Motif ID: Gcm2

Z-value: 1.780


Transcription factors associated with Gcm2:

Gene SymbolEntrez IDGene Name
Gcm2 ENSMUSG00000021362.6 Gcm2



Activity profile for motif Gcm2.

activity profile for motif Gcm2


Sorted Z-values histogram for motif Gcm2

Sorted Z-values for motif Gcm2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gcm2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_6065737 20.550 ENSMUST00000002817.5
ENSMUST00000109813.2
ENSMUST00000090443.3
 Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr15_-_66831625 17.000 ENSMUST00000164163.1
 Sla
src-like adaptor
chr7_+_121392266 14.383 ENSMUST00000084628.3
 Hs3st2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr4_-_138396438 11.649 ENSMUST00000105032.2
 Fam43b
family with sequence similarity 43, member B
chr11_-_6065538 11.576 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr15_-_44788016 8.794 ENSMUST00000090057.4
ENSMUST00000110269.1
 Sybu

syntabulin (syntaxin-interacting)

chr19_+_6400523 7.579 ENSMUST00000146831.1
ENSMUST00000035716.8
ENSMUST00000138555.1
ENSMUST00000167240.1
 Rasgrp2



RAS, guanyl releasing protein 2



chr2_-_32353247 7.371 ENSMUST00000078352.5
ENSMUST00000113352.2
ENSMUST00000113365.1
 Dnm1


dynamin 1


chr9_+_112234257 7.248 ENSMUST00000149308.3
ENSMUST00000144424.2
ENSMUST00000139552.2
 2900079G21Rik


RIKEN cDNA 2900079G21 gene


chr15_+_44787746 6.340 ENSMUST00000181839.1
 2310069G16Rik
RIKEN cDNA 2310069G16 gene
chr4_+_13743424 6.340 ENSMUST00000006761.3
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr11_+_98348404 6.303 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr14_+_62555737 6.130 ENSMUST00000039064.7
 Fam124a
family with sequence similarity 124, member A
chr3_+_96596628 5.900 ENSMUST00000058943.7
 Ankrd34a
ankyrin repeat domain 34A
chr1_+_50927511 5.832 ENSMUST00000081851.3
 Tmeff2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr19_+_8664005 5.794 ENSMUST00000035444.3
ENSMUST00000163785.1
 Chrm1

cholinergic receptor, muscarinic 1, CNS

chr5_-_37717122 5.576 ENSMUST00000094836.4
 Stk32b
serine/threonine kinase 32B
chr4_+_104367549 5.548 ENSMUST00000106830.2
 Dab1
disabled 1
chr17_+_48932368 5.482 ENSMUST00000046254.2
 Lrfn2
leucine rich repeat and fibronectin type III domain containing 2
chr5_+_110544326 5.467 ENSMUST00000040001.7
 Galnt9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 445 entries
Log-likelihood per target Total log-likelihoodTermDescription
10.7 32.1 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
0.3 15.7 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
1.8 12.5 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.2 8.7 GO:0034605 cellular response to heat(GO:0034605)
1.1 7.9 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.2 7.3 GO:0071625 vocalization behavior(GO:0071625)
0.3 6.7 GO:0030204 chondroitin sulfate metabolic process(GO:0030204)
0.1 6.7 GO:0022900 electron transport chain(GO:0022900)
0.9 6.4 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
2.1 6.3 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.3 6.0 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
1.5 5.8 GO:0045113 regulation of integrin biosynthetic process(GO:0045113)
1.2 5.8 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
1.8 5.5 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.3 5.1 GO:0001553 luteinization(GO:0001553)
0.4 5.0 GO:0048484 enteric nervous system development(GO:0048484)
1.6 4.7 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.9 4.7 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.1 4.7 GO:0071277 cellular response to calcium ion(GO:0071277)
0.9 4.6 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 194 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 48.1 GO:0016021 integral component of membrane(GO:0016021)
0.8 27.1 GO:0051233 spindle midzone(GO:0051233)
1.4 22.0 GO:0043196 varicosity(GO:0043196)
0.1 20.3 GO:0008021 synaptic vesicle(GO:0008021)
0.1 19.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 19.0 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 14.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 10.6 GO:0043025 neuronal cell body(GO:0043025)
1.2 9.3 GO:0097433 dense body(GO:0097433)
0.0 8.7 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 7.5 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 7.3 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.3 6.4 GO:0032279 asymmetric synapse(GO:0032279)
0.2 6.3 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 5.4 GO:0005581 collagen trimer(GO:0005581)
0.9 5.2 GO:0008091 spectrin(GO:0008091)
0.1 5.2 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 5.1 GO:0032590 dendrite membrane(GO:0032590)
0.4 4.9 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.3 4.6 GO:1990635 proximal dendrite(GO:1990635)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 293 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 35.4 GO:0043274 phospholipase binding(GO:0043274)
0.9 17.4 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.4 13.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.6 12.5 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.0 12.4 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.8 9.9 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.3 9.6 GO:0017046 peptide hormone binding(GO:0017046)
0.1 9.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.3 8.9 GO:0017075 syntaxin-1 binding(GO:0017075)
0.2 6.5 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 6.4 GO:0030165 PDZ domain binding(GO:0030165)
2.1 6.3 GO:0031750 D3 dopamine receptor binding(GO:0031750)
1.2 5.8 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.3 5.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.5 5.4 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.2 4.7 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.7 4.3 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.1 4.3 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.8 4.2 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.3 4.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 32.0 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 15.4 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.3 13.2 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 8.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 6.1 PID_RAS_PATHWAY Regulation of Ras family activation
0.2 6.0 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 5.4 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 4.1 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.3 3.9 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 3.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.4 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.1 3.2 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.2 2.9 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 2.9 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.1 2.7 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 2.6 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.1 2.5 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 2.5 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 2.3 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.1 2.0 PID_FGF_PATHWAY FGF signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 33.8 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.5 18.5 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.9 17.6 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.5 16.2 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.3 11.5 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.2 7.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 5.8 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 5.7 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.5 5.4 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.3 4.8 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 4.7 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.7 4.2 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.1 4.2 REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0 3.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 3.8 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 3.6 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 3.5 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 3.4 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.2 3.3 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 3.3 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters