Motif ID: Hmx2

Z-value: 0.378


Transcription factors associated with Hmx2:

Gene SymbolEntrez IDGene Name
Hmx2 ENSMUSG00000050100.7 Hmx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmx2mm10_v2_chr7_+_131548755_131548773-0.212.2e-01Click!


Activity profile for motif Hmx2.

activity profile for motif Hmx2


Sorted Z-values histogram for motif Hmx2

Sorted Z-values for motif Hmx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 129 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_73237891 1.503 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr12_-_98901478 1.405 ENSMUST00000065716.6
 Eml5
echinoderm microtubule associated protein like 5
chr5_-_28210022 1.364 ENSMUST00000118882.1
 Cnpy1
canopy 1 homolog (zebrafish)
chr7_-_37772868 1.152 ENSMUST00000176205.1
 Zfp536
zinc finger protein 536
chr5_+_3343893 1.068 ENSMUST00000165117.1
 Cdk6
cyclin-dependent kinase 6
chr18_-_88894322 0.992 ENSMUST00000070116.5
ENSMUST00000125362.1
 Socs6

suppressor of cytokine signaling 6

chr2_+_35132194 0.967 ENSMUST00000113034.1
ENSMUST00000113037.3
ENSMUST00000113033.2
 Cep110


centrosomal protein 110


chr11_-_100822525 0.942 ENSMUST00000107358.2
 Stat5b
signal transducer and activator of transcription 5B
chr10_+_128908907 0.823 ENSMUST00000105229.1
 Cd63
CD63 antigen
chr4_-_132398199 0.814 ENSMUST00000136711.1
ENSMUST00000084249.4
 Phactr4

phosphatase and actin regulator 4

chr8_-_123318553 0.781 ENSMUST00000118395.1
ENSMUST00000035495.8
 Fanca

Fanconi anemia, complementation group A

chr19_-_58454435 0.759 ENSMUST00000169850.1
 Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr5_-_53707532 0.753 ENSMUST00000031093.3
 Cckar
cholecystokinin A receptor
chr18_-_34579072 0.734 ENSMUST00000079287.5
 Nme5
NME/NM23 family member 5
chr6_-_137169678 0.699 ENSMUST00000119610.1
 Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chr18_+_50051702 0.698 ENSMUST00000134348.1
ENSMUST00000153873.2
 Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr11_-_3931960 0.686 ENSMUST00000109990.1
ENSMUST00000020710.4
ENSMUST00000109989.3
ENSMUST00000109991.1
ENSMUST00000109993.2
 Tcn2




transcobalamin 2




chr13_-_59675754 0.679 ENSMUST00000022039.5
ENSMUST00000095739.2
 Golm1

golgi membrane protein 1

chr3_-_88410295 0.664 ENSMUST00000056370.7
 Pmf1
polyamine-modulated factor 1
chr8_+_90828820 0.634 ENSMUST00000109614.2
ENSMUST00000048665.6
 Chd9

chromodomain helicase DNA binding protein 9


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.5 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 1.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 1.1 GO:0044838 cell quiescence(GO:0044838)
0.0 1.0 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.3 0.9 GO:0046544 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544)
0.3 0.8 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.2 0.8 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.2 0.8 GO:2000680 regulation of rubidium ion transport(GO:2000680)
0.2 0.7 GO:0015889 cobalamin transport(GO:0015889)
0.2 0.7 GO:0001887 selenium compound metabolic process(GO:0001887) selenocysteine metabolic process(GO:0016259)
0.1 0.7 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 0.7 GO:0032611 interleukin-1 beta production(GO:0032611)
0.2 0.6 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.1 0.6 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.1 0.6 GO:0070269 pyroptosis(GO:0070269)
0.1 0.6 GO:0072615 interleukin-17 secretion(GO:0072615)
0.1 0.6 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.1 0.5 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.1 0.5 GO:0046368 GDP-L-fucose metabolic process(GO:0046368)
0.1 0.5 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 GO:0001772 immunological synapse(GO:0001772)
0.0 1.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 0.8 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.1 0.8 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 0.7 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.1 0.7 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.6 GO:0061702 inflammasome complex(GO:0061702)
0.0 0.6 GO:0097470 ribbon synapse(GO:0097470)
0.0 0.5 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.5 GO:0002080 acrosomal membrane(GO:0002080)
0.1 0.4 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.4 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 0.3 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.3 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.1 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.1 GO:0071438 invadopodium membrane(GO:0071438)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.5 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 1.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.4 1.1 GO:0098770 FBXO family protein binding(GO:0098770)
0.0 0.9 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.2 0.8 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 0.8 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.2 0.7 GO:0070279 vitamin B6 binding(GO:0070279)
0.1 0.7 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.1 0.7 GO:0031419 cobalamin binding(GO:0031419)
0.1 0.7 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.7 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.2 0.6 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.1 0.6 GO:0008142 oxysterol binding(GO:0008142)
0.1 0.6 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.5 GO:0043495 protein anchor(GO:0043495)
0.0 0.5 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.1 0.4 GO:0008384 IkappaB kinase activity(GO:0008384)
0.0 0.4 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.4 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.9 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.8 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.8 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.4 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.0 0.4 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.2 PID_S1P_S1P4_PATHWAY S1P4 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.5 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 1.1 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 1.0 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.1 0.9 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.8 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.8 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.6 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.1 0.5 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.5 REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.0 0.4 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.4 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.1 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.1 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism