Motif ID: Hey2

Z-value: 0.720


Transcription factors associated with Hey2:

Gene SymbolEntrez IDGene Name
Hey2 ENSMUSG00000019789.8 Hey2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hey2mm10_v2_chr10_-_30842765_30842801-0.545.8e-04Click!


Activity profile for motif Hey2.

activity profile for motif Hey2


Sorted Z-values histogram for motif Hey2

Sorted Z-values for motif Hey2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hey2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_105518736 2.961 ENSMUST00000034363.5
 Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr4_+_104367549 2.446 ENSMUST00000106830.2
 Dab1
disabled 1
chr4_-_107683576 2.336 ENSMUST00000131776.1
 Dmrtb1
DMRT-like family B with proline-rich C-terminal, 1
chr8_+_87473116 2.295 ENSMUST00000182650.1
ENSMUST00000182758.1
ENSMUST00000181898.1
 Gm2694


predicted gene 2694


chr4_-_117133953 1.833 ENSMUST00000076859.5
 Plk3
polo-like kinase 3
chr4_+_117835387 1.765 ENSMUST00000169885.1
 Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr11_+_120721452 1.737 ENSMUST00000018156.5
 Rac3
RAS-related C3 botulinum substrate 3
chr11_-_120348513 1.735 ENSMUST00000071555.6
 Actg1
actin, gamma, cytoplasmic 1
chr8_+_87472805 1.668 ENSMUST00000180700.2
ENSMUST00000182174.1
ENSMUST00000181159.1
 Gm2694


predicted gene 2694


chr10_-_11080956 1.619 ENSMUST00000105560.1
 Grm1
glutamate receptor, metabotropic 1
chr5_-_138996087 1.601 ENSMUST00000110897.1
 Pdgfa
platelet derived growth factor, alpha
chr11_+_120721543 1.568 ENSMUST00000142229.1
 Rac3
RAS-related C3 botulinum substrate 3
chr9_+_21165714 1.490 ENSMUST00000039413.8
 Pde4a
phosphodiesterase 4A, cAMP specific
chr13_-_68999518 1.461 ENSMUST00000022013.7
 Adcy2
adenylate cyclase 2
chr1_+_182763961 1.409 ENSMUST00000153348.1
 Susd4
sushi domain containing 4
chr2_+_140395446 1.373 ENSMUST00000110061.1
 Macrod2
MACRO domain containing 2
chr19_+_22139028 1.369 ENSMUST00000099569.2
ENSMUST00000087576.4
ENSMUST00000074770.5
 Trpm3


transient receptor potential cation channel, subfamily M, member 3


chr8_+_87472838 1.369 ENSMUST00000180806.2
 Gm2694
predicted gene 2694
chr14_-_121797670 1.364 ENSMUST00000100299.3
 Dock9
dedicator of cytokinesis 9
chr11_-_120348475 1.292 ENSMUST00000062147.7
ENSMUST00000128055.1
 Actg1

actin, gamma, cytoplasmic 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 GO:0045214 sarcomere organization(GO:0045214)
0.4 3.3 GO:0021894 cerebral cortex GABAergic interneuron development(GO:0021894)
0.3 3.0 GO:0001977 renal system process involved in regulation of blood volume(GO:0001977)
0.8 2.4 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.6 1.8 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.2 1.8 GO:0090166 Golgi disassembly(GO:0090166) regulation of chaperone-mediated autophagy(GO:1904714)
0.1 1.8 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.5 1.6 GO:0010512 negative regulation of phosphatidylinositol biosynthetic process(GO:0010512)
0.4 1.6 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 1.5 GO:0007608 sensory perception of smell(GO:0007608)
0.4 1.4 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924)
0.3 1.4 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 1.4 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 1.3 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.4 1.2 GO:0060166 olfactory pit development(GO:0060166)
0.4 1.2 GO:0060167 regulation of adenosine receptor signaling pathway(GO:0060167) regulation of G-protein coupled receptor internalization(GO:1904020)
0.3 1.2 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.0 1.2 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.1 1.1 GO:0046512 sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520)
0.1 1.1 GO:0072643 interferon-gamma secretion(GO:0072643)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.7 GO:0031941 filamentous actin(GO:0031941)
0.0 2.8 GO:0098793 presynapse(GO:0098793)
0.0 2.4 GO:0005903 brush border(GO:0005903)
0.1 1.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 1.8 GO:0005795 Golgi stack(GO:0005795)
0.1 1.6 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.0 1.6 GO:0005902 microvillus(GO:0005902)
0.2 1.4 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 1.4 GO:0042734 presynaptic membrane(GO:0042734)
0.1 1.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.4 1.1 GO:0044194 cytolytic granule(GO:0044194)
0.0 1.1 GO:0000242 pericentriolar material(GO:0000242)
0.0 1.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 0.8 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.8 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.2 0.7 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.1 0.7 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.7 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 0.6 GO:0031080 nuclear pore outer ring(GO:0031080)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 3.4 GO:0003924 GTPase activity(GO:0003924)
0.0 3.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 3.0 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0033764)
0.0 2.4 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.2 1.8 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.2 1.8 GO:0004016 adenylate cyclase activity(GO:0004016)
0.1 1.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 1.8 GO:0002039 p53 binding(GO:0002039)
0.4 1.6 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.1 1.6 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 1.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.5 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 1.4 GO:0019213 deacetylase activity(GO:0019213)
0.2 1.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 1.3 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.6 1.2 GO:0031687 A2A adenosine receptor binding(GO:0031687)
0.3 1.2 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.3 1.1 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 1.0 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 2.4 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 1.8 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 1.7 PID_P73PATHWAY p73 transcription factor network
0.0 1.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.6 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.1 1.5 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 1.1 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 0.9 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.7 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.7 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 0.7 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.6 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.6 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.5 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.5 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.4 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.4 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 1.8 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.2 1.8 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 1.8 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 1.8 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.6 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 1.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.1 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 1.1 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.1 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.1 1.0 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 1.0 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 0.9 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 0.8 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.7 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.7 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.6 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.6 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.1 0.5 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.5 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling