Motif ID: Hnf1a

Z-value: 0.492


Transcription factors associated with Hnf1a:

Gene SymbolEntrez IDGene Name
Hnf1a ENSMUSG00000029556.6 Hnf1a



Activity profile for motif Hnf1a.

activity profile for motif Hnf1a


Sorted Z-values histogram for motif Hnf1a

Sorted Z-values for motif Hnf1a



Network of associatons between targets according to the STRING database.


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_14598031 3.600 ENSMUST00000167776.2
 Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr19_-_14597983 3.431 ENSMUST00000052011.7
 Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr14_-_70630149 2.407 ENSMUST00000022694.9
 Dmtn
dematin actin binding protein
chr9_+_53771499 2.166 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr13_+_55152640 1.981 ENSMUST00000005452.5
 Fgfr4
fibroblast growth factor receptor 4
chr1_+_133309778 1.766 ENSMUST00000094557.4
ENSMUST00000183457.1
ENSMUST00000183738.1
ENSMUST00000185157.1
ENSMUST00000184603.1
 Golt1a

Kiss1

GOLT1A
golgi transport 1 homolog A (S. cerevisiae)

KiSS-1 metastasis-suppressor

KISS1 isoform e
chr8_-_95142477 1.122 ENSMUST00000034240.7
ENSMUST00000169748.1
 Kifc3

kinesin family member C3

chrX_-_43167817 1.105 ENSMUST00000115058.1
ENSMUST00000115059.1
 Tenm1

teneurin transmembrane protein 1

chr9_+_99629496 0.927 ENSMUST00000131095.1
ENSMUST00000078367.5
ENSMUST00000112885.2
 Dzip1l


DAZ interacting protein 1-like


chr17_+_71204647 0.903 ENSMUST00000126681.1
 Lpin2
lipin 2
chr12_+_5411641 0.871 ENSMUST00000163627.1
 2810032G03Rik
RIKEN cDNA 2810032G03 gene
chr16_-_52296924 0.844 ENSMUST00000167115.1
 Alcam
activated leukocyte cell adhesion molecule
chr5_+_8046077 0.752 ENSMUST00000088786.4
 Sri
sorcin
chr9_+_99629823 0.707 ENSMUST00000112886.2
 Dzip1l
DAZ interacting protein 1-like
chr13_-_53286052 0.599 ENSMUST00000021918.8
 Ror2
receptor tyrosine kinase-like orphan receptor 2
chr7_+_141215852 0.508 ENSMUST00000046890.5
ENSMUST00000133763.1
 Rassf7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr4_+_150853919 0.494 ENSMUST00000073600.2
 Errfi1
ERBB receptor feedback inhibitor 1
chr17_-_35132050 0.455 ENSMUST00000025249.6
 Apom
apolipoprotein M
chr1_+_125676969 0.454 ENSMUST00000027581.6
 Gpr39
G protein-coupled receptor 39
chr14_-_36919314 0.378 ENSMUST00000182797.1
 Ccser2
coiled-coil serine rich 2
chr7_+_141216626 0.351 ENSMUST00000141804.1
ENSMUST00000148975.1
 Rassf7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr16_+_20591156 0.349 ENSMUST00000159780.1
 Vwa5b2
von Willebrand factor A domain containing 5B2
chr9_-_71163224 0.322 ENSMUST00000074465.2
 Aqp9
aquaporin 9
chr11_+_118428203 0.315 ENSMUST00000124861.1
 C1qtnf1
C1q and tumor necrosis factor related protein 1
chr8_+_64947177 0.300 ENSMUST00000079896.7
ENSMUST00000026595.5
 Tmem192

transmembrane protein 192

chr14_-_36919513 0.298 ENSMUST00000182042.1
 Ccser2
coiled-coil serine rich 2
chr11_-_98022594 0.282 ENSMUST00000103144.3
ENSMUST00000017552.6
ENSMUST00000092736.4
ENSMUST00000107562.1
 Cacnb1



calcium channel, voltage-dependent, beta 1 subunit



chr5_+_122391878 0.274 ENSMUST00000102525.4
 Arpc3
actin related protein 2/3 complex, subunit 3
chr18_-_33463747 0.271 ENSMUST00000171533.1
 Nrep
neuronal regeneration related protein
chr3_+_136670076 0.250 ENSMUST00000070198.7
 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr15_-_79285502 0.235 ENSMUST00000165408.1
 Baiap2l2
BAI1-associated protein 2-like 2
chr13_-_84064772 0.214 ENSMUST00000182477.1
 Gm17750
predicted gene, 17750
chr19_+_6105774 0.185 ENSMUST00000044451.3
 Naaladl1
N-acetylated alpha-linked acidic dipeptidase-like 1
chr2_-_32424005 0.172 ENSMUST00000113307.2
 Slc25a25
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25
chr18_-_33464007 0.171 ENSMUST00000168890.1
 Nrep
neuronal regeneration related protein
chr2_-_86347764 0.156 ENSMUST00000099894.2
 Olfr1055
olfactory receptor 1055
chr2_-_155357392 0.140 ENSMUST00000165234.1
ENSMUST00000077626.6
 Pigu

phosphatidylinositol glycan anchor biosynthesis, class U

chr12_+_76533540 0.129 ENSMUST00000075249.4
 Plekhg3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr7_-_45062393 0.128 ENSMUST00000129101.1
 Prrg2
proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
chr11_+_3983704 0.121 ENSMUST00000063004.7
 Gal3st1
galactose-3-O-sulfotransferase 1
chrX_+_101376359 0.094 ENSMUST00000119080.1
 Gjb1
gap junction protein, beta 1
chr16_+_20651652 0.092 ENSMUST00000007212.8
 Psmd2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr19_+_42045792 0.087 ENSMUST00000172244.1
ENSMUST00000081714.4
 Hoga1

4-hydroxy-2-oxoglutarate aldolase 1

chr2_-_68472138 0.064 ENSMUST00000102715.3
 Stk39
serine/threonine kinase 39
chr11_+_78178105 0.062 ENSMUST00000147819.1
 Tlcd1
TLC domain containing 1
chr11_+_3983636 0.061 ENSMUST00000078757.1
 Gal3st1
galactose-3-O-sulfotransferase 1
chr5_-_114443993 0.055 ENSMUST00000112245.1
 Mmab
methylmalonic aciduria (cobalamin deficiency) type B homolog (human)
chr2_+_91265252 0.036 ENSMUST00000028691.6
 Arfgap2
ADP-ribosylation factor GTPase activating protein 2
chr14_+_80000292 0.024 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr10_+_87859255 0.017 ENSMUST00000105300.2
 Igf1
insulin-like growth factor 1
chr11_-_11898092 0.016 ENSMUST00000178704.1
 Ddc
dopa decarboxylase
chr7_-_119895446 0.010 ENSMUST00000098080.2
 Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr10_+_87859062 0.009 ENSMUST00000095360.4
 Igf1
insulin-like growth factor 1
chr7_-_79842287 0.006 ENSMUST00000049004.6
 Anpep
alanyl (membrane) aminopeptidase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0035585 calcium-mediated signaling using extracellular calcium source(GO:0035585)
0.7 2.0 GO:0061144 alveolar secondary septum development(GO:0061144)
0.4 1.8 GO:0032275 luteinizing hormone secretion(GO:0032275) positive regulation of gonadotropin secretion(GO:0032278)
0.2 0.5 GO:0035482 gastric motility(GO:0035482) gastric emptying(GO:0035483)
0.2 1.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.2 0.5 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.1 0.8 GO:0055118 negative regulation of cardiac muscle contraction(GO:0055118)
0.1 0.6 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.1 0.5 GO:0050748 negative regulation of lipoprotein metabolic process(GO:0050748)
0.1 0.3 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203)
0.0 0.3 GO:0032782 bile acid secretion(GO:0032782)
0.0 0.3 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0 6.7 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 1.9 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.9 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.1 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.0 0.1 GO:0023016 signal transduction by trans-phosphorylation(GO:0023016) regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.0 0.2 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.2 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.4 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.3 0.8 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 0.5 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.1 1.1 GO:0005915 zonula adherens(GO:0005915)
0.1 0.8 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.3 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.2 GO:0071439 clathrin complex(GO:0071439)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 1.6 GO:0005814 centriole(GO:0005814)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.2 2.0 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 7.8 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 1.8 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 0.3 GO:0015254 glycerol channel activity(GO:0015254)
0.1 1.1 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.2 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733)
0.0 0.3 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 2.4 GO:0030507 spectrin binding(GO:0030507)
0.0 0.1 GO:0034235 GPI anchor binding(GO:0034235)
0.0 0.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.6 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.2 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.2 GO:0016805 dipeptidase activity(GO:0016805)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.0 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 2.0 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.9 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.6 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 0.3 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.0 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 6.5 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 0.9 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.3 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.1 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors