Motif ID: Hmga1

Z-value: 0.904


Transcription factors associated with Hmga1:

Gene SymbolEntrez IDGene Name
Hmga1 ENSMUSG00000046711.9 Hmga1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmga1mm10_v2_chr17_+_27556613_275566350.545.6e-04Click!


Activity profile for motif Hmga1.

activity profile for motif Hmga1


Sorted Z-values histogram for motif Hmga1

Sorted Z-values for motif Hmga1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmga1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 16.428 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr15_-_56694525 4.495 ENSMUST00000050544.7
 Has2
hyaluronan synthase 2
chr12_-_108003594 3.403 ENSMUST00000066060.4
 Bcl11b
B cell leukemia/lymphoma 11B
chr16_-_26989974 3.105 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr13_+_5861489 2.870 ENSMUST00000000080.6
 Klf6
Kruppel-like factor 6
chr8_-_87959560 2.562 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr19_-_19001099 2.487 ENSMUST00000040153.8
ENSMUST00000112828.1
 Rorb

RAR-related orphan receptor beta

chr1_+_107511416 2.471 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr3_+_134236483 2.462 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr4_-_36056726 2.294 ENSMUST00000108124.3
 Lingo2
leucine rich repeat and Ig domain containing 2
chr10_+_88091070 2.263 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chr1_-_158814469 2.132 ENSMUST00000161589.2
 Pappa2
pappalysin 2
chr4_-_97584605 2.059 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr17_+_43953191 1.960 ENSMUST00000044792.4
 Rcan2
regulator of calcineurin 2
chr18_-_62741387 1.946 ENSMUST00000097557.3
 Spink13
serine peptidase inhibitor, Kazal type 13
chr9_-_100506844 1.817 ENSMUST00000112874.3
 Nck1
non-catalytic region of tyrosine kinase adaptor protein 1
chr3_+_67892189 1.796 ENSMUST00000063263.3
 Iqcj
IQ motif containing J
chr3_-_120886691 1.784 ENSMUST00000182099.1
ENSMUST00000183168.1
ENSMUST00000183276.1
ENSMUST00000182124.1
 6530403H02Rik



RIKEN cDNA 6530403H02 gene



chr1_-_126830632 1.780 ENSMUST00000112583.1
ENSMUST00000094609.3
 Nckap5

NCK-associated protein 5

chr19_-_24861828 1.768 ENSMUST00000047666.4
 Pgm5
phosphoglucomutase 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 126 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 17.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 4.9 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
1.6 4.7 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
1.1 4.5 GO:1900623 positive regulation of keratinocyte proliferation(GO:0010838) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 3.8 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.6 3.4 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.3 3.4 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.0 3.2 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.1 2.9 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.1 2.7 GO:0006270 DNA replication initiation(GO:0006270)
0.0 2.7 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 2.6 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.4 2.5 GO:0046549 retinal cone cell development(GO:0046549)
0.8 2.3 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.0 2.2 GO:0060349 bone morphogenesis(GO:0060349)
0.4 1.9 GO:0060467 negative regulation of fertilization(GO:0060467)
0.6 1.8 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.4 1.7 GO:0010511 regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.1 1.7 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.5 1.6 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.0 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 4.7 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 2.9 GO:0044295 axonal growth cone(GO:0044295)
0.0 2.4 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 1.8 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 1.7 GO:0070852 cell body fiber(GO:0070852)
0.3 1.6 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 1.5 GO:0010369 chromocenter(GO:0010369)
0.0 1.5 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 1.4 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 1.4 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.3 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 1.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.3 GO:0031941 filamentous actin(GO:0031941)
0.2 1.2 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 1.2 GO:0043196 varicosity(GO:0043196)
0.4 1.1 GO:0042584 chromaffin granule membrane(GO:0042584)
0.2 1.1 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 1.1 GO:0032426 stereocilium tip(GO:0032426)
0.2 1.0 GO:0044316 cone cell pedicle(GO:0044316)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 5.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.2 4.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
1.5 4.5 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 3.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.5 3.2 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 2.8 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.8 2.5 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 2.0 GO:0033613 activating transcription factor binding(GO:0033613)
0.3 1.8 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.3 1.8 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.6 1.7 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 1.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.7 GO:0017124 SH3 domain binding(GO:0017124)
0.1 1.6 GO:0003680 AT DNA binding(GO:0003680)
0.1 1.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 1.6 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 1.6 GO:0035064 methylated histone binding(GO:0035064)
0.5 1.5 GO:0004335 galactokinase activity(GO:0004335)
0.0 1.5 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 3.5 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 3.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.2 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 2.1 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 1.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.6 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.3 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.2 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.1 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 1.1 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 0.8 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.7 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.6 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 0.5 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.5 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.4 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.2 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.5 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 3.9 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 3.6 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 3.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 3.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.2 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.1 2.1 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 2.0 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 2.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.6 1.7 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.0 1.7 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 1.5 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 1.1 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.0 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 1.0 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.9 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.8 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 0.7 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.7 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.0 0.7 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA