Motif ID: Hnf1b
Z-value: 0.449
Transcription factors associated with Hnf1b:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Hnf1b | ENSMUSG00000020679.5 | Hnf1b |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.9 | GO:0007223 | Wnt signaling pathway, calcium modulating pathway(GO:0007223) |
0.3 | 1.0 | GO:0061144 | alveolar secondary septum development(GO:0061144) |
0.3 | 1.4 | GO:0032275 | luteinizing hormone secretion(GO:0032275) positive regulation of gonadotropin secretion(GO:0032278) |
0.2 | 0.6 | GO:0042536 | negative regulation of tumor necrosis factor biosynthetic process(GO:0042536) |
0.2 | 0.3 | GO:0035482 | gastric motility(GO:0035482) gastric emptying(GO:0035483) |
0.1 | 0.6 | GO:0050748 | negative regulation of lipoprotein metabolic process(GO:0050748) |
0.1 | 0.7 | GO:0072757 | cellular response to camptothecin(GO:0072757) |
0.1 | 0.6 | GO:0015692 | vanadium ion transport(GO:0015676) lead ion transport(GO:0015692) |
0.1 | 0.4 | GO:0044861 | protein transport into plasma membrane raft(GO:0044861) |
0.1 | 0.6 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
0.1 | 0.5 | GO:1904659 | glucose transmembrane transport(GO:1904659) |
0.1 | 0.2 | GO:1904956 | regulation of endodermal cell fate specification(GO:0042663) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of heart induction(GO:1901321) regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066) |
0.1 | 0.3 | GO:0044830 | modulation by host of viral RNA genome replication(GO:0044830) |
0.1 | 1.0 | GO:0097034 | mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034) |
0.1 | 0.2 | GO:0021691 | cerebellar Purkinje cell layer maturation(GO:0021691) |
0.1 | 0.4 | GO:1901525 | negative regulation of macromitophagy(GO:1901525) |
0.1 | 0.2 | GO:0032382 | positive regulation of intracellular lipid transport(GO:0032379) positive regulation of intracellular sterol transport(GO:0032382) positive regulation of intracellular cholesterol transport(GO:0032385) lipid hydroperoxide transport(GO:1901373) |
0.1 | 0.2 | GO:0007217 | tachykinin receptor signaling pathway(GO:0007217) |
0.1 | 2.2 | GO:0006805 | xenobiotic metabolic process(GO:0006805) |
0.0 | 0.1 | GO:0097274 | urea homeostasis(GO:0097274) |
0.0 | 0.2 | GO:0034196 | acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) |
0.0 | 0.6 | GO:0010225 | response to UV-C(GO:0010225) |
0.0 | 0.2 | GO:1900220 | semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220) |
0.0 | 0.1 | GO:0052695 | cellular glucuronidation(GO:0052695) |
0.0 | 0.1 | GO:0000957 | mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960) |
0.0 | 0.3 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
0.0 | 0.1 | GO:0060737 | prostate epithelial cord elongation(GO:0060523) prostate gland morphogenetic growth(GO:0060737) |
0.0 | 0.3 | GO:0018095 | protein polyglutamylation(GO:0018095) |
0.0 | 0.1 | GO:1903347 | negative regulation of bicellular tight junction assembly(GO:1903347) |
0.0 | 0.4 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
0.0 | 0.1 | GO:0034436 | glycoprotein transport(GO:0034436) |
0.0 | 0.2 | GO:0032782 | bile acid secretion(GO:0032782) |
0.0 | 0.1 | GO:0015705 | iodide transport(GO:0015705) |
0.0 | 0.2 | GO:0006104 | succinyl-CoA metabolic process(GO:0006104) |
0.0 | 2.8 | GO:0060349 | bone morphogenesis(GO:0060349) |
0.0 | 0.6 | GO:2000651 | positive regulation of sodium ion transmembrane transporter activity(GO:2000651) |
0.0 | 0.1 | GO:2000857 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
0.0 | 1.0 | GO:0072698 | protein localization to microtubule cytoskeleton(GO:0072698) |
0.0 | 0.1 | GO:1904884 | telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884) |
0.0 | 0.1 | GO:0090400 | stress-induced premature senescence(GO:0090400) |
0.0 | 0.1 | GO:0090070 | positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234) |
0.0 | 0.3 | GO:0098743 | cartilage condensation(GO:0001502) cell aggregation(GO:0098743) |
0.0 | 0.2 | GO:0006817 | phosphate ion transport(GO:0006817) |
0.0 | 0.1 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
0.0 | 0.9 | GO:0010718 | positive regulation of epithelial to mesenchymal transition(GO:0010718) |
0.0 | 0.0 | GO:0015886 | heme transport(GO:0015886) |
0.0 | 0.1 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) |
0.0 | 0.4 | GO:0007608 | sensory perception of smell(GO:0007608) |
0.0 | 0.2 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
0.0 | 0.1 | GO:0042989 | sequestering of actin monomers(GO:0042989) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 0.6 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
0.1 | 0.6 | GO:0070826 | paraferritin complex(GO:0070826) |
0.1 | 0.4 | GO:0044352 | pinosome(GO:0044352) macropinosome(GO:0044354) |
0.1 | 1.0 | GO:0097431 | mitotic spindle pole(GO:0097431) |
0.0 | 0.2 | GO:0030062 | mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062) |
0.0 | 0.2 | GO:0031315 | extrinsic component of mitochondrial outer membrane(GO:0031315) |
0.0 | 0.6 | GO:0010369 | chromocenter(GO:0010369) |
0.0 | 0.1 | GO:0034361 | very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385) |
0.0 | 0.1 | GO:0061689 | tricellular tight junction(GO:0061689) |
0.0 | 1.0 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
0.0 | 0.2 | GO:0030126 | COPI vesicle coat(GO:0030126) |
0.0 | 0.1 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
0.0 | 0.2 | GO:0031528 | microvillus membrane(GO:0031528) |
0.0 | 0.6 | GO:0030027 | lamellipodium(GO:0030027) |
0.0 | 0.1 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
0.0 | 0.2 | GO:0030127 | COPII vesicle coat(GO:0030127) |
0.0 | 0.1 | GO:0035631 | IkappaB kinase complex(GO:0008385) CD40 receptor complex(GO:0035631) |
0.0 | 0.1 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
0.0 | 1.2 | GO:0005814 | centriole(GO:0005814) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 1.0 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
0.1 | 0.6 | GO:0015086 | cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639) |
0.1 | 1.7 | GO:0004033 | aldo-keto reductase (NADP) activity(GO:0004033) |
0.1 | 0.2 | GO:0004774 | succinate-CoA ligase activity(GO:0004774) |
0.1 | 0.2 | GO:0048019 | receptor antagonist activity(GO:0048019) |
0.1 | 0.3 | GO:0001733 | galactosylceramide sulfotransferase activity(GO:0001733) |
0.1 | 0.4 | GO:0004984 | olfactory receptor activity(GO:0004984) |
0.1 | 1.4 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
0.1 | 1.9 | GO:0017147 | Wnt-protein binding(GO:0017147) |
0.1 | 0.2 | GO:0050632 | propanoyl-CoA C-acyltransferase activity(GO:0033814) propionyl-CoA C2-trimethyltridecanoyltransferase activity(GO:0050632) phosphatidylethanolamine transporter activity(GO:1904121) |
0.1 | 0.2 | GO:0000832 | inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724) |
0.1 | 0.2 | GO:0004703 | G-protein coupled receptor kinase activity(GO:0004703) |
0.0 | 0.1 | GO:0005128 | erythropoietin receptor binding(GO:0005128) |
0.0 | 0.6 | GO:0005522 | profilin binding(GO:0005522) |
0.0 | 0.1 | GO:0008384 | IkappaB kinase activity(GO:0008384) |
0.0 | 0.1 | GO:0034437 | glycoprotein transporter activity(GO:0034437) |
0.0 | 3.1 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
0.0 | 0.4 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
0.0 | 0.1 | GO:0015111 | iodide transmembrane transporter activity(GO:0015111) |
0.0 | 2.8 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
0.0 | 0.3 | GO:0070739 | protein-glutamic acid ligase activity(GO:0070739) |
0.0 | 0.1 | GO:0031798 | type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
0.0 | 0.4 | GO:0005355 | glucose transmembrane transporter activity(GO:0005355) |
0.0 | 0.5 | GO:0070402 | NADPH binding(GO:0070402) |
0.0 | 0.1 | GO:0015254 | glycerol channel activity(GO:0015254) |
0.0 | 0.4 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
0.0 | 0.1 | GO:0032767 | copper-dependent protein binding(GO:0032767) |
0.0 | 0.6 | GO:0097602 | cullin family protein binding(GO:0097602) |
0.0 | 0.0 | GO:0001226 | RNA polymerase II transcription corepressor binding(GO:0001226) |
0.0 | 0.0 | GO:0015232 | heme transporter activity(GO:0015232) |
0.0 | 0.1 | GO:0031545 | peptidyl-proline 4-dioxygenase activity(GO:0031545) |
0.0 | 0.3 | GO:0042165 | neurotransmitter binding(GO:0042165) |
0.0 | 0.2 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
0.0 | 1.0 | GO:0019894 | kinesin binding(GO:0019894) |
0.0 | 0.1 | GO:0032405 | MutLalpha complex binding(GO:0032405) MutSalpha complex binding(GO:0032407) |
0.0 | 0.2 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
0.0 | 0.1 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
0.0 | 0.2 | GO:0005537 | mannose binding(GO:0005537) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 2.2 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
0.1 | 2.6 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
0.0 | 2.9 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
0.0 | 0.6 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
0.0 | 1.0 | PID_FGF_PATHWAY | FGF signaling pathway |
0.0 | 0.6 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
0.0 | 0.6 | PID_AURORA_B_PATHWAY | Aurora B signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 2.8 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
0.1 | 1.0 | REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
0.0 | 0.6 | REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES | Genes involved in Generation of second messenger molecules |
0.0 | 2.4 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
0.0 | 0.2 | REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
0.0 | 0.2 | REACTOME_COPI_MEDIATED_TRANSPORT | Genes involved in COPI Mediated Transport |
0.0 | 0.1 | REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL | Genes involved in NF-kB is activated and signals survival |
0.0 | 0.1 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
0.0 | 0.1 | REACTOME_GLUCURONIDATION | Genes involved in Glucuronidation |
0.0 | 1.0 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
0.0 | 0.3 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
0.0 | 0.2 | REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE | Genes involved in Citric acid cycle (TCA cycle) |