Motif ID: Gsx2_Hoxd3_Vax1
Z-value: 0.506
Transcription factors associated with Gsx2_Hoxd3_Vax1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Gsx2 | ENSMUSG00000035946.6 | Gsx2 |
Hoxd3 | ENSMUSG00000079277.3 | Hoxd3 |
Vax1 | ENSMUSG00000006270.6 | Vax1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Gsx2 | mm10_v2_chr5_+_75075464_75075601 | 0.55 | 3.8e-04 | Click! |
Vax1 | mm10_v2_chr19_-_59170978_59170978 | 0.35 | 3.1e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.2 | 8.8 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
1.5 | 10.2 | GO:0019532 | oxalate transport(GO:0019532) |
0.5 | 1.6 | GO:0072204 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
0.4 | 1.3 | GO:1904139 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
0.3 | 0.9 | GO:1904742 | regulation of telomeric DNA binding(GO:1904742) |
0.2 | 1.2 | GO:0052428 | modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428) |
0.2 | 0.6 | GO:0097212 | lysosomal membrane organization(GO:0097212) |
0.1 | 0.4 | GO:0006059 | hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401) |
0.1 | 0.3 | GO:0010700 | negative regulation of norepinephrine secretion(GO:0010700) |
0.1 | 0.5 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
0.1 | 0.6 | GO:0098706 | ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) |
0.1 | 0.4 | GO:0061743 | motor learning(GO:0061743) |
0.1 | 2.0 | GO:0002495 | antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) |
0.1 | 0.2 | GO:1903977 | positive regulation of Schwann cell migration(GO:1900149) positive regulation of glial cell migration(GO:1903977) |
0.1 | 1.1 | GO:0048240 | sperm capacitation(GO:0048240) |
0.1 | 0.7 | GO:0002098 | tRNA wobble uridine modification(GO:0002098) |
0.1 | 0.2 | GO:0061738 | abscission(GO:0009838) late endosomal microautophagy(GO:0061738) positive regulation of viral budding via host ESCRT complex(GO:1903774) |
0.1 | 0.8 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
0.1 | 0.5 | GO:0035372 | protein localization to microtubule(GO:0035372) |
0.0 | 0.2 | GO:0015822 | ornithine transport(GO:0015822) |
0.0 | 0.4 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
0.0 | 0.4 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
0.0 | 0.1 | GO:2000097 | arachidonic acid metabolite production involved in inflammatory response(GO:0002538) regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
0.0 | 0.6 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
0.0 | 0.1 | GO:0045575 | basophil activation involved in immune response(GO:0002276) basophil activation(GO:0045575) |
0.0 | 0.1 | GO:0051795 | positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364) |
0.0 | 0.1 | GO:0046947 | hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947) |
0.0 | 0.5 | GO:0001553 | luteinization(GO:0001553) |
0.0 | 0.3 | GO:0045602 | negative regulation of endothelial cell differentiation(GO:0045602) |
0.0 | 0.5 | GO:0031987 | locomotion involved in locomotory behavior(GO:0031987) |
0.0 | 0.3 | GO:0048199 | vesicle targeting, to, from or within Golgi(GO:0048199) |
0.0 | 0.5 | GO:1902259 | regulation of delayed rectifier potassium channel activity(GO:1902259) |
0.0 | 1.1 | GO:0034605 | cellular response to heat(GO:0034605) |
0.0 | 0.1 | GO:0050787 | glycolate metabolic process(GO:0009441) enzyme active site formation(GO:0018307) enzyme active site formation via L-cysteine sulfinic acid(GO:0018323) primary alcohol biosynthetic process(GO:0034309) cellular response to glyoxal(GO:0036471) glycolate biosynthetic process(GO:0046295) detoxification of mercury ion(GO:0050787) negative regulation of TRAIL-activated apoptotic signaling pathway(GO:1903122) regulation of pyrroline-5-carboxylate reductase activity(GO:1903167) positive regulation of pyrroline-5-carboxylate reductase activity(GO:1903168) regulation of tyrosine 3-monooxygenase activity(GO:1903176) positive regulation of tyrosine 3-monooxygenase activity(GO:1903178) L-dopa metabolic process(GO:1903184) L-dopa biosynthetic process(GO:1903185) glyoxal metabolic process(GO:1903189) regulation of L-dopa biosynthetic process(GO:1903195) positive regulation of L-dopa biosynthetic process(GO:1903197) regulation of L-dopa decarboxylase activity(GO:1903198) positive regulation of L-dopa decarboxylase activity(GO:1903200) positive regulation of cellular amino acid biosynthetic process(GO:2000284) |
0.0 | 0.1 | GO:0090310 | negative regulation of methylation-dependent chromatin silencing(GO:0090310) |
0.0 | 1.4 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
0.0 | 0.1 | GO:0021972 | corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260) |
0.0 | 0.1 | GO:0006421 | asparaginyl-tRNA aminoacylation(GO:0006421) |
0.0 | 0.1 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
0.0 | 0.1 | GO:0098707 | positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707) |
0.0 | 1.2 | GO:0003073 | regulation of systemic arterial blood pressure(GO:0003073) |
0.0 | 3.2 | GO:0031032 | actomyosin structure organization(GO:0031032) |
0.0 | 0.1 | GO:0030282 | bone mineralization(GO:0030282) |
0.0 | 0.2 | GO:0097186 | amelogenesis(GO:0097186) |
0.0 | 0.1 | GO:0051012 | microtubule sliding(GO:0051012) |
0.0 | 0.2 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
0.0 | 0.2 | GO:0042541 | hemoglobin biosynthetic process(GO:0042541) |
0.0 | 0.2 | GO:0031937 | positive regulation of chromatin silencing(GO:0031937) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 0.5 | GO:0097637 | intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637) |
0.1 | 0.4 | GO:0097454 | Schwann cell microvillus(GO:0097454) |
0.1 | 0.6 | GO:0097443 | sorting endosome(GO:0097443) |
0.1 | 2.6 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
0.1 | 1.1 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
0.1 | 0.3 | GO:0033093 | Weibel-Palade body(GO:0033093) |
0.1 | 19.5 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
0.1 | 0.8 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
0.0 | 0.9 | GO:0097431 | mitotic spindle pole(GO:0097431) |
0.0 | 0.4 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
0.0 | 0.8 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
0.0 | 0.2 | GO:0060091 | kinocilium(GO:0060091) |
0.0 | 0.1 | GO:0042583 | chromaffin granule(GO:0042583) |
0.0 | 0.3 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
0.0 | 1.1 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
0.0 | 0.2 | GO:0090543 | ESCRT III complex(GO:0000815) Flemming body(GO:0090543) |
0.0 | 0.1 | GO:0031673 | H zone(GO:0031673) |
0.0 | 1.1 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.5 | 8.8 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
0.9 | 10.2 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
0.3 | 0.8 | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity(GO:0008113) |
0.2 | 1.3 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
0.2 | 1.2 | GO:0046790 | virion binding(GO:0046790) |
0.1 | 1.6 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
0.1 | 0.6 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
0.1 | 0.7 | GO:0016300 | tRNA (uracil) methyltransferase activity(GO:0016300) |
0.1 | 0.4 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
0.1 | 0.5 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
0.1 | 0.4 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
0.1 | 0.5 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
0.1 | 0.5 | GO:0045134 | uridine-diphosphatase activity(GO:0045134) |
0.1 | 0.6 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
0.1 | 0.2 | GO:0000064 | L-ornithine transmembrane transporter activity(GO:0000064) |
0.1 | 0.2 | GO:0016748 | succinyltransferase activity(GO:0016748) |
0.1 | 0.4 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
0.1 | 0.9 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
0.0 | 0.9 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
0.0 | 1.0 | GO:0042287 | MHC protein binding(GO:0042287) |
0.0 | 0.3 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
0.0 | 1.2 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
0.0 | 0.3 | GO:0019865 | immunoglobulin binding(GO:0019865) |
0.0 | 0.2 | GO:0022821 | calcium, potassium:sodium antiporter activity(GO:0008273) potassium ion antiporter activity(GO:0022821) |
0.0 | 0.1 | GO:0008475 | procollagen-lysine 5-dioxygenase activity(GO:0008475) |
0.0 | 0.8 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
0.0 | 0.1 | GO:0036470 | tyrosine 3-monooxygenase activator activity(GO:0036470) L-dopa decarboxylase activator activity(GO:0036478) |
0.0 | 0.1 | GO:0015091 | ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510) |
0.0 | 0.1 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
0.0 | 1.1 | GO:0005516 | calmodulin binding(GO:0005516) |
0.0 | 0.1 | GO:0070579 | methylcytosine dioxygenase activity(GO:0070579) |
0.0 | 0.4 | GO:0003774 | motor activity(GO:0003774) |
0.0 | 0.3 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
0.0 | 3.4 | GO:0005096 | GTPase activator activity(GO:0005096) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 1.2 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
0.0 | 0.3 | PID_S1P_META_PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
0.0 | 1.0 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
0.0 | 0.6 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
0.0 | 0.5 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
0.0 | 0.4 | PID_IL2_PI3K_PATHWAY | IL2 signaling events mediated by PI3K |
0.0 | 0.8 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 19.7 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
0.1 | 1.2 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
0.1 | 0.6 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
0.0 | 0.6 | REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
0.0 | 0.3 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
0.0 | 0.4 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
0.0 | 0.9 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
0.0 | 0.8 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |