Motif ID: Hey1_Myc_Mxi1

Z-value: 0.851

Transcription factors associated with Hey1_Myc_Mxi1:

Gene SymbolEntrez IDGene Name
Hey1 ENSMUSG00000040289.3 Hey1
Mxi1 ENSMUSG00000025025.7 Mxi1
Myc ENSMUSG00000022346.8 Myc

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mxi1mm10_v2_chr19_+_53329413_53329478-0.501.8e-03Click!
Hey1mm10_v2_chr3_-_8667033_8667046-0.401.5e-02Click!
Mycmm10_v2_chr15_+_61987410_619874910.202.2e-01Click!


Activity profile for motif Hey1_Myc_Mxi1.

activity profile for motif Hey1_Myc_Mxi1


Sorted Z-values histogram for motif Hey1_Myc_Mxi1

Sorted Z-values for motif Hey1_Myc_Mxi1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hey1_Myc_Mxi1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_44788016 8.575 ENSMUST00000090057.4
ENSMUST00000110269.1
 Sybu

syntabulin (syntaxin-interacting)

chr11_+_98348404 5.119 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr15_+_44787746 5.024 ENSMUST00000181839.1
 2310069G16Rik
RIKEN cDNA 2310069G16 gene
chr4_+_148591482 4.637 ENSMUST00000006611.8
 Srm
spermidine synthase
chr9_+_34486125 4.058 ENSMUST00000115148.2
ENSMUST00000183580.1
 Kirrel3
RP24-225I21.1
kin of IRRE like 3 (Drosophila)
RP24-225I21.1
chr13_-_54055650 3.850 ENSMUST00000021932.5
 Drd1a
dopamine receptor D1A
chr19_+_43440404 3.845 ENSMUST00000165311.1
 Cnnm1
cyclin M1
chr15_-_77956658 3.665 ENSMUST00000117725.1
ENSMUST00000016696.6
 Foxred2

FAD-dependent oxidoreductase domain containing 2

chr6_+_108660616 3.629 ENSMUST00000032194.4
 Bhlhe40
basic helix-loop-helix family, member e40
chr14_-_124677089 3.341 ENSMUST00000095529.3
 Fgf14
fibroblast growth factor 14
chr6_+_88724828 3.240 ENSMUST00000089449.2
 Mgll
monoglyceride lipase
chr6_+_88724412 3.118 ENSMUST00000113585.2
 Mgll
monoglyceride lipase
chr15_+_83791939 3.113 ENSMUST00000172115.1
ENSMUST00000172398.1
 Mpped1

metallophosphoesterase domain containing 1

chr7_-_68749170 3.069 ENSMUST00000118110.1
ENSMUST00000048068.7
 Arrdc4

arrestin domain containing 4

chr5_-_122779278 3.067 ENSMUST00000111668.3
 Camkk2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr8_-_122551316 3.063 ENSMUST00000067252.7
 Piezo1
piezo-type mechanosensitive ion channel component 1
chr8_+_13159135 3.041 ENSMUST00000033824.6
 Lamp1
lysosomal-associated membrane protein 1
chr3_+_104638658 2.990 ENSMUST00000046212.1
 Slc16a1
solute carrier family 16 (monocarboxylic acid transporters), member 1
chr17_-_26201363 2.973 ENSMUST00000121959.1
 Arhgdig
Rho GDP dissociation inhibitor (GDI) gamma
chr6_+_108660772 2.877 ENSMUST00000163617.1
 Bhlhe40
basic helix-loop-helix family, member e40

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 430 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 11.5 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.1 6.6 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.2 6.5 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.2 6.4 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.1 6.4 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.5 5.0 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
1.6 4.7 GO:0007621 negative regulation of female receptivity(GO:0007621)
1.2 4.6 GO:0008295 spermidine biosynthetic process(GO:0008295)
1.2 4.6 GO:0044268 multicellular organismal protein metabolic process(GO:0044268)
0.6 4.4 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.8 4.2 GO:0008355 olfactory learning(GO:0008355)
0.8 4.1 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.2 3.8 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0 3.7 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 3.7 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.1 3.5 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 3.5 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.7 3.4 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.2 3.4 GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000466)
0.7 3.3 GO:1902683 regulation of receptor localization to synapse(GO:1902683)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 192 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.3 GO:0000139 Golgi membrane(GO:0000139)
0.6 8.9 GO:0043196 varicosity(GO:0043196)
1.1 8.8 GO:0097433 dense body(GO:0097433)
0.0 5.9 GO:0014069 postsynaptic density(GO:0014069)
0.3 5.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 5.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 5.7 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 5.0 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
1.6 4.7 GO:0044194 cytolytic granule(GO:0044194)
0.0 4.6 GO:0043198 dendritic shaft(GO:0043198)
0.2 4.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.2 4.1 GO:0030686 90S preribosome(GO:0030686)
0.1 4.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 3.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 3.4 GO:0005642 annulate lamellae(GO:0005642)
0.2 3.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 3.1 GO:0005882 intermediate filament(GO:0005882)
0.0 3.0 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.7 2.9 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 2.9 GO:0005797 Golgi medial cisterna(GO:0005797)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 293 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 12.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.9 11.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.2 6.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 6.3 GO:0003735 structural constituent of ribosome(GO:0003735)
1.0 6.0 GO:0043426 MRF binding(GO:0043426)
1.0 5.8 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.3 5.7 GO:0005351 sugar:proton symporter activity(GO:0005351)
1.7 5.1 GO:0031750 D3 dopamine receptor binding(GO:0031750)
0.2 4.9 GO:0008139 nuclear localization sequence binding(GO:0008139)
1.5 4.6 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.7 4.6 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.2 4.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 4.0 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.2 3.9 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 3.8 GO:0015485 cholesterol binding(GO:0015485)
0.1 3.6 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.4 3.5 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.2 3.5 GO:0043274 phospholipase binding(GO:0043274)
0.1 3.5 GO:0000049 tRNA binding(GO:0000049)
0.2 3.4 GO:0017070 U6 snRNA binding(GO:0017070)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 8.8 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.4 7.6 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 5.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 5.5 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 5.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 5.4 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 4.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.2 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.1 3.9 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 3.1 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 2.4 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 2.4 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 2.3 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 2.2 PID_IL4_2PATHWAY IL4-mediated signaling events
1.0 2.1 PID_IFNG_PATHWAY IFN-gamma pathway
0.0 1.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.9 NABA_MATRISOME_ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.1 1.7 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.1 1.6 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 1.5 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 12.1 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 9.8 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.2 6.9 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.1 6.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 6.3 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.5 6.2 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.2 6.2 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 6.1 REACTOME_TRIGLYCERIDE_BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.0 5.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.4 5.6 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 4.2 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.1 4.1 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 3.7 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.2 3.6 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.2 3.4 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 3.1 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 3.1 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 3.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 3.0 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 3.0 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling