Motif ID: Gli3_Zic1

Z-value: 0.889

Transcription factors associated with Gli3_Zic1:

Gene SymbolEntrez IDGene Name
Gli3 ENSMUSG00000021318.9 Gli3
Zic1 ENSMUSG00000032368.8 Zic1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli3mm10_v2_chr13_+_15463202_15463240-0.617.3e-05Click!
Zic1mm10_v2_chr9_-_91365778_91365815-0.391.7e-02Click!


Activity profile for motif Gli3_Zic1.

activity profile for motif Gli3_Zic1


Sorted Z-values histogram for motif Gli3_Zic1

Sorted Z-values for motif Gli3_Zic1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli3_Zic1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_91269759 5.704 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr8_+_70501116 4.659 ENSMUST00000127983.1
 Crlf1
cytokine receptor-like factor 1
chr11_-_42182163 4.258 ENSMUST00000153147.1
 Gabra1
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1
chr1_+_195017399 3.947 ENSMUST00000181273.1
 A330023F24Rik
RIKEN cDNA A330023F24 gene
chr7_+_5056706 3.914 ENSMUST00000144802.1
 Ccdc106
coiled-coil domain containing 106
chr2_-_155945282 3.867 ENSMUST00000040162.2
 Gdf5
growth differentiation factor 5
chr6_+_17463749 3.804 ENSMUST00000115443.1
 Met
met proto-oncogene
chr7_+_5056856 3.757 ENSMUST00000131368.1
ENSMUST00000123956.1
 Ccdc106

coiled-coil domain containing 106

chr17_-_68004075 3.748 ENSMUST00000024840.5
 Arhgap28
Rho GTPase activating protein 28
chr7_+_5057161 3.704 ENSMUST00000045543.5
 Ccdc106
coiled-coil domain containing 106
chr8_-_105966038 2.936 ENSMUST00000116429.2
ENSMUST00000034370.9
 Slc12a4

solute carrier family 12, member 4

chr13_+_118714678 2.843 ENSMUST00000022246.8
 Fgf10
fibroblast growth factor 10
chr8_+_76902277 2.692 ENSMUST00000109912.1
ENSMUST00000128862.1
ENSMUST00000109911.1
 Nr3c2


nuclear receptor subfamily 3, group C, member 2


chr9_-_56418023 2.627 ENSMUST00000061552.8
 C230081A13Rik
RIKEN cDNA C230081A13 gene
chr7_-_142657466 2.622 ENSMUST00000097936.2
ENSMUST00000000033.5
 Igf2

insulin-like growth factor 2

chr15_-_95528228 2.522 ENSMUST00000075275.2
 Nell2
NEL-like 2
chr6_+_17463826 2.436 ENSMUST00000140070.1
 Met
met proto-oncogene
chr6_+_110645572 2.372 ENSMUST00000071076.6
ENSMUST00000172951.1
 Grm7

glutamate receptor, metabotropic 7

chr3_+_68494208 2.323 ENSMUST00000182719.1
 Schip1
schwannomin interacting protein 1
chr9_-_54661870 2.313 ENSMUST00000034822.5
 Acsbg1
acyl-CoA synthetase bubblegum family member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 170 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 12.6 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
1.1 10.0 GO:0071420 cellular response to histamine(GO:0071420)
0.1 5.7 GO:0048663 neuron fate commitment(GO:0048663)
0.4 5.2 GO:2000465 regulation of glycogen (starch) synthase activity(GO:2000465)
0.8 4.7 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.4 4.6 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.9 3.7 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.2 3.7 GO:0001553 luteinization(GO:0001553)
0.1 3.4 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.6 3.2 GO:0060591 chondroblast differentiation(GO:0060591)
0.5 3.1 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.2 2.7 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.5 2.4 GO:0001661 conditioned taste aversion(GO:0001661)
0.4 2.2 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.2 2.2 GO:0015838 proline transport(GO:0015824) amino-acid betaine transport(GO:0015838)
0.1 2.2 GO:0042092 type 2 immune response(GO:0042092)
0.4 2.1 GO:0007021 tubulin complex assembly(GO:0007021)
0.5 1.9 GO:0060032 notochord regression(GO:0060032)
0.2 1.9 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 1.9 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 10.0 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 8.8 GO:0009925 basal plasma membrane(GO:0009925)
1.6 4.7 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 3.8 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 3.5 GO:0043235 receptor complex(GO:0043235)
0.6 3.1 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0 2.6 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 2.5 GO:0060077 inhibitory synapse(GO:0060077)
0.1 2.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.4 2.4 GO:0097512 cardiac myofibril(GO:0097512)
0.2 2.4 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 2.3 GO:0016324 apical plasma membrane(GO:0016324)
0.1 2.2 GO:0045178 basal part of cell(GO:0045178)
0.0 2.2 GO:0030175 filopodium(GO:0030175)
0.0 2.2 GO:0043204 perikaryon(GO:0043204)
0.0 2.1 GO:0032420 stereocilium(GO:0032420)
0.2 2.0 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.2 2.0 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1 1.9 GO:0097542 ciliary tip(GO:0097542)
0.6 1.8 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 116 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 9.8 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
1.1 6.4 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.5 4.9 GO:0036122 BMP binding(GO:0036122)
0.7 4.7 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 4.4 GO:0008201 heparin binding(GO:0008201)
0.3 3.5 GO:0004890 GABA-A receptor activity(GO:0004890)
0.3 3.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 3.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.6 3.1 GO:0097643 amylin receptor activity(GO:0097643)
0.0 3.0 GO:0042562 hormone binding(GO:0042562)
0.4 2.9 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.7 2.8 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 2.6 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.8 2.4 GO:0070905 serine binding(GO:0070905)
0.1 2.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.3 2.2 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.1 2.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.5 2.0 GO:2001069 glycogen binding(GO:2001069)
0.2 2.0 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.2 2.0 GO:0032050 clathrin heavy chain binding(GO:0032050)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 10.1 PID_ARF6_PATHWAY Arf6 signaling events
0.0 2.3 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 2.1 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.8 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 1.8 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.1 1.6 PID_ARF_3PATHWAY Arf1 pathway
0.0 1.6 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 1.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.3 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 1.2 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 1.2 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.1 1.1 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 1.0 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.0 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.8 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.7 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.0 0.6 PID_BMP_PATHWAY BMP receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 10.0 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.2 9.7 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.3 3.8 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 3.7 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.1 3.1 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.2 2.9 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.2 2.8 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 2.0 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 2.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 1.9 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.7 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 1.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.5 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 1.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.4 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 1.3 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 1.2 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.1 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.1 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.0 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors