Motif ID: Glis2

Z-value: 1.053


Transcription factors associated with Glis2:

Gene SymbolEntrez IDGene Name
Glis2 ENSMUSG00000014303.7 Glis2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Glis2mm10_v2_chr16_+_4594683_45947350.325.7e-02Click!


Activity profile for motif Glis2.

activity profile for motif Glis2


Sorted Z-values histogram for motif Glis2

Sorted Z-values for motif Glis2



Network of associatons between targets according to the STRING database.



First level regulatory network of Glis2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 180 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_87948666 11.304 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr6_-_48840988 7.505 ENSMUST00000164733.1
 Tmem176b
transmembrane protein 176B
chr6_-_48841098 5.439 ENSMUST00000101429.4
 Tmem176b
transmembrane protein 176B
chr6_-_48841373 5.321 ENSMUST00000166247.1
 Tmem176b
transmembrane protein 176B
chr19_+_7268296 5.218 ENSMUST00000066646.4
 Rcor2
REST corepressor 2
chr4_+_109978004 5.173 ENSMUST00000061187.3
 Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr11_+_101468164 4.985 ENSMUST00000001347.6
 Rnd2
Rho family GTPase 2
chr6_+_48841476 4.727 ENSMUST00000101426.4
 Tmem176a
transmembrane protein 176A
chr6_+_48841633 4.659 ENSMUST00000168406.1
 Tmem176a
transmembrane protein 176A
chr7_-_103843154 4.284 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr6_+_120666388 4.038 ENSMUST00000112686.1
 Cecr2
cat eye syndrome chromosome region, candidate 2
chr13_-_29984219 3.886 ENSMUST00000146092.1
 E2f3
E2F transcription factor 3
chr14_+_55854115 3.714 ENSMUST00000168479.1
 Nynrin
NYN domain and retroviral integrase containing
chr2_-_54085542 3.635 ENSMUST00000100089.2
 Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr5_+_136083916 3.452 ENSMUST00000042135.7
 Rasa4
RAS p21 protein activator 4
chr17_-_56830916 3.350 ENSMUST00000002444.7
ENSMUST00000086801.5
 Rfx2

regulatory factor X, 2 (influences HLA class II expression)

chr5_+_136084022 3.203 ENSMUST00000100570.3
 Rasa4
RAS p21 protein activator 4
chr11_+_72042455 2.921 ENSMUST00000021164.3
 Fam64a
family with sequence similarity 64, member A
chr5_+_30105161 2.803 ENSMUST00000058045.4
 Gareml
GRB2 associated, regulator of MAPK1-like
chr5_-_30105359 2.779 ENSMUST00000127749.3
 3110082J24Rik
RIKEN cDNA 3110082J24 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.0 27.7 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
1.1 16.3 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.2 6.7 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.5 5.2 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.8 5.0 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.9 4.4 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) positive regulation of cell fate specification(GO:0042660) sensory neuron migration(GO:1904937)
0.9 4.3 GO:0015671 oxygen transport(GO:0015671)
0.4 4.0 GO:0001842 neural fold formation(GO:0001842)
0.4 3.9 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.5 3.7 GO:0015074 DNA integration(GO:0015074)
0.3 3.4 GO:0001675 acrosome assembly(GO:0001675)
0.3 3.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 3.2 GO:0007050 cell cycle arrest(GO:0007050)
0.7 2.9 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986) general adaptation syndrome(GO:0051866)
0.9 2.6 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.6 2.5 GO:1902037 proteasomal ubiquitin-independent protein catabolic process(GO:0010499) positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091) negative regulation of hematopoietic stem cell differentiation(GO:1902037)
0.5 2.4 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.5 2.4 GO:0035984 response to trichostatin A(GO:0035983) cellular response to trichostatin A(GO:0035984)
0.2 2.4 GO:0090394 negative regulation of excitatory postsynaptic potential(GO:0090394)
0.1 2.4 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 6.7 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 6.3 GO:0005769 early endosome(GO:0005769)
0.1 6.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.7 5.4 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.5 4.3 GO:0005833 hemoglobin complex(GO:0005833)
1.0 4.0 GO:0090537 CERF complex(GO:0090537)
0.0 3.6 GO:0005667 transcription factor complex(GO:0005667)
0.0 3.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.2 3.3 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 3.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 3.1 GO:0005925 focal adhesion(GO:0005925)
0.1 2.9 GO:0016235 aggresome(GO:0016235)
0.0 2.9 GO:0032993 protein-DNA complex(GO:0032993)
0.0 2.6 GO:0009986 cell surface(GO:0009986)
0.1 2.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.2 2.3 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 2.3 GO:0001726 ruffle(GO:0001726)
0.1 2.1 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 1.9 GO:0097060 synaptic membrane(GO:0097060)
0.0 1.8 GO:0005882 intermediate filament(GO:0005882)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 11.3 GO:0019841 retinol binding(GO:0019841)
0.8 5.4 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 5.0 GO:0047485 protein N-terminus binding(GO:0047485)
0.3 4.4 GO:0003680 AT DNA binding(GO:0003680)
1.1 4.3 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.0 3.5 GO:0001047 core promoter binding(GO:0001047)
0.5 3.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 3.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 3.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.7 2.6 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.0 2.5 GO:0001221 transcription cofactor binding(GO:0001221)
0.4 2.4 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.5 2.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 2.3 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.7 2.2 GO:0071936 coreceptor activity involved in Wnt signaling pathway(GO:0071936)
0.7 2.0 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.0 2.0 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.3 1.8 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.2 1.8 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.6 1.7 GO:0070052 collagen V binding(GO:0070052)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.9 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 4.4 PID_CDC42_PATHWAY CDC42 signaling events
0.1 4.2 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 3.9 PID_E2F_PATHWAY E2F transcription factor network
0.0 3.3 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 2.3 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 2.3 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.7 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.7 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.6 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.5 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 1.2 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.1 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 1.0 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.0 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.7 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.5 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.4 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.3 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.0 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.3 4.4 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 4.2 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 3.8 REACTOME_SIGNALING_BY_NOTCH1 Genes involved in Signaling by NOTCH1
0.0 2.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.8 REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.1 2.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.3 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 2.3 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.8 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 1.7 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 1.7 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.7 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.5 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 1.5 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 1.4 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 1.2 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 1.1 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 1.0 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.1 1.0 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport