Motif ID: Gbx2
Z-value: 0.532
Transcription factors associated with Gbx2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Gbx2 | ENSMUSG00000034486.7 | Gbx2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Gbx2 | mm10_v2_chr1_-_89933290_89933290 | -0.27 | 1.1e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 5.6 | GO:0042891 | antibiotic transport(GO:0042891) dipeptide transport(GO:0042938) |
0.7 | 2.7 | GO:0035609 | C-terminal protein deglutamylation(GO:0035609) |
0.6 | 1.8 | GO:0099548 | drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by nitric oxide(GO:0099548) |
0.3 | 0.9 | GO:2000564 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187) |
0.3 | 1.1 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
0.2 | 2.2 | GO:0061032 | visceral serous pericardium development(GO:0061032) |
0.2 | 1.0 | GO:0000707 | meiotic DNA recombinase assembly(GO:0000707) |
0.1 | 1.1 | GO:0071802 | negative regulation of podosome assembly(GO:0071802) |
0.1 | 1.1 | GO:0072615 | interleukin-17 secretion(GO:0072615) |
0.1 | 0.8 | GO:0071883 | activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883) |
0.1 | 0.3 | GO:0086046 | membrane depolarization during SA node cell action potential(GO:0086046) |
0.1 | 0.2 | GO:0036292 | DNA rewinding(GO:0036292) |
0.1 | 1.2 | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482) |
0.0 | 0.4 | GO:0046477 | glycosylceramide catabolic process(GO:0046477) |
0.0 | 0.2 | GO:0070171 | negative regulation of tooth mineralization(GO:0070171) |
0.0 | 0.2 | GO:0033762 | response to glucagon(GO:0033762) |
0.0 | 0.3 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
0.0 | 0.3 | GO:0007406 | negative regulation of neuroblast proliferation(GO:0007406) |
0.0 | 1.9 | GO:0009063 | cellular amino acid catabolic process(GO:0009063) |
0.0 | 0.2 | GO:0048630 | skeletal muscle tissue growth(GO:0048630) |
0.0 | 0.1 | GO:0006824 | cobalt ion transport(GO:0006824) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 1.0 | GO:0033063 | Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) |
0.2 | 1.8 | GO:0042582 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
0.1 | 3.4 | GO:0002102 | podosome(GO:0002102) |
0.1 | 0.9 | GO:0042612 | MHC class I protein complex(GO:0042612) |
0.0 | 0.3 | GO:0070652 | HAUS complex(GO:0070652) |
0.0 | 0.3 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
0.0 | 0.3 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
0.0 | 0.2 | GO:0045275 | respiratory chain complex III(GO:0045275) |
0.0 | 2.7 | GO:0005814 | centriole(GO:0005814) |
0.0 | 1.3 | GO:0070469 | respiratory chain(GO:0070469) |
0.0 | 0.2 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
0.0 | 0.7 | GO:0000786 | nucleosome(GO:0000786) |
0.0 | 0.0 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.9 | 5.6 | GO:0042936 | dipeptide transporter activity(GO:0042936) |
0.6 | 1.9 | GO:0001716 | L-amino-acid oxidase activity(GO:0001716) |
0.6 | 1.8 | GO:0004517 | nitric-oxide synthase activity(GO:0004517) |
0.6 | 2.2 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
0.3 | 1.1 | GO:0008142 | oxysterol binding(GO:0008142) |
0.2 | 1.2 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915) |
0.1 | 2.7 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
0.1 | 1.0 | GO:0000150 | recombinase activity(GO:0000150) |
0.1 | 0.9 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
0.1 | 0.8 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
0.1 | 0.2 | GO:0008192 | RNA guanylyltransferase activity(GO:0008192) |
0.0 | 1.3 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
0.0 | 0.3 | GO:0086007 | voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007) |
0.0 | 1.1 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
0.0 | 0.3 | GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162) |
0.0 | 0.1 | GO:0098639 | collagen binding involved in cell-matrix adhesion(GO:0098639) |
0.0 | 0.2 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
0.0 | 0.1 | GO:0050436 | microfibril binding(GO:0050436) |
0.0 | 0.2 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
0.0 | 0.3 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
0.0 | 0.0 | GO:1990050 | phosphatidic acid transporter activity(GO:1990050) |
0.0 | 0.1 | GO:0015087 | cobalt ion transmembrane transporter activity(GO:0015087) |
0.0 | 0.2 | GO:0036310 | annealing helicase activity(GO:0036310) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 2.2 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
0.1 | 1.2 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
0.0 | 1.9 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 1.2 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
0.1 | 2.2 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
0.1 | 5.6 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
0.1 | 1.8 | REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
0.0 | 0.7 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
0.0 | 1.9 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
0.0 | 0.2 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
0.0 | 1.1 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
0.0 | 0.4 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |