Motif ID: Gsx2_Hoxd3_Vax1

Z-value: 0.506

Transcription factors associated with Gsx2_Hoxd3_Vax1:

Gene SymbolEntrez IDGene Name
Gsx2 ENSMUSG00000035946.6 Gsx2
Hoxd3 ENSMUSG00000079277.3 Hoxd3
Vax1 ENSMUSG00000006270.6 Vax1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gsx2mm10_v2_chr5_+_75075464_750756010.553.8e-04Click!
Vax1mm10_v2_chr19_-_59170978_591709780.353.1e-02Click!


Activity profile for motif Gsx2_Hoxd3_Vax1.

activity profile for motif Gsx2_Hoxd3_Vax1


Sorted Z-values histogram for motif Gsx2_Hoxd3_Vax1

Sorted Z-values for motif Gsx2_Hoxd3_Vax1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gsx2_Hoxd3_Vax1

PNG image of the network

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Top targets:


Showing 1 to 20 of 146 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_14621805 4.870 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr15_-_8710734 4.593 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710409 4.218 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr4_-_14621669 2.708 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr4_-_14621494 2.664 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr8_+_66386292 2.046 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr5_+_66968559 1.817 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr5_+_66968416 1.620 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr2_+_109917639 1.611 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr9_-_90255927 1.425 ENSMUST00000144646.1
 Tbc1d2b
TBC1 domain family, member 2B
chr2_+_116067213 1.375 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr3_-_59220150 1.273 ENSMUST00000170388.1
 P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr3_+_66219909 1.217 ENSMUST00000029421.5
 Ptx3
pentraxin related gene
chr15_-_37459327 1.195 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chr18_+_12741324 1.124 ENSMUST00000115857.2
ENSMUST00000121018.1
ENSMUST00000119108.1
 Cabyr


calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)


chr2_-_164171113 0.905 ENSMUST00000045196.3
 Kcns1
K+ voltage-gated channel, subfamily S, 1
chr8_-_34965631 0.856 ENSMUST00000033929.4
 Tnks
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr14_-_64455903 0.849 ENSMUST00000067927.7
 Msra
methionine sulfoxide reductase A
chr6_+_145934113 0.829 ENSMUST00000032383.7
 Sspn
sarcospan
chr15_+_92597104 0.778 ENSMUST00000035399.8
 Pdzrn4
PDZ domain containing RING finger 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 10.2 GO:0019532 oxalate transport(GO:0019532)
2.2 8.8 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 3.2 GO:0031032 actomyosin structure organization(GO:0031032)
0.1 2.0 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.5 1.6 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.0 1.4 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.4 1.3 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.2 1.2 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.0 1.2 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.1 1.1 GO:0048240 sperm capacitation(GO:0048240)
0.0 1.1 GO:0034605 cellular response to heat(GO:0034605)
0.3 0.9 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.1 0.8 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.7 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.2 0.6 GO:0097212 lysosomal membrane organization(GO:0097212)
0.1 0.6 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.0 0.6 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 0.5 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 0.5 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.5 GO:0001553 luteinization(GO:0001553)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 19.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 2.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 1.1 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 1.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.9 GO:0097431 mitotic spindle pole(GO:0097431)
0.1 0.8 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.8 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.6 GO:0097443 sorting endosome(GO:0097443)
0.2 0.5 GO:0097637 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.1 0.4 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 0.4 GO:0000138 Golgi trans cisterna(GO:0000138)
0.1 0.3 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.3 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.2 GO:0060091 kinocilium(GO:0060091)
0.0 0.2 GO:0090543 ESCRT III complex(GO:0000815) Flemming body(GO:0090543)
0.0 0.1 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.1 GO:0031673 H zone(GO:0031673)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 10.2 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
1.5 8.8 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 3.4 GO:0005096 GTPase activator activity(GO:0005096)
0.1 1.6 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.2 1.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.2 1.2 GO:0046790 virion binding(GO:0046790)
0.0 1.2 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.1 GO:0005516 calmodulin binding(GO:0005516)
0.0 1.0 GO:0042287 MHC protein binding(GO:0042287)
0.1 0.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.9 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.3 0.8 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 0.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 0.7 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.1 0.6 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 0.6 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1 0.5 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 0.5 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 0.5 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.1 0.4 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.0 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.8 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 0.6 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.5 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.4 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 0.3 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 19.7 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.2 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 0.6 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.6 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.4 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.3 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway