Motif ID: Glis3

Z-value: 0.559


Transcription factors associated with Glis3:

Gene SymbolEntrez IDGene Name
Glis3 ENSMUSG00000052942.7 Glis3
Glis3 ENSMUSG00000091294.1 Glis3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Glis3mm10_v2_chr19_-_28680077_286801220.438.1e-03Click!


Activity profile for motif Glis3.

activity profile for motif Glis3


Sorted Z-values histogram for motif Glis3

Sorted Z-values for motif Glis3



Network of associatons between targets according to the STRING database.



First level regulatory network of Glis3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_144892813 3.129 ENSMUST00000105744.1
ENSMUST00000171001.1
Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr6_+_108660616 2.914 ENSMUST00000032194.4
Bhlhe40
basic helix-loop-helix family, member e40
chr4_+_144893077 2.580 ENSMUST00000154208.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_144893127 2.294 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr8_+_70501116 2.231 ENSMUST00000127983.1
Crlf1
cytokine receptor-like factor 1
chr6_+_17463749 2.145 ENSMUST00000115443.1
Met
met proto-oncogene
chr6_+_17463927 1.727 ENSMUST00000115442.1
Met
met proto-oncogene
chr6_+_17463826 1.524 ENSMUST00000140070.1
Met
met proto-oncogene
chr6_+_108660772 1.253 ENSMUST00000163617.1
Bhlhe40
basic helix-loop-helix family, member e40
chr7_-_142657466 1.117 ENSMUST00000097936.2
ENSMUST00000000033.5
Igf2

insulin-like growth factor 2

chr3_+_52268337 0.789 ENSMUST00000053764.5
Foxo1
forkhead box O1
chr7_+_45017953 0.720 ENSMUST00000044111.7
Rras
Harvey rat sarcoma oncogene, subgroup R
chr13_+_38345716 0.634 ENSMUST00000171970.1
Bmp6
bone morphogenetic protein 6
chr2_+_32646586 0.631 ENSMUST00000009705.7
ENSMUST00000167841.1
Eng

endoglin

chr10_-_68278713 0.605 ENSMUST00000020106.7
Arid5b
AT rich interactive domain 5B (MRF1-like)
chr17_-_23745829 0.511 ENSMUST00000046525.8
Kremen2
kringle containing transmembrane protein 2
chr11_-_102296618 0.497 ENSMUST00000107132.2
ENSMUST00000073234.2
Atxn7l3

ataxin 7-like 3

chrX_-_136868537 0.486 ENSMUST00000058814.6
Rab9b
RAB9B, member RAS oncogene family
chr11_+_5861886 0.456 ENSMUST00000102923.3
Aebp1
AE binding protein 1
chr14_-_55560340 0.454 ENSMUST00000066106.3
A730061H03Rik
RIKEN cDNA A730061H03 gene
chr15_+_102407144 0.446 ENSMUST00000169619.1
Sp1
trans-acting transcription factor 1
chr4_+_118428078 0.445 ENSMUST00000006557.6
ENSMUST00000167636.1
ENSMUST00000102673.4
Elovl1


elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1


chr7_+_90442729 0.433 ENSMUST00000061767.4
ENSMUST00000107206.1
Crebzf

CREB/ATF bZIP transcription factor

chr11_+_97663366 0.425 ENSMUST00000044730.5
Mllt6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chrM_+_9452 0.408 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr18_-_78206408 0.386 ENSMUST00000163367.1
Slc14a2
solute carrier family 14 (urea transporter), member 2
chr14_+_62292475 0.379 ENSMUST00000166879.1
Rnaseh2b
ribonuclease H2, subunit B
chr14_+_54640952 0.377 ENSMUST00000169818.2
Gm17606
predicted gene, 17606
chrX_-_94123359 0.350 ENSMUST00000137853.1
ENSMUST00000088102.5
ENSMUST00000113927.1
Zfx


zinc finger protein X-linked


chrX_-_23365044 0.348 ENSMUST00000115313.1
Klhl13
kelch-like 13
chrX_+_101254528 0.336 ENSMUST00000062000.4
Foxo4
forkhead box O4
chr9_+_108306205 0.330 ENSMUST00000007959.8
Rhoa
ras homolog gene family, member A
chr14_-_62292959 0.320 ENSMUST00000063169.8
Dleu7
deleted in lymphocytic leukemia, 7
chr13_+_119690462 0.313 ENSMUST00000179869.1
Hmgcs1
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
chr11_+_69632927 0.302 ENSMUST00000018909.3
Fxr2
fragile X mental retardation, autosomal homolog 2
chrX_-_94123087 0.299 ENSMUST00000113925.1
Zfx
zinc finger protein X-linked
chr5_+_104459450 0.278 ENSMUST00000086831.3
Pkd2
polycystic kidney disease 2
chr7_-_142899985 0.269 ENSMUST00000000219.3
Th
tyrosine hydroxylase
chr1_-_64121456 0.258 ENSMUST00000142009.1
ENSMUST00000114086.1
Klf7

Kruppel-like factor 7 (ubiquitous)

chr2_-_119477613 0.253 ENSMUST00000110808.1
ENSMUST00000049920.7
Ino80

INO80 homolog (S. cerevisiae)

chrX_-_7574120 0.252 ENSMUST00000045924.7
ENSMUST00000115742.2
ENSMUST00000150787.1
Ppp1r3f


protein phosphatase 1, regulatory (inhibitor) subunit 3F


chr15_+_102406143 0.252 ENSMUST00000170884.1
ENSMUST00000165924.1
ENSMUST00000163709.1
ENSMUST00000001326.6
Sp1



trans-acting transcription factor 1



chr7_-_4778141 0.248 ENSMUST00000094892.5
Il11
interleukin 11
chr14_+_45219993 0.238 ENSMUST00000146150.1
Gpr137c
G protein-coupled receptor 137C
chr16_+_20733104 0.235 ENSMUST00000115423.1
ENSMUST00000007171.6
Chrd

chordin

chr13_-_40730416 0.222 ENSMUST00000021787.5
Tfap2a
transcription factor AP-2, alpha
chr6_+_88198656 0.218 ENSMUST00000015197.7
Gata2
GATA binding protein 2
chr4_-_134018829 0.216 ENSMUST00000051674.2
Lin28a
lin-28 homolog A (C. elegans)
chr10_-_105574435 0.215 ENSMUST00000061506.8
Tmtc2
transmembrane and tetratricopeptide repeat containing 2
chr1_-_64121389 0.213 ENSMUST00000055001.3
Klf7
Kruppel-like factor 7 (ubiquitous)
chrX_-_142966709 0.212 ENSMUST00000041317.2
Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr7_+_25282179 0.206 ENSMUST00000163320.1
ENSMUST00000005578.6
Cic

capicua homolog (Drosophila)

chr13_+_119428888 0.202 ENSMUST00000026520.7
Paip1
polyadenylate binding protein-interacting protein 1
chrM_+_8600 0.198 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr13_-_29984219 0.196 ENSMUST00000146092.1
E2f3
E2F transcription factor 3
chr3_-_94582716 0.189 ENSMUST00000029783.9
Snx27
sorting nexin family member 27
chr13_+_119428583 0.189 ENSMUST00000109203.2
Paip1
polyadenylate binding protein-interacting protein 1
chrX_-_38564519 0.179 ENSMUST00000016681.8
Cul4b
cullin 4B
chr6_+_95117740 0.179 ENSMUST00000032107.7
ENSMUST00000119582.1
Kbtbd8

kelch repeat and BTB (POZ) domain containing 8

chr9_-_108305941 0.178 ENSMUST00000044725.7
Tcta
T cell leukemia translocation altered gene
chr7_-_16286744 0.176 ENSMUST00000150528.2
ENSMUST00000118976.2
ENSMUST00000146609.2
Ccdc9


coiled-coil domain containing 9


chr6_+_145934113 0.174 ENSMUST00000032383.7
Sspn
sarcospan
chr13_+_118714678 0.173 ENSMUST00000022246.8
Fgf10
fibroblast growth factor 10
chr19_-_6987621 0.170 ENSMUST00000130048.1
ENSMUST00000025914.6
Vegfb

vascular endothelial growth factor B

chr10_-_7663245 0.159 ENSMUST00000163085.1
ENSMUST00000159917.1
Pcmt1

protein-L-isoaspartate (D-aspartate) O-methyltransferase 1

chr3_+_103914560 0.155 ENSMUST00000106806.1
Rsbn1
rosbin, round spermatid basic protein 1
chr11_-_102317860 0.154 ENSMUST00000107117.2
Ubtf
upstream binding transcription factor, RNA polymerase I
chr19_+_46305682 0.154 ENSMUST00000111881.2
Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chr3_-_142881942 0.148 ENSMUST00000043812.8
Pkn2
protein kinase N2
chr11_-_52000432 0.148 ENSMUST00000020657.6
Ube2b
ubiquitin-conjugating enzyme E2B
chr3_+_107595031 0.147 ENSMUST00000014747.1
Alx3
aristaless-like homeobox 3
chr11_-_97187872 0.147 ENSMUST00000001479.4
Kpnb1
karyopherin (importin) beta 1
chr11_-_115536181 0.144 ENSMUST00000118155.1
ENSMUST00000153892.1
Sumo2

SMT3 suppressor of mif two 3 homolog 2 (yeast)

chr13_+_37826225 0.144 ENSMUST00000128570.1
Rreb1
ras responsive element binding protein 1
chr11_-_52000748 0.142 ENSMUST00000109086.1
Ube2b
ubiquitin-conjugating enzyme E2B
chr3_-_94582548 0.138 ENSMUST00000107283.1
Snx27
sorting nexin family member 27
chr13_-_107022027 0.134 ENSMUST00000117539.1
ENSMUST00000122233.1
ENSMUST00000022204.9
ENSMUST00000159772.1
Kif2a



kinesin family member 2A



chr6_-_83572429 0.117 ENSMUST00000068054.7
Stambp
STAM binding protein
chr9_+_56418624 0.116 ENSMUST00000034879.3
Hmg20a
high mobility group 20A
chr2_+_25242929 0.114 ENSMUST00000114355.1
ENSMUST00000060818.1
Rnf208

ring finger protein 208

chr3_-_66981279 0.113 ENSMUST00000162098.2
Shox2
short stature homeobox 2
chr2_-_29253001 0.112 ENSMUST00000071201.4
Ntng2
netrin G2
chr11_-_100619576 0.108 ENSMUST00000155152.1
Dnajc7
DnaJ (Hsp40) homolog, subfamily C, member 7
chr7_+_25282784 0.106 ENSMUST00000165239.1
Cic
capicua homolog (Drosophila)
chr5_-_24527276 0.098 ENSMUST00000088311.4
Gbx1
gastrulation brain homeobox 1
chr3_+_66981352 0.094 ENSMUST00000162036.1
Rsrc1
arginine/serine-rich coiled-coil 1
chr8_-_88362154 0.088 ENSMUST00000034085.7
Brd7
bromodomain containing 7
chr2_+_131234043 0.087 ENSMUST00000041362.5
ENSMUST00000110199.2
Mavs

mitochondrial antiviral signaling protein

chr7_+_126781483 0.082 ENSMUST00000172352.1
ENSMUST00000094037.4
Tbx6

T-box 6

chr19_+_8941865 0.081 ENSMUST00000096240.2
Mta2
metastasis-associated gene family, member 2
chr14_+_55560480 0.081 ENSMUST00000121622.1
ENSMUST00000143431.1
ENSMUST00000150481.1
Dcaf11


DDB1 and CUL4 associated factor 11


chr11_-_96065350 0.076 ENSMUST00000100528.4
Ube2z
ubiquitin-conjugating enzyme E2Z (putative)
chr11_-_115535804 0.076 ENSMUST00000117589.1
ENSMUST00000121185.1
Sumo2

SMT3 suppressor of mif two 3 homolog 2 (yeast)

chr11_+_3289880 0.070 ENSMUST00000110043.1
ENSMUST00000094471.3
Patz1

POZ (BTB) and AT hook containing zinc finger 1

chrX_-_101419788 0.058 ENSMUST00000117901.1
ENSMUST00000120201.1
ENSMUST00000117637.1
ENSMUST00000134005.1
ENSMUST00000121520.1
Zmym3




zinc finger, MYM-type 3




chr5_-_121502980 0.051 ENSMUST00000079368.3
Adam1b
a disintegrin and metallopeptidase domain 1b
chrX_-_104201126 0.050 ENSMUST00000056502.6
ENSMUST00000118314.1
C77370

expressed sequence C77370

chr1_-_168431896 0.050 ENSMUST00000176540.1
Pbx1
pre B cell leukemia homeobox 1
chr7_+_46796088 0.049 ENSMUST00000006774.4
ENSMUST00000165031.1
Gtf2h1

general transcription factor II H, polypeptide 1

chr10_-_127211528 0.047 ENSMUST00000013970.7
Pip4k2c
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr11_-_70237761 0.043 ENSMUST00000108576.3
0610010K14Rik
RIKEN cDNA 0610010K14 gene
chr14_+_55561060 0.041 ENSMUST00000117701.1
Dcaf11
DDB1 and CUL4 associated factor 11
chr7_-_46795661 0.036 ENSMUST00000123725.1
Hps5
Hermansky-Pudlak syndrome 5 homolog (human)
chr7_-_46795881 0.033 ENSMUST00000107653.1
ENSMUST00000107654.1
ENSMUST00000014562.7
ENSMUST00000152759.1
Hps5



Hermansky-Pudlak syndrome 5 homolog (human)



chr3_+_89245952 0.028 ENSMUST00000040888.5
Krtcap2
keratinocyte associated protein 2
chr4_+_137993445 0.028 ENSMUST00000105831.2
ENSMUST00000084214.5
Eif4g3

eukaryotic translation initiation factor 4 gamma, 3

chr11_-_70237638 0.022 ENSMUST00000100950.3
0610010K14Rik
RIKEN cDNA 0610010K14 gene
chr10_+_127739516 0.020 ENSMUST00000054287.7
Zbtb39
zinc finger and BTB domain containing 39
chr14_+_55560904 0.018 ENSMUST00000072530.4
ENSMUST00000128490.1
Dcaf11

DDB1 and CUL4 associated factor 11

chr11_+_116030304 0.017 ENSMUST00000021116.5
ENSMUST00000106452.1
Unk

unkempt homolog (Drosophila)

chr2_-_73892619 0.011 ENSMUST00000112007.1
ENSMUST00000112016.2
Atf2

activating transcription factor 2

chrX_-_94542037 0.009 ENSMUST00000026142.7
Maged1
melanoma antigen, family D, 1
chr9_-_29412204 0.007 ENSMUST00000115237.1
Ntm
neurotrimin
chr17_-_65613521 0.007 ENSMUST00000024897.8
Vapa
vesicle-associated membrane protein, associated protein A
chr17_-_34031684 0.007 ENSMUST00000169397.1
Slc39a7
solute carrier family 39 (zinc transporter), member 7
chr16_+_20673264 0.004 ENSMUST00000154950.1
ENSMUST00000115461.1
Eif4g1

eukaryotic translation initiation factor 4, gamma 1

chr7_+_90130227 0.000 ENSMUST00000049537.7
Picalm
phosphatidylinositol binding clathrin assembly protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 5.4 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.7 8.0 GO:0042572 retinol metabolic process(GO:0042572)
0.4 2.2 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.2 0.6 GO:1905072 detection of oxygen(GO:0003032) cardiac jelly development(GO:1905072)
0.1 0.4 GO:2001160 regulation of histone H3-K79 methylation(GO:2001160)
0.1 1.1 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 4.2 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.1 0.4 GO:0071918 urea transmembrane transport(GO:0071918)
0.1 0.3 GO:0003100 angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001998) regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072) regulation of systemic arterial blood pressure by endothelin(GO:0003100) beta selection(GO:0043366) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.1 0.6 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.1 0.7 GO:0043353 enucleate erythrocyte differentiation(GO:0043353) hydrogen sulfide biosynthetic process(GO:0070814)
0.1 0.3 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.1 0.2 GO:0070172 oculomotor nerve development(GO:0021557) positive regulation of tooth mineralization(GO:0070172)
0.1 0.2 GO:0010725 regulation of primitive erythrocyte differentiation(GO:0010725)
0.1 0.8 GO:0071455 response to hyperoxia(GO:0055093) cellular response to hyperoxia(GO:0071455)
0.1 0.3 GO:0051599 response to hydrostatic pressure(GO:0051599)
0.1 0.6 GO:0060613 fat pad development(GO:0060613)
0.1 0.3 GO:0042414 epinephrine metabolic process(GO:0042414)
0.1 0.2 GO:0071336 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
0.0 0.2 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.0 0.2 GO:0035470 positive regulation of vascular wound healing(GO:0035470)
0.0 0.3 GO:2000465 regulation of glycogen (starch) synthase activity(GO:2000465)
0.0 0.3 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.0 0.4 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.2 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.0 0.1 GO:0051305 chromosome movement towards spindle pole(GO:0051305)
0.0 0.2 GO:0072675 osteoclast fusion(GO:0072675)
0.0 0.4 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 0.6 GO:0060746 parental behavior(GO:0060746)
0.0 0.1 GO:0071649 regulation of chemokine (C-C motif) ligand 5 production(GO:0071649)
0.0 0.2 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.1 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.0 0.3 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.0 0.4 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.5 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.2 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0 0.2 GO:0014029 neural crest formation(GO:0014029)
0.0 0.1 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601) regulation of wound healing, spreading of epidermal cells(GO:1903689) positive regulation of lamellipodium morphogenesis(GO:2000394)
0.0 0.7 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.3 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 0.4 GO:0071385 cellular response to glucocorticoid stimulus(GO:0071385)
0.0 0.1 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.0 0.1 GO:0014043 negative regulation of neuron maturation(GO:0014043)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 0.3 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 5.7 GO:0009925 basal plasma membrane(GO:0009925)
0.1 0.4 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.3 GO:0071203 WASH complex(GO:0071203)
0.0 0.3 GO:0033503 HULC complex(GO:0033503)
0.0 0.5 GO:0000124 SAGA complex(GO:0000124)
0.0 0.2 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.2 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.1 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 0.3 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.4 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
1.1 8.0 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.7 4.2 GO:0043426 MRF binding(GO:0043426)
0.3 2.2 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 0.6 GO:0005534 galactose binding(GO:0005534)
0.1 0.3 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.1 0.4 GO:0008494 translation activator activity(GO:0008494)
0.1 0.4 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.1 0.6 GO:0070700 BMP receptor binding(GO:0070700)
0.1 0.3 GO:2001069 glycogen binding(GO:2001069)
0.1 0.2 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 0.4 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 0.3 GO:0035240 dopamine binding(GO:0035240)
0.1 0.3 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.5 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.2 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.4 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.2 GO:0045545 syndecan binding(GO:0045545)
0.0 1.1 GO:0043539 insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.3 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.2 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.2 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.0 0.8 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.1 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.7 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.2 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.0 1.2 GO:0019003 GDP binding(GO:0019003)
0.0 0.2 GO:0031386 protein tag(GO:0031386)
0.0 0.2 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.1 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 8.7 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 5.3 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.1 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.3 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.6 PID_ALK1_PATHWAY ALK1 signaling events
0.0 1.1 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.7 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.9 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.2 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.5 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.4 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 4.2 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 1.1 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.8 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.3 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.2 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.4 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.4 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.2 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.2 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.3 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.5 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.1 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.3 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.3 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling