Motif ID: Hivep1
Z-value: 0.868
Transcription factors associated with Hivep1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Hivep1 | ENSMUSG00000021366.7 | Hivep1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Hivep1 | mm10_v2_chr13_+_42052015_42052072 | 0.22 | 1.9e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.2 | 6.2 | GO:0002158 | osteoclast proliferation(GO:0002158) |
0.9 | 2.8 | GO:0072382 | minus-end-directed vesicle transport along microtubule(GO:0072382) |
0.9 | 4.5 | GO:0032224 | positive regulation of synaptic transmission, cholinergic(GO:0032224) |
0.6 | 1.7 | GO:0032916 | positive regulation of transforming growth factor beta3 production(GO:0032916) |
0.5 | 1.0 | GO:0046878 | positive regulation of saliva secretion(GO:0046878) |
0.5 | 1.5 | GO:0021998 | neural plate mediolateral regionalization(GO:0021998) mesoderm structural organization(GO:0048338) paraxial mesoderm structural organization(GO:0048352) positive regulation of cardiac ventricle development(GO:1904414) |
0.5 | 2.0 | GO:0002484 | antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway(GO:0002484) antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent(GO:0002485) |
0.5 | 1.8 | GO:0009597 | detection of virus(GO:0009597) |
0.4 | 1.7 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
0.4 | 4.6 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
0.4 | 1.1 | GO:1990046 | positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046) |
0.3 | 1.0 | GO:1904884 | telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884) |
0.3 | 1.0 | GO:0070944 | neutrophil mediated killing of bacterium(GO:0070944) |
0.3 | 1.3 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
0.3 | 0.9 | GO:0001827 | inner cell mass cell fate commitment(GO:0001827) |
0.3 | 1.7 | GO:0097473 | cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473) |
0.3 | 2.0 | GO:2001199 | negative regulation of dendritic cell differentiation(GO:2001199) |
0.2 | 0.7 | GO:0032918 | polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918) |
0.2 | 0.9 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
0.2 | 0.8 | GO:0007066 | female meiosis sister chromatid cohesion(GO:0007066) |
0.2 | 1.6 | GO:1902373 | negative regulation of mRNA catabolic process(GO:1902373) |
0.2 | 1.5 | GO:0042487 | regulation of odontogenesis of dentin-containing tooth(GO:0042487) |
0.2 | 1.1 | GO:0016584 | nucleosome positioning(GO:0016584) |
0.1 | 0.5 | GO:0002175 | protein localization to paranode region of axon(GO:0002175) |
0.1 | 0.6 | GO:0032329 | serine transport(GO:0032329) |
0.1 | 0.5 | GO:0034729 | histone H3-K79 methylation(GO:0034729) |
0.1 | 0.9 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
0.1 | 3.7 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
0.1 | 0.4 | GO:2000319 | negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320) |
0.1 | 1.1 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
0.1 | 0.4 | GO:0006545 | glycine biosynthetic process(GO:0006545) |
0.1 | 1.0 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
0.1 | 0.3 | GO:2000508 | regulation of dendritic cell chemotaxis(GO:2000508) |
0.1 | 0.5 | GO:1904659 | glucose transmembrane transport(GO:1904659) |
0.1 | 0.8 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
0.1 | 2.2 | GO:0040034 | regulation of development, heterochronic(GO:0040034) |
0.1 | 1.0 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
0.1 | 0.7 | GO:0001842 | neural fold formation(GO:0001842) |
0.1 | 0.4 | GO:0042699 | follicle-stimulating hormone signaling pathway(GO:0042699) |
0.1 | 1.7 | GO:1900027 | regulation of ruffle assembly(GO:1900027) |
0.1 | 3.0 | GO:1901998 | toxin transport(GO:1901998) |
0.1 | 0.2 | GO:0010626 | negative regulation of Schwann cell proliferation(GO:0010626) |
0.1 | 0.4 | GO:0044034 | negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034) |
0.1 | 0.8 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
0.1 | 5.1 | GO:0021766 | hippocampus development(GO:0021766) |
0.0 | 2.2 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) |
0.0 | 0.5 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
0.0 | 7.5 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
0.0 | 0.2 | GO:1905169 | protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171) |
0.0 | 0.7 | GO:0060219 | camera-type eye photoreceptor cell differentiation(GO:0060219) |
0.0 | 0.7 | GO:0071378 | growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378) |
0.0 | 0.2 | GO:0048852 | diencephalon morphogenesis(GO:0048852) |
0.0 | 0.1 | GO:0060217 | hemangioblast cell differentiation(GO:0060217) |
0.0 | 0.5 | GO:0035090 | maintenance of apical/basal cell polarity(GO:0035090) |
0.0 | 1.9 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
0.0 | 1.0 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
0.0 | 0.8 | GO:0050919 | negative chemotaxis(GO:0050919) |
0.0 | 0.2 | GO:0051001 | negative regulation of nitric-oxide synthase activity(GO:0051001) |
0.0 | 0.1 | GO:0061086 | negative regulation of histone H3-K27 methylation(GO:0061086) |
0.0 | 0.5 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
0.0 | 0.4 | GO:0034453 | microtubule anchoring(GO:0034453) |
0.0 | 0.3 | GO:0031507 | heterochromatin assembly(GO:0031507) |
0.0 | 0.1 | GO:0006741 | NADP biosynthetic process(GO:0006741) |
0.0 | 1.6 | GO:0043149 | contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149) |
0.0 | 0.1 | GO:0018344 | protein geranylgeranylation(GO:0018344) |
0.0 | 0.1 | GO:0070427 | nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.0 | 3.0 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
0.9 | 2.7 | GO:0071953 | elastic fiber(GO:0071953) |
0.5 | 5.7 | GO:0042612 | MHC class I protein complex(GO:0042612) |
0.3 | 1.0 | GO:0032127 | dense core granule membrane(GO:0032127) |
0.3 | 0.8 | GO:0000802 | transverse filament(GO:0000802) |
0.2 | 1.1 | GO:0032983 | kainate selective glutamate receptor complex(GO:0032983) |
0.2 | 2.2 | GO:0042581 | specific granule(GO:0042581) |
0.2 | 0.7 | GO:0090537 | CERF complex(GO:0090537) |
0.2 | 1.4 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
0.1 | 1.0 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
0.1 | 2.8 | GO:0031616 | spindle pole centrosome(GO:0031616) |
0.1 | 1.7 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
0.1 | 0.4 | GO:0070552 | BRISC complex(GO:0070552) |
0.1 | 1.7 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
0.1 | 1.6 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
0.1 | 1.5 | GO:0005605 | basal lamina(GO:0005605) |
0.1 | 1.1 | GO:0036038 | MKS complex(GO:0036038) |
0.1 | 1.1 | GO:0031010 | ISWI-type complex(GO:0031010) |
0.1 | 0.7 | GO:0034464 | BBSome(GO:0034464) |
0.1 | 6.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.0 | 0.5 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
0.0 | 0.8 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
0.0 | 1.7 | GO:0005719 | nuclear euchromatin(GO:0005719) |
0.0 | 0.9 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
0.0 | 1.0 | GO:0001741 | XY body(GO:0001741) |
0.0 | 0.2 | GO:0070776 | H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776) |
0.0 | 0.1 | GO:0033193 | Lsd1/2 complex(GO:0033193) |
0.0 | 0.3 | GO:0005677 | chromatin silencing complex(GO:0005677) |
0.0 | 0.1 | GO:0005968 | Rab-protein geranylgeranyltransferase complex(GO:0005968) |
0.0 | 0.2 | GO:0031315 | extrinsic component of mitochondrial outer membrane(GO:0031315) |
0.0 | 2.8 | GO:0032587 | ruffle membrane(GO:0032587) |
0.0 | 1.0 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
0.0 | 0.4 | GO:0031143 | pseudopodium(GO:0031143) |
0.0 | 1.1 | GO:0008180 | COP9 signalosome(GO:0008180) |
0.0 | 0.2 | GO:0042382 | paraspeckles(GO:0042382) |
0.0 | 0.7 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
0.0 | 2.2 | GO:0001726 | ruffle(GO:0001726) |
0.0 | 0.2 | GO:0033270 | paranode region of axon(GO:0033270) |
0.0 | 1.5 | GO:0005901 | caveola(GO:0005901) |
0.0 | 4.6 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
0.0 | 0.8 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
0.0 | 0.5 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
0.0 | 0.4 | GO:0000421 | autophagosome membrane(GO:0000421) |
0.0 | 0.9 | GO:0005871 | kinesin complex(GO:0005871) |
0.0 | 0.5 | GO:0031526 | brush border membrane(GO:0031526) |
0.0 | 2.1 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 2.1 | GO:0036132 | 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522) |
0.6 | 1.7 | GO:0001225 | RNA polymerase II transcription coactivator binding(GO:0001225) |
0.5 | 4.6 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
0.4 | 5.7 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
0.3 | 3.1 | GO:0036122 | BMP binding(GO:0036122) |
0.3 | 6.0 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
0.3 | 1.3 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
0.3 | 1.5 | GO:0098821 | BMP receptor activity(GO:0098821) |
0.2 | 0.7 | GO:0004145 | diamine N-acetyltransferase activity(GO:0004145) |
0.2 | 1.0 | GO:0015166 | polyol transmembrane transporter activity(GO:0015166) glycerol transmembrane transporter activity(GO:0015168) |
0.2 | 2.8 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
0.2 | 0.8 | GO:0004096 | catalase activity(GO:0004096) |
0.2 | 1.1 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
0.2 | 1.0 | GO:0032405 | MutLalpha complex binding(GO:0032405) MutSalpha complex binding(GO:0032407) |
0.2 | 1.4 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
0.2 | 1.1 | GO:1901612 | phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612) |
0.1 | 0.7 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
0.1 | 0.4 | GO:0031896 | V2 vasopressin receptor binding(GO:0031896) |
0.1 | 0.4 | GO:0008732 | threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
0.1 | 0.4 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
0.1 | 0.9 | GO:0030274 | LIM domain binding(GO:0030274) |
0.1 | 2.7 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
0.1 | 0.9 | GO:0001025 | RNA polymerase III transcription factor binding(GO:0001025) |
0.1 | 1.0 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
0.1 | 1.0 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
0.1 | 7.5 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
0.1 | 0.2 | GO:0010484 | H3 histone acetyltransferase activity(GO:0010484) |
0.0 | 1.7 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
0.0 | 1.5 | GO:0005109 | frizzled binding(GO:0005109) |
0.0 | 0.2 | GO:0016936 | galactoside binding(GO:0016936) |
0.0 | 3.0 | GO:0008083 | growth factor activity(GO:0008083) |
0.0 | 0.7 | GO:0017147 | Wnt-protein binding(GO:0017147) |
0.0 | 1.1 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
0.0 | 0.1 | GO:0004111 | creatine kinase activity(GO:0004111) |
0.0 | 1.8 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
0.0 | 0.8 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
0.0 | 1.3 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
0.0 | 1.2 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
0.0 | 1.7 | GO:0005080 | protein kinase C binding(GO:0005080) |
0.0 | 0.7 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
0.0 | 0.9 | GO:0030331 | estrogen receptor binding(GO:0030331) |
0.0 | 0.8 | GO:0032452 | histone demethylase activity(GO:0032452) |
0.0 | 0.9 | GO:0003777 | microtubule motor activity(GO:0003777) |
0.0 | 0.5 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
0.0 | 0.3 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
0.0 | 0.2 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 4.5 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
0.3 | 3.0 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
0.2 | 6.0 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
0.2 | 3.0 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
0.1 | 1.7 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
0.1 | 4.4 | PID_BMP_PATHWAY | BMP receptor signaling |
0.1 | 0.7 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
0.1 | 1.7 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
0.1 | 1.0 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
0.0 | 1.9 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
0.0 | 1.7 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
0.0 | 1.7 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
0.0 | 0.9 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
0.0 | 3.8 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.0 | 0.3 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
0.0 | 1.2 | PID_RB_1PATHWAY | Regulation of retinoblastoma protein |
0.0 | 0.7 | PID_IL2_1PATHWAY | IL2-mediated signaling events |
0.0 | 1.0 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
0.0 | 0.5 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
0.0 | 1.9 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
0.0 | 0.4 | PID_IL8_CXCR1_PATHWAY | IL8- and CXCR1-mediated signaling events |
0.0 | 0.1 | PID_IL23_PATHWAY | IL23-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 6.0 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
0.2 | 3.1 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
0.1 | 1.0 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
0.1 | 1.0 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
0.1 | 1.7 | REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
0.1 | 2.8 | REACTOME_KINESINS | Genes involved in Kinesins |
0.1 | 1.0 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
0.1 | 1.7 | REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB | Genes involved in PKA-mediated phosphorylation of CREB |
0.1 | 1.7 | REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
0.1 | 1.1 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
0.1 | 0.9 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
0.1 | 1.7 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
0.0 | 0.7 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
0.0 | 1.3 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
0.0 | 1.4 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
0.0 | 0.9 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |
0.0 | 0.7 | REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING | Genes involved in Growth hormone receptor signaling |
0.0 | 1.1 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
0.0 | 0.8 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |
0.0 | 1.5 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
0.0 | 0.4 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
0.0 | 1.1 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
0.0 | 0.5 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
0.0 | 0.3 | REACTOME_PIP3_ACTIVATES_AKT_SIGNALING | Genes involved in PIP3 activates AKT signaling |
0.0 | 0.4 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |