Motif ID: Gsc2_Dmbx1

Z-value: 0.467

Transcription factors associated with Gsc2_Dmbx1:

Gene SymbolEntrez IDGene Name
Dmbx1 ENSMUSG00000028707.9 Dmbx1
Gsc2 ENSMUSG00000022738.6 Gsc2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dmbx1mm10_v2_chr4_-_115939923_1159399280.202.3e-01Click!


Activity profile for motif Gsc2_Dmbx1.

activity profile for motif Gsc2_Dmbx1


Sorted Z-values histogram for motif Gsc2_Dmbx1

Sorted Z-values for motif Gsc2_Dmbx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gsc2_Dmbx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 90 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_18818895 3.832 ENSMUST00000166873.2
 Cdh10
cadherin 10
chr5_+_3343893 3.499 ENSMUST00000165117.1
 Cdk6
cyclin-dependent kinase 6
chr5_+_3344194 3.334 ENSMUST00000042410.4
 Cdk6
cyclin-dependent kinase 6
chr14_-_118052235 1.692 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr2_-_104257400 1.539 ENSMUST00000141159.1
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chr3_-_103737995 1.528 ENSMUST00000029440.8
 Olfml3
olfactomedin-like 3
chr8_-_113848615 1.369 ENSMUST00000093113.4
 Adamts18
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18
chr2_+_91259822 1.158 ENSMUST00000138470.1
 Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr1_-_168431502 0.914 ENSMUST00000064438.4
 Pbx1
pre B cell leukemia homeobox 1
chr7_-_80403315 0.870 ENSMUST00000147150.1
 Furin
furin (paired basic amino acid cleaving enzyme)
chr13_-_97747399 0.845 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr13_-_97747373 0.840 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr7_-_25398697 0.831 ENSMUST00000105177.2
ENSMUST00000149349.1
 Lipe

lipase, hormone sensitive

chr1_-_168431695 0.781 ENSMUST00000176790.1
 Pbx1
pre B cell leukemia homeobox 1
chr1_+_177444653 0.774 ENSMUST00000094276.3
 Zbtb18
zinc finger and BTB domain containing 18
chr19_+_8617991 0.765 ENSMUST00000010250.2
 Slc22a6
solute carrier family 22 (organic anion transporter), member 6
chr13_+_3361029 0.719 ENSMUST00000179981.1
 Gm16505
predicted gene 16505
chr1_-_155232710 0.681 ENSMUST00000035914.3
 BC034090
cDNA sequence BC034090
chr14_-_31640878 0.669 ENSMUST00000167066.1
ENSMUST00000127204.2
ENSMUST00000022437.8
 Hacl1


2-hydroxyacyl-CoA lyase 1


chr1_-_168431896 0.626 ENSMUST00000176540.1
 Pbx1
pre B cell leukemia homeobox 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 6.8 GO:0044838 cell quiescence(GO:0044838)
0.0 3.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 2.3 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.3 1.7 GO:0006570 tyrosine metabolic process(GO:0006570)
0.1 1.4 GO:0090331 negative regulation of platelet aggregation(GO:0090331)
0.1 1.2 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.2 0.9 GO:0090472 dibasic protein processing(GO:0090472)
0.3 0.8 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.3 0.8 GO:0015747 urate transport(GO:0015747)
0.1 0.8 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.1 0.7 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.0 0.7 GO:0010389 regulation of G2/M transition of mitotic cell cycle(GO:0010389)
0.1 0.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.2 0.5 GO:1902524 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.2 0.5 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.1 0.5 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 0.5 GO:0036089 cleavage furrow formation(GO:0036089)
0.1 0.5 GO:0002681 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.0 0.5 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.4 GO:0010818 T cell chemotaxis(GO:0010818)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 2.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.8 GO:0005901 caveola(GO:0005901)
0.1 1.7 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 0.9 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.8 GO:0045171 intercellular bridge(GO:0045171)
0.1 0.5 GO:1990761 growth cone lamellipodium(GO:1990761)
0.0 0.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.5 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.4 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 0.3 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.2 GO:0071564 npBAF complex(GO:0071564)
0.0 0.2 GO:0042581 specific granule(GO:0042581)
0.0 0.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 6.8 GO:0098770 FBXO family protein binding(GO:0098770)
0.1 1.7 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 1.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.2 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 1.0 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin binding(GO:0030332)
0.1 0.9 GO:0048406 nerve growth factor binding(GO:0048406)
0.2 0.8 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.2 0.8 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.1 0.8 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.8 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity(GO:0004114)
0.1 0.7 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.1 0.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 0.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 0.4 GO:1990450 linear polyubiquitin binding(GO:1990450)
0.0 0.4 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.4 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.3 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.3 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.2 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.8 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.9 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 1.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.3 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.8 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.2 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.8 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 3.8 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 0.9 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 0.8 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.8 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.7 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.4 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.4 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.3 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.2 REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis