Motif ID: Hes5_Hes7

Z-value: 1.375

Transcription factors associated with Hes5_Hes7:

Gene SymbolEntrez IDGene Name
Hes5 ENSMUSG00000048001.7 Hes5
Hes7 ENSMUSG00000023781.2 Hes7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hes7mm10_v2_chr11_+_69120404_69120404-0.382.1e-02Click!
Hes5mm10_v2_chr4_+_154960915_1549609300.019.3e-01Click!


Activity profile for motif Hes5_Hes7.

activity profile for motif Hes5_Hes7


Sorted Z-values histogram for motif Hes5_Hes7

Sorted Z-values for motif Hes5_Hes7



Network of associatons between targets according to the STRING database.



First level regulatory network of Hes5_Hes7

PNG image of the network

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Top targets:


Showing 1 to 20 of 97 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_12026732 48.302 ENSMUST00000143915.1
 Grb10
growth factor receptor bound protein 10
chr11_-_12026237 48.246 ENSMUST00000150972.1
 Grb10
growth factor receptor bound protein 10
chr13_+_51846673 13.518 ENSMUST00000021903.2
 Gadd45g
growth arrest and DNA-damage-inducible 45 gamma
chr13_+_108316332 6.328 ENSMUST00000051594.5
 Depdc1b
DEP domain containing 1B
chr13_+_108316395 5.832 ENSMUST00000171178.1
 Depdc1b
DEP domain containing 1B
chr8_-_87804411 5.386 ENSMUST00000165770.2
 Zfp423
zinc finger protein 423
chr15_+_72913357 4.933 ENSMUST00000166418.2
 Gm3150
predicted gene 3150
chr12_+_109459843 4.776 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr15_+_32244801 4.374 ENSMUST00000067458.6
 Sema5a
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr9_-_36726374 3.994 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
 Chek1


checkpoint kinase 1


chr1_+_72824482 3.632 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr6_+_4755327 3.614 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr15_-_32244632 3.096 ENSMUST00000181536.1
 0610007N19Rik
RIKEN cDNA 0610007N19
chr14_+_31019125 3.047 ENSMUST00000112095.1
ENSMUST00000112098.3
ENSMUST00000112106.1
ENSMUST00000146325.1
 Pbrm1



polybromo 1



chr1_-_75219245 3.026 ENSMUST00000079464.6
 Tuba4a
tubulin, alpha 4A
chr15_+_39076885 2.583 ENSMUST00000067072.3
 Cthrc1
collagen triple helix repeat containing 1
chr14_+_59201209 2.574 ENSMUST00000173547.1
ENSMUST00000043227.6
ENSMUST00000022551.7
 Rcbtb1


regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1


chr18_-_46280820 2.566 ENSMUST00000025354.3
 Pggt1b
protein geranylgeranyltransferase type I, beta subunit
chr10_+_79682169 2.530 ENSMUST00000020550.5
 Cdc34
cell division cycle 34
chr8_+_119446719 2.268 ENSMUST00000098363.3
 Necab2
N-terminal EF-hand calcium binding protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
10.7 96.5 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
1.4 13.5 GO:0042095 interferon-gamma biosynthetic process(GO:0042095)
0.1 11.6 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
2.1 6.4 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.1 5.4 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.7 5.1 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.2 4.8 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.8 4.5 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.5 4.4 GO:0090091 positive regulation of axon extension involved in axon guidance(GO:0048842) positive regulation of extracellular matrix disassembly(GO:0090091)
0.4 4.0 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.1 3.8 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.2 3.6 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.9 2.6 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.2 2.6 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.8 2.3 GO:0060167 regulation of adenosine receptor signaling pathway(GO:0060167) regulation of G-protein coupled receptor internalization(GO:1904020)
0.0 2.0 GO:0045214 sarcomere organization(GO:0045214)
0.4 1.5 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.4 1.5 GO:0015744 succinate transport(GO:0015744)
0.0 1.5 GO:0007129 synapsis(GO:0007129)
0.1 1.4 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 74.9 GO:0005829 cytosol(GO:0005829)
0.2 8.3 GO:0090544 BAF-type complex(GO:0090544)
0.0 4.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 4.0 GO:0005657 replication fork(GO:0005657)
0.0 3.9 GO:0005874 microtubule(GO:0005874)
0.4 3.1 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 2.6 GO:0005581 collagen trimer(GO:0005581)
0.0 2.2 GO:0005903 brush border(GO:0005903)
0.0 2.0 GO:0043034 costamere(GO:0043034)
0.5 1.5 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.5 1.5 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.2 1.4 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 1.2 GO:0005923 bicellular tight junction(GO:0005923)
0.1 1.1 GO:0005652 nuclear lamina(GO:0005652)
0.0 1.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.9 GO:0097225 sperm midpiece(GO:0097225)
0.1 0.8 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 0.8 GO:0005869 dynactin complex(GO:0005869)
0.0 0.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 96.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 8.9 GO:0005096 GTPase activator activity(GO:0005096)
0.1 5.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 4.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
1.5 4.4 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
1.3 4.0 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.5 3.6 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 3.6 GO:0017147 Wnt-protein binding(GO:0017147)
0.8 3.1 GO:0035851 histone deacetylase activity (H4-K16 specific)(GO:0034739) Krueppel-associated box domain binding(GO:0035851)
0.5 2.6 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.6 2.3 GO:0031687 A2A adenosine receptor binding(GO:0031687)
0.6 2.2 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 1.9 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 1.7 GO:0031996 thioesterase binding(GO:0031996)
0.0 1.7 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.5 1.5 GO:0015140 malate transmembrane transporter activity(GO:0015140)
0.4 1.5 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 1.5 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 1.4 GO:0071253 connexin binding(GO:0071253)
0.0 1.4 GO:0004402 histone acetyltransferase activity(GO:0004402)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 96.5 PID_IGF1_PATHWAY IGF1 pathway
0.4 13.5 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 5.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 4.6 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.4 4.0 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 3.8 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 3.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 3.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.0 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 1.5 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.1 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.8 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.7 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.7 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 0.4 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.6 96.5 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 12.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 4.8 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 4.5 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 4.4 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 4.1 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.4 4.0 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 3.6 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 3.0 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.5 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 1.5 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 1.5 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 1.4 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 1.4 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.7 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 0.6 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.4 REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.2 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism