Motif ID: Gmeb2

Z-value: 0.761


Transcription factors associated with Gmeb2:

Gene SymbolEntrez IDGene Name
Gmeb2 ENSMUSG00000038705.7 Gmeb2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gmeb2mm10_v2_chr2_-_181288016_1812880410.316.4e-02Click!


Activity profile for motif Gmeb2.

activity profile for motif Gmeb2


Sorted Z-values histogram for motif Gmeb2

Sorted Z-values for motif Gmeb2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gmeb2

PNG image of the network

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Top targets:


Showing 1 to 20 of 185 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_78544345 2.601 ENSMUST00000053239.2
 Sstr3
somatostatin receptor 3
chr1_+_185454803 2.323 ENSMUST00000061093.6
 Slc30a10
solute carrier family 30, member 10
chr4_+_101419696 1.881 ENSMUST00000131397.1
ENSMUST00000133055.1
 Ak4

adenylate kinase 4

chr5_-_31291026 1.567 ENSMUST00000041565.7
 Ift172
intraflagellar transport 172
chr7_-_119896285 1.519 ENSMUST00000106519.1
 Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr6_-_39725193 1.472 ENSMUST00000101497.3
 Braf
Braf transforming gene
chr1_-_77515048 1.458 ENSMUST00000027451.6
 Epha4
Eph receptor A4
chr1_+_82316452 1.409 ENSMUST00000027322.7
 Rhbdd1
rhomboid domain containing 1
chr4_+_101419277 1.399 ENSMUST00000102780.1
ENSMUST00000106946.1
ENSMUST00000106945.1
 Ak4


adenylate kinase 4


chr9_-_56928350 1.339 ENSMUST00000050916.5
 Snx33
sorting nexin 33
chr1_-_162740350 1.252 ENSMUST00000182331.1
ENSMUST00000183011.1
ENSMUST00000182593.1
ENSMUST00000182149.1
 Prrc2c



proline-rich coiled-coil 2C



chr15_+_82016420 1.237 ENSMUST00000168581.1
ENSMUST00000170630.1
ENSMUST00000164779.1
 Xrcc6


X-ray repair complementing defective repair in Chinese hamster cells 6


chr15_-_50889691 1.212 ENSMUST00000165201.2
ENSMUST00000184458.1
 Trps1

trichorhinophalangeal syndrome I (human)

chr12_+_102554966 1.210 ENSMUST00000021610.5
 Chga
chromogranin A
chr7_-_119895446 1.184 ENSMUST00000098080.2
 Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr7_+_66839726 1.135 ENSMUST00000098382.3
 Adamts17
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17
chr1_-_161034794 1.134 ENSMUST00000177003.1
ENSMUST00000162226.2
ENSMUST00000159250.2
 Zbtb37


zinc finger and BTB domain containing 37


chr10_-_42583628 1.125 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr1_-_156035891 1.107 ENSMUST00000126448.1
 Tor1aip1
torsin A interacting protein 1
chr7_-_119895697 1.106 ENSMUST00000059851.6
 Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.8 GO:0010225 response to UV-C(GO:0010225)
0.2 3.3 GO:0046033 AMP metabolic process(GO:0046033)
0.8 2.3 GO:0071579 regulation of zinc ion transport(GO:0071579)
0.5 2.1 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
0.3 2.1 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.2 2.1 GO:0071763 nuclear membrane organization(GO:0071763)
0.5 2.0 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 1.9 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 1.6 GO:0070986 left/right axis specification(GO:0070986)
0.5 1.4 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.0 1.4 GO:0045454 cell redox homeostasis(GO:0045454)
0.4 1.3 GO:0002447 eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308) regulation of eosinophil activation(GO:1902566)
0.2 1.3 GO:0044351 macropinocytosis(GO:0044351)
0.4 1.2 GO:1901079 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) positive regulation of relaxation of muscle(GO:1901079)
0.0 1.2 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.2 1.1 GO:0021764 amygdala development(GO:0021764)
0.0 0.9 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.3 0.8 GO:0042939 glutathione transport(GO:0034635) oligopeptide transmembrane transport(GO:0035672) xenobiotic transport(GO:0042908) tripeptide transport(GO:0042939)
0.3 0.8 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.1 0.8 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 GO:0060170 ciliary membrane(GO:0060170)
0.5 2.1 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.0 2.1 GO:0055037 recycling endosome(GO:0055037)
0.1 1.6 GO:0097225 sperm midpiece(GO:0097225)
0.0 1.5 GO:0031901 early endosome membrane(GO:0031901)
0.1 1.4 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.2 1.3 GO:0000322 storage vacuole(GO:0000322)
0.2 1.2 GO:0042583 chromaffin granule(GO:0042583)
0.0 1.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.8 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 0.8 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 0.7 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.7 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.7 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.7 GO:1990391 DNA repair complex(GO:1990391)
0.1 0.6 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.0 0.6 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.5 GO:0071004 U2-type prespliceosome(GO:0071004)
0.1 0.3 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.1 0.3 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 GO:0097602 cullin family protein binding(GO:0097602)
1.1 3.3 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.2 2.9 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.1 2.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.9 2.6 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 2.1 GO:0005521 lamin binding(GO:0005521)
0.1 2.1 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.3 1.8 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 1.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.4 GO:0035064 methylated histone binding(GO:0035064)
0.3 1.3 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.0 1.1 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 1.0 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1 0.9 GO:0009008 DNA-methyltransferase activity(GO:0009008)
0.1 0.9 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.9 GO:1990939 ATP-dependent microtubule motor activity(GO:1990939)
0.3 0.8 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673) sphingolipid transporter activity(GO:0046624)
0.1 0.8 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.8 GO:1990226 histone methyltransferase binding(GO:1990226)
0.2 0.7 GO:0017084 glutamate 5-kinase activity(GO:0004349) glutamate-5-semialdehyde dehydrogenase activity(GO:0004350) delta1-pyrroline-5-carboxylate synthetase activity(GO:0017084) amino acid kinase activity(GO:0019202)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 2.0 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.6 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.5 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.2 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 1.2 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.9 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.8 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 0.8 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 0.6 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.5 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.2 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.1 2.1 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 1.9 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.9 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 0.8 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 0.7 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.7 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.5 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.4 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.3 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.3 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.3 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.3 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.3 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.2 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.2 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis