---

Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr11_-_12026732	48.302	ENSMUST00000143915.1	Grb10	growth factor receptor bound protein 10
chr11_-_12026237	48.246	ENSMUST00000150972.1	Grb10	growth factor receptor bound protein 10
chr13_+_51846673	13.518	ENSMUST00000021903.2	Gadd45g	growth arrest and DNA-damage-inducible 45 gamma
chr13_+_108316332	6.328	ENSMUST00000051594.5	Depdc1b	DEP domain containing 1B
chr13_+_108316395	5.832	ENSMUST00000171178.1	Depdc1b	DEP domain containing 1B
chr8_-_87804411	5.386	ENSMUST00000165770.2	Zfp423	zinc finger protein 423
chr15_+_72913357	4.933	ENSMUST00000166418.2	Gm3150	predicted gene 3150
chr12_+_109459843	4.776	ENSMUST00000173812.1	Dlk1	delta-like 1 homolog (Drosophila)
chr15_+_32244801	4.374	ENSMUST00000067458.6	Sema5a	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr9_-_36726374	3.994	ENSMUST00000172702.2 ENSMUST00000172742.1 ENSMUST00000034625.5	Chek1	checkpoint kinase 1
chr1_+_72824482	3.632	ENSMUST00000047328.4	Igfbp2	insulin-like growth factor binding protein 2
chr6_+_4755327	3.614	ENSMUST00000176551.1	Peg10	paternally expressed 10
chr15_-_32244632	3.096	ENSMUST00000181536.1	0610007N19Rik	RIKEN cDNA 0610007N19
chr14_+_31019125	3.047	ENSMUST00000112095.1 ENSMUST00000112098.3 ENSMUST00000112106.1 ENSMUST00000146325.1	Pbrm1	polybromo 1
chr1_-_75219245	3.026	ENSMUST00000079464.6	Tuba4a	tubulin, alpha 4A
chr15_+_39076885	2.583	ENSMUST00000067072.3	Cthrc1	collagen triple helix repeat containing 1
chr14_+_59201209	2.574	ENSMUST00000173547.1 ENSMUST00000043227.6 ENSMUST00000022551.7	Rcbtb1	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr18_-_46280820	2.566	ENSMUST00000025354.3	Pggt1b	protein geranylgeranyltransferase type I, beta subunit
chr10_+_79682169	2.530	ENSMUST00000020550.5	Cdc34	cell division cycle 34
chr8_+_119446719	2.268	ENSMUST00000098363.3	Necab2	N-terminal EF-hand calcium binding protein 2
chr10_+_36974536	2.225	ENSMUST00000019911.7	Hdac2	histone deacetylase 2
chr9_+_64121501	2.220	ENSMUST00000118215.1	Lctl	lactase-like
chr10_+_79682304	2.009	ENSMUST00000166603.1	Cdc34	cell division cycle 34
chr14_+_59201418	2.005	ENSMUST00000140136.2 ENSMUST00000142326.1	Rcbtb1	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr4_-_133756769	1.941	ENSMUST00000008024.6	Arid1a	AT rich interactive domain 1A (SWI-like)
chr2_+_163203072	1.938	ENSMUST00000109428.2	Tox2	TOX high mobility group box family member 2
chr8_+_60632818	1.710	ENSMUST00000161421.1	Mfap3l	microfibrillar-associated protein 3-like
chr14_+_31019183	1.687	ENSMUST00000052239.5	Pbrm1	polybromo 1
chr8_+_60632856	1.685	ENSMUST00000160719.1	Mfap3l	microfibrillar-associated protein 3-like
chr14_+_31019159	1.654	ENSMUST00000112094.1 ENSMUST00000144009.1	Pbrm1	polybromo 1
chr11_-_95041335	1.513	ENSMUST00000038431.7	Pdk2	pyruvate dehydrogenase kinase, isoenzyme 2
chr11_+_120491840	1.472	ENSMUST00000026899.3	Slc25a10	solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10
chr4_+_11191354	1.466	ENSMUST00000170901.1	Ccne2	cyclin E2
chr17_-_24960620	1.440	ENSMUST00000024981.7	Hn1l	hematological and neurological expressed 1-like
chr5_+_31251678	1.314	ENSMUST00000054829.7 ENSMUST00000114570.1 ENSMUST00000075611.7	Krtcap3	keratinocyte associated protein 3
chr11_-_120348091	1.238	ENSMUST00000106215.4	Actg1	actin, gamma, cytoplasmic 1
chr11_-_78165521	1.232	ENSMUST00000017530.3	Traf4	TNF receptor associated factor 4
chr13_+_35741313	1.127	ENSMUST00000163595.2	Cdyl	chromodomain protein, Y chromosome-like
chr2_-_92370999	1.064	ENSMUST00000176810.1 ENSMUST00000090582.4	Gyltl1b	glycosyltransferase-like 1B
chr17_+_35861318	1.055	ENSMUST00000074259.8 ENSMUST00000174873.1	Nrm	nurim (nuclear envelope membrane protein)
chr5_+_128601106	1.028	ENSMUST00000117102.2	Fzd10	frizzled homolog 10 (Drosophila)
chr11_-_86807624	1.019	ENSMUST00000018569.7	Dhx40	DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr7_-_65370908	0.974	ENSMUST00000032729.6	Tjp1	tight junction protein 1
chr2_-_92371039	0.973	ENSMUST00000068586.6	Gyltl1b	glycosyltransferase-like 1B
chr6_+_91157373	0.970	ENSMUST00000155007.1	Hdac11	histone deacetylase 11
chr1_-_193035651	0.931	ENSMUST00000016344.7	Syt14	synaptotagmin XIV
chr5_+_28165690	0.916	ENSMUST00000036177.7	En2	engrailed 2
chr10_+_36974558	0.902	ENSMUST00000105510.1	Hdac2	histone deacetylase 2
chr1_-_161876656	0.894	ENSMUST00000048377.5	Suco	SUN domain containing ossification factor
chr2_+_156065738	0.884	ENSMUST00000137966.1	Spag4	sperm associated antigen 4
chr17_-_28080567	0.859	ENSMUST00000114836.1 ENSMUST00000042692.5	Tcp11	t-complex protein 11
chr3_-_88177671	0.841	ENSMUST00000181837.1	1700113A16Rik	RIKEN cDNA 1700113A16 gene
chr11_-_120348513	0.807	ENSMUST00000071555.6	Actg1	actin, gamma, cytoplasmic 1
chr6_+_83165920	0.779	ENSMUST00000077407.5 ENSMUST00000113913.1 ENSMUST00000130212.1	Dctn1	dynactin 1
chr6_-_47813512	0.778	ENSMUST00000077290.7	Pdia4	protein disulfide isomerase associated 4
chr12_+_109549157	0.729	ENSMUST00000128458.1 ENSMUST00000150851.1	Meg3	maternally expressed 3
chr2_-_92370968	0.701	ENSMUST00000176774.1	Gyltl1b	glycosyltransferase-like 1B
chr10_-_87493651	0.700	ENSMUST00000020243.7	Ascl1	achaete-scute complex homolog 1 (Drosophila)
chr11_+_97315716	0.680	ENSMUST00000019026.3 ENSMUST00000132168.1	Mrpl45	mitochondrial ribosomal protein L45
chr4_+_118428078	0.670	ENSMUST00000006557.6 ENSMUST00000167636.1 ENSMUST00000102673.4	Elovl1	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
chr2_+_91526756	0.661	ENSMUST00000111338.3	Ckap5	cytoskeleton associated protein 5
chr4_-_43562397	0.635	ENSMUST00000030187.7	Tln1	talin 1
chr18_+_11839220	0.634	ENSMUST00000171109.1 ENSMUST00000046948.8	Cables1	CDK5 and Abl enzyme substrate 1
chr4_+_154869585	0.604	ENSMUST00000079269.7 ENSMUST00000163732.1 ENSMUST00000080559.6	Mmel1	membrane metallo-endopeptidase-like 1
chr11_+_4637734	0.598	ENSMUST00000109930.2 ENSMUST00000070257.7	Ascc2	activating signal cointegrator 1 complex subunit 2
chr16_-_45724600	0.583	ENSMUST00000096057.4	Tagln3	transgelin 3
chr4_+_137913471	0.564	ENSMUST00000151110.1	Ece1	endothelin converting enzyme 1
chr9_+_46012822	0.497	ENSMUST00000120463.2 ENSMUST00000120247.1	Sik3	SIK family kinase 3
chr12_+_69372112	0.492	ENSMUST00000050063.7	Arf6	ADP-ribosylation factor 6
chr7_-_65371210	0.445	ENSMUST00000102592.3	Tjp1	tight junction protein 1
chr19_+_47178820	0.438	ENSMUST00000111808.3	Neurl1a	neuralized homolog 1A (Drosophila)
chr15_-_89373810	0.416	ENSMUST00000167643.2	Sco2	SCO cytochrome oxidase deficient homolog 2 (yeast)
chr12_+_72761211	0.387	ENSMUST00000021514.8	Ppm1a	protein phosphatase 1A, magnesium dependent, alpha isoform
chr17_-_25274299	0.319	ENSMUST00000172587.1 ENSMUST00000049911.9 ENSMUST00000173713.1	Ube2i	ubiquitin-conjugating enzyme E2I
chr2_+_49451486	0.280	ENSMUST00000092123.4	Epc2	enhancer of polycomb homolog 2 (Drosophila)
chr2_-_150255591	0.273	ENSMUST00000063463.5	Gm21994	predicted gene 21994
chr3_+_90052814	0.255	ENSMUST00000160640.1 ENSMUST00000029552.6 ENSMUST00000162114.1 ENSMUST00000068798.6	4933434E20Rik	RIKEN cDNA 4933434E20 gene
chr1_+_193173469	0.248	ENSMUST00000161235.1 ENSMUST00000110831.2 ENSMUST00000178744.1	A130010J15Rik	RIKEN cDNA A130010J15 gene
chr2_+_6322621	0.243	ENSMUST00000114937.1	Usp6nl	USP6 N-terminal like
chr6_-_57692007	0.231	ENSMUST00000053386.5 ENSMUST00000185014.1	Pyurf PYURF	Pigy upstream reading frame protein preY, mitochondrial precursor
chr6_-_145076106	0.228	ENSMUST00000111742.1 ENSMUST00000048252.4	Bcat1	branched chain aminotransferase 1, cytosolic
chr17_-_25273861	0.222	ENSMUST00000172868.1 ENSMUST00000172618.1	Ube2i	ubiquitin-conjugating enzyme E2I
chr11_+_70844745	0.206	ENSMUST00000076270.6 ENSMUST00000179114.1 ENSMUST00000100928.4 ENSMUST00000177731.1 ENSMUST00000108533.3 ENSMUST00000081362.6 ENSMUST00000178245.1	Rabep1	rabaptin, RAB GTPase binding effector protein 1
chr12_-_56536895	0.181	ENSMUST00000001536.8	Nkx2-1	NK2 homeobox 1
chr3_-_95882193	0.164	ENSMUST00000159863.1 ENSMUST00000159739.1 ENSMUST00000036418.3	Gm129	predicted gene 129
chr3_-_95855753	0.152	ENSMUST00000161476.1	Prpf3	PRP3 pre-mRNA processing factor 3 homolog (yeast)
chr3_-_90052463	0.144	ENSMUST00000029553.9 ENSMUST00000064639.8 ENSMUST00000090908.6	Ubap2l	ubiquitin associated protein 2-like
chr4_+_123904907	0.133	ENSMUST00000106202.3	Mycbp	c-myc binding protein
chr4_-_123904826	0.132	ENSMUST00000181292.1	Gm26606	predicted gene, 26606
chr5_-_45857473	0.130	ENSMUST00000016026.7 ENSMUST00000067997.6 ENSMUST00000045586.6	Lcorl	ligand dependent nuclear receptor corepressor-like
chr2_+_29060239	0.124	ENSMUST00000100237.3	Ttf1	transcription termination factor, RNA polymerase I
chr1_+_9908638	0.064	ENSMUST00000171802.1 ENSMUST00000052843.5 ENSMUST00000125294.2 ENSMUST00000140948.2	Mcmdc2	minichromosome maintenance domain containing 2
chr3_-_95882232	0.057	ENSMUST00000161866.1	Gm129	predicted gene 129
chr3_-_95315086	0.050	ENSMUST00000098867.3	Gm10691	predicted gene 10691
chr7_-_131362687	0.046	ENSMUST00000059438.9	2310057M21Rik	RIKEN cDNA 2310057M21 gene
chr4_+_123904832	0.040	ENSMUST00000030400.7	Mycbp	c-myc binding protein
chr5_+_147860615	0.030	ENSMUST00000031654.6	Pomp	proteasome maturation protein

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
10.7	96.5	GO:0070874	negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
2.1	6.4	GO:0003349	epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
1.4	13.5	GO:0042095	interferon-gamma biosynthetic process(GO:0042095)
0.9	2.6	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.8	4.5	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.8	2.3	GO:0060167	regulation of adenosine receptor signaling pathway(GO:0060167) regulation of G-protein coupled receptor internalization(GO:1904020)
0.7	5.1	GO:0006344	maintenance of chromatin silencing(GO:0006344)
0.5	4.4	GO:0090091	positive regulation of axon extension involved in axon guidance(GO:0048842) positive regulation of extracellular matrix disassembly(GO:0090091)
0.4	4.0	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.4	1.5	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.4	1.5	GO:0015744	succinate transport(GO:0015744)
0.3	0.8	GO:1903334	positive regulation of protein folding(GO:1903334)
0.2	2.6	GO:0033690	positive regulation of osteoblast proliferation(GO:0033690)
0.2	0.7	GO:0021529	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) musculoskeletal movement, spinal reflex action(GO:0050883) olfactory pit development(GO:0060166)
0.2	4.8	GO:0045780	positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.2	3.6	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.2	0.6	GO:0010814	substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.2	0.8	GO:0090063	positive regulation of microtubule nucleation(GO:0090063)
0.1	0.7	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1	5.4	GO:0030513	positive regulation of BMP signaling pathway(GO:0030513)
0.1	1.0	GO:0038031	non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.1	1.4	GO:0090557	establishment of endothelial intestinal barrier(GO:0090557)
0.1	0.9	GO:0060046	regulation of acrosome reaction(GO:0060046)
0.1	0.5	GO:1903755	regulation of SUMO transferase activity(GO:1903182) positive regulation of SUMO transferase activity(GO:1903755)
0.1	0.9	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.1	11.6	GO:0030177	positive regulation of Wnt signaling pathway(GO:0030177)
0.1	1.2	GO:0007250	activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1	0.2	GO:0035526	retrograde transport, plasma membrane to Golgi(GO:0035526)
0.1	0.6	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.1	0.7	GO:0019368	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1	3.8	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.1	0.9	GO:1990403	embryonic brain development(GO:1990403)
0.1	0.4	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.9	GO:0046850	regulation of bone remodeling(GO:0046850)
0.0	2.0	GO:0045214	sarcomere organization(GO:0045214)
0.0	1.5	GO:0007129	synapsis(GO:0007129)
0.0	0.2	GO:0009098	branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.0	0.5	GO:0034143	regulation of toll-like receptor 4 signaling pathway(GO:0034143)
0.0	0.7	GO:0008340	determination of adult lifespan(GO:0008340)
0.0	1.0	GO:0014003	oligodendrocyte development(GO:0014003)
0.0	0.4	GO:0014823	response to activity(GO:0014823)
0.0	0.1	GO:0006361	transcription initiation from RNA polymerase I promoter(GO:0006361) termination of RNA polymerase I transcription(GO:0006363)
0.0	0.1	GO:0061484	hematopoietic stem cell homeostasis(GO:0061484)
0.0	0.5	GO:0036075	endochondral ossification(GO:0001958) replacement ossification(GO:0036075)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.5	GO:0005967	mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.5	1.5	GO:0097135	cyclin E2-CDK2 complex(GO:0097135)
0.4	3.1	GO:0090571	RNA polymerase II transcription repressor complex(GO:0090571)
0.2	8.3	GO:0090544	BAF-type complex(GO:0090544)
0.2	1.4	GO:0046581	intercellular canaliculus(GO:0046581)
0.1	0.6	GO:0033093	Weibel-Palade body(GO:0033093)
0.1	0.5	GO:1990356	sumoylated E2 ligase complex(GO:1990356)
0.1	0.8	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.1	1.1	GO:0005652	nuclear lamina(GO:0005652)
0.1	0.3	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1	0.8	GO:0005869	dynactin complex(GO:0005869)
0.1	4.0	GO:0005657	replication fork(GO:0005657)
0.0	0.5	GO:0090543	Flemming body(GO:0090543)
0.0	0.9	GO:0097225	sperm midpiece(GO:0097225)
0.0	2.0	GO:0043034	costamere(GO:0043034)
0.0	2.6	GO:0005581	collagen trimer(GO:0005581)
0.0	0.7	GO:0000930	gamma-tubulin complex(GO:0000930)
0.0	4.8	GO:0009897	external side of plasma membrane(GO:0009897)
0.0	2.2	GO:0005903	brush border(GO:0005903)
0.0	74.9	GO:0005829	cytosol(GO:0005829)
0.0	0.4	GO:0097440	apical dendrite(GO:0097440)
0.0	0.2	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0	1.0	GO:0000118	histone deacetylase complex(GO:0000118)
0.0	1.2	GO:0005923	bicellular tight junction(GO:0005923)
0.0	0.7	GO:0000315	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0	3.9	GO:0005874	microtubule(GO:0005874)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.5	96.5	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
1.5	4.4	GO:0035373	chondroitin sulfate proteoglycan binding(GO:0035373)
1.3	4.0	GO:0035402	histone kinase activity (H3-T11 specific)(GO:0035402)
0.8	3.1	GO:0035851	histone deacetylase activity (H4-K16 specific)(GO:0034739) Krueppel-associated box domain binding(GO:0035851)
0.6	2.3	GO:0031687	A2A adenosine receptor binding(GO:0031687)
0.6	2.2	GO:0008422	beta-glucosidase activity(GO:0008422)
0.5	2.6	GO:0004661	protein geranylgeranyltransferase activity(GO:0004661)
0.5	1.5	GO:0015140	malate transmembrane transporter activity(GO:0015140)
0.5	3.6	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.4	1.5	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.2	1.4	GO:0071253	connexin binding(GO:0071253)
0.1	1.7	GO:0031996	thioesterase binding(GO:0031996)
0.1	3.6	GO:0017147	Wnt-protein binding(GO:0017147)
0.1	4.5	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
0.1	0.5	GO:0061656	SUMO conjugating enzyme activity(GO:0061656)
0.1	0.8	GO:0015037	peptide disulfide oxidoreductase activity(GO:0015037)
0.1	0.6	GO:0030274	LIM domain binding(GO:0030274)
0.1	0.4	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1	0.9	GO:0043495	protein anchor(GO:0043495)
0.1	5.1	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.1	0.7	GO:0009922	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0	1.0	GO:0031078	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0	1.9	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.0	1.5	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0	0.7	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.2	GO:0052654	branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0	0.4	GO:0005507	copper ion binding(GO:0005507)
0.0	0.8	GO:0070840	dynein complex binding(GO:0070840)
0.0	8.9	GO:0005096	GTPase activator activity(GO:0005096)
0.0	1.4	GO:0004402	histone acetyltransferase activity(GO:0004402)
0.0	0.7	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.0	0.2	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0	0.1	GO:0001135	transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0	1.2	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.0	1.0	GO:0004004	RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0	1.7	GO:0001085	RNA polymerase II transcription factor binding(GO:0001085)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.9	96.5	PID_IGF1_PATHWAY	IGF1 pathway
0.4	4.0	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.4	13.5	PID_P38_MKK3_6PATHWAY	p38 MAPK signaling pathway
0.1	3.6	PID_WNT_SIGNALING_PATHWAY	Wnt signaling network
0.1	5.0	PID_HNF3B_PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	1.5	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	2.0	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	4.6	PID_HDAC_CLASSI_PATHWAY	Signaling events mediated by HDAC Class I
0.0	1.9	PID_TAP63_PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	3.8	PID_MYC_ACTIV_PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	1.1	PID_INTEGRIN_A4B1_PATHWAY	Alpha4 beta1 integrin signaling events
0.0	3.6	NABA_ECM_GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	0.8	PID_NCADHERIN_PATHWAY	N-cadherin signaling events
0.0	0.7	PID_AURORA_A_PATHWAY	Aurora A signaling
0.0	0.4	PID_SMAD2_3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.7	PID_HES_HEY_PATHWAY	Notch-mediated HES/HEY network
0.0	1.4	NABA_ECM_AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
4.6	96.5	REACTOME_SIGNAL_ATTENUATION	Genes involved in Signal attenuation
0.4	4.0	REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.2	3.6	REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2	3.0	REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.2	4.4	REACTOME_OTHER_SEMAPHORIN_INTERACTIONS	Genes involved in Other semaphorin interactions
0.1	4.8	REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1	1.5	REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1	12.2	REACTOME_SIGNALING_BY_RHO_GTPASES	Genes involved in Signaling by Rho GTPases
0.1	1.5	REACTOME_SULFUR_AMINO_ACID_METABOLISM	Genes involved in Sulfur amino acid metabolism
0.1	1.5	REACTOME_G0_AND_EARLY_G1	Genes involved in G0 and Early G1
0.1	0.6	REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1	4.1	REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0	1.4	REACTOME_SIGNALING_BY_HIPPO	Genes involved in Signaling by Hippo
0.0	0.7	REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0	0.4	REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1	Genes involved in Regulation of AMPK activity via LKB1
0.0	1.4	REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.0	4.5	REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0	0.2	REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.0	0.8	REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)

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