Motif ID: Gli2

Z-value: 0.698


Transcription factors associated with Gli2:

Gene SymbolEntrez IDGene Name
Gli2 ENSMUSG00000048402.8 Gli2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli2mm10_v2_chr1_-_118982551_1189826060.124.8e-01Click!


Activity profile for motif Gli2.

activity profile for motif Gli2


Sorted Z-values histogram for motif Gli2

Sorted Z-values for motif Gli2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli2

PNG image of the network

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Top targets:


Showing 1 to 20 of 137 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 5.912 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr15_-_56694525 4.752 ENSMUST00000050544.7
 Has2
hyaluronan synthase 2
chrX_-_141725181 4.320 ENSMUST00000067841.7
 Irs4
insulin receptor substrate 4
chr7_-_137314394 3.253 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr6_-_72789240 2.980 ENSMUST00000069536.5
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr12_+_58211772 2.833 ENSMUST00000110671.2
ENSMUST00000044299.2
 Sstr1

somatostatin receptor 1

chr12_+_38780284 2.762 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr6_-_72788952 2.616 ENSMUST00000114053.2
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr7_-_4752972 2.430 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr8_+_127064022 2.119 ENSMUST00000160272.1
ENSMUST00000079777.5
ENSMUST00000162907.1
 Pard3


par-3 (partitioning defective 3) homolog (C. elegans)


chr8_+_127064107 2.066 ENSMUST00000162536.1
ENSMUST00000026921.6
ENSMUST00000162665.1
ENSMUST00000160766.1
ENSMUST00000162602.1
ENSMUST00000162531.1
ENSMUST00000160581.1
ENSMUST00000161355.1
ENSMUST00000159537.1
 Pard3








par-3 (partitioning defective 3) homolog (C. elegans)








chr4_+_36952930 1.902 ENSMUST00000144029.1
 Gm12371
predicted gene 12371
chr8_+_127063893 1.723 ENSMUST00000162309.1
 Pard3
par-3 (partitioning defective 3) homolog (C. elegans)
chrX_-_9662950 1.657 ENSMUST00000033519.2
 Dynlt3
dynein light chain Tctex-type 3
chr9_-_43239816 1.595 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr10_-_114801364 1.432 ENSMUST00000061632.7
 Trhde
TRH-degrading enzyme
chr18_+_86394952 1.334 ENSMUST00000058829.2
 Neto1
neuropilin (NRP) and tolloid (TLL)-like 1
chr13_+_5861489 1.323 ENSMUST00000000080.6
 Klf6
Kruppel-like factor 6
chr6_+_120666388 1.316 ENSMUST00000112686.1
 Cecr2
cat eye syndrome chromosome region, candidate 2
chr1_+_167001417 1.301 ENSMUST00000165874.1
 Fam78b
family with sequence similarity 78, member B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 5.9 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.0 5.9 GO:0003383 apical constriction(GO:0003383)
1.9 5.6 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
1.2 4.8 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 3.4 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.3 2.8 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 2.8 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.3 2.6 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.2 2.1 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 1.7 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.2 1.6 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 1.6 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.0 1.4 GO:0043171 peptide catabolic process(GO:0043171)
0.4 1.3 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.4 1.3 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.2 1.3 GO:0032229 negative regulation of synaptic transmission, GABAergic(GO:0032229)
0.1 1.3 GO:0001842 neural fold formation(GO:0001842)
0.3 1.2 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.2 1.1 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.3 1.0 GO:0061588 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylserine scrambling(GO:0061589) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591) phosphatidylserine exposure on apoptotic cell surface(GO:0070782)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 5.9 GO:0033269 internode region of axon(GO:0033269)
0.0 5.2 GO:0005667 transcription factor complex(GO:0005667)
0.1 3.7 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 2.6 GO:0097470 ribbon synapse(GO:0097470)
0.2 2.4 GO:0030061 mitochondrial crista(GO:0030061)
0.1 1.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.3 1.6 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 1.6 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.3 1.3 GO:0090537 CERF complex(GO:0090537)
0.2 1.3 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 1.3 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 1.0 GO:0033270 paranode region of axon(GO:0033270)
0.1 0.9 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.7 GO:0070876 SOSS complex(GO:0070876)
0.0 0.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.6 GO:0005915 zonula adherens(GO:0005915)
0.0 0.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 0.5 GO:0005594 collagen type IX trimer(GO:0005594)
0.1 0.5 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 7.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 5.6 GO:0008013 beta-catenin binding(GO:0008013)
0.1 4.2 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
1.3 4.0 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.9 2.8 GO:0004994 somatostatin receptor activity(GO:0004994)
0.3 2.6 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 2.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.8 GO:0003774 motor activity(GO:0003774)
0.4 1.6 GO:0097100 supercoiled DNA binding(GO:0097100)
0.1 1.6 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 1.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.3 1.3 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.2 1.3 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 1.3 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.0 1.3 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.1 1.2 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 1.1 GO:0050811 GABA receptor binding(GO:0050811)
0.3 1.0 GO:0005119 smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158)
0.1 1.0 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.2 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 4.2 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 2.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 2.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 1.7 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.3 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.3 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.9 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.6 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.9 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.3 4.0 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 2.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 2.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 1.6 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 1.6 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 1.4 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 1.3 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.3 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 1.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.9 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.7 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 0.6 REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.0 0.5 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.5 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.1 0.3 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.3 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.1 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs