Motif ID: Gata6

Z-value: 0.256


Transcription factors associated with Gata6:

Gene SymbolEntrez IDGene Name
Gata6 ENSMUSG00000005836.8 Gata6



Activity profile for motif Gata6.

activity profile for motif Gata6


Sorted Z-values histogram for motif Gata6

Sorted Z-values for motif Gata6



Network of associatons between targets according to the STRING database.



First level regulatory network of Gata6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_103853199 1.396 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr6_-_23248264 1.289 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr8_+_45628176 0.870 ENSMUST00000130850.1
 Sorbs2
sorbin and SH3 domain containing 2
chr8_+_45627946 0.780 ENSMUST00000145458.1
 Sorbs2
sorbin and SH3 domain containing 2
chr8_+_45627709 0.732 ENSMUST00000134321.1
ENSMUST00000135336.1
 Sorbs2

sorbin and SH3 domain containing 2

chr4_+_13751297 0.595 ENSMUST00000105566.2
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr8_-_122699066 0.439 ENSMUST00000127984.1
 Cbfa2t3
core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)
chr12_+_95692212 0.420 ENSMUST00000057324.3
 Flrt2
fibronectin leucine rich transmembrane protein 2
chr16_-_46010212 0.351 ENSMUST00000130481.1
 Plcxd2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr2_+_65930117 0.347 ENSMUST00000176109.1
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr1_+_179803376 0.342 ENSMUST00000097454.2
 Gm10518
predicted gene 10518
chr5_-_73191848 0.310 ENSMUST00000176910.1
 Fryl
furry homolog-like (Drosophila)
chr1_-_25829511 0.280 ENSMUST00000135518.1
ENSMUST00000151309.1
 Bai3

brain-specific angiogenesis inhibitor 3

chr2_+_80617045 0.277 ENSMUST00000028384.4
 Dusp19
dual specificity phosphatase 19
chr2_+_71786923 0.270 ENSMUST00000112101.1
ENSMUST00000028522.3
 Itga6

integrin alpha 6

chr16_-_34262945 0.255 ENSMUST00000114953.1
 Kalrn
kalirin, RhoGEF kinase
chr9_+_66350465 0.250 ENSMUST00000042824.6
 Herc1
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
chr4_-_110287479 0.247 ENSMUST00000106598.1
ENSMUST00000102723.4
ENSMUST00000153906.1
 Elavl4


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)


chr2_-_172370506 0.247 ENSMUST00000109139.1
ENSMUST00000028997.7
ENSMUST00000109140.3
 Aurka


aurora kinase A


chr6_-_127109517 0.241 ENSMUST00000039913.8
 9630033F20Rik
RIKEN cDNA 9630033F20 gene
chr11_+_67586675 0.226 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr9_+_62342449 0.197 ENSMUST00000156461.1
 Anp32a
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr9_+_44379490 0.191 ENSMUST00000066601.6
 Hyou1
hypoxia up-regulated 1
chr6_+_58831748 0.185 ENSMUST00000126292.1
ENSMUST00000031823.5
 Herc3

hect domain and RLD 3

chr2_+_125859134 0.185 ENSMUST00000028636.6
ENSMUST00000125084.1
 Galk2

galactokinase 2

chr6_+_58833689 0.174 ENSMUST00000041401.8
 Herc3
hect domain and RLD 3
chr5_+_121777929 0.168 ENSMUST00000160821.1
 Atxn2
ataxin 2
chr17_+_71204647 0.168 ENSMUST00000126681.1
 Lpin2
lipin 2
chr17_+_34604819 0.165 ENSMUST00000173242.1
 Agpat1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr11_+_4883186 0.158 ENSMUST00000139737.1
 Nipsnap1
4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (C. elegans)
chr6_+_86078070 0.150 ENSMUST00000032069.5
 Add2
adducin 2 (beta)
chr7_-_119895446 0.142 ENSMUST00000098080.2
 Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr19_+_4711153 0.139 ENSMUST00000008991.6
 Sptbn2
spectrin beta, non-erythrocytic 2
chr15_-_103251465 0.137 ENSMUST00000133600.1
ENSMUST00000134554.1
ENSMUST00000156927.1
ENSMUST00000149111.1
ENSMUST00000132836.1
 Nfe2




nuclear factor, erythroid derived 2




chr11_-_102365111 0.132 ENSMUST00000006749.9
 Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr2_+_68104671 0.130 ENSMUST00000042456.3
 B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr3_-_92429403 0.121 ENSMUST00000047300.7
 Gm9774
predicted pseudogene 9774
chr11_+_95712673 0.112 ENSMUST00000107717.1
 Zfp652
zinc finger protein 652
chr10_+_40883469 0.110 ENSMUST00000019975.7
 Wasf1
WAS protein family, member 1
chr17_-_33713372 0.107 ENSMUST00000173392.1
 March2
membrane-associated ring finger (C3HC4) 2
chr2_+_110597298 0.106 ENSMUST00000045972.6
ENSMUST00000111026.2
 Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chr2_+_143915273 0.106 ENSMUST00000103172.3
 Dstn
destrin
chr2_-_7395879 0.103 ENSMUST00000182404.1
 Celf2
CUGBP, Elav-like family member 2
chr2_-_7081207 0.102 ENSMUST00000114923.2
ENSMUST00000182706.1
 Celf2

CUGBP, Elav-like family member 2

chr2_-_7396192 0.100 ENSMUST00000137733.2
 Celf2
CUGBP, Elav-like family member 2
chr16_+_58670208 0.099 ENSMUST00000060077.5
 Cpox
coproporphyrinogen oxidase
chr2_-_59948155 0.095 ENSMUST00000153136.1
 Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr10_-_40883073 0.082 ENSMUST00000044166.7
 Cdc40
cell division cycle 40
chr6_-_38124568 0.076 ENSMUST00000040259.4
 Atp6v0a4
ATPase, H+ transporting, lysosomal V0 subunit A4
chr6_-_7983424 0.073 ENSMUST00000178598.1
 Gm9825
predicted gene 9825
chr2_-_7081256 0.061 ENSMUST00000183209.1
 Celf2
CUGBP, Elav-like family member 2
chr3_-_154330543 0.057 ENSMUST00000184966.1
ENSMUST00000177846.2
 Lhx8

LIM homeobox protein 8

chr9_-_106887000 0.055 ENSMUST00000055843.7
 Rbm15b
RNA binding motif protein 15B
chr15_-_83170168 0.054 ENSMUST00000162834.1
 Cyb5r3
cytochrome b5 reductase 3
chr9_+_65032413 0.052 ENSMUST00000034960.6
 Dpp8
dipeptidylpeptidase 8
chr8_-_64205970 0.050 ENSMUST00000066166.4
 Tll1
tolloid-like
chr10_-_34207551 0.046 ENSMUST00000048010.7
 Dse
dermatan sulfate epimerase
chr18_-_43477764 0.044 ENSMUST00000057110.9
 Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr13_+_24802020 0.039 ENSMUST00000155575.1
 BC005537
cDNA sequence BC005537
chr1_+_152954966 0.038 ENSMUST00000043313.8
 Nmnat2
nicotinamide nucleotide adenylyltransferase 2
chr10_+_52417532 0.037 ENSMUST00000023830.8
 Nus1
nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)
chr9_-_44342332 0.033 ENSMUST00000097558.3
 Hmbs
hydroxymethylbilane synthase
chr11_-_70220969 0.033 ENSMUST00000060010.2
 Slc16a13
solute carrier family 16 (monocarboxylic acid transporters), member 13
chr7_-_99238564 0.028 ENSMUST00000064231.7
 Mogat2
monoacylglycerol O-acyltransferase 2
chr15_-_83170498 0.024 ENSMUST00000162178.1
 Cyb5r3
cytochrome b5 reductase 3
chr2_-_125859139 0.009 ENSMUST00000110463.1
ENSMUST00000028635.5
 Cops2

COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana)

chr15_-_50890396 0.006 ENSMUST00000185183.1
 Trps1
trichorhinophalangeal syndrome I (human)
chr10_+_53337686 0.006 ENSMUST00000046221.6
ENSMUST00000163319.1
 Pln

phospholamban

chr17_+_57249450 0.004 ENSMUST00000019631.9
 Trip10
thyroid hormone receptor interactor 10

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0015671 oxygen transport(GO:0015671)
0.2 1.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 0.4 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.1 0.2 GO:0007056 spindle assembly involved in female meiosis(GO:0007056) positive regulation of oocyte development(GO:0060282)
0.1 2.4 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.4 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.0 0.3 GO:0035878 nail development(GO:0035878)
0.0 0.3 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0 0.3 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.1 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.6 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.0 0.2 GO:1903298 regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298)
0.0 0.1 GO:1990416 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.0 0.0 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.2 GO:0006012 galactose metabolic process(GO:0006012)
0.0 0.1 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.3 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.1 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.0 0.2 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 0.6 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0005833 hemoglobin complex(GO:0005833)
0.1 0.2 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.3 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0008091 spectrin(GO:0008091)
0.0 0.1 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.2 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.2 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.2 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.1 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.1 0.3 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.1 0.2 GO:0004335 galactokinase activity(GO:0004335)
0.1 0.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.3 GO:0038132 neuregulin binding(GO:0038132)
0.0 0.2 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.1 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.0 0.4 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.1 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.1 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.2 GO:0050692 DBD domain binding(GO:0050692)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE