Motif ID: Gsx1_Alx1_Mixl1_Lbx2

Z-value: 0.505

Transcription factors associated with Gsx1_Alx1_Mixl1_Lbx2:

Gene SymbolEntrez IDGene Name
Alx1 ENSMUSG00000036602.7 Alx1
Gsx1 ENSMUSG00000053129.5 Gsx1
Lbx2 ENSMUSG00000034968.2 Lbx2
Mixl1 ENSMUSG00000026497.7 Mixl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gsx1mm10_v2_chr5_+_147188678_1471886960.038.6e-01Click!
Alx1mm10_v2_chr10_-_103029043_1030290540.009.9e-01Click!


Activity profile for motif Gsx1_Alx1_Mixl1_Lbx2.

activity profile for motif Gsx1_Alx1_Mixl1_Lbx2


Sorted Z-values histogram for motif Gsx1_Alx1_Mixl1_Lbx2

Sorted Z-values for motif Gsx1_Alx1_Mixl1_Lbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gsx1_Alx1_Mixl1_Lbx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_62766153 6.705 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_-_190170671 4.928 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr13_+_44121167 4.397 ENSMUST00000163056.1
ENSMUST00000159595.1
 Gm5083

predicted gene 5083

chr3_-_49757257 4.353 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr2_+_116067213 3.239 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr18_+_57468478 2.787 ENSMUST00000091892.2
 Ctxn3
cortexin 3
chr9_+_118478182 2.714 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478344 2.618 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr16_+_33684538 2.429 ENSMUST00000126532.1
 Heg1
HEG homolog 1 (zebrafish)
chr1_-_163725123 2.215 ENSMUST00000159679.1
 Mettl11b
methyltransferase like 11B
chr2_-_116067391 2.139 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr2_+_20737306 1.980 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chrX_+_56454871 1.978 ENSMUST00000039374.2
ENSMUST00000101553.2
 Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chr15_+_25773985 1.959 ENSMUST00000125667.1
 Myo10
myosin X
chr11_-_98053415 1.780 ENSMUST00000017544.2
 Stac2
SH3 and cysteine rich domain 2
chr15_+_55307743 1.660 ENSMUST00000023053.5
ENSMUST00000110221.2
ENSMUST00000110217.3
 Col14a1


collagen, type XIV, alpha 1


chr5_-_84417359 1.551 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr8_+_23411490 1.536 ENSMUST00000033952.7
 Sfrp1
secreted frizzled-related protein 1
chr7_+_51879041 1.499 ENSMUST00000107591.2
 Gas2
growth arrest specific 2
chr3_-_66296807 1.487 ENSMUST00000029419.7
 Veph1
ventricular zone expressed PH domain-containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 5.3 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
1.6 4.9 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.0 4.8 GO:0008360 regulation of cell shape(GO:0008360)
0.2 4.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 3.9 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.1 3.6 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.5 3.4 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
1.0 3.0 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.2 2.2 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 2.2 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.5 1.5 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.0 1.4 GO:0046488 phosphatidylinositol metabolic process(GO:0046488)
0.1 1.3 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.3 1.0 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.3 1.0 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.2 1.0 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.1 1.0 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 1.0 GO:0033194 response to hydroperoxide(GO:0033194)
0.3 0.9 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344)
0.3 0.9 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.4 GO:0070469 respiratory chain(GO:0070469)
0.0 4.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 2.6 GO:0016459 myosin complex(GO:0016459)
0.0 2.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 1.7 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.2 1.3 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 1.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.3 1.0 GO:0060187 cell pole(GO:0060187)
0.3 0.9 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.9 GO:0002102 podosome(GO:0002102)
0.0 0.8 GO:0097440 apical dendrite(GO:0097440)
0.0 0.8 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 0.7 GO:0031523 Myb complex(GO:0031523)
0.0 0.7 GO:0051286 cell tip(GO:0051286)
0.1 0.6 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.6 GO:0016235 aggresome(GO:0016235)
0.0 0.6 GO:0072562 blood microparticle(GO:0072562)
0.1 0.4 GO:0097487 vesicle lumen(GO:0031983) multivesicular body, internal vesicle(GO:0097487)
0.1 0.4 GO:0001940 male pronucleus(GO:0001940)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.9 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 6.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.4 4.9 GO:0050693 LBD domain binding(GO:0050693)
0.2 4.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.3 3.4 GO:0038191 neuropilin binding(GO:0038191)
0.0 2.3 GO:0030507 spectrin binding(GO:0030507)
0.3 2.2 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 2.2 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 2.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 1.7 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 1.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.2 1.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 1.1 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 1.0 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 1.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 0.9 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 0.9 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.2 0.8 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.8 GO:0001849 complement component C1q binding(GO:0001849)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.7 PID_ARF6_PATHWAY Arf6 signaling events
0.1 5.5 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 3.3 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 3.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 2.3 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.6 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.4 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 1.1 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 0.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.8 ST_ADRENERGIC Adrenergic Pathway
0.0 0.6 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.6 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.5 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.5 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 0.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.4 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.3 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 0.1 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.1 PID_S1P_S1P4_PATHWAY S1P4 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.5 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 2.5 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 1.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.1 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 1.0 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 0.9 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.9 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.8 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 0.6 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.6 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.6 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.4 REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.4 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.4 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.3 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.3 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.3 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.3 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction