Motif ID: Hmx1

Z-value: 0.649


Transcription factors associated with Hmx1:

Gene SymbolEntrez IDGene Name
Hmx1 ENSMUSG00000067438.3 Hmx1



Activity profile for motif Hmx1.

activity profile for motif Hmx1


Sorted Z-values histogram for motif Hmx1

Sorted Z-values for motif Hmx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_172057573 4.726 ENSMUST00000059794.3
 Nhlh1
nescient helix loop helix 1
chr6_-_127151044 2.548 ENSMUST00000000188.8
 Ccnd2
cyclin D2
chr19_+_25610533 2.100 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr2_+_168081004 2.004 ENSMUST00000052125.6
 Pard6b
par-6 (partitioning defective 6) homolog beta (C. elegans)
chr7_-_48881032 1.883 ENSMUST00000058745.8
 E2f8
E2F transcription factor 8
chr15_-_32244632 1.739 ENSMUST00000181536.1
 0610007N19Rik
RIKEN cDNA 0610007N19
chr9_+_80165079 1.598 ENSMUST00000184480.1
 Myo6
myosin VI
chr8_+_45628176 1.492 ENSMUST00000130850.1
 Sorbs2
sorbin and SH3 domain containing 2
chr8_+_45627946 1.478 ENSMUST00000145458.1
 Sorbs2
sorbin and SH3 domain containing 2
chr7_-_144939823 1.459 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr17_-_33890584 1.406 ENSMUST00000114361.2
ENSMUST00000173492.1
 Kifc1

kinesin family member C1

chr6_-_95718800 1.378 ENSMUST00000079847.5
 Suclg2
succinate-Coenzyme A ligase, GDP-forming, beta subunit
chr17_-_33890539 1.366 ENSMUST00000173386.1
 Kifc1
kinesin family member C1
chr5_-_98030727 1.363 ENSMUST00000031281.9
 Antxr2
anthrax toxin receptor 2
chr10_-_80261004 1.353 ENSMUST00000105363.1
 Gamt
guanidinoacetate methyltransferase
chr1_+_135729147 1.346 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr10_-_80260959 1.332 ENSMUST00000020359.6
 Gamt
guanidinoacetate methyltransferase
chr15_+_32244801 1.242 ENSMUST00000067458.6
 Sema5a
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr10_+_93641041 1.236 ENSMUST00000020204.4
 Ntn4
netrin 4
chr15_+_55307743 1.234 ENSMUST00000023053.5
ENSMUST00000110221.2
ENSMUST00000110217.3
 Col14a1


collagen, type XIV, alpha 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.4 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.9 2.8 GO:0072382 minus-end-directed vesicle transport along microtubule(GO:0072382)
0.9 2.7 GO:0006601 creatine biosynthetic process(GO:0006601)
0.1 2.6 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.2 2.5 GO:0071481 cellular response to X-ray(GO:0071481)
0.2 2.1 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.6 1.9 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.1 1.6 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.2 1.5 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.0 1.5 GO:0007043 cell-cell junction assembly(GO:0007043)
0.2 1.4 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.0 1.4 GO:1901998 toxin transport(GO:1901998)
0.0 1.3 GO:0070527 platelet aggregation(GO:0070527)
0.2 1.2 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.2 1.2 GO:0030836 positive regulation of actin filament depolymerization(GO:0030836) positive regulation of axon extension involved in axon guidance(GO:0048842) positive regulation of extracellular matrix disassembly(GO:0090091)
0.1 1.2 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.1 1.2 GO:0035036 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036)
0.0 1.2 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 1.2 GO:0008584 male gonad development(GO:0008584) development of primary male sexual characteristics(GO:0046546)
0.3 1.0 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 2.7 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 2.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.6 2.5 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 1.8 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.7 GO:0005871 kinesin complex(GO:0005871)
0.1 1.6 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 1.6 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 1.5 GO:0005844 polysome(GO:0005844)
0.2 1.4 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.1 1.3 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.0 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 0.9 GO:0005775 vacuolar lumen(GO:0005775)
0.1 0.8 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.8 GO:0032433 filopodium tip(GO:0032433)
0.0 0.8 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 0.8 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 0.7 GO:0097513 myosin II filament(GO:0097513)
0.1 0.6 GO:0061574 ASAP complex(GO:0061574)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.4 GO:0003774 motor activity(GO:0003774)
0.0 2.9 GO:0001047 core promoter binding(GO:0001047)
0.4 2.8 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.2 2.8 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 2.5 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity(GO:0008757)
0.3 1.8 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 1.7 GO:0005537 mannose binding(GO:0005537)
0.1 1.5 GO:0070064 proline-rich region binding(GO:0070064)
0.5 1.4 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.4 1.2 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 1.2 GO:0043237 laminin-1 binding(GO:0043237)
0.0 1.2 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.2 1.1 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.2 1.0 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.2 1.0 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 1.0 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 1.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 0.9 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.2 0.8 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.1 0.8 GO:0004645 phosphorylase activity(GO:0004645)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.2 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.1 2.7 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 2.0 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 1.8 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 1.8 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.7 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 1.7 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 1.6 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 1.4 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.3 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.2 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.0 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.7 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.6 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.5 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.5 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.5 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.3 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.3 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.5 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 2.9 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.2 2.8 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 2.8 REACTOME_KINESINS Genes involved in Kinesins
0.1 2.3 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 2.3 REACTOME_CELL_CELL_JUNCTION_ORGANIZATION Genes involved in Cell-cell junction organization
0.1 1.6 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 1.4 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.4 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.3 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 1.2 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.2 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.9 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.8 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.1 0.7 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 0.6 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.6 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.5 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.5 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)