830 0.008 ENSMUST00000079698.5
Phactr2
phosphatase and actin regulator 2
chr8_+_107436355 0.005 ENSMUST00000166615.1
Wwp2
WW domain containing E3 ubiquitin protein ligase 2
chr1_+_135818593 0.003 ENSMUST00000038760.8
Lad1
ladinin

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.4 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.6 3.9 GO:0001955 blood vessel maturation(GO:0001955)
0.5 2.5 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504)
0.5 1.4 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913)
0.4 2.7 GO:0019532 oxalate transport(GO:0019532)
0.4 3.7 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.3 1.0 GO:0015920 regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920)
0.3 1.6 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.3 1.9 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.3 1.7 GO:0002317 plasma cell differentiation(GO:0002317) negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.3 1.7 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.2 2.9 GO:0070995 toxin metabolic process(GO:0009404) NADPH oxidation(GO:0070995)
0.2 0.7 GO:0003100 regulation of systemic arterial blood pressure by endothelin(GO:0003100) regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.2 1.3 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.2 1.5 GO:0015862 uridine transport(GO:0015862)
0.2 1.4 GO:0006586 tryptophan metabolic process(GO:0006568) indolalkylamine metabolic process(GO:0006586)
0.2 0.6 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.2 1.4 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.2 1.2 GO:0046880 regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884)
0.2 0.8 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.2 0.6 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.2 1.3 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.2 0.9 GO:0010593 negative regulation of lamellipodium assembly(GO:0010593)
0.2 0.5 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.2 0.3 GO:0048859 formation of anatomical boundary(GO:0048859)
0.2 0.8 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.2 0.9 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.1 1.5 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 0.9 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)
0.1 1.4 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 0.7 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 0.4 GO:0036482 neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036482) positive regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902958) regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903383) negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903384)
0.1 0.7 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.1 0.4 GO:0045578 negative regulation of B cell differentiation(GO:0045578) epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1 0.9 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.1 0.4 GO:0051684 maintenance of Golgi location(GO:0051684)
0.1 0.1 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.1 0.2 GO:0072592 oxygen metabolic process(GO:0072592)
0.1 1.7 GO:0035855 megakaryocyte development(GO:0035855)
0.1 0.1 GO:2000040 regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.1 0.4 GO:0006172 ADP biosynthetic process(GO:0006172)
0.1 2.3 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.1 0.3 GO:0033632 regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.1 1.7 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 0.4 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0 0.1 GO:0046462 monoacylglycerol metabolic process(GO:0046462)
0.0 0.1 GO:0071918 urea transmembrane transport(GO:0071918)
0.0 1.0 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.0 0.2 GO:0071476 cellular hypotonic response(GO:0071476)
0.0 0.2 GO:0033762 response to glucagon(GO:0033762)
0.0 0.2 GO:0000019 regulation of mitotic recombination(GO:0000019) telomeric 3' overhang formation(GO:0031860)
0.0 0.2 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0 0.2 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
0.0 4.1 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.2 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
0.0 3.1 GO:0030168 platelet activation(GO:0030168)
0.0 0.4 GO:0044539 long-chain fatty acid import(GO:0044539)
0.0 0.2 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.2 GO:0061032 visceral serous pericardium development(GO:0061032)
0.0 0.2 GO:0086023 adrenergic receptor signaling pathway involved in heart process(GO:0086023)
0.0 0.7 GO:0021860 pyramidal neuron development(GO:0021860)
0.0 0.4 GO:0045579 phospholipid translocation(GO:0045332) positive regulation of B cell differentiation(GO:0045579)
0.0 0.1 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.1 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.1 GO:0090472 dibasic protein processing(GO:0090472)
0.0 0.9 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.3 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.8 GO:0051642 centrosome localization(GO:0051642)
0.0 0.1 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.0 0.2 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.0 0.2 GO:0043254 regulation of protein complex assembly(GO:0043254)
0.0 0.2 GO:0031272 regulation of pseudopodium assembly(GO:0031272)
0.0 0.4 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.4 GO:0045687 positive regulation of glial cell differentiation(GO:0045687)
0.0 0.0 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.9 GO:0021766 hippocampus development(GO:0021766)
0.0 1.0 GO:0045921 positive regulation of exocytosis(GO:0045921)
0.0 0.3 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.1 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.5 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.0 0.4 GO:0032728 positive regulation of interferon-beta production(GO:0032728)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.4 GO:1990584 cardiac Troponin complex(GO:1990584)
0.4 2.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.4 1.2 GO:0043512 inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512)
0.2 3.3 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.7 GO:0097441 basilar dendrite(GO:0097441)
0.1 0.5 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 1.6 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 1.2 GO:0097449 astrocyte projection(GO:0097449)
0.1 0.5 GO:1990393 3M complex(GO:1990393)
0.1 0.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 1.3 GO:0097228 sperm principal piece(GO:0097228)
0.1 0.2 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.8 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.4 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.3 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.8 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.2 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.9 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 2.3 GO:0016605 PML body(GO:0016605)
0.0 0.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 4.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.2 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.2 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 0.3 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 1.9 GO:0043204 perikaryon(GO:0043204)
0.0 0.1 GO:0045298 tubulin complex(GO:0045298)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.4 GO:0030172 troponin C binding(GO:0030172)
0.8 0.8 GO:0070051 fibrinogen binding(GO:0070051)
0.6 2.9 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.5 1.4 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.3 1.0 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.3 1.6 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.3 0.9 GO:0016748 succinyltransferase activity(GO:0016748)
0.3 1.6 GO:0016936 galactoside binding(GO:0016936)
0.3 1.3 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.3 0.8 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.2 2.7 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.2 4.0 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 0.7 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.2 2.2 GO:0019865 immunoglobulin binding(GO:0019865)
0.2 0.7 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.2 0.6 GO:0004875 complement receptor activity(GO:0004875)
0.2 0.7 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.2 1.7 GO:0070700 BMP receptor binding(GO:0070700)
0.2 4.5 GO:0001968 fibronectin binding(GO:0001968)
0.1 3.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.9 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 0.4 GO:0043758 acetate-CoA ligase (ADP-forming) activity(GO:0043758)
0.1 1.2 GO:0034711 inhibin binding(GO:0034711)
0.1 0.9 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.1 1.5 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 0.6 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.2 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.1 0.2 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.1 1.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.5 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.1 0.4 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.1 1.0 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 0.8 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 0.6 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.1 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0 1.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.2 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 2.3 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.0 0.2 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 1.7 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.1 GO:0015265 urea channel activity(GO:0015265)
0.0 1.4 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.7 GO:0035591 signaling adaptor activity(GO:0035591)
0.0 0.2 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 1.3 GO:0005179 hormone activity(GO:0005179)
0.0 0.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.7 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.2 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.1 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.0 0.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.5 GO:0005112 Notch binding(GO:0005112)
0.0 0.2 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 2.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.4 GO:0070888 E-box binding(GO:0070888)
0.0 0.2 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 0.1 GO:0048406 nerve growth factor binding(GO:0048406)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 1.9 PID_EPO_PATHWAY EPO signaling pathway
0.0 0.8 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 3.1 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.7 PID_VEGFR1_PATHWAY VEGFR1 specific signals
0.0 4.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 0.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.7 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.7 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.0 0.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.3 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.2 2.2 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.2 3.7 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 1.4 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 2.9 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 1.4 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 0.8 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1 2.2 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 0.5 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 1.0 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 1.6 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.1 1.1 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 2.2 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.1 0.6 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 1.5 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.9 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 3.2 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.3 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 1.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.2 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.4 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.8 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.7 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.4 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.1 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases