Motif ID: Gsc2_Dmbx1

Z-value: 0.467

Transcription factors associated with Gsc2_Dmbx1:

Gene SymbolEntrez IDGene Name
Dmbx1 ENSMUSG00000028707.9 Dmbx1
Gsc2 ENSMUSG00000022738.6 Gsc2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dmbx1mm10_v2_chr4_-_115939923_1159399280.202.3e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Gsc2_Dmbx1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_18818895 3.832 ENSMUST00000166873.2
Cdh10
cadherin 10
chr5_+_3343893 3.499 ENSMUST00000165117.1
Cdk6
cyclin-dependent kinase 6
chr5_+_3344194 3.334 ENSMUST00000042410.4
Cdk6
cyclin-dependent kinase 6
chr14_-_118052235 1.692 ENSMUST00000022725.2
Dct
dopachrome tautomerase
chr2_-_104257400 1.539 ENSMUST00000141159.1
D430041D05Rik
RIKEN cDNA D430041D05 gene
chr3_-_103737995 1.528 ENSMUST00000029440.8
Olfml3
olfactomedin-like 3
chr8_-_113848615 1.369 ENSMUST00000093113.4
Adamts18
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18
chr2_+_91259822 1.158 ENSMUST00000138470.1
Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr1_-_168431502 0.914 ENSMUST00000064438.4
Pbx1
pre B cell leukemia homeobox 1
chr7_-_80403315 0.870 ENSMUST00000147150.1
Furin
furin (paired basic amino acid cleaving enzyme)
chr13_-_97747399 0.845 ENSMUST00000144993.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr13_-_97747373 0.840 ENSMUST00000123535.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr7_-_25398697 0.831 ENSMUST00000105177.2
ENSMUST00000149349.1
Lipe

lipase, hormone sensitive

chr1_-_168431695 0.781 ENSMUST00000176790.1
Pbx1
pre B cell leukemia homeobox 1
chr1_+_177444653 0.774 ENSMUST00000094276.3
Zbtb18
zinc finger and BTB domain containing 18
chr19_+_8617991 0.765 ENSMUST00000010250.2
Slc22a6
solute carrier family 22 (organic anion transporter), member 6
chr13_+_3361029 0.719 ENSMUST00000179981.1
Gm16505
predicted gene 16505
chr1_-_155232710 0.681 ENSMUST00000035914.3
BC034090
cDNA sequence BC034090
chr14_-_31640878 0.669 ENSMUST00000167066.1
ENSMUST00000127204.2
ENSMUST00000022437.8
Hacl1


2-hydroxyacyl-CoA lyase 1


chr1_-_168431896 0.626 ENSMUST00000176540.1
Pbx1
pre B cell leukemia homeobox 1
chr12_+_81631369 0.616 ENSMUST00000036116.5
Ttc9
tetratricopeptide repeat domain 9
chr15_-_74734313 0.585 ENSMUST00000023260.3
Lypd2
Ly6/Plaur domain containing 2
chr11_+_78322965 0.562 ENSMUST00000017534.8
Aldoc
aldolase C, fructose-bisphosphate
chr1_+_12692430 0.528 ENSMUST00000180062.1
ENSMUST00000177608.1
Sulf1

sulfatase 1

chr11_+_19924403 0.520 ENSMUST00000093298.5
Spred2
sprouty-related, EVH1 domain containing 2
chr13_-_113618549 0.518 ENSMUST00000109241.3
Snx18
sorting nexin 18
chr4_+_102589687 0.510 ENSMUST00000097949.4
ENSMUST00000106901.1
Pde4b

phosphodiesterase 4B, cAMP specific

chr11_-_52282564 0.509 ENSMUST00000086844.3
Tcf7
transcription factor 7, T cell specific
chr6_+_4902913 0.488 ENSMUST00000175889.1
ENSMUST00000168998.2
Ppp1r9a

protein phosphatase 1, regulatory (inhibitor) subunit 9A

chr11_+_70459940 0.445 ENSMUST00000147289.1
ENSMUST00000126105.1
Zmynd15

zinc finger, MYND-type containing 15

chr7_-_15879844 0.429 ENSMUST00000172758.1
ENSMUST00000044434.6
Crx

cone-rod homeobox containing gene

chr11_-_70459957 0.423 ENSMUST00000019064.2
Cxcl16
chemokine (C-X-C motif) ligand 16
chr9_-_60838200 0.373 ENSMUST00000063858.7
Gm9869
predicted gene 9869
chr2_+_102659213 0.353 ENSMUST00000111213.1
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chrX_+_74424632 0.327 ENSMUST00000114129.2
ENSMUST00000132749.1
Ikbkg

inhibitor of kappaB kinase gamma

chr2_-_51972990 0.317 ENSMUST00000145481.1
ENSMUST00000112705.2
Nmi

N-myc (and STAT) interactor

chr11_-_107337556 0.315 ENSMUST00000040380.6
Pitpnc1
phosphatidylinositol transfer protein, cytoplasmic 1
chr7_-_127725616 0.313 ENSMUST00000076091.2
Ctf2
cardiotrophin 2
chr5_-_134456702 0.305 ENSMUST00000073161.5
ENSMUST00000171794.2
ENSMUST00000111245.2
ENSMUST00000100654.3
ENSMUST00000167084.2
ENSMUST00000100652.3
ENSMUST00000100650.3
ENSMUST00000074114.5
Gtf2ird1







general transcription factor II I repeat domain-containing 1







chr14_+_99298652 0.303 ENSMUST00000005279.6
Klf5
Kruppel-like factor 5
chr10_-_22149270 0.295 ENSMUST00000179054.1
ENSMUST00000069372.6
E030030I06Rik

RIKEN cDNA E030030I06 gene

chr6_-_59426279 0.288 ENSMUST00000051065.4
Gprin3
GPRIN family member 3
chr7_+_101969796 0.282 ENSMUST00000084852.5
Numa1
nuclear mitotic apparatus protein 1
chr11_+_19924354 0.246 ENSMUST00000093299.6
Spred2
sprouty-related, EVH1 domain containing 2
chr6_+_136954521 0.241 ENSMUST00000137768.1
Pde6h
phosphodiesterase 6H, cGMP-specific, cone, gamma
chr19_+_26605106 0.212 ENSMUST00000025862.7
ENSMUST00000176030.1
Smarca2

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

chr2_-_51973219 0.202 ENSMUST00000028314.2
Nmi
N-myc (and STAT) interactor
chr8_+_78509319 0.200 ENSMUST00000034111.8
Slc10a7
solute carrier family 10 (sodium/bile acid cotransporter family), member 7
chr13_+_75089826 0.196 ENSMUST00000022075.4
Pcsk1
proprotein convertase subtilisin/kexin type 1
chr2_+_91265252 0.186 ENSMUST00000028691.6
Arfgap2
ADP-ribosylation factor GTPase activating protein 2
chr10_+_18407658 0.184 ENSMUST00000037341.7
Nhsl1
NHS-like 1
chr11_-_68973840 0.184 ENSMUST00000038644.4
Rangrf
RAN guanine nucleotide release factor
chrX_+_134295225 0.181 ENSMUST00000037687.7
Tmem35
transmembrane protein 35
chr11_+_4186789 0.167 ENSMUST00000041042.6
ENSMUST00000180088.1
Tbc1d10a

TBC1 domain family, member 10a

chr8_-_60954726 0.161 ENSMUST00000110302.1
Clcn3
chloride channel 3
chr9_-_50617228 0.141 ENSMUST00000147671.1
ENSMUST00000145139.1
ENSMUST00000155435.1
AU019823


expressed sequence AU019823


chr11_+_5099608 0.140 ENSMUST00000139742.1
Rhbdd3
rhomboid domain containing 3
chr11_+_5099406 0.134 ENSMUST00000134267.1
ENSMUST00000036320.5
ENSMUST00000150632.1
Rhbdd3


rhomboid domain containing 3


chr19_-_53371766 0.134 ENSMUST00000086887.1
Gm10197
predicted gene 10197
chr5_+_19907502 0.119 ENSMUST00000101558.3
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr4_+_84884418 0.118 ENSMUST00000169371.2
Cntln
centlein, centrosomal protein
chr11_-_5099084 0.116 ENSMUST00000063232.6
Ewsr1
Ewing sarcoma breakpoint region 1
chr5_-_144223516 0.116 ENSMUST00000085701.6
Tecpr1
tectonin beta-propeller repeat containing 1
chr15_-_93595877 0.114 ENSMUST00000048982.4
Prickle1
prickle homolog 1 (Drosophila)
chrX_+_74424534 0.109 ENSMUST00000135165.1
ENSMUST00000114128.1
ENSMUST00000114133.2
ENSMUST00000004330.3
Ikbkg



inhibitor of kappaB kinase gamma



chr11_+_95010277 0.108 ENSMUST00000124735.1
Samd14
sterile alpha motif domain containing 14
chrM_+_8600 0.107 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr10_+_80292453 0.106 ENSMUST00000068408.7
ENSMUST00000062674.6
Rps15

ribosomal protein S15

chr2_-_24049389 0.105 ENSMUST00000051416.5
Hnmt
histamine N-methyltransferase
chr16_-_46010212 0.104 ENSMUST00000130481.1
Plcxd2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr17_-_35164891 0.099 ENSMUST00000025253.5
Prrc2a
proline-rich coiled-coil 2A
chr16_-_4213404 0.099 ENSMUST00000023165.6
Crebbp
CREB binding protein
chr1_-_44218952 0.087 ENSMUST00000054801.3
Mettl21e
methyltransferase like 21E
chr11_-_59187738 0.086 ENSMUST00000170895.2
Guk1
guanylate kinase 1
chr7_-_98656530 0.085 ENSMUST00000038359.4
2210018M11Rik
RIKEN cDNA 2210018M11 gene
chrX_+_7728439 0.078 ENSMUST00000033489.7
Praf2
PRA1 domain family 2
chr10_-_9901079 0.072 ENSMUST00000141722.1
Stxbp5
syntaxin binding protein 5 (tomosyn)
chr1_+_178187721 0.065 ENSMUST00000159284.1
Desi2
desumoylating isopeptidase 2
chr4_-_133968611 0.061 ENSMUST00000102552.1
Hmgn2
high mobility group nucleosomal binding domain 2
chr11_-_90687572 0.060 ENSMUST00000107869.2
ENSMUST00000154599.1
ENSMUST00000107868.1
ENSMUST00000020849.2
Tom1l1



target of myb1-like 1 (chicken)



chr4_+_154960915 0.059 ENSMUST00000049621.6
Hes5
hairy and enhancer of split 5 (Drosophila)
chrX_+_134585644 0.050 ENSMUST00000113211.1
Rpl36a
ribosomal protein L36A
chr1_+_178187417 0.049 ENSMUST00000161075.1
ENSMUST00000027783.7
Desi2

desumoylating isopeptidase 2

chrX_+_48623737 0.044 ENSMUST00000114936.1
Slc25a14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr8_+_19682268 0.044 ENSMUST00000153710.1
ENSMUST00000127799.1
Gm6483

predicted gene 6483

chr10_+_128225830 0.018 ENSMUST00000026455.7
Mip
major intrinsic protein of eye lens fiber
chr11_-_5099223 0.006 ENSMUST00000079949.6
Ewsr1
Ewing sarcoma breakpoint region 1
chr4_-_141053704 0.005 ENSMUST00000102491.3
Crocc
ciliary rootlet coiled-coil, rootletin
chr19_+_46056539 0.003 ENSMUST00000111899.1
ENSMUST00000099392.3
ENSMUST00000062322.4
Pprc1


peroxisome proliferative activated receptor, gamma, coactivator-related 1


chr3_+_103809520 0.000 ENSMUST00000076599.1
ENSMUST00000106824.1
ENSMUST00000106823.1
ENSMUST00000047285.2
Ap4b1



adaptor-related protein complex AP-4, beta 1




Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 6.8 GO:0044838 cell quiescence(GO:0044838)
0.3 1.7 GO:0006570 tyrosine metabolic process(GO:0006570)
0.3 0.8 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.3 0.8 GO:0015747 urate transport(GO:0015747)
0.2 0.9 GO:0090472 dibasic protein processing(GO:0090472)
0.2 0.5 GO:1902524 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.2 0.5 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.1 0.7 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.1 0.5 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 1.4 GO:0090331 negative regulation of platelet aggregation(GO:0090331)
0.1 2.3 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.1 0.5 GO:0036089 cleavage furrow formation(GO:0036089)
0.1 0.3 GO:1904778 regulation of metaphase plate congression(GO:0090235) regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.1 0.5 GO:0002681 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.1 0.3 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.1 0.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 0.8 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.1 0.2 GO:0097401 synaptic vesicle lumen acidification(GO:0097401)
0.1 1.2 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.1 GO:0045358 negative regulation of interferon-beta biosynthetic process(GO:0045358)
0.0 0.3 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.0 3.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.3 GO:0060576 regulation of microvillus assembly(GO:0032534) intestinal epithelial cell development(GO:0060576)
0.0 0.5 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.1 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.0 0.4 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 0.2 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.2 GO:0086028 bundle of His cell to Purkinje myocyte signaling(GO:0086028) bundle of His cell action potential(GO:0086043)
0.0 0.4 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.1 GO:0009182 purine deoxyribonucleotide biosynthetic process(GO:0009153) purine deoxyribonucleoside diphosphate metabolic process(GO:0009182) dGDP metabolic process(GO:0046066) GDP metabolic process(GO:0046710)
0.0 0.1 GO:0001692 histamine metabolic process(GO:0001692) imidazole-containing compound catabolic process(GO:0052805)
0.0 0.2 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 0.2 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.1 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0 0.1 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.0 0.2 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.7 GO:0010389 regulation of G2/M transition of mitotic cell cycle(GO:0010389)
0.0 0.2 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 0.5 GO:1990761 growth cone lamellipodium(GO:1990761)
0.1 0.3 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 1.7 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 0.9 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.4 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.8 GO:0005901 caveola(GO:0005901)
0.0 2.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.8 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.5 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.2 GO:0071564 npBAF complex(GO:0071564)
0.0 0.2 GO:0042581 specific granule(GO:0042581)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 6.8 GO:0098770 FBXO family protein binding(GO:0098770)
0.2 0.8 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.2 0.8 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.1 0.4 GO:1990450 linear polyubiquitin binding(GO:1990450)
0.1 1.7 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 0.8 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 1.2 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 0.9 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 0.7 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.0 0.4 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.2 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.4 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.3 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.3 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 1.0 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin binding(GO:0030332)
0.0 0.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.1 GO:0043426 MRF binding(GO:0043426)
0.0 0.8 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity(GO:0004114)
0.0 1.4 GO:0004222 metalloendopeptidase activity(GO:0004222)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.8 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.9 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 1.3 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.8 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.2 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.8 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 0.8 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.1 3.8 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 0.9 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.4 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.8 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.2 REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis
0.0 0.3 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.7 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.4 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis