Motif ID: Gsx2_Hoxd3_Vax1

Z-value: 0.506

Transcription factors associated with Gsx2_Hoxd3_Vax1:

Gene SymbolEntrez IDGene Name
Gsx2 ENSMUSG00000035946.6 Gsx2
Hoxd3 ENSMUSG00000079277.3 Hoxd3
Vax1 ENSMUSG00000006270.6 Vax1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gsx2mm10_v2_chr5_+_75075464_750756010.553.8e-04Click!
Vax1mm10_v2_chr19_-_59170978_591709780.353.1e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Gsx2_Hoxd3_Vax1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_14621805 4.870 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr15_-_8710734 4.593 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710409 4.218 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr4_-_14621669 2.708 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr4_-_14621494 2.664 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr8_+_66386292 2.046 ENSMUST00000039540.5
ENSMUST00000110253.2
March1

membrane-associated ring finger (C3HC4) 1

chr5_+_66968559 1.817 ENSMUST00000127184.1
Limch1
LIM and calponin homology domains 1
chr5_+_66968416 1.620 ENSMUST00000038188.7
Limch1
LIM and calponin homology domains 1
chr2_+_109917639 1.611 ENSMUST00000046548.7
ENSMUST00000111037.2
Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr9_-_90255927 1.425 ENSMUST00000144646.1
Tbc1d2b
TBC1 domain family, member 2B
chr2_+_116067213 1.375 ENSMUST00000152412.1
G630016G05Rik
RIKEN cDNA G630016G05 gene
chr3_-_59220150 1.273 ENSMUST00000170388.1
P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr3_+_66219909 1.217 ENSMUST00000029421.5
Ptx3
pentraxin related gene
chr15_-_37459327 1.195 ENSMUST00000119730.1
ENSMUST00000120746.1
Ncald

neurocalcin delta

chr18_+_12741324 1.124 ENSMUST00000115857.2
ENSMUST00000121018.1
ENSMUST00000119108.1
Cabyr


calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)


chr2_-_164171113 0.905 ENSMUST00000045196.3
Kcns1
K+ voltage-gated channel, subfamily S, 1
chr8_-_34965631 0.856 ENSMUST00000033929.4
Tnks
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr14_-_64455903 0.849 ENSMUST00000067927.7
Msra
methionine sulfoxide reductase A
chr6_+_145934113 0.829 ENSMUST00000032383.7
Sspn
sarcospan
chr15_+_92597104 0.778 ENSMUST00000035399.8
Pdzrn4
PDZ domain containing RING finger 4
chr4_+_102589687 0.764 ENSMUST00000097949.4
ENSMUST00000106901.1
Pde4b

phosphodiesterase 4B, cAMP specific

chr9_+_32116040 0.724 ENSMUST00000174641.1
Arhgap32
Rho GTPase activating protein 32
chr8_+_36489191 0.684 ENSMUST00000171777.1
6430573F11Rik
RIKEN cDNA 6430573F11 gene
chr15_+_82256023 0.669 ENSMUST00000143238.1
1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr18_+_56432116 0.637 ENSMUST00000070166.5
Gramd3
GRAM domain containing 3
chr9_-_112187898 0.624 ENSMUST00000178410.1
ENSMUST00000172380.3
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr4_+_154964117 0.613 ENSMUST00000030931.4
ENSMUST00000070953.4
Pank4

pantothenate kinase 4

chr8_+_94152607 0.603 ENSMUST00000034211.8
Mt3
metallothionein 3
chr19_-_57360668 0.580 ENSMUST00000181921.1
B230217O12Rik
RIKEN cDNA B230217O12 gene
chr12_+_112760652 0.552 ENSMUST00000063888.3
Pld4
phospholipase D family, member 4
chr1_-_152625212 0.534 ENSMUST00000027760.7
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr9_-_112187766 0.514 ENSMUST00000111872.2
ENSMUST00000164754.2
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr3_+_103739366 0.509 ENSMUST00000106852.1
Gm10964
predicted gene 10964
chr2_-_33087169 0.508 ENSMUST00000102810.3
Garnl3
GTPase activating RANGAP domain-like 3
chr14_+_69347587 0.498 ENSMUST00000064831.5
Entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chrX_+_169685191 0.494 ENSMUST00000112104.1
ENSMUST00000112107.1
Mid1

midline 1

chr16_-_92400067 0.453 ENSMUST00000023672.8
Rcan1
regulator of calcineurin 1
chr3_+_68584154 0.452 ENSMUST00000182997.1
Schip1
schwannomin interacting protein 1
chr6_-_34317442 0.446 ENSMUST00000154655.1
ENSMUST00000102980.4
Akr1b3

aldo-keto reductase family 1, member B3 (aldose reductase)

chr15_+_98571004 0.444 ENSMUST00000023728.6
4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr3_-_116253467 0.441 ENSMUST00000090473.5
Gpr88
G-protein coupled receptor 88
chr2_+_125136692 0.435 ENSMUST00000099452.2
Ctxn2
cortexin 2
chr9_+_94669876 0.425 ENSMUST00000033463.9
Slc9a9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr19_-_32196393 0.405 ENSMUST00000151822.1
Sgms1
sphingomyelin synthase 1
chr4_-_15149755 0.398 ENSMUST00000108273.1
Necab1
N-terminal EF-hand calcium binding protein 1
chr10_+_116018213 0.359 ENSMUST00000063470.4
Ptprr
protein tyrosine phosphatase, receptor type, R
chr3_+_53488677 0.358 ENSMUST00000029307.3
Stoml3
stomatin (Epb7.2)-like 3
chr2_-_116067391 0.353 ENSMUST00000140185.1
2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr2_+_91650169 0.346 ENSMUST00000090614.4
Arhgap1
Rho GTPase activating protein 1
chr6_+_125552948 0.337 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
Vwf


Von Willebrand factor homolog


chr11_-_109611417 0.296 ENSMUST00000103060.3
ENSMUST00000047186.3
ENSMUST00000106689.1
Wipi1


WD repeat domain, phosphoinositide interacting 1


chr13_+_51408618 0.292 ENSMUST00000087978.3
S1pr3
sphingosine-1-phosphate receptor 3
chr14_+_64589802 0.289 ENSMUST00000180610.1
A930011O12Rik
RIKEN cDNA A930011O12 gene
chr2_+_36230426 0.283 ENSMUST00000062069.5
Ptgs1
prostaglandin-endoperoxide synthase 1
chr10_-_33995054 0.280 ENSMUST00000164429.1
Gm17567
predicted gene, 17567
chr13_-_102906046 0.278 ENSMUST00000171791.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr9_-_55919605 0.268 ENSMUST00000037408.8
Scaper
S phase cyclin A-associated protein in the ER
chr17_+_85028347 0.262 ENSMUST00000024944.7
Slc3a1
solute carrier family 3, member 1
chr2_+_91650116 0.259 ENSMUST00000111331.2
Arhgap1
Rho GTPase activating protein 1
chr1_+_75436002 0.256 ENSMUST00000131545.1
ENSMUST00000141124.1
Gmppa

GDP-mannose pyrophosphorylase A

chr18_+_59062462 0.244 ENSMUST00000058633.2
ENSMUST00000175897.1
ENSMUST00000118510.1
ENSMUST00000175830.1
A730017C20Rik



RIKEN cDNA A730017C20 gene



chr18_+_37355271 0.243 ENSMUST00000051163.1
Pcdhb8
protocadherin beta 8
chrX_-_101086020 0.233 ENSMUST00000113710.1
Slc7a3
solute carrier family 7 (cationic amino acid transporter, y+ system), member 3
chr5_-_62765618 0.230 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr16_-_89818338 0.226 ENSMUST00000164263.2
Tiam1
T cell lymphoma invasion and metastasis 1
chr18_+_59062282 0.211 ENSMUST00000165666.2
A730017C20Rik
RIKEN cDNA A730017C20 gene
chr4_+_108719649 0.202 ENSMUST00000178992.1
3110021N24Rik
RIKEN cDNA 3110021N24 gene
chr6_-_136875794 0.200 ENSMUST00000032342.1
Mgp
matrix Gla protein
chr5_+_26817357 0.193 ENSMUST00000071500.6
Dpp6
dipeptidylpeptidase 6
chr9_-_110476637 0.192 ENSMUST00000111934.1
ENSMUST00000068025.6
Klhl18

kelch-like 18

chr1_-_36557517 0.178 ENSMUST00000114990.1
ENSMUST00000128104.1
ENSMUST00000027295.4
Sema4c


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C


chr8_+_107031218 0.176 ENSMUST00000034388.9
Vps4a
vacuolar protein sorting 4a (yeast)
chrX_+_150547375 0.172 ENSMUST00000066337.6
ENSMUST00000112715.1
Alas2

aminolevulinic acid synthase 2, erythroid

chrX_-_143933089 0.169 ENSMUST00000087313.3
Dcx
doublecortin
chr10_+_116143881 0.167 ENSMUST00000105271.2
Ptprr
protein tyrosine phosphatase, receptor type, R
chr13_-_102905740 0.167 ENSMUST00000167462.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr12_+_80644212 0.167 ENSMUST00000085245.5
Slc39a9
solute carrier family 39 (zinc transporter), member 9
chr8_-_54724474 0.165 ENSMUST00000175915.1
Wdr17
WD repeat domain 17
chr12_+_102128718 0.161 ENSMUST00000159329.1
Slc24a4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr4_+_103143052 0.158 ENSMUST00000106855.1
Mier1
mesoderm induction early response 1 homolog (Xenopus laevis
chr18_+_33464163 0.154 ENSMUST00000097634.3
Gm10549
predicted gene 10549
chr17_+_66111605 0.151 ENSMUST00000116556.2
Wash
WAS protein family homolog
chr12_-_87775755 0.148 ENSMUST00000164517.2
Gm21319
predicted gene, 21319
chr1_+_75435930 0.148 ENSMUST00000037796.7
ENSMUST00000113584.1
ENSMUST00000145166.1
ENSMUST00000143730.1
ENSMUST00000133418.1
ENSMUST00000144874.1
ENSMUST00000140287.1
Gmppa






GDP-mannose pyrophosphorylase A






chr12_-_79296266 0.138 ENSMUST00000021547.6
Zfyve26
zinc finger, FYVE domain containing 26
chr16_-_32877723 0.131 ENSMUST00000119810.1
1700021K19Rik
RIKEN cDNA 1700021K19 gene
chr17_-_47502276 0.131 ENSMUST00000067103.2
Taf8
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factorq
chr9_-_103222063 0.130 ENSMUST00000170904.1
Trf
transferrin
chr2_-_120154600 0.128 ENSMUST00000028755.7
Ehd4
EH-domain containing 4
chr17_+_66111529 0.128 ENSMUST00000072383.6
Wash
WAS protein family homolog
chr8_-_86580664 0.126 ENSMUST00000131423.1
ENSMUST00000152438.1
Abcc12

ATP-binding cassette, sub-family C (CFTR/MRP), member 12

chr5_-_137072254 0.125 ENSMUST00000077523.3
ENSMUST00000041388.4
Serpine1

serine (or cysteine) peptidase inhibitor, clade E, member 1

chr4_+_136347286 0.119 ENSMUST00000140052.2
9130020K20Rik
RIKEN cDNA 9130020K20 gene
chr7_+_126950687 0.112 ENSMUST00000106333.1
Sez6l2
seizure related 6 homolog like 2
chrX_-_157415286 0.110 ENSMUST00000079945.4
ENSMUST00000138396.1
Phex

phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)

chr5_+_136987019 0.109 ENSMUST00000004968.4
Plod3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr10_+_90071095 0.098 ENSMUST00000183109.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr2_-_45112890 0.098 ENSMUST00000076836.6
Zeb2
zinc finger E-box binding homeobox 2
chr14_-_104522615 0.095 ENSMUST00000022716.2
Rnf219
ring finger protein 219
chr10_-_62814539 0.094 ENSMUST00000173087.1
ENSMUST00000174121.1
Tet1

tet methylcytosine dioxygenase 1

chrX_+_93675088 0.093 ENSMUST00000045898.3
Pcyt1b
phosphate cytidylyltransferase 1, choline, beta isoform
chr12_-_80643799 0.085 ENSMUST00000166931.1
Erh
enhancer of rudimentary homolog (Drosophila)
chr13_-_53473074 0.084 ENSMUST00000021922.8
Msx2
msh homeobox 2
chr6_-_54566484 0.081 ENSMUST00000019268.4
Scrn1
secernin 1
chr4_+_59035088 0.078 ENSMUST00000041160.6
Gng10
guanine nucleotide binding protein (G protein), gamma 10
chr5_+_107497718 0.078 ENSMUST00000112671.2
A830010M20Rik
RIKEN cDNA A830010M20 gene
chr6_+_63255971 0.077 ENSMUST00000159561.1
ENSMUST00000095852.3
Grid2

glutamate receptor, ionotropic, delta 2

chr4_+_105789869 0.070 ENSMUST00000184254.1
Gm12728
predicted gene 12728
chr1_+_34121250 0.070 ENSMUST00000183006.1
Dst
dystonin
chr12_+_111814170 0.069 ENSMUST00000021714.7
Zfyve21
zinc finger, FYVE domain containing 21
chr3_+_88297147 0.069 ENSMUST00000164166.1
ENSMUST00000168062.1
Cct3

chaperonin containing Tcp1, subunit 3 (gamma)

chr9_+_110052016 0.067 ENSMUST00000164930.1
ENSMUST00000163979.1
Map4

microtubule-associated protein 4

chr1_-_161070613 0.067 ENSMUST00000035430.3
Dars2
aspartyl-tRNA synthetase 2 (mitochondrial)
chr3_+_88297115 0.066 ENSMUST00000001452.7
Cct3
chaperonin containing Tcp1, subunit 3 (gamma)
chr4_-_117682233 0.066 ENSMUST00000102687.3
Dmap1
DNA methyltransferase 1-associated protein 1
chr4_+_95557494 0.064 ENSMUST00000079223.4
ENSMUST00000177394.1
Fggy

FGGY carbohydrate kinase domain containing

chr4_-_150914401 0.062 ENSMUST00000105675.1
Park7
Parkinson disease (autosomal recessive, early onset) 7
chr12_+_38780284 0.061 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
Etv1


ets variant gene 1


chr8_-_41016749 0.061 ENSMUST00000117735.1
Mtus1
mitochondrial tumor suppressor 1
chr11_+_114851142 0.059 ENSMUST00000133245.1
ENSMUST00000122967.2
Gprc5c

G protein-coupled receptor, family C, group 5, member C

chr18_-_24603464 0.056 ENSMUST00000154205.1
Slc39a6
solute carrier family 39 (metal ion transporter), member 6
chr8_-_112011266 0.055 ENSMUST00000164470.1
ENSMUST00000093120.5
Kars

lysyl-tRNA synthetase

chr12_-_98577940 0.055 ENSMUST00000110113.1
Kcnk10
potassium channel, subfamily K, member 10
chr5_+_48242549 0.051 ENSMUST00000172493.1
Slit2
slit homolog 2 (Drosophila)
chr8_-_21906412 0.050 ENSMUST00000051965.4
Defb11
defensin beta 11
chr2_-_164389095 0.040 ENSMUST00000167427.1
Slpi
secretory leukocyte peptidase inhibitor
chr2_+_106693185 0.040 ENSMUST00000111063.1
Mpped2
metallophosphoesterase domain containing 2
chr5_-_100416115 0.038 ENSMUST00000182886.1
ENSMUST00000094578.4
Sec31a

Sec31 homolog A (S. cerevisiae)

chr8_-_112011320 0.029 ENSMUST00000034426.6
Kars
lysyl-tRNA synthetase
chr1_+_180109192 0.028 ENSMUST00000143176.1
ENSMUST00000135056.1
Cdc42bpa

CDC42 binding protein kinase alpha

chr8_-_13890233 0.027 ENSMUST00000033839.7
Coprs
coordinator of PRMT5, differentiation stimulator
chr2_-_29787622 0.026 ENSMUST00000177467.1
ENSMUST00000113807.3
Trub2

TruB pseudouridine (psi) synthase homolog 2 (E. coli)

chr2_-_73625731 0.026 ENSMUST00000070579.6
Chn1
chimerin (chimaerin) 1
chr5_-_63968867 0.025 ENSMUST00000154169.1
Rell1
RELT-like 1
chr14_-_108914237 0.018 ENSMUST00000100322.2
Slitrk1
SLIT and NTRK-like family, member 1
chr9_+_72958785 0.016 ENSMUST00000098567.2
ENSMUST00000034734.8
Dyx1c1

dyslexia susceptibility 1 candidate 1 homolog (human)

chr7_-_4778141 0.016 ENSMUST00000094892.5
Il11
interleukin 11
chr7_+_100159241 0.014 ENSMUST00000032967.3
Lipt2
lipoyl(octanoyl) transferase 2 (putative)
chr1_-_33814516 0.013 ENSMUST00000044455.5
ENSMUST00000115167.1
Zfp451

zinc finger protein 451

chr5_-_106926245 0.012 ENSMUST00000117588.1
Hfm1
HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
chr7_+_101896817 0.012 ENSMUST00000143835.1
Anapc15
anaphase prompoting complex C subunit 15
chr6_-_122340499 0.012 ENSMUST00000160843.1
Phc1
polyhomeotic-like 1 (Drosophila)
chr9_+_121950988 0.010 ENSMUST00000043011.7
Fam198a
family with sequence similarity 198, member A
chrX_-_99470672 0.009 ENSMUST00000113797.3
ENSMUST00000113790.1
ENSMUST00000036354.6
ENSMUST00000167246.1
Pja1



praja1, RING-H2 motif containing



chr7_+_19368498 0.006 ENSMUST00000132655.1
Ppp1r13l
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
chr12_+_38780817 0.001 ENSMUST00000160856.1
Etv1
ets variant gene 1

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 8.8 GO:0043490 malate-aspartate shuttle(GO:0043490)
1.5 10.2 GO:0019532 oxalate transport(GO:0019532)
0.5 1.6 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.4 1.3 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.3 0.9 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.2 1.2 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.2 0.6 GO:0097212 lysosomal membrane organization(GO:0097212)
0.1 0.4 GO:0006059 hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401)
0.1 0.3 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.1 0.5 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 0.6 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.1 0.4 GO:0061743 motor learning(GO:0061743)
0.1 2.0 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.1 0.2 GO:1903977 positive regulation of Schwann cell migration(GO:1900149) positive regulation of glial cell migration(GO:1903977)
0.1 1.1 GO:0048240 sperm capacitation(GO:0048240)
0.1 0.7 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.1 0.2 GO:0061738 abscission(GO:0009838) late endosomal microautophagy(GO:0061738) positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.1 0.8 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.5 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.2 GO:0015822 ornithine transport(GO:0015822)
0.0 0.4 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.4 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.1 GO:2000097 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0 0.6 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.1 GO:0045575 basophil activation involved in immune response(GO:0002276) basophil activation(GO:0045575)
0.0 0.1 GO:0051795 positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.0 0.1 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.0 0.5 GO:0001553 luteinization(GO:0001553)
0.0 0.3 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.0 0.5 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.0 0.3 GO:0048199 vesicle targeting, to, from or within Golgi(GO:0048199)
0.0 0.5 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.0 1.1 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.1 GO:0050787 glycolate metabolic process(GO:0009441) enzyme active site formation(GO:0018307) enzyme active site formation via L-cysteine sulfinic acid(GO:0018323) primary alcohol biosynthetic process(GO:0034309) cellular response to glyoxal(GO:0036471) glycolate biosynthetic process(GO:0046295) detoxification of mercury ion(GO:0050787) negative regulation of TRAIL-activated apoptotic signaling pathway(GO:1903122) regulation of pyrroline-5-carboxylate reductase activity(GO:1903167) positive regulation of pyrroline-5-carboxylate reductase activity(GO:1903168) regulation of tyrosine 3-monooxygenase activity(GO:1903176) positive regulation of tyrosine 3-monooxygenase activity(GO:1903178) L-dopa metabolic process(GO:1903184) L-dopa biosynthetic process(GO:1903185) glyoxal metabolic process(GO:1903189) regulation of L-dopa biosynthetic process(GO:1903195) positive regulation of L-dopa biosynthetic process(GO:1903197) regulation of L-dopa decarboxylase activity(GO:1903198) positive regulation of L-dopa decarboxylase activity(GO:1903200) positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.0 0.1 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.0 1.4 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.1 GO:0021972 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.0 0.1 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.0 0.1 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 0.1 GO:0098707 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.0 1.2 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 3.2 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 0.1 GO:0030282 bone mineralization(GO:0030282)
0.0 0.2 GO:0097186 amelogenesis(GO:0097186)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.2 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.2 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.0 0.2 GO:0031937 positive regulation of chromatin silencing(GO:0031937)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0097637 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.1 0.4 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 0.6 GO:0097443 sorting endosome(GO:0097443)
0.1 2.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 1.1 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 0.3 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 19.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 0.8 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.9 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.4 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.8 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.2 GO:0060091 kinocilium(GO:0060091)
0.0 0.1 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.3 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 1.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.2 GO:0090543 ESCRT III complex(GO:0000815) Flemming body(GO:0090543)
0.0 0.1 GO:0031673 H zone(GO:0031673)
0.0 1.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 8.8 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.9 10.2 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.3 0.8 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.2 1.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.2 1.2 GO:0046790 virion binding(GO:0046790)
0.1 1.6 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 0.6 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 0.7 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.1 0.4 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 0.5 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 0.4 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 0.5 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 0.5 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.1 0.6 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1 0.2 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.1 0.2 GO:0016748 succinyltransferase activity(GO:0016748)
0.1 0.4 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 0.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.9 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 1.0 GO:0042287 MHC protein binding(GO:0042287)
0.0 0.3 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 1.2 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.3 GO:0019865 immunoglobulin binding(GO:0019865)
0.0 0.2 GO:0022821 calcium, potassium:sodium antiporter activity(GO:0008273) potassium ion antiporter activity(GO:0022821)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.1 GO:0036470 tyrosine 3-monooxygenase activator activity(GO:0036470) L-dopa decarboxylase activator activity(GO:0036478)
0.0 0.1 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.0 0.1 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 1.1 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.1 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.4 GO:0003774 motor activity(GO:0003774)
0.0 0.3 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 3.4 GO:0005096 GTPase activator activity(GO:0005096)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.3 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 1.0 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.6 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.5 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.4 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 0.8 PID_TELOMERASE_PATHWAY Regulation of Telomerase

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 19.7 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.2 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 0.6 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.6 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.3 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.4 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events