Motif ID: Hnf4a

Z-value: 0.816


Transcription factors associated with Hnf4a:

Gene SymbolEntrez IDGene Name
Hnf4a ENSMUSG00000017950.10 Hnf4a



Activity profile for motif Hnf4a.

activity profile for motif Hnf4a


Sorted Z-values histogram for motif Hnf4a

Sorted Z-values for motif Hnf4a



Network of associatons between targets according to the STRING database.



First level regulatory network of Hnf4a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_101840602 5.918 ENSMUST00000159314.1
 Lmo7
LIM domain only 7
chr14_+_101840501 5.393 ENSMUST00000159026.1
 Lmo7
LIM domain only 7
chr15_+_3270767 5.080 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr9_-_77347816 4.382 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
 Mlip



muscular LMNA-interacting protein



chr16_-_22439719 4.071 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr9_-_77347787 3.540 ENSMUST00000184848.1
ENSMUST00000184415.1
 Mlip

muscular LMNA-interacting protein

chr7_+_45896941 3.536 ENSMUST00000069772.7
ENSMUST00000107716.1
 Tmem143

transmembrane protein 143

chr2_-_131042682 3.282 ENSMUST00000028787.5
ENSMUST00000110239.1
ENSMUST00000110234.1
 Gfra4


glial cell line derived neurotrophic factor family receptor alpha 4


chr7_+_112225856 3.031 ENSMUST00000050149.5
ENSMUST00000106647.1
ENSMUST00000106648.1
 Mical2


microtubule associated monooxygenase, calponin and LIM domain containing 2


chr11_-_81968415 2.913 ENSMUST00000066197.6
 Asic2
acid-sensing (proton-gated) ion channel 2
chr2_-_131043088 2.902 ENSMUST00000110240.3
ENSMUST00000066958.4
ENSMUST00000110235.1
 Gfra4


glial cell line derived neurotrophic factor family receptor alpha 4


chr11_+_104282371 2.845 ENSMUST00000106988.1
ENSMUST00000106989.1
 Mapt

microtubule-associated protein tau

chr4_+_136286061 2.541 ENSMUST00000069195.4
ENSMUST00000130658.1
 Zfp46

zinc finger protein 46

chrX_-_162565514 2.493 ENSMUST00000154424.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chr15_+_82252397 2.463 ENSMUST00000136948.1
 1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr7_+_45897429 2.365 ENSMUST00000140243.1
 Tmem143
transmembrane protein 143
chr8_-_113848615 2.096 ENSMUST00000093113.4
 Adamts18
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18
chr8_-_13200576 1.982 ENSMUST00000165605.2
 Grtp1
GH regulated TBC protein 1
chr11_+_78499087 1.951 ENSMUST00000017488.4
 Vtn
vitronectin
chr7_+_25268387 1.879 ENSMUST00000169392.1
 Cic
capicua homolog (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.9 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.1 6.2 GO:0030279 negative regulation of ossification(GO:0030279)
0.0 5.0 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.8 4.1 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.5 4.0 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.6 3.0 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
1.0 2.9 GO:0050915 sensory perception of sour taste(GO:0050915)
0.5 2.8 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.3 2.8 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.3 2.8 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.4 2.7 GO:0015862 uridine transport(GO:0015862)
0.2 2.6 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.4 2.4 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.0 2.4 GO:0007605 sensory perception of sound(GO:0007605)
0.1 2.1 GO:0033344 cholesterol efflux(GO:0033344)
0.2 2.0 GO:0097421 liver regeneration(GO:0097421)
0.0 2.0 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.3 1.9 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 1.8 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.1 1.8 GO:0032467 positive regulation of cytokinesis(GO:0032467)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 7.1 GO:0016605 PML body(GO:0016605)
0.0 4.1 GO:0043197 dendritic spine(GO:0043197)
0.4 4.0 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 3.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 3.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 3.0 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.3 2.8 GO:0045298 tubulin complex(GO:0045298)
0.1 2.8 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.4 2.0 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 1.8 GO:0030057 desmosome(GO:0030057)
0.1 1.7 GO:0016460 myosin II complex(GO:0016460)
0.0 1.7 GO:0031225 anchored component of membrane(GO:0031225)
0.4 1.6 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.1 1.6 GO:0031528 microvillus membrane(GO:0031528)
0.2 1.5 GO:0070695 FHF complex(GO:0070695)
0.0 1.4 GO:0016324 apical plasma membrane(GO:0016324)
0.1 1.2 GO:0097427 microtubule bundle(GO:0097427)
0.0 1.0 GO:0048786 presynaptic active zone(GO:0048786)
0.0 1.0 GO:0005882 intermediate filament(GO:0005882)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.3 GO:0042805 actinin binding(GO:0042805)
0.1 7.2 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
2.1 6.2 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.1 2.9 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 2.9 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
0.5 2.8 GO:0070699 type II activin receptor binding(GO:0070699)
0.4 2.8 GO:0099609 microtubule lateral binding(GO:0099609)
0.1 2.8 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.1 2.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 2.4 GO:0051059 NF-kappaB binding(GO:0051059)
0.6 2.3 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.1 2.1 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 2.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 2.0 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 2.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.6 1.9 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.4 1.8 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 1.8 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 1.8 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.2 1.6 GO:0015616 DNA translocase activity(GO:0015616)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.1 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 3.0 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 2.8 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 2.7 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 2.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.0 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 1.8 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.3 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 1.2 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.2 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.0 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 0.8 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.7 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.7 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.6 PID_SHP2_PATHWAY SHP2 signaling
0.0 0.3 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 0.2 PID_EPHA_FWDPATHWAY EPHA forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 4.6 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 3.0 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.1 2.8 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 2.8 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 2.8 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 2.6 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.2 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 1.1 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.1 1.0 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 1.0 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 1.0 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 0.9 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 0.8 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.8 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.8 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 0.8 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.7 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.7 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D Genes involved in Metabolism of steroid hormones and vitamins A and D