Motif ID: Hcfc1_Six5_Smarcc2_Zfp143

Z-value: 2.471

Transcription factors associated with Hcfc1_Six5_Smarcc2_Zfp143:

Gene SymbolEntrez IDGene Name
Hcfc1 ENSMUSG00000031386.8 Hcfc1
Six5 ENSMUSG00000040841.5 Six5
Smarcc2 ENSMUSG00000025369.8 Smarcc2
Zfp143 ENSMUSG00000061079.7 Zfp143

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfp143mm10_v2_chr7_+_110061702_1100617320.756.8e-08Click!
Hcfc1mm10_v2_chrX_-_73966329_739663760.463.9e-03Click!
Six5mm10_v2_chr7_+_19094594_190946330.353.3e-02Click!
Smarcc2mm10_v2_chr10_+_128459236_1284592480.325.3e-02Click!


Activity profile for motif Hcfc1_Six5_Smarcc2_Zfp143.

activity profile for motif Hcfc1_Six5_Smarcc2_Zfp143


Sorted Z-values histogram for motif Hcfc1_Six5_Smarcc2_Zfp143

Sorted Z-values for motif Hcfc1_Six5_Smarcc2_Zfp143



Network of associatons between targets according to the STRING database.



First level regulatory network of Hcfc1_Six5_Smarcc2_Zfp143

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_116708571 15.070 ENSMUST00000106462.2
ENSMUST00000138305.1
ENSMUST00000125671.1
ENSMUST00000130828.1
 Ccdc163



coiled-coil domain containing 163



chr4_+_116708624 13.775 ENSMUST00000106463.1
 Ccdc163
coiled-coil domain containing 163
chr4_+_116708687 12.163 ENSMUST00000135499.1
 Ccdc163
coiled-coil domain containing 163
chr4_+_116708467 9.831 ENSMUST00000030452.6
 Ccdc163
coiled-coil domain containing 163
chr11_-_101551837 7.478 ENSMUST00000017290.4
 Brca1
breast cancer 1
chr6_+_124829540 7.463 ENSMUST00000150120.1
 Cdca3
cell division cycle associated 3
chr2_+_118598209 7.232 ENSMUST00000038341.7
 Bub1b
budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)
chr2_-_69206146 6.890 ENSMUST00000127243.1
ENSMUST00000149643.1
ENSMUST00000167875.2
ENSMUST00000005365.8
 Spc25



SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)



chr5_+_33658123 6.859 ENSMUST00000074849.6
ENSMUST00000079534.4
 Tacc3

transforming, acidic coiled-coil containing protein 3

chr7_-_44997221 6.803 ENSMUST00000152341.1
 Bcl2l12
BCL2-like 12 (proline rich)
chr2_+_152847961 6.765 ENSMUST00000164120.1
ENSMUST00000178997.1
ENSMUST00000109816.1
 Tpx2


TPX2, microtubule-associated protein homolog (Xenopus laevis)


chr2_+_152847993 6.304 ENSMUST00000028969.8
 Tpx2
TPX2, microtubule-associated protein homolog (Xenopus laevis)
chr14_-_64949632 6.226 ENSMUST00000176832.1
 Hmbox1
homeobox containing 1
chr14_-_64949838 6.137 ENSMUST00000067843.3
ENSMUST00000176489.1
ENSMUST00000175905.1
ENSMUST00000022544.7
ENSMUST00000175744.1
ENSMUST00000176128.1
 Hmbox1





homeobox containing 1





chr2_-_69206133 6.027 ENSMUST00000112320.1
 Spc25
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr11_+_117849223 5.984 ENSMUST00000081387.4
 Birc5
baculoviral IAP repeat-containing 5
chr7_-_44997535 5.883 ENSMUST00000124232.1
ENSMUST00000003290.4
 Bcl2l12

BCL2-like 12 (proline rich)

chrX_+_139684980 5.587 ENSMUST00000096313.3
 Tbc1d8b
TBC1 domain family, member 8B
chr9_+_83548309 5.223 ENSMUST00000113215.3
 Sh3bgrl2
SH3 domain binding glutamic acid-rich protein like 2
chr6_+_124829582 4.740 ENSMUST00000024270.7
 Cdca3
cell division cycle associated 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 332 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 31.2 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
2.0 22.1 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.8 12.4 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.2 11.2 GO:0007052 mitotic spindle organization(GO:0007052)
0.0 9.2 GO:0000375 RNA splicing, via transesterification reactions(GO:0000375)
0.1 8.0 GO:0030500 regulation of bone mineralization(GO:0030500)
1.6 7.9 GO:0014886 transition between slow and fast fiber(GO:0014886)
2.5 7.5 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
2.4 7.2 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
1.3 6.5 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
1.5 6.1 GO:0044565 dendritic cell proliferation(GO:0044565)
0.6 5.8 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.8 5.6 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
1.0 5.2 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
0.7 5.2 GO:0042148 strand invasion(GO:0042148)
1.3 5.1 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.6 5.0 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.2 5.0 GO:0006270 DNA replication initiation(GO:0006270)
0.3 4.7 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.3 4.7 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 139 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 20.2 GO:0005813 centrosome(GO:0005813)
1.6 13.1 GO:0005818 aster(GO:0005818)
2.2 12.9 GO:0031262 Ndc80 complex(GO:0031262)
0.1 12.7 GO:0005913 cell-cell adherens junction(GO:0005913)
0.5 12.5 GO:0005697 telomerase holoenzyme complex(GO:0005697)
2.5 12.4 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 9.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.7 9.2 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
1.2 7.5 GO:0070531 BRCA1-A complex(GO:0070531)
0.1 6.7 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.2 6.0 GO:0035869 ciliary transition zone(GO:0035869)
0.2 5.7 GO:0035371 microtubule plus-end(GO:0035371)
0.1 5.7 GO:0030175 filopodium(GO:0030175)
0.4 5.1 GO:0035748 myelin sheath abaxonal region(GO:0035748)
1.2 4.8 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.6 4.4 GO:0001940 male pronucleus(GO:0001940)
0.1 4.4 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 4.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.4 3.8 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.3 3.7 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 222 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 14.6 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
1.4 12.5 GO:0061676 importin-alpha family protein binding(GO:0061676)
1.2 11.7 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.2 9.6 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 8.9 GO:0002039 p53 binding(GO:0002039)
0.1 8.6 GO:0003684 damaged DNA binding(GO:0003684)
0.1 8.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
1.1 6.8 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 6.7 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 6.4 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.8 5.8 GO:0048256 flap endonuclease activity(GO:0048256)
1.0 5.1 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.8 5.0 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.3 4.8 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.3 4.6 GO:1990226 histone methyltransferase binding(GO:1990226)
0.6 4.4 GO:0000150 recombinase activity(GO:0000150)
0.3 4.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 4.4 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2 3.9 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 3.9 GO:0003735 structural constituent of ribosome(GO:0003735)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 42.3 PID_AURORA_A_PATHWAY Aurora A signaling
0.3 12.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 11.8 PID_PLK1_PATHWAY PLK1 signaling events
0.2 5.8 PID_ATR_PATHWAY ATR signaling pathway
0.1 5.3 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 4.7 PID_MYC_PATHWAY C-MYC pathway
0.0 3.1 PID_CDC42_PATHWAY CDC42 signaling events
0.0 3.0 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 2.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.3 2.3 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.8 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.6 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.6 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 1.5 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 1.5 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.5 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.4 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.3 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.3 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 35.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.7 12.2 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.4 8.9 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.2 6.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.2 6.0 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.1 6.0 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.3 4.9 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 4.7 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.3 4.5 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.5 3.8 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.4 3.0 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.2 3.0 REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 3.0 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.8 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.2 2.4 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 2.4 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.1 2.3 REACTOME_G1_PHASE Genes involved in G1 Phase
0.3 2.2 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 2.1 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.2 1.9 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway