Motif ID: Gli2

Z-value: 0.698


Transcription factors associated with Gli2:

Gene SymbolEntrez IDGene Name
Gli2 ENSMUSG00000048402.8 Gli2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli2mm10_v2_chr1_-_118982551_1189826060.124.8e-01Click!


Activity profile for motif Gli2.

activity profile for motif Gli2


Sorted Z-values histogram for motif Gli2

Sorted Z-values for motif Gli2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_23248264 5.912 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr15_-_56694525 4.752 ENSMUST00000050544.7
Has2
hyaluronan synthase 2
chrX_-_141725181 4.320 ENSMUST00000067841.7
Irs4
insulin receptor substrate 4
chr7_-_137314394 3.253 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
Ebf3



early B cell factor 3



chr6_-_72789240 2.980 ENSMUST00000069536.5
Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr12_+_58211772 2.833 ENSMUST00000110671.2
ENSMUST00000044299.2
Sstr1

somatostatin receptor 1

chr12_+_38780284 2.762 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
Etv1


ets variant gene 1


chr6_-_72788952 2.616 ENSMUST00000114053.2
Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr7_-_4752972 2.430 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr8_+_127064022 2.119 ENSMUST00000160272.1
ENSMUST00000079777.5
ENSMUST00000162907.1
Pard3


par-3 (partitioning defective 3) homolog (C. elegans)


chr8_+_127064107 2.066 ENSMUST00000162536.1
ENSMUST00000026921.6
ENSMUST00000162665.1
ENSMUST00000160766.1
ENSMUST00000162602.1
ENSMUST00000162531.1
ENSMUST00000160581.1
ENSMUST00000161355.1
ENSMUST00000159537.1
Pard3








par-3 (partitioning defective 3) homolog (C. elegans)








chr4_+_36952930 1.902 ENSMUST00000144029.1
Gm12371
predicted gene 12371
chr8_+_127063893 1.723 ENSMUST00000162309.1
Pard3
par-3 (partitioning defective 3) homolog (C. elegans)
chrX_-_9662950 1.657 ENSMUST00000033519.2
Dynlt3
dynein light chain Tctex-type 3
chr9_-_43239816 1.595 ENSMUST00000034512.5
Oaf
OAF homolog (Drosophila)
chr10_-_114801364 1.432 ENSMUST00000061632.7
Trhde
TRH-degrading enzyme
chr18_+_86394952 1.334 ENSMUST00000058829.2
Neto1
neuropilin (NRP) and tolloid (TLL)-like 1
chr13_+_5861489 1.323 ENSMUST00000000080.6
Klf6
Kruppel-like factor 6
chr6_+_120666388 1.316 ENSMUST00000112686.1
Cecr2
cat eye syndrome chromosome region, candidate 2
chr1_+_167001417 1.301 ENSMUST00000165874.1
Fam78b
family with sequence similarity 78, member B
chr5_-_53213447 1.295 ENSMUST00000031090.6
Sel1l3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr15_-_85581809 1.266 ENSMUST00000023015.7
Wnt7b
wingless-related MMTV integration site 7B
chr16_-_88056176 1.261 ENSMUST00000072256.5
ENSMUST00000023652.8
ENSMUST00000114137.1
Grik1


glutamate receptor, ionotropic, kainate 1


chr1_+_55406163 1.110 ENSMUST00000042986.8
Plcl1
phospholipase C-like 1
chr4_-_126256226 1.092 ENSMUST00000122129.1
ENSMUST00000061143.8
ENSMUST00000106132.2
Map7d1


MAP7 domain containing 1


chr11_+_101176041 1.039 ENSMUST00000103109.3
Cntnap1
contactin associated protein-like 1
chr4_+_117096049 1.012 ENSMUST00000030443.5
Ptch2
patched homolog 2
chr15_+_95790831 0.998 ENSMUST00000071874.6
Ano6
anoctamin 6
chr4_-_135971894 0.994 ENSMUST00000105852.1
Lypla2
lysophospholipase 2
chr13_+_35741313 0.964 ENSMUST00000163595.2
Cdyl
chromodomain protein, Y chromosome-like
chr19_+_6975048 0.948 ENSMUST00000070850.6
Ppp1r14b
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr5_-_24527276 0.943 ENSMUST00000088311.4
Gbx1
gastrulation brain homeobox 1
chr1_-_51915901 0.900 ENSMUST00000018561.7
ENSMUST00000114537.2
Myo1b

myosin IB

chr16_+_19760902 0.890 ENSMUST00000119468.1
B3gnt5
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr4_-_83486453 0.870 ENSMUST00000107214.2
ENSMUST00000107215.2
ENSMUST00000030207.8
Psip1


PC4 and SFRS1 interacting protein 1


chr4_+_63215402 0.869 ENSMUST00000036300.6
Col27a1
collagen, type XXVII, alpha 1
chr1_-_51915968 0.847 ENSMUST00000046390.7
Myo1b
myosin IB
chr19_+_6047081 0.830 ENSMUST00000025723.8
Syvn1
synovial apoptosis inhibitor 1, synoviolin
chr7_-_133123160 0.786 ENSMUST00000166439.1
Ctbp2
C-terminal binding protein 2
chr11_+_100619217 0.781 ENSMUST00000107376.1
Nkiras2
NFKB inhibitor interacting Ras-like protein 2
chr4_-_83486178 0.766 ENSMUST00000130626.1
Psip1
PC4 and SFRS1 interacting protein 1
chr19_+_6047055 0.753 ENSMUST00000134667.1
Syvn1
synovial apoptosis inhibitor 1, synoviolin
chr4_-_19708922 0.751 ENSMUST00000108246.2
Wwp1
WW domain containing E3 ubiquitin protein ligase 1
chr2_+_71211706 0.732 ENSMUST00000112142.1
ENSMUST00000112139.1
ENSMUST00000112140.1
ENSMUST00000112138.1
Dync1i2



dynein cytoplasmic 1 intermediate chain 2



chr7_-_133123409 0.722 ENSMUST00000170459.1
ENSMUST00000166400.1
Ctbp2

C-terminal binding protein 2

chr4_-_59783800 0.709 ENSMUST00000107526.1
ENSMUST00000095063.4
Inip

INTS3 and NABP interacting protein

chr3_+_107036156 0.693 ENSMUST00000052718.3
Kcna3
potassium voltage-gated channel, shaker-related subfamily, member 3
chr13_+_44730726 0.689 ENSMUST00000173704.1
ENSMUST00000044608.7
ENSMUST00000173367.1
Jarid2


jumonji, AT rich interactive domain 2


chr5_-_115300957 0.677 ENSMUST00000009157.3
Dynll1
dynein light chain LC8-type 1
chr3_+_28781305 0.658 ENSMUST00000060500.7
Eif5a2
eukaryotic translation initiation factor 5A2
chr5_-_115300912 0.652 ENSMUST00000112090.1
Dynll1
dynein light chain LC8-type 1
chr7_-_116308241 0.634 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
Plekha7


pleckstrin homology domain containing, family A member 7


chr16_-_17132377 0.629 ENSMUST00000023453.7
Sdf2l1
stromal cell-derived factor 2-like 1
chr11_-_42000284 0.620 ENSMUST00000109292.2
ENSMUST00000109290.1
Gabrg2

gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2

chr2_+_69861562 0.618 ENSMUST00000090852.4
ENSMUST00000166411.1
Ssb

Sjogren syndrome antigen B

chr9_+_62342449 0.609 ENSMUST00000156461.1
Anp32a
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr4_+_32800246 0.599 ENSMUST00000062802.4
Lyrm2
LYR motif containing 2
chr7_-_133123312 0.588 ENSMUST00000124096.1
ENSMUST00000171022.1
ENSMUST00000163601.1
ENSMUST00000165534.1
ENSMUST00000033269.8
Fgfr2
Ctbp2



fibroblast growth factor receptor 2
C-terminal binding protein 2



chr3_+_127633134 0.576 ENSMUST00000029587.7
Neurog2
neurogenin 2
chr18_-_35662180 0.558 ENSMUST00000025209.4
ENSMUST00000096573.2
Spata24

spermatogenesis associated 24

chr2_+_69861638 0.556 ENSMUST00000112260.1
Ssb
Sjogren syndrome antigen B
chr7_-_133122615 0.552 ENSMUST00000167218.1
Ctbp2
C-terminal binding protein 2
chr11_-_107794557 0.544 ENSMUST00000021066.3
Cacng4
calcium channel, voltage-dependent, gamma subunit 4
chr6_+_67266979 0.519 ENSMUST00000042990.4
Serbp1
serpine1 mRNA binding protein 1
chr10_+_80151154 0.512 ENSMUST00000146516.1
ENSMUST00000144526.1
Midn

midnolin

chr18_-_38250157 0.502 ENSMUST00000181871.1
1700086O06Rik
RIKEN cDNA 1700086O06 gene
chr2_+_130576170 0.494 ENSMUST00000028764.5
Oxt
oxytocin
chr4_+_121039385 0.477 ENSMUST00000030372.5
Col9a2
collagen, type IX, alpha 2
chr3_+_36552600 0.469 ENSMUST00000029269.5
ENSMUST00000136890.1
Exosc9

exosome component 9

chr1_+_71652837 0.465 ENSMUST00000097699.2
Apol7d
apolipoprotein L 7d
chr3_+_9250602 0.438 ENSMUST00000155203.1
Zbtb10
zinc finger and BTB domain containing 10
chr9_+_55149364 0.435 ENSMUST00000121677.1
Ube2q2
ubiquitin-conjugating enzyme E2Q (putative) 2
chr14_+_64950037 0.424 ENSMUST00000043914.5
Ints9
integrator complex subunit 9
chrX_+_161717055 0.419 ENSMUST00000112338.1
Rai2
retinoic acid induced 2
chrX_+_137049586 0.418 ENSMUST00000047852.7
Fam199x
family with sequence similarity 199, X-linked
chr2_-_157566319 0.417 ENSMUST00000109528.2
ENSMUST00000088494.2
Blcap

bladder cancer associated protein homolog (human)

chr11_-_42000532 0.416 ENSMUST00000070735.3
Gabrg2
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2
chr3_-_135608221 0.400 ENSMUST00000132668.1
Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
chrX_+_161717498 0.384 ENSMUST00000061514.7
Rai2
retinoic acid induced 2
chr11_+_117308135 0.379 ENSMUST00000153668.1
Sept9
septin 9
chr11_-_100620165 0.376 ENSMUST00000014339.8
Dnajc7
DnaJ (Hsp40) homolog, subfamily C, member 7
chr6_-_137649211 0.376 ENSMUST00000134630.1
ENSMUST00000058210.6
ENSMUST00000111878.1
Eps8


epidermal growth factor receptor pathway substrate 8


chr9_-_69760924 0.366 ENSMUST00000071281.4
Foxb1
forkhead box B1
chr12_-_69357120 0.363 ENSMUST00000021368.8
Nemf
nuclear export mediator factor
chr5_-_117319242 0.363 ENSMUST00000100834.1
Gm10399
predicted gene 10399
chr2_-_37703275 0.355 ENSMUST00000072186.5
Strbp
spermatid perinuclear RNA binding protein
chr4_-_46536096 0.347 ENSMUST00000102924.2
Trim14
tripartite motif-containing 14
chr7_+_81571246 0.315 ENSMUST00000165460.1
Whamm
WAS protein homolog associated with actin, golgi membranes and microtubules
chr2_+_121955964 0.308 ENSMUST00000036647.6
Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr10_-_99126321 0.308 ENSMUST00000060761.5
Phxr2
per-hexamer repeat gene 2
chr9_+_114978507 0.302 ENSMUST00000183104.1
Osbpl10
oxysterol binding protein-like 10
chr11_+_70844745 0.284 ENSMUST00000076270.6
ENSMUST00000179114.1
ENSMUST00000100928.4
ENSMUST00000177731.1
ENSMUST00000108533.3
ENSMUST00000081362.6
ENSMUST00000178245.1
Rabep1






rabaptin, RAB GTPase binding effector protein 1






chr9_+_114401076 0.263 ENSMUST00000063042.9
ENSMUST00000111820.2
Glb1
Tmppe
galactosidase, beta 1
transmembrane protein with metallophosphoesterase domain
chr17_-_31658729 0.263 ENSMUST00000166526.1
ENSMUST00000014684.4
U2af1

U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1

chr14_-_70443442 0.244 ENSMUST00000000793.5
Polr3d
polymerase (RNA) III (DNA directed) polypeptide D
chr2_-_120609319 0.217 ENSMUST00000102497.3
Lrrc57
leucine rich repeat containing 57
chr9_-_107770945 0.211 ENSMUST00000183248.1
ENSMUST00000182022.1
ENSMUST00000035199.6
ENSMUST00000182659.1
Rbm5



RNA binding motif protein 5



chr4_+_33310306 0.201 ENSMUST00000108153.2
ENSMUST00000029942.7
Rngtt

RNA guanylyltransferase and 5'-phosphatase

chr11_+_95712673 0.184 ENSMUST00000107717.1
Zfp652
zinc finger protein 652
chr18_+_61555258 0.181 ENSMUST00000165123.1
Csnk1a1
casein kinase 1, alpha 1
chr2_-_120609500 0.180 ENSMUST00000133612.1
ENSMUST00000102498.1
ENSMUST00000102499.1
Lrrc57


leucine rich repeat containing 57


chr5_+_23850590 0.179 ENSMUST00000181574.1
2700038G22Rik
RIKEN cDNA 2700038G22 gene
chr2_-_120609283 0.178 ENSMUST00000102496.1
Lrrc57
leucine rich repeat containing 57
chr3_+_105452326 0.166 ENSMUST00000098761.3
Kcnd3
potassium voltage-gated channel, Shal-related family, member 3
chr8_-_27174623 0.165 ENSMUST00000033878.6
ENSMUST00000054212.6
Rab11fip1

RAB11 family interacting protein 1 (class I)

chr4_-_121098190 0.164 ENSMUST00000058754.2
Zmpste24
zinc metallopeptidase, STE24
chr2_+_69897255 0.157 ENSMUST00000131553.1
Ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr2_-_104712122 0.151 ENSMUST00000111118.1
ENSMUST00000028597.3
Tcp11l1

t-complex 11 like 1

chr9_-_108578657 0.137 ENSMUST00000068700.5
Wdr6
WD repeat domain 6
chr11_-_100619576 0.134 ENSMUST00000155152.1
Dnajc7
DnaJ (Hsp40) homolog, subfamily C, member 7
chrX_+_99003224 0.128 ENSMUST00000149999.1
Stard8
START domain containing 8
chr10_-_127263346 0.128 ENSMUST00000099172.3
Kif5a
kinesin family member 5A
chr10_-_93589621 0.127 ENSMUST00000020203.6
Snrpf
small nuclear ribonucleoprotein polypeptide F
chr11_-_118909487 0.122 ENSMUST00000117731.1
ENSMUST00000106278.2
ENSMUST00000120061.1
ENSMUST00000017576.4
Rbfox3



RNA binding protein, fox-1 homolog (C. elegans) 3



chr9_+_109095427 0.119 ENSMUST00000072093.6
Plxnb1
plexin B1
chr2_+_164486455 0.114 ENSMUST00000069385.8
ENSMUST00000143690.1
Dbndd2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr18_+_61555689 0.111 ENSMUST00000167187.1
Csnk1a1
casein kinase 1, alpha 1
chr3_+_95427575 0.105 ENSMUST00000181809.1
Gm4349
predicted gene 4349
chr16_-_20302358 0.104 ENSMUST00000048642.8
Parl
presenilin associated, rhomboid-like
chr7_-_121035096 0.102 ENSMUST00000065740.2
Gm9905
predicted gene 9905
chr18_+_80206775 0.099 ENSMUST00000125127.1
ENSMUST00000025463.7
ENSMUST00000145963.1
ENSMUST00000025464.7
Gm16286

Txnl4a

predicted gene 16286

thioredoxin-like 4A

chr9_+_108795971 0.090 ENSMUST00000085018.4
Ip6k2
inositol hexaphosphate kinase 2
chr10_+_93589413 0.089 ENSMUST00000181835.1
4933408J17Rik
RIKEN cDNA 4933408J17 gene
chr1_+_167349976 0.086 ENSMUST00000028004.9
Aldh9a1
aldehyde dehydrogenase 9, subfamily A1
chr5_+_105519388 0.079 ENSMUST00000067924.6
ENSMUST00000150981.1
Lrrc8c

leucine rich repeat containing 8 family, member C

chrX_-_95956890 0.075 ENSMUST00000079987.6
ENSMUST00000113864.2
Las1l

LAS1-like (S. cerevisiae)

chr7_+_30650385 0.075 ENSMUST00000181529.1
Gm26610
predicted gene, 26610
chr2_+_49451486 0.048 ENSMUST00000092123.4
Epc2
enhancer of polycomb homolog 2 (Drosophila)
chr10_+_76531593 0.035 ENSMUST00000048678.6
Lss
lanosterol synthase
chr13_+_55445301 0.032 ENSMUST00000001115.8
ENSMUST00000099482.3
Grk6

G protein-coupled receptor kinase 6

chr11_+_51619731 0.032 ENSMUST00000127405.1
Nhp2
NHP2 ribonucleoprotein
chr18_+_61555308 0.028 ENSMUST00000165721.1
ENSMUST00000115246.2
ENSMUST00000166990.1
ENSMUST00000163205.1
ENSMUST00000170862.1
Csnk1a1




casein kinase 1, alpha 1




chr5_-_134456227 0.028 ENSMUST00000111244.1
Gtf2ird1
general transcription factor II I repeat domain-containing 1
chr19_+_6057888 0.017 ENSMUST00000043074.5
ENSMUST00000178310.1
Fau

Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)

chr17_+_24669730 0.013 ENSMUST00000047179.5
Zfp598
zinc finger protein 598
chr18_+_80206887 0.010 ENSMUST00000127234.1
Gm16286
predicted gene 16286
chr11_+_29526407 0.001 ENSMUST00000133452.1
Mtif2
mitochondrial translational initiation factor 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.6 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
1.2 4.8 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
1.0 5.9 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.0 5.9 GO:0003383 apical constriction(GO:0003383)
0.4 1.3 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.4 1.3 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.3 1.0 GO:0061588 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylserine scrambling(GO:0061589) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591) phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.3 1.2 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.3 2.6 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.3 1.0 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.3 1.0 GO:0009957 epidermal cell fate specification(GO:0009957)
0.3 2.8 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.2 0.9 GO:0019230 proprioception(GO:0019230) sensory neuron axon guidance(GO:0097374)
0.2 1.1 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.2 1.3 GO:0032229 negative regulation of synaptic transmission, GABAergic(GO:0032229)
0.2 1.6 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.2 2.1 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.2 0.4 GO:0007412 axon target recognition(GO:0007412)
0.2 1.0 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.2 0.5 GO:0042713 sperm ejaculation(GO:0042713) negative regulation of gastric acid secretion(GO:0060455)
0.2 0.5 GO:0034473 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.1 1.3 GO:0001842 neural fold formation(GO:0001842)
0.1 0.9 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.1 2.8 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.1 1.0 GO:0071420 cellular response to histamine(GO:0071420)
0.1 0.7 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.1 0.6 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 0.4 GO:1900127 positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.1 0.4 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 0.5 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 0.7 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.1 1.6 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.1 0.2 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.0 1.4 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.5 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.6 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.0 0.2 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.2 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.0 0.3 GO:0019388 galactose catabolic process(GO:0019388)
0.0 0.0 GO:0010360 negative regulation of anion channel activity(GO:0010360)
0.0 0.1 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.0 3.4 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.0 0.3 GO:0051127 positive regulation of actin nucleation(GO:0051127)
0.0 0.2 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.0 0.1 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.0 0.3 GO:1904424 regulation of GTP binding(GO:1904424)
0.0 0.4 GO:0016180 snRNA processing(GO:0016180)
0.0 0.2 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.0 0.3 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.0 1.7 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.0 0.1 GO:0099640 axo-dendritic protein transport(GO:0099640)
0.0 0.4 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.4 GO:0030262 apoptotic nuclear changes(GO:0030262)
0.0 0.4 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.3 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.9 GO:0030148 sphingolipid biosynthetic process(GO:0030148)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.9 GO:0033269 internode region of axon(GO:0033269)
0.3 1.3 GO:0090537 CERF complex(GO:0090537)
0.3 1.6 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.2 1.3 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.2 2.4 GO:0030061 mitochondrial crista(GO:0030061)
0.1 0.7 GO:0070876 SOSS complex(GO:0070876)
0.1 2.6 GO:0097470 ribbon synapse(GO:0097470)
0.1 0.5 GO:0005594 collagen type IX trimer(GO:0005594)
0.1 3.7 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 1.6 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 0.9 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.5 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 0.6 GO:0005915 zonula adherens(GO:0005915)
0.1 0.4 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 1.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 0.3 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 1.3 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 0.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 1.0 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.3 GO:0089701 U2AF(GO:0089701)
0.0 0.4 GO:0032039 integrator complex(GO:0032039)
0.0 0.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.1 GO:0034715 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.0 0.4 GO:0031105 septin complex(GO:0031105)
0.0 0.3 GO:0045095 keratin filament(GO:0045095)
0.0 0.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.0 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)
0.0 0.0 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 5.2 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.2 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.5 GO:0043195 terminal bouton(GO:0043195)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.9 2.8 GO:0004994 somatostatin receptor activity(GO:0004994)
0.4 1.6 GO:0097100 supercoiled DNA binding(GO:0097100)
0.3 1.0 GO:0005119 smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158)
0.3 2.6 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.3 1.3 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.3 0.9 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.2 1.3 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.2 7.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 0.6 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 1.3 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.1 1.0 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 1.6 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 1.2 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 0.9 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 4.2 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.1 0.2 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.1 0.9 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 1.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 1.1 GO:0050811 GABA receptor binding(GO:0050811)
0.1 0.6 GO:0070097 delta-catenin binding(GO:0070097)
0.1 0.3 GO:0004565 beta-galactosidase activity(GO:0004565)
0.0 5.6 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.7 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.3 GO:0050733 RS domain binding(GO:0050733)
0.0 1.3 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 0.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.6 GO:0070888 E-box binding(GO:0070888)
0.0 0.1 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.0 0.1 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.0 7.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.1 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 1.0 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 2.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.8 GO:0003774 motor activity(GO:0003774)
0.0 0.5 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.4 GO:0042805 actinin binding(GO:0042805)
0.0 0.5 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.1 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 0.2 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.5 GO:0031072 heat shock protein binding(GO:0031072)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 10.2 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 4.2 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 2.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 1.7 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.3 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.3 NABA_COLLAGENS Genes encoding collagen proteins
0.0 2.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.9 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.6 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.0 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.2 5.9 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2 1.6 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 1.3 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 0.3 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.1 0.6 REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.1 1.4 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 1.3 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.5 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 2.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.3 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 1.6 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 2.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.7 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.9 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.5 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.1 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs