Motif ID: Grhl1

Z-value: 0.350


Transcription factors associated with Grhl1:

Gene SymbolEntrez IDGene Name
Grhl1 ENSMUSG00000020656.9 Grhl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Grhl1mm10_v2_chr12_+_24572276_245723080.029.0e-01Click!


Activity profile for motif Grhl1.

activity profile for motif Grhl1


Sorted Z-values histogram for motif Grhl1

Sorted Z-values for motif Grhl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Grhl1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_85722474 1.040 ENSMUST00000119077.1
 Fam160a1
family with sequence similarity 160, member A1
chr1_-_192855723 0.632 ENSMUST00000155579.1
 Sertad4
SERTA domain containing 4
chrX_-_38456407 0.627 ENSMUST00000074913.5
ENSMUST00000016678.7
ENSMUST00000061755.8
 Lamp2


lysosomal-associated membrane protein 2


chr4_-_19570073 0.546 ENSMUST00000029885.4
 Cpne3
copine III
chr18_+_56432116 0.540 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr14_-_57133268 0.520 ENSMUST00000160703.1
 Gjb6
gap junction protein, beta 6
chr17_+_87635974 0.495 ENSMUST00000053577.8
 Epcam
epithelial cell adhesion molecule
chr2_-_151973387 0.431 ENSMUST00000109863.1
 Fam110a
family with sequence similarity 110, member A
chr16_-_26989974 0.423 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr2_+_172550761 0.423 ENSMUST00000099058.3
 Tfap2c
transcription factor AP-2, gamma
chr14_+_79481164 0.422 ENSMUST00000040131.5
 Elf1
E74-like factor 1
chr14_+_63943666 0.396 ENSMUST00000079652.5
 Sox7
SRY-box containing gene 7
chr3_-_87263518 0.387 ENSMUST00000090986.4
 Fcrls
Fc receptor-like S, scavenger receptor
chr2_-_105399286 0.381 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr14_-_73385225 0.364 ENSMUST00000022704.7
 Itm2b
integral membrane protein 2B
chrX_+_100730178 0.356 ENSMUST00000113744.1
 Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr17_-_56005566 0.316 ENSMUST00000043785.6
 Stap2
signal transducing adaptor family member 2
chr9_+_21337828 0.309 ENSMUST00000034697.7
 Slc44a2
solute carrier family 44, member 2
chr8_-_71381907 0.307 ENSMUST00000002466.8
 Nr2f6
nuclear receptor subfamily 2, group F, member 6
chr2_-_30205772 0.292 ENSMUST00000113662.1
 Ccbl1
cysteine conjugate-beta lyase 1
chr12_+_76417598 0.288 ENSMUST00000063977.7
 Ppp1r36
protein phosphatase 1, regulatory subunit 36
chr19_-_18631754 0.287 ENSMUST00000025631.6
 Ostf1
osteoclast stimulating factor 1
chr4_+_155086577 0.286 ENSMUST00000030915.4
ENSMUST00000155775.1
ENSMUST00000127457.1
 Morn1


MORN repeat containing 1


chr4_+_141242850 0.278 ENSMUST00000138096.1
ENSMUST00000006618.2
ENSMUST00000125392.1
 Arhgef19


Rho guanine nucleotide exchange factor (GEF) 19


chr2_-_30205794 0.274 ENSMUST00000113663.2
ENSMUST00000044038.3
 Ccbl1

cysteine conjugate-beta lyase 1

chr14_+_75136326 0.261 ENSMUST00000145303.1
 Lcp1
lymphocyte cytosolic protein 1
chr7_+_101321703 0.254 ENSMUST00000174291.1
ENSMUST00000167888.2
ENSMUST00000172662.1
ENSMUST00000173270.1
ENSMUST00000174083.1
 Stard10




START domain containing 10




chr14_-_79481268 0.252 ENSMUST00000022601.5
 Wbp4
WW domain binding protein 4
chr17_+_43389436 0.235 ENSMUST00000113599.1
 Gpr116
G protein-coupled receptor 116
chr3_-_87263703 0.226 ENSMUST00000146512.1
 Fcrls
Fc receptor-like S, scavenger receptor
chr19_+_18631927 0.189 ENSMUST00000159572.1
ENSMUST00000042392.7
 Nmrk1

nicotinamide riboside kinase 1

chr8_+_80494032 0.189 ENSMUST00000063359.6
 Gypa
glycophorin A
chr18_-_25753852 0.179 ENSMUST00000025117.6
ENSMUST00000115816.2
 Celf4

CUGBP, Elav-like family member 4

chr17_-_34628005 0.175 ENSMUST00000166040.2
 Ppt2
palmitoyl-protein thioesterase 2
chr18_-_46280820 0.167 ENSMUST00000025354.3
 Pggt1b
protein geranylgeranyltransferase type I, beta subunit
chr7_+_12927410 0.163 ENSMUST00000045870.4
 2310014L17Rik
RIKEN cDNA 2310014L17 gene
chr6_+_128438757 0.113 ENSMUST00000144745.1
 Gm10069
predicted gene 10069
chr12_-_54656496 0.110 ENSMUST00000056228.6
 Sptssa
serine palmitoyltransferase, small subunit A
chr12_+_90738201 0.108 ENSMUST00000181874.1
 Gm26512
predicted gene, 26512
chr9_-_44268156 0.104 ENSMUST00000169651.1
 Nlrx1
NLR family member X1
chr7_+_65693417 0.078 ENSMUST00000032726.7
ENSMUST00000107495.3
 Tm2d3

TM2 domain containing 3

chr9_-_7872983 0.075 ENSMUST00000115672.1
 Birc3
baculoviral IAP repeat-containing 3
chr4_+_108834601 0.062 ENSMUST00000030296.8
 Txndc12
thioredoxin domain containing 12 (endoplasmic reticulum)
chr9_+_15239045 0.061 ENSMUST00000034413.6
 Vstm5
V-set and transmembrane domain containing 5
chr1_+_135818593 0.054 ENSMUST00000038760.8
 Lad1
ladinin
chr4_+_109676568 0.034 ENSMUST00000102724.4
 Faf1
Fas-associated factor 1
chr8_+_45628176 0.030 ENSMUST00000130850.1
 Sorbs2
sorbin and SH3 domain containing 2
chr10_+_128747850 0.028 ENSMUST00000163377.2
 Wibg
within bgcn homolog (Drosophila)
chr12_-_20900867 0.021 ENSMUST00000079237.5
 Zfp125
zinc finger protein 125
chr17_-_34628380 0.021 ENSMUST00000167097.2
 Ppt2
palmitoyl-protein thioesterase 2
chr4_-_155086271 0.006 ENSMUST00000030914.3
 Rer1
RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0071211 protein targeting to vacuole involved in autophagy(GO:0071211)
0.1 0.4 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.1 0.5 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 0.5 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.1 0.4 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.1 0.2 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0 0.3 GO:0032782 bile acid secretion(GO:0032782) positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0 0.4 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.4 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.2 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.1 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.0 0.3 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0 0.2 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.0 0.3 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.3 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.2 GO:0019363 pyridine nucleotide biosynthetic process(GO:0019363)
0.0 0.4 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.4 GO:0001706 endoderm formation(GO:0001706)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0031088 platelet dense granule membrane(GO:0031088) intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.0 0.5 GO:0005922 connexon complex(GO:0005922)
0.0 0.3 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.1 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.3 GO:0001891 phagocytic cup(GO:0001891)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.1 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.2 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.0 0.5 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.1 GO:0019153 protein-disulfide reductase (glutathione) activity(GO:0019153)
0.0 0.2 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.5 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.3 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters