Motif ID: Hivep1

Z-value: 0.868


Transcription factors associated with Hivep1:

Gene SymbolEntrez IDGene Name
Hivep1 ENSMUSG00000021366.7 Hivep1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hivep1mm10_v2_chr13_+_42052015_420520720.221.9e-01Click!


Activity profile for motif Hivep1.

activity profile for motif Hivep1


Sorted Z-values histogram for motif Hivep1

Sorted Z-values for motif Hivep1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hivep1

PNG image of the network

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Top targets:


Showing 1 to 20 of 160 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_88000350 5.995 ENSMUST00000090971.5
 Bcan
brevican
chr10_-_27616895 4.533 ENSMUST00000092639.5
 Lama2
laminin, alpha 2
chr2_-_113758638 3.181 ENSMUST00000099575.3
 Grem1
gremlin 1
chr3_-_107760221 3.005 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
 Csf1


colony stimulating factor 1 (macrophage)


chr5_-_98030727 2.972 ENSMUST00000031281.9
 Antxr2
anthrax toxin receptor 2
chr14_+_51984857 2.908 ENSMUST00000100639.4
ENSMUST00000182909.1
ENSMUST00000182760.1
ENSMUST00000182061.1
ENSMUST00000182193.1
 Arhgef40




Rho guanine nucleotide exchange factor (GEF) 40




chr5_-_134747241 2.663 ENSMUST00000015138.9
 Eln
elastin
chr14_+_51984826 2.636 ENSMUST00000093813.5
 Arhgef40
Rho guanine nucleotide exchange factor (GEF) 40
chr14_+_80000292 2.171 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr18_+_84088077 2.139 ENSMUST00000060223.2
 Zadh2
zinc binding alcohol dehydrogenase, domain containing 2
chr1_-_156204998 2.064 ENSMUST00000015628.3
 Fam163a
family with sequence similarity 163, member A
chr17_-_35701937 2.040 ENSMUST00000155628.1
 Ddr1
discoidin domain receptor family, member 1
chr17_-_34000257 1.964 ENSMUST00000087189.6
ENSMUST00000173075.1
ENSMUST00000172760.1
ENSMUST00000172912.1
ENSMUST00000025181.10
 H2-K1




histocompatibility 2, K1, K region




chr14_+_60732906 1.937 ENSMUST00000162945.1
 Spata13
spermatogenesis associated 13
chr11_-_100411874 1.814 ENSMUST00000141840.1
 Leprel4
leprecan-like 4
chr17_+_35439155 1.785 ENSMUST00000071951.6
ENSMUST00000078205.7
ENSMUST00000116598.3
ENSMUST00000076256.7
 H2-Q7



histocompatibility 2, Q region locus 7



chr11_+_62077018 1.784 ENSMUST00000092415.5
 Specc1
sperm antigen with calponin homology and coiled-coil domains 1
chr4_-_82505749 1.747 ENSMUST00000107245.2
ENSMUST00000107246.1
 Nfib

nuclear factor I/B

chr1_+_64532790 1.675 ENSMUST00000049932.5
ENSMUST00000087366.4
ENSMUST00000171164.1
 Creb1


cAMP responsive element binding protein 1


chr7_-_102250086 1.654 ENSMUST00000106923.1
ENSMUST00000098230.4
 Rhog

ras homolog gene family, member G


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.5 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
1.2 6.2 GO:0002158 osteoclast proliferation(GO:0002158)
0.1 5.1 GO:0021766 hippocampus development(GO:0021766)
0.4 4.6 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.9 4.5 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.1 3.7 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.1 3.0 GO:1901998 toxin transport(GO:1901998)
0.9 2.8 GO:0072382 minus-end-directed vesicle transport along microtubule(GO:0072382)
0.1 2.2 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.0 2.2 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.5 2.0 GO:0002484 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway(GO:0002484) antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent(GO:0002485)
0.3 2.0 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.0 1.9 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.5 1.8 GO:0009597 detection of virus(GO:0009597)
0.6 1.7 GO:0032916 positive regulation of transforming growth factor beta3 production(GO:0032916)
0.4 1.7 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.3 1.7 GO:0097473 cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.1 1.7 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.2 1.6 GO:1902373 negative regulation of mRNA catabolic process(GO:1902373)
0.0 1.6 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.5 GO:0031225 anchored component of membrane(GO:0031225)
0.5 5.7 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 4.6 GO:0016323 basolateral plasma membrane(GO:0016323)
1.0 3.0 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 2.8 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 2.8 GO:0032587 ruffle membrane(GO:0032587)
0.9 2.7 GO:0071953 elastic fiber(GO:0071953)
0.2 2.2 GO:0042581 specific granule(GO:0042581)
0.0 2.2 GO:0001726 ruffle(GO:0001726)
0.0 2.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 1.7 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 1.7 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 1.7 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 1.6 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 1.5 GO:0005605 basal lamina(GO:0005605)
0.0 1.5 GO:0005901 caveola(GO:0005901)
0.2 1.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 1.1 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 1.1 GO:0036038 MKS complex(GO:0036038)
0.1 1.1 GO:0031010 ISWI-type complex(GO:0031010)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.3 6.0 GO:0005540 hyaluronic acid binding(GO:0005540)
0.4 5.7 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.5 4.6 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.3 3.1 GO:0036122 BMP binding(GO:0036122)
0.0 3.0 GO:0008083 growth factor activity(GO:0008083)
0.2 2.8 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 2.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.7 2.1 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.0 1.8 GO:0003725 double-stranded RNA binding(GO:0003725)
0.6 1.7 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
0.0 1.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 1.7 GO:0005080 protein kinase C binding(GO:0005080)
0.3 1.5 GO:0098821 BMP receptor activity(GO:0098821)
0.0 1.5 GO:0005109 frizzled binding(GO:0005109)
0.2 1.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.3 1.3 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 1.3 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 1.2 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.2 1.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.0 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.6 4.5 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 4.4 PID_BMP_PATHWAY BMP receptor signaling
0.0 3.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 3.0 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 3.0 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 1.9 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.9 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 1.7 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 1.7 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 1.7 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.7 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.2 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.1 1.0 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.0 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 0.9 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.1 0.7 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.7 PID_IL2_1PATHWAY IL2-mediated signaling events
0.0 0.5 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.4 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.0 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.2 3.1 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 2.8 REACTOME_KINESINS Genes involved in Kinesins
0.1 1.7 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 1.7 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 1.7 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 1.7 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.5 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.4 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.3 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 1.1 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.1 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 1.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.0 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 1.0 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 1.0 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 0.9 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.9 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.8 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.7 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines