Motif ID: Hic2

Z-value: 1.853


Transcription factors associated with Hic2:

Gene SymbolEntrez IDGene Name
Hic2 ENSMUSG00000050240.8 Hic2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hic2mm10_v2_chr16_+_17233560_17233664-0.222.0e-01Click!


Activity profile for motif Hic2.

activity profile for motif Hic2


Sorted Z-values histogram for motif Hic2

Sorted Z-values for motif Hic2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hic2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_61523889 14.856 ENSMUST00000119481.1
ENSMUST00000055815.7
 Lrfn5

leucine rich repeat and fibronectin type III domain containing 5

chr7_-_74554474 10.348 ENSMUST00000134539.1
ENSMUST00000026897.7
ENSMUST00000098371.2
 Slco3a1


solute carrier organic anion transporter family, member 3a1


chr15_-_66831625 8.541 ENSMUST00000164163.1
 Sla
src-like adaptor
chr10_-_109010955 7.517 ENSMUST00000105276.1
ENSMUST00000064054.7
 Syt1

synaptotagmin I

chr13_-_54055650 6.961 ENSMUST00000021932.5
 Drd1a
dopamine receptor D1A
chr2_-_163918683 6.914 ENSMUST00000044734.2
 Rims4
regulating synaptic membrane exocytosis 4
chr15_+_99224976 6.899 ENSMUST00000041415.3
 Kcnh3
potassium voltage-gated channel, subfamily H (eag-related), member 3
chr11_+_75193783 6.875 ENSMUST00000102514.3
 Rtn4rl1
reticulon 4 receptor-like 1
chr11_+_104231465 6.623 ENSMUST00000145227.1
 Mapt
microtubule-associated protein tau
chr11_+_104231573 6.575 ENSMUST00000132977.1
ENSMUST00000132245.1
ENSMUST00000100347.4
 Mapt


microtubule-associated protein tau


chr11_+_104231515 6.555 ENSMUST00000106993.3
 Mapt
microtubule-associated protein tau
chr11_+_104231390 6.464 ENSMUST00000106992.3
 Mapt
microtubule-associated protein tau
chr2_+_180499893 6.429 ENSMUST00000029084.2
 Ntsr1
neurotensin receptor 1
chr1_+_74854954 6.359 ENSMUST00000160379.2
 Cdk5r2
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
chr7_-_74554726 6.337 ENSMUST00000107453.1
 Slco3a1
solute carrier organic anion transporter family, member 3a1
chr3_+_68584154 6.280 ENSMUST00000182997.1
 Schip1
schwannomin interacting protein 1
chr12_+_109549157 5.864 ENSMUST00000128458.1
ENSMUST00000150851.1
 Meg3

maternally expressed 3

chr2_-_181156993 5.855 ENSMUST00000055990.7
 Eef1a2
eukaryotic translation elongation factor 1 alpha 2
chr15_+_92051153 5.851 ENSMUST00000169825.1
 Cntn1
contactin 1
chr5_+_81021583 5.704 ENSMUST00000121707.1
 Lphn3
latrophilin 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 424 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 26.2 GO:1900034 regulation of cellular response to heat(GO:1900034)
1.3 16.6 GO:0015732 prostaglandin transport(GO:0015732)
0.7 13.9 GO:0001553 luteinization(GO:0001553)
0.8 13.1 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.5 12.2 GO:0008340 determination of adult lifespan(GO:0008340)
1.4 9.5 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.3 8.9 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
2.8 8.5 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
0.3 8.5 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
1.2 7.4 GO:0000160 phosphorelay signal transduction system(GO:0000160)
1.2 7.1 GO:0032796 uropod organization(GO:0032796)
0.9 7.0 GO:0005513 detection of calcium ion(GO:0005513)
0.4 6.9 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.3 6.9 GO:0030204 chondroitin sulfate metabolic process(GO:0030204)
0.1 6.8 GO:0006414 translational elongation(GO:0006414)
1.6 6.4 GO:0090238 positive regulation of arachidonic acid secretion(GO:0090238)
1.6 6.4 GO:0021586 pons maturation(GO:0021586)
0.9 6.2 GO:0098909 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.2 5.7 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.8 5.6 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 182 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 26.2 GO:0045298 tubulin complex(GO:0045298)
0.4 25.4 GO:0009925 basal plasma membrane(GO:0009925)
0.2 21.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.3 15.0 GO:0048786 presynaptic active zone(GO:0048786)
0.3 13.7 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.7 13.6 GO:0098984 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.1 12.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.3 11.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.6 10.3 GO:0043196 varicosity(GO:0043196)
0.5 8.2 GO:0031045 dense core granule(GO:0031045)
0.2 7.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.6 7.1 GO:0032426 stereocilium tip(GO:0032426)
0.4 6.8 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 6.6 GO:0044309 neuron spine(GO:0044309)
2.1 6.4 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
1.6 6.4 GO:0032280 symmetric synapse(GO:0032280)
1.0 5.9 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.4 5.2 GO:0043083 synaptic cleft(GO:0043083)
0.1 4.6 GO:0042734 presynaptic membrane(GO:0042734)
0.2 4.4 GO:0000242 pericentriolar material(GO:0000242)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 281 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.6 25.2 GO:0099609 microtubule lateral binding(GO:0099609)
2.4 16.7 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.6 9.4 GO:0045499 chemorepellent activity(GO:0045499)
0.7 8.7 GO:0047372 acylglycerol lipase activity(GO:0047372)
1.2 8.5 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
0.3 8.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.3 7.9 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.2 7.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
1.9 7.5 GO:0030348 syntaxin-3 binding(GO:0030348)
1.2 7.4 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.6 7.1 GO:0032036 myosin heavy chain binding(GO:0032036)
0.2 7.1 GO:0030552 cAMP binding(GO:0030552)
0.8 6.9 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.2 6.6 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.5 6.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.3 6.4 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.2 6.4 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 6.2 GO:0030246 carbohydrate binding(GO:0030246)
0.3 5.8 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
0.3 5.8 GO:0005044 scavenger receptor activity(GO:0005044)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 26.0 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 14.8 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 10.6 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.2 8.7 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.4 6.7 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.2 6.6 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 6.4 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.2 6.2 PID_ALK1_PATHWAY ALK1 signaling events
0.1 5.9 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.1 5.6 PID_BMP_PATHWAY BMP receptor signaling
0.2 5.4 PID_ARF_3PATHWAY Arf1 pathway
0.1 4.7 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 4.5 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 4.4 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.1 4.2 PID_FGF_PATHWAY FGF signaling pathway
0.4 4.0 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 3.9 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.1 3.8 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 3.7 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.2 3.6 ST_G_ALPHA_S_PATHWAY G alpha s Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 25.8 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
1.9 15.2 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.6 14.5 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 13.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.8 10.1 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.4 9.1 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.2 8.2 REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH Genes involved in NCAM signaling for neurite out-growth
0.1 8.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 7.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.8 7.5 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.2 6.9 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.2 5.8 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.2 5.6 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 5.3 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.4 5.1 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.7 5.0 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 4.7 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.1 4.7 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.3 4.2 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 4.2 REACTOME_GLYCOLYSIS Genes involved in Glycolysis