Motif ID: Hes1

Z-value: 1.446


Transcription factors associated with Hes1:

Gene SymbolEntrez IDGene Name
Hes1 ENSMUSG00000022528.7 Hes1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hes1mm10_v2_chr16_+_30065333_30065351-0.307.0e-02Click!


Activity profile for motif Hes1.

activity profile for motif Hes1


Sorted Z-values histogram for motif Hes1

Sorted Z-values for motif Hes1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hes1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_12026237 31.904 ENSMUST00000150972.1
 Grb10
growth factor receptor bound protein 10
chr11_-_12026732 29.938 ENSMUST00000143915.1
 Grb10
growth factor receptor bound protein 10
chr9_+_118478182 9.777 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478344 9.420 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr3_+_127633134 8.827 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr10_-_127534540 8.472 ENSMUST00000095266.2
 Nxph4
neurexophilin 4
chr1_+_153652943 7.718 ENSMUST00000041776.5
 Rgs8
regulator of G-protein signaling 8
chr6_+_120666388 7.160 ENSMUST00000112686.1
 Cecr2
cat eye syndrome chromosome region, candidate 2
chr4_+_116877376 6.285 ENSMUST00000044823.3
 Zswim5
zinc finger SWIM-type containing 5
chr1_-_189688074 5.977 ENSMUST00000171929.1
ENSMUST00000165962.1
 Cenpf

centromere protein F

chr11_+_113619318 5.808 ENSMUST00000146390.2
ENSMUST00000106630.1
 Sstr2

somatostatin receptor 2

chr17_-_25797032 5.301 ENSMUST00000165838.1
ENSMUST00000002344.6
 Metrn

meteorin, glial cell differentiation regulator

chr18_+_82910863 4.867 ENSMUST00000171238.1
 Zfp516
zinc finger protein 516
chr4_+_65124174 4.843 ENSMUST00000084501.3
 Pappa
pregnancy-associated plasma protein A
chr11_-_102925086 4.817 ENSMUST00000021311.9
 Kif18b
kinesin family member 18B
chr8_+_71406003 4.788 ENSMUST00000119976.1
ENSMUST00000120725.1
 Ankle1

ankyrin repeat and LEM domain containing 1

chr9_-_75409951 4.763 ENSMUST00000049355.10
 Mapk6
mitogen-activated protein kinase 6
chr6_-_90716489 4.578 ENSMUST00000101153.3
 Iqsec1
IQ motif and Sec7 domain 1
chr5_+_93093428 4.563 ENSMUST00000074733.7
 Sept11
septin 11
chr1_+_132316112 4.419 ENSMUST00000082125.5
ENSMUST00000072177.7
 Nuak2

NUAK family, SNF1-like kinase, 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 138 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.9 61.8 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
6.4 19.2 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.9 8.3 GO:0001842 neural fold formation(GO:0001842)
2.0 8.1 GO:0003360 brainstem development(GO:0003360)
0.6 7.7 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.1 6.0 GO:0021591 ventricular system development(GO:0021591)
0.5 5.8 GO:0030432 peristalsis(GO:0030432)
1.4 5.7 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.1 5.0 GO:0007019 microtubule depolymerization(GO:0007019)
0.1 4.9 GO:0009409 response to cold(GO:0009409)
0.1 4.8 GO:0051384 response to glucocorticoid(GO:0051384)
0.0 4.7 GO:0050772 positive regulation of axonogenesis(GO:0050772)
0.2 4.6 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
1.5 4.4 GO:0018298 protein-chromophore linkage(GO:0018298)
1.1 4.2 GO:0060032 notochord regression(GO:0060032)
1.0 3.9 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.0 3.9 GO:0021954 central nervous system neuron development(GO:0021954)
0.0 3.9 GO:0006334 nucleosome assembly(GO:0006334)
0.9 3.8 GO:0044565 dendritic cell proliferation(GO:0044565)
1.2 3.7 GO:1990859 cellular response to endothelin(GO:1990859)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 8.1 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.2 7.7 GO:0032809 neuronal cell body membrane(GO:0032809)
1.8 7.2 GO:0090537 CERF complex(GO:0090537)
0.1 6.1 GO:0000786 nucleosome(GO:0000786)
0.5 6.0 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 5.3 GO:0030139 endocytic vesicle(GO:0030139)
0.0 5.1 GO:0001726 ruffle(GO:0001726)
0.8 4.8 GO:0000235 astral microtubule(GO:0000235)
0.3 4.8 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.3 4.8 GO:0032156 septin cytoskeleton(GO:0032156)
0.0 4.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 4.4 GO:0001750 photoreceptor outer segment(GO:0001750)
0.3 4.2 GO:0097542 ciliary tip(GO:0097542)
0.0 4.1 GO:0005768 endosome(GO:0005768)
0.2 3.2 GO:0035102 PRC1 complex(GO:0035102)
0.2 3.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 2.7 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.4 2.3 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.3 2.2 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 2.2 GO:0005643 nuclear pore(GO:0005643)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 62.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.3 20.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.3 11.1 GO:0070888 E-box binding(GO:0070888)
1.4 8.1 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.2 7.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 6.6 GO:0003777 microtubule motor activity(GO:0003777)
0.2 6.0 GO:0070840 dynein complex binding(GO:0070840)
1.9 5.8 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 5.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.8 5.7 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 5.7 GO:0042393 histone binding(GO:0042393)
0.1 5.3 GO:0031490 chromatin DNA binding(GO:0031490)
0.2 4.9 GO:0004707 MAP kinase activity(GO:0004707)
0.1 4.7 GO:0033613 activating transcription factor binding(GO:0033613)
0.2 4.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
1.5 4.4 GO:0009881 photoreceptor activity(GO:0009881)
0.2 3.9 GO:0003680 AT DNA binding(GO:0003680)
0.1 3.8 GO:0005158 insulin receptor binding(GO:0005158)
0.0 3.7 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.1 3.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 68.1 PID_IGF1_PATHWAY IGF1 pathway
0.3 19.2 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 5.3 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.2 4.3 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 3.9 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.2 3.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 3.8 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 3.4 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 3.3 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 3.2 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 2.9 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 2.9 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.9 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 2.3 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 2.3 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 1.8 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 1.7 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 1.6 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.6 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 61.8 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 19.8 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.4 7.1 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.4 4.7 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.3 4.1 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.2 3.9 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 3.8 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.1 3.4 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 3.4 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.3 3.2 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.2 3.0 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 3.0 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 2.8 REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.1 2.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 2.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.3 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 2.2 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 2.0 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.2 1.9 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.2 1.9 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha