Motif ID: Gata3

Z-value: 1.786


Transcription factors associated with Gata3:

Gene SymbolEntrez IDGene Name
Gata3 ENSMUSG00000015619.10 Gata3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gata3mm10_v2_chr2_-_9890026_9890035-0.607.5e-05Click!


Activity profile for motif Gata3.

activity profile for motif Gata3


Sorted Z-values histogram for motif Gata3

Sorted Z-values for motif Gata3



Network of associatons between targets according to the STRING database.



First level regulatory network of Gata3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_119053339 17.995 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
 Gli2


GLI-Kruppel family member GLI2


chr1_-_119053619 13.915 ENSMUST00000062483.8
 Gli2
GLI-Kruppel family member GLI2
chr6_-_23248264 11.177 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr11_+_102604370 9.671 ENSMUST00000057893.5
 Fzd2
frizzled homolog 2 (Drosophila)
chr4_-_117178726 8.714 ENSMUST00000153953.1
ENSMUST00000106436.1
 Kif2c

kinesin family member 2C

chr1_+_6730051 8.540 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr3_+_102010138 8.288 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr14_+_67234620 8.060 ENSMUST00000176029.1
 Ebf2
early B cell factor 2
chr16_-_50432340 7.198 ENSMUST00000066037.6
ENSMUST00000089399.4
ENSMUST00000089404.3
ENSMUST00000114477.1
ENSMUST00000138166.1
 Bbx




bobby sox homolog (Drosophila)




chr4_+_148041172 6.998 ENSMUST00000069604.8
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr7_-_116031047 6.984 ENSMUST00000106612.1
 Sox6
SRY-box containing gene 6
chr7_-_103853199 6.947 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr2_+_25372315 6.843 ENSMUST00000028329.6
ENSMUST00000114293.2
ENSMUST00000100323.2
 Sapcd2


suppressor APC domain containing 2


chr7_-_37772868 6.755 ENSMUST00000176205.1
 Zfp536
zinc finger protein 536
chr9_+_65265173 6.679 ENSMUST00000048762.1
 Cilp
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr11_+_32276400 6.242 ENSMUST00000020531.2
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr6_-_48840988 6.217 ENSMUST00000164733.1
 Tmem176b
transmembrane protein 176B
chr6_-_48841098 6.199 ENSMUST00000101429.4
 Tmem176b
transmembrane protein 176B
chr4_-_117182623 6.169 ENSMUST00000065896.2
 Kif2c
kinesin family member 2C
chr4_+_9269285 6.121 ENSMUST00000038841.7
 Clvs1
clavesin 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 365 entries
Log-likelihood per target Total log-likelihoodTermDescription
8.0 31.9 GO:0060032 notochord regression(GO:0060032)
4.2 29.4 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
2.1 23.4 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
4.3 21.5 GO:0015671 oxygen transport(GO:0015671)
3.0 14.9 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.3 14.1 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
1.1 13.7 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
2.0 12.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.0 11.4 GO:0060539 diaphragm development(GO:0060539)
2.7 10.9 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.8 10.6 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
1.9 9.7 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.1 9.7 GO:0043488 regulation of mRNA stability(GO:0043488)
0.6 9.5 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.6 9.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
1.3 9.2 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.6 9.2 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085)
1.3 8.9 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
2.2 8.8 GO:0070829 heterochromatin maintenance(GO:0070829)
0.3 8.7 GO:0032467 positive regulation of cytokinesis(GO:0032467)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 167 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 72.9 GO:0005634 nucleus(GO:0005634)
2.5 32.1 GO:0097542 ciliary tip(GO:0097542)
0.1 24.7 GO:0005667 transcription factor complex(GO:0005667)
1.8 14.4 GO:0005833 hemoglobin complex(GO:0005833)
0.4 13.3 GO:0035371 microtubule plus-end(GO:0035371)
0.1 13.1 GO:0032993 protein-DNA complex(GO:0032993)
0.2 11.0 GO:0008180 COP9 signalosome(GO:0008180)
0.2 9.4 GO:0005871 kinesin complex(GO:0005871)
0.3 9.2 GO:0005721 pericentric heterochromatin(GO:0005721)
0.4 8.5 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.2 7.8 GO:0002102 podosome(GO:0002102)
0.2 7.4 GO:0072562 blood microparticle(GO:0072562)
0.5 7.0 GO:0042788 polysomal ribosome(GO:0042788)
0.8 6.7 GO:0033269 internode region of axon(GO:0033269)
1.2 6.1 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 6.0 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 5.8 GO:0005925 focal adhesion(GO:0005925)
0.1 5.7 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2 5.3 GO:0060077 inhibitory synapse(GO:0060077)
0.1 5.2 GO:0000786 nucleosome(GO:0000786)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 239 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 47.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.0 34.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
4.3 21.5 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 20.0 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 17.1 GO:0001047 core promoter binding(GO:0001047)
0.9 15.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 13.0 GO:0033613 activating transcription factor binding(GO:0033613)
0.6 11.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.6 10.9 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
1.5 9.2 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.2 9.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 8.5 GO:0004386 helicase activity(GO:0004386)
1.6 7.9 GO:0043532 angiostatin binding(GO:0043532)
0.4 7.7 GO:0001848 complement binding(GO:0001848)
0.3 7.7 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.8 7.6 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.5 7.5 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.2 7.4 GO:0017091 AU-rich element binding(GO:0017091)
0.1 7.4 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 7.1 GO:0019904 protein domain specific binding(GO:0019904)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 34.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.5 22.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.4 13.3 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.3 12.6 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 11.2 PID_E2F_PATHWAY E2F transcription factor network
0.1 8.7 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.1 8.0 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 7.2 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 6.6 PID_RHOA_PATHWAY RhoA signaling pathway
0.2 6.1 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 5.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 5.7 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.2 5.7 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 5.3 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.2 4.9 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.7 3.7 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.1 3.0 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 2.9 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 2.7 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 2.6 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 19.1 REACTOME_KINESINS Genes involved in Kinesins
0.3 10.5 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 8.9 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 8.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.8 7.6 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 7.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 7.1 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.3 6.9 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2 6.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 6.7 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.3 6.5 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 6.3 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS Genes involved in G alpha (12/13) signalling events
0.2 6.2 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.1 4.4 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 4.4 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.1 4.2 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 4.2 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.3 3.8 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 3.7 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.3 3.6 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling