Motif ID: Gfi1_Gfi1b

Z-value: 1.216

Transcription factors associated with Gfi1_Gfi1b:

Gene SymbolEntrez IDGene Name
Gfi1 ENSMUSG00000029275.11 Gfi1
Gfi1b ENSMUSG00000026815.8 Gfi1b



Activity profile for motif Gfi1_Gfi1b.

activity profile for motif Gfi1_Gfi1b


Sorted Z-values histogram for motif Gfi1_Gfi1b

Sorted Z-values for motif Gfi1_Gfi1b



Network of associatons between targets according to the STRING database.



First level regulatory network of Gfi1_Gfi1b

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 10.557 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr7_+_62376979 5.228 ENSMUST00000080403.5
 Magel2
melanoma antigen, family L, 2
chr16_-_26989974 4.298 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr12_+_109544498 4.146 ENSMUST00000126289.1
 Meg3
maternally expressed 3
chr12_+_109545390 3.826 ENSMUST00000146701.1
 Meg3
maternally expressed 3
chr9_+_3027439 3.726 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr12_+_74297474 3.662 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain
chr9_+_3000922 3.482 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr8_+_106935720 3.413 ENSMUST00000047425.3
 Sntb2
syntrophin, basic 2
chr9_+_3005125 3.264 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3013140 3.173 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3034599 3.087 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3017408 2.857 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3023547 2.855 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3015654 2.761 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3025417 2.730 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr13_+_5861489 2.540 ENSMUST00000000080.6
 Klf6
Kruppel-like factor 6
chr9_+_3037111 2.444 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3036877 2.360 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr7_-_17062384 2.258 ENSMUST00000153833.1
ENSMUST00000108492.2
 Hif3a

hypoxia inducible factor 3, alpha subunit


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 176 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 10.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 7.1 GO:0008340 determination of adult lifespan(GO:0008340)
0.4 5.3 GO:0051127 positive regulation of actin nucleation(GO:0051127)
0.1 5.1 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.1 4.5 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 3.9 GO:0006270 DNA replication initiation(GO:0006270)
0.0 3.6 GO:0030032 lamellipodium assembly(GO:0030032)
0.5 3.0 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.2 2.3 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.7 2.2 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.7 2.1 GO:0072284 cervix development(GO:0060067) metanephric S-shaped body morphogenesis(GO:0072284) anterior head development(GO:0097065) regulation of anterior head development(GO:2000742) positive regulation of anterior head development(GO:2000744)
0.3 2.1 GO:0046880 regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884)
0.7 2.0 GO:1902336 neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) positive regulation of retinal ganglion cell axon guidance(GO:1902336)
0.3 2.0 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.2 1.9 GO:0005513 detection of calcium ion(GO:0005513)
0.0 1.9 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 1.8 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.5 1.6 GO:0030070 insulin processing(GO:0030070)
0.4 1.6 GO:1900623 positive regulation of keratinocyte proliferation(GO:0010838) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.4 1.6 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.3 GO:0030027 lamellipodium(GO:0030027)
0.1 5.6 GO:0016605 PML body(GO:0016605)
0.1 5.2 GO:0030904 retromer complex(GO:0030904)
0.0 3.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 2.3 GO:0043034 costamere(GO:0043034)
0.2 2.2 GO:0005883 neurofilament(GO:0005883)
0.5 1.9 GO:0090537 CERF complex(GO:0090537)
0.1 1.9 GO:0031045 dense core granule(GO:0031045)
0.1 1.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 1.6 GO:0005797 Golgi medial cisterna(GO:0005797)
0.1 1.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.3 1.3 GO:0001533 cornified envelope(GO:0001533)
0.1 1.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 1.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.3 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 1.3 GO:0030118 clathrin coat(GO:0030118)
0.0 1.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.4 1.2 GO:0043512 inhibin A complex(GO:0043512)
0.2 1.1 GO:0042627 chylomicron(GO:0042627)
0.1 1.1 GO:1990909 Wnt signalosome(GO:1990909)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 126 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 4.6 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.5 3.3 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.6 2.8 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 2.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 2.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.3 2.3 GO:0034711 inhibin binding(GO:0034711)
0.2 2.3 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.2 2.3 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 2.3 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.7 2.0 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.2 2.0 GO:0015643 toxic substance binding(GO:0015643)
0.6 1.9 GO:0070615 nucleosome-dependent ATPase activity(GO:0070615)
0.5 1.9 GO:0030348 syntaxin-3 binding(GO:0030348)
0.1 1.9 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.8 GO:0035064 methylated histone binding(GO:0035064)
0.0 1.8 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 1.7 GO:0003713 transcription coactivator activity(GO:0003713)
0.5 1.6 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 1.6 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.2 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 2.3 PID_ALK1_PATHWAY ALK1 signaling events
0.1 2.1 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.2 2.0 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 2.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.9 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.1 1.8 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 1.6 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.0 1.4 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 1.3 PID_INSULIN_PATHWAY Insulin Pathway
0.0 1.1 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 1.0 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 0.9 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 0.9 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.9 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.9 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.8 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.7 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.7 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.1 0.6 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.4 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.1 3.9 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 3.3 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 3.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.3 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 2.3 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 2.0 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 2.0 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.2 1.9 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 1.9 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 1.7 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.7 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.6 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.5 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.3 1.2 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 1.1 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 1.1 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.1 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 1.0 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 1.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase