Motif ID: Hmx3

Z-value: 0.335


Transcription factors associated with Hmx3:

Gene SymbolEntrez IDGene Name
Hmx3 ENSMUSG00000040148.5 Hmx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmx3mm10_v2_chr7_+_131542867_131542867-0.038.8e-01Click!


Activity profile for motif Hmx3.

activity profile for motif Hmx3


Sorted Z-values histogram for motif Hmx3

Sorted Z-values for motif Hmx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_144893127 1.371 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr3_-_49757257 1.079 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr13_-_92131494 1.048 ENSMUST00000099326.3
ENSMUST00000146492.1
 Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2

chr3_+_62419668 0.924 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr15_+_9436028 0.871 ENSMUST00000042360.3
 Capsl
calcyphosine-like
chr10_+_106470281 0.786 ENSMUST00000029404.9
ENSMUST00000169303.1
 Ppfia2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr9_-_123678782 0.743 ENSMUST00000170591.1
ENSMUST00000171647.1
 Slc6a20a

solute carrier family 6 (neurotransmitter transporter), member 20A

chr13_+_118714678 0.732 ENSMUST00000022246.8
 Fgf10
fibroblast growth factor 10
chr9_-_123678873 0.685 ENSMUST00000040960.6
 Slc6a20a
solute carrier family 6 (neurotransmitter transporter), member 20A
chr1_-_190170671 0.657 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr10_+_99263224 0.653 ENSMUST00000020118.4
 Dusp6
dual specificity phosphatase 6
chr12_-_83487708 0.648 ENSMUST00000177959.1
ENSMUST00000178756.1
 Dpf3

D4, zinc and double PHD fingers, family 3

chr11_+_103133303 0.630 ENSMUST00000107037.1
 Hexim2
hexamethylene bis-acetamide inducible 2
chr14_-_55560340 0.630 ENSMUST00000066106.3
 A730061H03Rik
RIKEN cDNA A730061H03 gene
chr4_+_154960915 0.593 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr5_-_137684665 0.590 ENSMUST00000100544.4
ENSMUST00000031736.9
ENSMUST00000151839.1
 Agfg2


ArfGAP with FG repeats 2


chr11_+_103133333 0.473 ENSMUST00000124928.1
ENSMUST00000062530.4
 Hexim2

hexamethylene bis-acetamide inducible 2

chr7_-_126897424 0.466 ENSMUST00000120007.1
 Tmem219
transmembrane protein 219
chr1_+_165788681 0.430 ENSMUST00000161971.1
ENSMUST00000178336.1
ENSMUST00000005907.5
ENSMUST00000027849.4
 Cd247



CD247 antigen



chr6_+_92092369 0.400 ENSMUST00000113463.1
 Nr2c2
nuclear receptor subfamily 2, group C, member 2
chr4_-_62470868 0.397 ENSMUST00000135811.1
ENSMUST00000120095.1
ENSMUST00000030087.7
ENSMUST00000107452.1
ENSMUST00000155522.1
 Wdr31




WD repeat domain 31




chr19_+_11965817 0.338 ENSMUST00000025590.9
 Osbp
oxysterol binding protein
chr7_+_25267669 0.337 ENSMUST00000169266.1
 Cic
capicua homolog (Drosophila)
chr7_+_79273201 0.330 ENSMUST00000037315.6
 Abhd2
abhydrolase domain containing 2
chr19_-_41933276 0.317 ENSMUST00000075280.4
ENSMUST00000112123.2
 Exosc1

exosome component 1

chr2_-_130424242 0.316 ENSMUST00000089581.4
 Pced1a
PC-esterase domain containing 1A
chr7_-_45510400 0.298 ENSMUST00000033096.7
 Nucb1
nucleobindin 1
chr2_-_130424673 0.275 ENSMUST00000110277.1
 Pced1a
PC-esterase domain containing 1A
chr2_+_130424321 0.254 ENSMUST00000128994.1
ENSMUST00000028900.9
 Vps16

vacuolar protein sorting 16 (yeast)

chr3_+_109573907 0.253 ENSMUST00000106576.2
 Vav3
vav 3 oncogene
chr7_+_3645267 0.213 ENSMUST00000038913.9
 Cnot3
CCR4-NOT transcription complex, subunit 3
chr19_+_41933464 0.208 ENSMUST00000026154.7
 Zdhhc16
zinc finger, DHHC domain containing 16
chr19_+_8802486 0.202 ENSMUST00000172175.1
 Zbtb3
zinc finger and BTB domain containing 3
chr17_-_57247632 0.199 ENSMUST00000005975.6
 Gpr108
G protein-coupled receptor 108
chr2_-_45112890 0.186 ENSMUST00000076836.6
 Zeb2
zinc finger E-box binding homeobox 2
chr2_-_153015331 0.172 ENSMUST00000028972.8
 Pdrg1
p53 and DNA damage regulated 1
chrX_+_159708593 0.171 ENSMUST00000080394.6
 Sh3kbp1
SH3-domain kinase binding protein 1
chr7_+_25681158 0.165 ENSMUST00000108403.3
 B9d2
B9 protein domain 2
chr11_+_114668524 0.148 ENSMUST00000106602.3
ENSMUST00000077915.3
ENSMUST00000106599.1
ENSMUST00000082092.4
 Rpl38



ribosomal protein L38



chrM_+_3906 0.146 ENSMUST00000082396.1
 mt-Nd2
mitochondrially encoded NADH dehydrogenase 2
chr14_+_54464141 0.142 ENSMUST00000022782.8
 Lrp10
low-density lipoprotein receptor-related protein 10
chr2_-_72986716 0.139 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr10_+_62980233 0.131 ENSMUST00000131718.1
ENSMUST00000119567.1
ENSMUST00000122231.1
 Rufy2


RUN and FYVE domain-containing 2


chr13_+_23746734 0.130 ENSMUST00000099703.2
 Hist1h2bb
histone cluster 1, H2bb
chr1_-_119836999 0.130 ENSMUST00000163621.1
ENSMUST00000168303.1
 Ptpn4

protein tyrosine phosphatase, non-receptor type 4

chr3_+_66985947 0.126 ENSMUST00000161726.1
ENSMUST00000160504.1
 Rsrc1

arginine/serine-rich coiled-coil 1

chr2_-_84715160 0.126 ENSMUST00000035840.5
 Zdhhc5
zinc finger, DHHC domain containing 5
chr4_+_65604984 0.105 ENSMUST00000050850.7
ENSMUST00000107366.1
 Trim32

tripartite motif-containing 32

chr3_-_142169311 0.099 ENSMUST00000106230.1
 Bmpr1b
bone morphogenetic protein receptor, type 1B
chr18_+_61639542 0.084 ENSMUST00000183083.1
ENSMUST00000183087.1
 Gm20748

predicted gene, 20748

chr7_-_30559600 0.069 ENSMUST00000043975.4
ENSMUST00000156241.1
 Lin37

lin-37 homolog (C. elegans)

chr5_-_87482258 0.047 ENSMUST00000079811.6
ENSMUST00000144144.1
 Ugt2a1

UDP glucuronosyltransferase 2 family, polypeptide A1

chr7_-_30559828 0.032 ENSMUST00000108164.1
 Lin37
lin-37 homolog (C. elegans)
chr7_-_127208423 0.016 ENSMUST00000120705.1
 Tbc1d10b
TBC1 domain family, member 10b

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0071336 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
0.2 0.7 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.2 0.7 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.2 0.6 GO:2000977 regulation of forebrain neuron differentiation(GO:2000977)
0.1 1.4 GO:0015838 proline transport(GO:0015824) amino-acid betaine transport(GO:0015838)
0.1 1.4 GO:0042572 retinol metabolic process(GO:0042572)
0.0 1.1 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.9 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 1.0 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0 1.1 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 0.3 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.2 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 0.1 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0 0.3 GO:0032570 response to progesterone(GO:0032570)
0.0 0.1 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.3 GO:0044144 regulation of growth of symbiont in host(GO:0044126) modulation of growth of symbiont involved in interaction with host(GO:0044144)
0.0 0.1 GO:0048318 axial mesoderm development(GO:0048318)
0.0 0.4 GO:0048520 positive regulation of behavior(GO:0048520)
0.0 0.4 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.3 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.3 GO:0018345 protein palmitoylation(GO:0018345)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 0.3 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.0 0.3 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.3 GO:0033263 CORVET complex(GO:0033263)
0.0 0.3 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.6 GO:0071565 nBAF complex(GO:0071565)
0.0 0.1 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.2 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 0.7 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.2 1.4 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.1 1.1 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 0.7 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.3 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.1 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.3 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 1.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 1.4 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.7 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.3 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.4 ST_P38_MAPK_PATHWAY p38 MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 0.7 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.7 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 1.0 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.3 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease