Motif ID: Gtf2i_Gtf2f1

Z-value: 1.572

Transcription factors associated with Gtf2i_Gtf2f1:

Gene SymbolEntrez IDGene Name
Gtf2f1 ENSMUSG00000002658.9 Gtf2f1
Gtf2i ENSMUSG00000060261.9 Gtf2i

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gtf2imm10_v2_chr5_-_134314678_134314760-0.271.1e-01Click!
Gtf2f1mm10_v2_chr17_-_57011271_570113260.153.9e-01Click!


Activity profile for motif Gtf2i_Gtf2f1.

activity profile for motif Gtf2i_Gtf2f1


Sorted Z-values histogram for motif Gtf2i_Gtf2f1

Sorted Z-values for motif Gtf2i_Gtf2f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gtf2i_Gtf2f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66948419 23.032 ENSMUST00000167817.1
 Ndrg1
N-myc downstream regulated gene 1
chr5_-_44799643 11.743 ENSMUST00000070748.5
 Ldb2
LIM domain binding 2
chr1_-_56971762 10.667 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chr7_-_78578308 10.006 ENSMUST00000039431.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr13_+_91461050 9.749 ENSMUST00000004094.8
ENSMUST00000042122.8
 Ssbp2

single-stranded DNA binding protein 2

chr7_+_44310213 8.997 ENSMUST00000107938.1
 Shank1
SH3/ankyrin domain gene 1
chr19_+_8664005 6.894 ENSMUST00000035444.3
ENSMUST00000163785.1
 Chrm1

cholinergic receptor, muscarinic 1, CNS

chr7_-_78577771 6.495 ENSMUST00000039438.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr7_+_36698002 6.467 ENSMUST00000021641.6
 Tshz3
teashirt zinc finger family member 3
chrX_-_104201126 6.239 ENSMUST00000056502.6
ENSMUST00000118314.1
 C77370

expressed sequence C77370

chr12_+_105336922 6.216 ENSMUST00000180503.1
 2810011L19Rik
RIKEN cDNA 2810011L19 gene
chr17_+_26941420 5.646 ENSMUST00000081285.3
ENSMUST00000177932.1
 Syngap1

synaptic Ras GTPase activating protein 1 homolog (rat)

chr10_+_13966268 5.450 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr11_+_75193783 5.363 ENSMUST00000102514.3
 Rtn4rl1
reticulon 4 receptor-like 1
chr4_-_123527648 5.284 ENSMUST00000147228.1
 Macf1
microtubule-actin crosslinking factor 1
chr13_+_42709482 5.274 ENSMUST00000066928.5
ENSMUST00000148891.1
 Phactr1

phosphatase and actin regulator 1

chr5_+_32136458 5.254 ENSMUST00000031017.9
 Fosl2
fos-like antigen 2
chr15_+_83791939 5.243 ENSMUST00000172115.1
ENSMUST00000172398.1
 Mpped1

metallophosphoesterase domain containing 1

chr4_+_13751297 5.219 ENSMUST00000105566.2
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr1_-_56969827 5.125 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 661 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 24.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
2.1 23.0 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
5.5 16.5 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
1.4 14.5 GO:0046959 habituation(GO:0046959)
2.4 14.2 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.2 12.2 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.7 11.3 GO:0048681 negative regulation of axon regeneration(GO:0048681)
2.6 10.4 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
1.7 10.4 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.8 10.1 GO:2000821 regulation of grooming behavior(GO:2000821)
0.1 9.5 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.3 9.4 GO:0035162 embryonic hemopoiesis(GO:0035162)
3.0 9.0 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.5 8.2 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481)
1.9 7.7 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
1.5 7.7 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.2 7.6 GO:0001919 regulation of receptor recycling(GO:0001919)
0.5 7.2 GO:0071625 vocalization behavior(GO:0071625)
1.4 6.9 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.8 6.9 GO:0071420 cellular response to histamine(GO:0071420)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 258 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 42.4 GO:0045211 postsynaptic membrane(GO:0045211)
0.7 24.8 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 18.3 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
1.1 17.9 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 15.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 15.2 GO:0005905 clathrin-coated pit(GO:0005905)
0.8 13.8 GO:0032279 asymmetric synapse(GO:0032279)
0.4 13.0 GO:0030673 axolemma(GO:0030673)
0.8 11.8 GO:1902711 GABA-A receptor complex(GO:1902711)
0.2 10.7 GO:0042734 presynaptic membrane(GO:0042734)
0.1 10.7 GO:0000139 Golgi membrane(GO:0000139)
0.6 10.6 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
1.7 10.4 GO:0016035 zeta DNA polymerase complex(GO:0016035)
2.1 10.3 GO:0030314 junctional membrane complex(GO:0030314)
0.7 9.3 GO:0030057 desmosome(GO:0030057)
0.2 8.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.8 7.5 GO:0032591 dendritic spine membrane(GO:0032591)
0.4 6.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.5 6.6 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
1.3 6.5 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 391 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 24.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 16.6 GO:0017124 SH3 domain binding(GO:0017124)
3.3 16.5 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.4 14.9 GO:0070412 R-SMAD binding(GO:0070412)
0.3 13.0 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 12.9 GO:0008017 microtubule binding(GO:0008017)
0.0 11.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
3.4 10.1 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
2.4 9.7 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.3 9.5 GO:0046965 retinoid X receptor binding(GO:0046965)
1.1 9.1 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
1.0 9.0 GO:0008046 axon guidance receptor activity(GO:0008046)
0.9 8.1 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 8.1 GO:0035254 glutamate receptor binding(GO:0035254)
0.9 7.0 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 7.0 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
1.4 6.9 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.6 6.8 GO:0004890 GABA-A receptor activity(GO:0004890)
0.4 6.7 GO:0004383 guanylate cyclase activity(GO:0004383)
2.2 6.5 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 21.0 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.3 15.9 PID_SHP2_PATHWAY SHP2 signaling
0.3 15.2 PID_REELIN_PATHWAY Reelin signaling pathway
0.4 13.9 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.3 11.7 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.2 11.0 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.4 10.5 ST_GA12_PATHWAY G alpha 12 Pathway
0.2 8.0 PID_RAS_PATHWAY Regulation of Ras family activation
0.2 7.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.4 6.9 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.2 6.4 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 6.4 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.3 6.0 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.2 5.9 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.2 5.5 PID_FGF_PATHWAY FGF signaling pathway
0.2 4.7 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 4.4 PID_LKB1_PATHWAY LKB1 signaling events
0.2 4.2 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.3 3.6 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.2 3.5 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 128 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 15.3 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.9 14.5 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 9.5 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.6 7.2 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 6.8 REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.7 6.6 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.7 6.6 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.2 6.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 6.2 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.3 5.9 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 5.6 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.4 5.3 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.3 4.8 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 4.8 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 4.6 REACTOME_CIRCADIAN_CLOCK Genes involved in Circadian Clock
0.2 4.1 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.3 4.0 REACTOME_ACTIVATED_POINT_MUTANTS_OF_FGFR2 Genes involved in Activated point mutants of FGFR2
0.3 3.7 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 3.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 3.5 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins