Motif ID: Hand1

Z-value: 1.360


Transcription factors associated with Hand1:

Gene SymbolEntrez IDGene Name
Hand1 ENSMUSG00000037335.7 Hand1



Activity profile for motif Hand1.

activity profile for motif Hand1


Sorted Z-values histogram for motif Hand1

Sorted Z-values for motif Hand1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hand1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_138396438 8.603 ENSMUST00000105032.2
 Fam43b
family with sequence similarity 43, member B
chr19_-_59076069 7.367 ENSMUST00000047511.7
ENSMUST00000163821.1
 4930506M07Rik

RIKEN cDNA 4930506M07 gene

chr11_+_101246960 7.027 ENSMUST00000107282.3
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr13_-_92131494 6.687 ENSMUST00000099326.3
ENSMUST00000146492.1
 Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2

chr13_-_37049203 6.624 ENSMUST00000037491.8
 F13a1
coagulation factor XIII, A1 subunit
chr1_+_75507077 6.487 ENSMUST00000037330.4
 Inha
inhibin alpha
chr15_+_92051153 5.747 ENSMUST00000169825.1
 Cntn1
contactin 1
chr9_+_53771499 5.672 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr17_-_47692466 5.573 ENSMUST00000113300.1
 Prickle4
prickle homolog 4 (Drosophila)
chr8_-_11312731 5.418 ENSMUST00000033898.9
 Col4a1
collagen, type IV, alpha 1
chr11_-_81968415 5.402 ENSMUST00000066197.6
 Asic2
acid-sensing (proton-gated) ion channel 2
chr10_+_97479470 5.390 ENSMUST00000105287.3
 Dcn
decorin
chr8_+_11312805 5.270 ENSMUST00000033899.7
 Col4a2
collagen, type IV, alpha 2
chr2_+_155940728 5.230 ENSMUST00000109629.1
 Gm15557
predicted gene 15557
chr2_+_85136355 4.815 ENSMUST00000057019.7
 Aplnr
apelin receptor
chr2_+_149830840 4.733 ENSMUST00000109934.1
ENSMUST00000140870.1
 Syndig1

synapse differentiation inducing 1

chr3_+_86084434 4.713 ENSMUST00000107664.2
 Sh3d19
SH3 domain protein D19
chr9_-_20879718 4.664 ENSMUST00000043726.6
 Angptl6
angiopoietin-like 6
chr4_-_42034726 4.538 ENSMUST00000084677.2
 Gm21093
predicted gene, 21093
chr4_+_130913264 4.491 ENSMUST00000156225.1
ENSMUST00000156742.1
 Laptm5

lysosomal-associated protein transmembrane 5


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 158 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 15.0 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.1 12.3 GO:0007416 synapse assembly(GO:0007416)
0.1 8.7 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.1 8.6 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
1.7 8.5 GO:1905169 protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171)
1.7 8.3 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.3 7.6 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0 7.4 GO:0031032 actomyosin structure organization(GO:0031032)
1.2 7.0 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
2.2 6.6 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
1.1 6.5 GO:0046880 regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884)
1.6 6.2 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.9 6.0 GO:2001023 regulation of response to drug(GO:2001023)
0.4 5.7 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.1 5.5 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
1.8 5.4 GO:0050915 sensory perception of sour taste(GO:0050915)
0.8 5.4 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.8 5.4 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1 5.4 GO:0021680 cerebellar Purkinje cell layer development(GO:0021680)
0.1 4.9 GO:0045838 positive regulation of membrane potential(GO:0045838)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.0 GO:0031985 Golgi cisterna(GO:0031985)
0.2 10.8 GO:0031901 early endosome membrane(GO:0031901)
2.0 9.9 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.1 9.2 GO:0072562 blood microparticle(GO:0072562)
2.8 8.4 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
1.4 7.0 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.4 6.7 GO:1990635 proximal dendrite(GO:1990635)
2.2 6.5 GO:0043512 inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512)
0.0 6.1 GO:0043197 dendritic spine(GO:0043197)
0.0 6.0 GO:0043209 myelin sheath(GO:0043209)
0.1 5.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.4 5.4 GO:0098644 complex of collagen trimers(GO:0098644)
0.4 5.3 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 5.2 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.8 4.8 GO:0044308 axonal spine(GO:0044308)
0.3 4.1 GO:0043203 axon hillock(GO:0043203)
0.0 4.1 GO:0031594 neuromuscular junction(GO:0031594)
0.8 4.0 GO:0033093 Weibel-Palade body(GO:0033093)
0.4 4.0 GO:0032426 stereocilium tip(GO:0032426)
0.0 4.0 GO:0036126 sperm flagellum(GO:0036126)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 16.9 GO:0035254 glutamate receptor binding(GO:0035254)
0.3 8.6 GO:0043014 alpha-tubulin binding(GO:0043014)
0.4 8.5 GO:0017160 Ral GTPase binding(GO:0017160)
2.1 8.4 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)
0.0 7.3 GO:0003779 actin binding(GO:0003779)
0.1 7.1 GO:0005518 collagen binding(GO:0005518)
1.4 7.0 GO:0097643 amylin receptor activity(GO:0097643)
1.7 6.6 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.7 6.5 GO:0034711 inhibin binding(GO:0034711)
1.3 6.4 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
1.6 6.2 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 6.0 GO:0030246 carbohydrate binding(GO:0030246)
0.2 5.8 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
0.4 5.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.8 4.9 GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.3 4.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 4.7 GO:0070064 proline-rich region binding(GO:0070064)
0.2 4.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
1.1 4.3 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.9 4.3 GO:0003945 N-acetyllactosamine synthase activity(GO:0003945)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.9 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.3 9.9 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 9.9 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.3 7.0 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.3 6.7 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 5.0 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 4.8 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.1 4.5 PID_ARF6_PATHWAY Arf6 signaling events
0.1 3.8 PID_IL23_PATHWAY IL23-mediated signaling events
0.1 3.8 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 3.5 PID_NOTCH_PATHWAY Notch signaling pathway
0.3 3.2 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 2.8 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 2.7 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.3 2.6 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 2.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.4 PID_ATR_PATHWAY ATR signaling pathway
0.1 2.1 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.1 1.9 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 1.8 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.4 7.1 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 7.0 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.4 6.8 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
1.1 6.6 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
1.6 6.5 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.3 6.4 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.2 6.3 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 6.2 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.4 5.4 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 5.4 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.7 4.9 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 4.7 REACTOME_SIGNALING_BY_PDGF Genes involved in Signaling by PDGF
0.2 4.3 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
1.4 4.1 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.4 4.0 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.2 4.0 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 3.9 REACTOME_TOLL_RECEPTOR_CASCADES Genes involved in Toll Receptor Cascades
0.2 3.8 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.1 3.8 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions