ISMARA results: Glis3

Motif ID: Glis3

Z-value: 0.559

Transcription factors associated with Glis3:

Gene Symbol	Entrez ID	Gene Name
Glis3	ENSMUSG00000052942.7	Glis3
Glis3	ENSMUSG00000091294.1	Glis3

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
Glis3	mm10_v2_chr19_-_28680077_28680122	0.43	8.1e-03	Click!

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Top targets:

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Showing 1 to 20 of 117 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr4_+_144892813	3.129	ENSMUST00000105744.1 ENSMUST00000171001.1	Dhrs3	dehydrogenase/reductase (SDR family) member 3
chr6_+_108660616	2.914	ENSMUST00000032194.4	Bhlhe40	basic helix-loop-helix family, member e40
chr4_+_144893077	2.580	ENSMUST00000154208.1	Dhrs3	dehydrogenase/reductase (SDR family) member 3
chr4_+_144893127	2.294	ENSMUST00000142808.1	Dhrs3	dehydrogenase/reductase (SDR family) member 3
chr8_+_70501116	2.231	ENSMUST00000127983.1	Crlf1	cytokine receptor-like factor 1
chr6_+_17463749	2.145	ENSMUST00000115443.1	Met	met proto-oncogene
chr6_+_17463927	1.727	ENSMUST00000115442.1	Met	met proto-oncogene
chr6_+_17463826	1.524	ENSMUST00000140070.1	Met	met proto-oncogene
chr6_+_108660772	1.253	ENSMUST00000163617.1	Bhlhe40	basic helix-loop-helix family, member e40
chr7_-_142657466	1.117	ENSMUST00000097936.2 ENSMUST00000000033.5	Igf2	insulin-like growth factor 2
chr3_+_52268337	0.789	ENSMUST00000053764.5	Foxo1	forkhead box O1
chr7_+_45017953	0.720	ENSMUST00000044111.7	Rras	Harvey rat sarcoma oncogene, subgroup R
chr13_+_38345716	0.634	ENSMUST00000171970.1	Bmp6	bone morphogenetic protein 6
chr2_+_32646586	0.631	ENSMUST00000009705.7 ENSMUST00000167841.1	Eng	endoglin
chr10_-_68278713	0.605	ENSMUST00000020106.7	Arid5b	AT rich interactive domain 5B (MRF1-like)
chr17_-_23745829	0.511	ENSMUST00000046525.8	Kremen2	kringle containing transmembrane protein 2
chr11_-_102296618	0.497	ENSMUST00000107132.2 ENSMUST00000073234.2	Atxn7l3	ataxin 7-like 3
chrX_-_136868537	0.486	ENSMUST00000058814.6	Rab9b	RAB9B, member RAS oncogene family
chr11_+_5861886	0.456	ENSMUST00000102923.3	Aebp1	AE binding protein 1
chr14_-_55560340	0.454	ENSMUST00000066106.3	A730061H03Rik	RIKEN cDNA A730061H03 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Showing 1 to 20 of 43 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.7	8.0	GO:0042572	retinol metabolic process(GO:0042572)
0.8	5.4	GO:0070494	regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.1	4.2	GO:0043153	entrainment of circadian clock by photoperiod(GO:0043153)
0.4	2.2	GO:2000672	negative regulation of motor neuron apoptotic process(GO:2000672)
0.1	1.1	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1	0.8	GO:0071455	response to hyperoxia(GO:0055093) cellular response to hyperoxia(GO:0071455)
0.1	0.7	GO:0043353	enucleate erythrocyte differentiation(GO:0043353) hydrogen sulfide biosynthetic process(GO:0070814)
0.0	0.7	GO:0060325	face morphogenesis(GO:0060325)
0.2	0.6	GO:1905072	detection of oxygen(GO:0003032) cardiac jelly development(GO:1905072)
0.1	0.6	GO:0032346	positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.1	0.6	GO:0060613	fat pad development(GO:0060613)
0.0	0.6	GO:0060746	parental behavior(GO:0060746)
0.0	0.5	GO:0016578	histone deubiquitination(GO:0016578)
0.1	0.4	GO:2001160	regulation of histone H3-K79 methylation(GO:2001160)
0.1	0.4	GO:0071918	urea transmembrane transport(GO:0071918)
0.0	0.4	GO:0019368	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.4	GO:0070914	UV-damage excision repair(GO:0070914)
0.0	0.4	GO:2000001	regulation of DNA damage checkpoint(GO:2000001)
0.0	0.4	GO:0071385	cellular response to glucocorticoid stimulus(GO:0071385)
0.1	0.3	GO:0003100	angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001998) regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072) regulation of systemic arterial blood pressure by endothelin(GO:0003100) beta selection(GO:0043366) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)

Gene overrepresentation in cellular_component category:

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Showing 1 to 13 of 13 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.7	GO:0009925	basal plasma membrane(GO:0009925)
0.7	2.2	GO:0097058	CRLF-CLCF1 complex(GO:0097058)
0.0	0.6	GO:0097610	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0	0.5	GO:0000124	SAGA complex(GO:0000124)
0.1	0.4	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.1	0.3	GO:0045009	melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0	0.3	GO:0071203	WASH complex(GO:0071203)
0.0	0.3	GO:0033503	HULC complex(GO:0033503)
0.0	0.3	GO:0031011	Ino80 complex(GO:0031011)
0.0	0.2	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	0.2	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.2	GO:0016010	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0	0.1	GO:0031084	BLOC-2 complex(GO:0031084)

Gene overrepresentation in molecular_function category:

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Showing 1 to 20 of 31 entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.1	8.0	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
1.3	5.4	GO:0005008	hepatocyte growth factor-activated receptor activity(GO:0005008)
0.7	4.2	GO:0043426	MRF binding(GO:0043426)
0.3	2.2	GO:0005127	ciliary neurotrophic factor receptor binding(GO:0005127)
0.0	1.2	GO:0019003	GDP binding(GO:0019003)
0.0	1.1	GO:0043539	insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.8	GO:0001223	transcription coactivator binding(GO:0001223)
0.0	0.7	GO:0071837	HMG box domain binding(GO:0071837)
0.1	0.6	GO:0005534	galactose binding(GO:0005534)
0.1	0.6	GO:0070700	BMP receptor binding(GO:0070700)
0.0	0.5	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.1	0.4	GO:0008494	translation activator activity(GO:0008494)
0.1	0.4	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.1	0.4	GO:0004523	RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0	0.4	GO:0009922	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0	0.4	GO:0050136	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1	0.3	GO:0048763	calcium-induced calcium release activity(GO:0048763)
0.1	0.3	GO:2001069	glycogen binding(GO:2001069)
0.1	0.3	GO:0035240	dopamine binding(GO:0035240)
0.1	0.3	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)

Gene overrepresentation in C2:CP category:

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Showing 1 to 11 of 11 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.7	PID_TAP63_PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	5.3	PID_ARF6_PATHWAY	Arf6 signaling events
0.2	4.1	PID_CIRCADIAN_PATHWAY	Circadian rhythm pathway
0.0	1.1	PID_HDAC_CLASSIII_PATHWAY	Signaling events mediated by HDAC Class III
0.0	1.1	PID_AJDISS_2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.0	0.9	PID_BMP_PATHWAY	BMP receptor signaling
0.0	0.7	PID_RAS_PATHWAY	Regulation of Ras family activation
0.0	0.6	PID_ALK1_PATHWAY	ALK1 signaling events
0.0	0.5	PID_PS1_PATHWAY	Presenilin action in Notch and Wnt signaling
0.0	0.3	PID_THROMBIN_PAR4_PATHWAY	PAR4-mediated thrombin signaling events
0.0	0.2	PID_VEGF_VEGFR_PATHWAY	VEGF and VEGFR signaling network

Gene overrepresentation in C2:CP:REACTOME category:

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Showing 1 to 15 of 15 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	6.4	REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING	Genes involved in Sema4D in semaphorin signaling
0.1	4.2	REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1	1.1	REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.8	REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	0.5	REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0	0.4	REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.0	0.4	REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0	0.3	REACTOME_AMINE_DERIVED_HORMONES	Genes involved in Amine-derived hormones
0.0	0.3	REACTOME_CHOLESTEROL_BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.0	0.3	REACTOME_DEADENYLATION_OF_MRNA	Genes involved in Deadenylation of mRNA
0.0	0.3	REACTOME_PIP3_ACTIVATES_AKT_SIGNALING	Genes involved in PIP3 activates AKT signaling
0.0	0.2	REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.0	0.2	REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
0.0	0.2	REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.1	REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation