Motif ID: Hnf1b

Z-value: 0.449


Transcription factors associated with Hnf1b:

Gene SymbolEntrez IDGene Name
Hnf1b ENSMUSG00000020679.5 Hnf1b



Activity profile for motif Hnf1b.

activity profile for motif Hnf1b


Sorted Z-values histogram for motif Hnf1b

Sorted Z-values for motif Hnf1b



Network of associatons between targets according to the STRING database.



First level regulatory network of Hnf1b

PNG image of the network

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Top targets:


Showing 1 to 20 of 119 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_158814469 2.815 ENSMUST00000161589.2
 Pappa2
pappalysin 2
chr13_-_53286052 1.941 ENSMUST00000021918.8
 Ror2
receptor tyrosine kinase-like orphan receptor 2
chr13_+_4191163 1.713 ENSMUST00000021634.2
 Akr1c13
aldo-keto reductase family 1, member C13
chr1_+_133309778 1.357 ENSMUST00000094557.4
ENSMUST00000183457.1
ENSMUST00000183738.1
ENSMUST00000185157.1
ENSMUST00000184603.1
 Golt1a

Kiss1

GOLT1A
golgi transport 1 homolog A (S. cerevisiae)

KiSS-1 metastasis-suppressor

KISS1 isoform e
chr19_-_14598031 1.343 ENSMUST00000167776.2
 Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr19_-_14597983 1.296 ENSMUST00000052011.7
 Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr13_+_55152640 1.042 ENSMUST00000005452.5
 Fgfr4
fibroblast growth factor receptor 4
chr7_+_100537192 1.010 ENSMUST00000120454.1
 Coa4
cytochrome c oxidase assembly factor 4
chr2_+_158768083 0.989 ENSMUST00000029183.2
 Fam83d
family with sequence similarity 83, member D
chr4_+_43957401 0.880 ENSMUST00000030202.7
 Glipr2
GLI pathogenesis-related 2
chr19_+_23723279 0.804 ENSMUST00000067077.1
 Gm9938
predicted gene 9938
chr16_-_16146771 0.691 ENSMUST00000040248.7
 Spidr
scaffolding protein involved i DNA repair
chr10_-_7212222 0.621 ENSMUST00000015346.5
 Cnksr3
Cnksr family member 3
chr12_+_108605757 0.619 ENSMUST00000109854.2
 Evl
Ena-vasodilator stimulated phosphoprotein
chr9_+_99629496 0.601 ENSMUST00000131095.1
ENSMUST00000078367.5
ENSMUST00000112885.2
 Dzip1l


DAZ interacting protein 1-like


chr7_-_119895446 0.598 ENSMUST00000098080.2
 Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr15_-_103215285 0.594 ENSMUST00000122182.1
ENSMUST00000108813.3
ENSMUST00000127191.1
 Cbx5


chromobox 5


chr4_+_150853919 0.579 ENSMUST00000073600.2
 Errfi1
ERBB receptor feedback inhibitor 1
chr12_+_5411641 0.567 ENSMUST00000163627.1
 2810032G03Rik
RIKEN cDNA 2810032G03 gene
chr17_-_35132050 0.566 ENSMUST00000025249.6
 Apom
apolipoprotein M

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 GO:0060349 bone morphogenesis(GO:0060349)
0.1 2.2 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.4 1.9 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.3 1.4 GO:0032275 luteinizing hormone secretion(GO:0032275) positive regulation of gonadotropin secretion(GO:0032278)
0.3 1.0 GO:0061144 alveolar secondary septum development(GO:0061144)
0.1 1.0 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 1.0 GO:0072698 protein localization to microtubule cytoskeleton(GO:0072698)
0.0 0.9 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.1 0.7 GO:0072757 cellular response to camptothecin(GO:0072757)
0.2 0.6 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.1 0.6 GO:0050748 negative regulation of lipoprotein metabolic process(GO:0050748)
0.1 0.6 GO:0015692 vanadium ion transport(GO:0015676) lead ion transport(GO:0015692)
0.1 0.6 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 0.6 GO:0010225 response to UV-C(GO:0010225)
0.0 0.6 GO:2000651 positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.1 0.5 GO:1904659 glucose transmembrane transport(GO:1904659)
0.1 0.4 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.1 0.4 GO:1901525 negative regulation of macromitophagy(GO:1901525)
0.0 0.4 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.4 GO:0007608 sensory perception of smell(GO:0007608)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 GO:0005814 centriole(GO:0005814)
0.1 1.0 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 1.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 0.6 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.1 0.6 GO:0070826 paraferritin complex(GO:0070826)
0.0 0.6 GO:0010369 chromocenter(GO:0010369)
0.0 0.6 GO:0030027 lamellipodium(GO:0030027)
0.1 0.4 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.2 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0 0.2 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.2 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.1 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.0 0.1 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.1 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.1 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.1 GO:0035631 IkappaB kinase complex(GO:0008385) CD40 receptor complex(GO:0035631)
0.0 0.1 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 2.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.9 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 1.7 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.1 1.4 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 1.0 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 1.0 GO:0019894 kinesin binding(GO:0019894)
0.1 0.6 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 0.6 GO:0005522 profilin binding(GO:0005522)
0.0 0.6 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.5 GO:0070402 NADPH binding(GO:0070402)
0.1 0.4 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.4 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.4 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 0.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.3 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733)
0.0 0.3 GO:0070739 protein-glutamic acid ligase activity(GO:0070739)
0.0 0.3 GO:0042165 neurotransmitter binding(GO:0042165)
0.1 0.2 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.1 0.2 GO:0048019 receptor antagonist activity(GO:0048019)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.6 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 2.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.0 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.6 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.6 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.6 PID_AURORA_B_PATHWAY Aurora B signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.8 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 2.4 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.0 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 1.0 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.6 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.3 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.2 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0 0.2 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.2 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.1 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.1 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.1 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation