Motif ID: Hic1

Z-value: 1.310


Transcription factors associated with Hic1:

Gene SymbolEntrez IDGene Name
Hic1 ENSMUSG00000043099.4 Hic1



Activity profile for motif Hic1.

activity profile for motif Hic1


Sorted Z-values histogram for motif Hic1

Sorted Z-values for motif Hic1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hic1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_84800024 7.413 ENSMUST00000126806.1
ENSMUST00000076715.6
 Nfix

nuclear factor I/X

chr5_-_146585239 5.529 ENSMUST00000036211.6
 Gpr12
G-protein coupled receptor 12
chr11_+_7063423 5.141 ENSMUST00000020706.4
 Adcy1
adenylate cyclase 1
chr8_-_84800344 5.025 ENSMUST00000099070.3
 Nfix
nuclear factor I/X
chr13_+_109903089 4.864 ENSMUST00000120664.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chr5_+_141241490 4.766 ENSMUST00000085774.4
 Sdk1
sidekick homolog 1 (chicken)
chr8_+_70493156 4.642 ENSMUST00000008032.7
 Crlf1
cytokine receptor-like factor 1
chr11_-_6065538 4.559 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr12_+_105336922 4.381 ENSMUST00000180503.1
 2810011L19Rik
RIKEN cDNA 2810011L19 gene
chr18_-_58209926 4.237 ENSMUST00000025497.6
 Fbn2
fibrillin 2
chr8_-_36249292 3.819 ENSMUST00000065297.5
 Lonrf1
LON peptidase N-terminal domain and ring finger 1
chr4_+_141368116 3.818 ENSMUST00000006380.4
 Fam131c
family with sequence similarity 131, member C
chr4_-_46991842 3.753 ENSMUST00000107749.2
 Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr6_-_148444336 3.734 ENSMUST00000060095.8
ENSMUST00000100772.3
 Tmtc1

transmembrane and tetratricopeptide repeat containing 1

chr14_-_102982630 3.719 ENSMUST00000184744.1
 KCTD12
mmu-mir-5130
chr6_+_22875496 3.611 ENSMUST00000090568.3
 Ptprz1
protein tyrosine phosphatase, receptor type Z, polypeptide 1
chr17_-_83631892 3.539 ENSMUST00000051482.1
 Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr9_-_29412204 3.439 ENSMUST00000115237.1
 Ntm
neurotrimin
chr4_-_139092958 3.393 ENSMUST00000042844.6
 Nbl1
neuroblastoma, suppression of tumorigenicity 1
chr5_+_37047464 3.369 ENSMUST00000137019.1
 Jakmip1
janus kinase and microtubule interacting protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 448 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 20.2 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.7 12.6 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.4 11.1 GO:0030204 chondroitin sulfate metabolic process(GO:0030204)
1.3 9.3 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
1.5 7.6 GO:0071692 protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694)
0.1 7.4 GO:0034605 cellular response to heat(GO:0034605)
0.3 7.3 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 7.1 GO:0050885 neuromuscular process controlling balance(GO:0050885)
2.3 7.0 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
0.5 6.5 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.4 6.0 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.1 5.9 GO:0030032 lamellipodium assembly(GO:0030032)
0.3 5.8 GO:0006491 N-glycan processing(GO:0006491)
1.8 5.5 GO:0035604 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) coronal suture morphogenesis(GO:0060365) squamous basal epithelial stem cell differentiation involved in prostate gland acinus development(GO:0060529)
0.3 5.0 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 4.9 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.8 4.7 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.2 4.7 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.6 4.5 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 4.2 GO:0006914 autophagy(GO:0006914)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 186 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 47.3 GO:0016021 integral component of membrane(GO:0016021)
0.1 30.4 GO:0060076 excitatory synapse(GO:0060076)
0.1 17.3 GO:0000139 Golgi membrane(GO:0000139)
0.2 11.0 GO:0009925 basal plasma membrane(GO:0009925)
0.0 10.0 GO:0030425 dendrite(GO:0030425)
0.3 8.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 8.2 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 8.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.4 7.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
2.2 6.7 GO:0098855 HCN channel complex(GO:0098855)
0.2 5.7 GO:0051233 spindle midzone(GO:0051233)
0.1 5.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 5.5 GO:0031901 early endosome membrane(GO:0031901)
0.0 4.8 GO:0070382 exocytic vesicle(GO:0070382)
1.5 4.6 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 4.4 GO:0034702 ion channel complex(GO:0034702)
0.3 4.2 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 4.2 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 4.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.8 3.8 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 304 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 9.3 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.4 8.4 GO:0043274 phospholipase binding(GO:0043274)
0.2 8.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.5 7.2 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.1 7.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
1.2 7.0 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.2 7.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 6.8 GO:0005096 GTPase activator activity(GO:0005096)
1.7 6.7 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.9 6.3 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.2 6.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
1.0 6.0 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.3 6.0 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 5.9 GO:0072509 divalent inorganic cation transmembrane transporter activity(GO:0072509)
0.3 5.1 GO:0050811 GABA receptor binding(GO:0050811)
0.5 4.9 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.5 4.9 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.3 4.8 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.3 4.7 GO:0022842 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
0.1 4.7 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 8.9 PID_ARF6_PATHWAY Arf6 signaling events
0.5 8.3 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.4 8.3 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 7.5 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 6.1 PID_SHP2_PATHWAY SHP2 signaling
0.1 5.5 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 4.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.9 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 3.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 3.4 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.1 3.4 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.2 3.3 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.1 3.1 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 3.0 PID_FGF_PATHWAY FGF signaling pathway
0.1 2.8 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.1 2.8 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 2.3 PID_ARF_3PATHWAY Arf1 pathway
0.1 2.2 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 2.2 PID_TNF_PATHWAY TNF receptor signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 17.8 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.3 11.6 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.3 10.0 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.2 8.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.3 7.9 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.6 7.3 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.2 6.8 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 6.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 5.7 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.2 5.5 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.5 5.4 REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.1 5.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 4.9 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 4.8 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.2 4.7 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.2 4.6 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.2 4.3 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 4.2 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 4.1 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.3 3.8 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)