Motif ID: Hnf4g

Z-value: 1.435


Transcription factors associated with Hnf4g:

Gene SymbolEntrez IDGene Name
Hnf4g ENSMUSG00000017688.8 Hnf4g



Activity profile for motif Hnf4g.

activity profile for motif Hnf4g


Sorted Z-values histogram for motif Hnf4g

Sorted Z-values for motif Hnf4g



Network of associatons between targets according to the STRING database.



First level regulatory network of Hnf4g

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_112159034 10.665 ENSMUST00000033036.5
 Dkk3
dickkopf homolog 3 (Xenopus laevis)
chr16_+_18776839 8.651 ENSMUST00000043577.1
 Cldn5
claudin 5
chr16_+_91269759 8.450 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr15_-_66801577 7.015 ENSMUST00000168589.1
 Sla
src-like adaptor
chr2_-_104257400 6.764 ENSMUST00000141159.1
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chr2_-_131042682 6.072 ENSMUST00000028787.5
ENSMUST00000110239.1
ENSMUST00000110234.1
 Gfra4


glial cell line derived neurotrophic factor family receptor alpha 4


chr2_-_25470031 5.989 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr15_-_66948419 5.565 ENSMUST00000167817.1
 Ndrg1
N-myc downstream regulated gene 1
chr15_+_82252397 5.426 ENSMUST00000136948.1
 1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr18_+_61105561 5.379 ENSMUST00000025523.6
 Csf1r
colony stimulating factor 1 receptor
chr2_-_25469742 5.094 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr1_+_91179822 4.840 ENSMUST00000097648.4
ENSMUST00000165855.1
 Ramp1

receptor (calcitonin) activity modifying protein 1

chr2_+_76406529 4.199 ENSMUST00000111929.1
ENSMUST00000077972.4
ENSMUST00000111930.2
 Osbpl6


oxysterol binding protein-like 6


chr13_-_92131494 3.958 ENSMUST00000099326.3
ENSMUST00000146492.1
 Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2

chr2_+_25395866 3.882 ENSMUST00000028328.2
 Entpd2
ectonucleoside triphosphate diphosphohydrolase 2
chr1_-_162866502 3.851 ENSMUST00000046049.7
 Fmo1
flavin containing monooxygenase 1
chr11_+_111066154 3.794 ENSMUST00000042970.2
 Kcnj2
potassium inwardly-rectifying channel, subfamily J, member 2
chr13_-_37050237 3.758 ENSMUST00000164727.1
 F13a1
coagulation factor XIII, A1 subunit
chr2_-_131043088 3.647 ENSMUST00000110240.3
ENSMUST00000066958.4
ENSMUST00000110235.1
 Gfra4


glial cell line derived neurotrophic factor family receptor alpha 4


chr15_-_77956658 3.639 ENSMUST00000117725.1
ENSMUST00000016696.6
 Foxred2

FAD-dependent oxidoreductase domain containing 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 553 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 10.8 GO:2000065 negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065)
2.1 10.6 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
1.4 8.7 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.1 8.7 GO:0030279 negative regulation of ossification(GO:0030279)
2.5 7.4 GO:0042196 dichloromethane metabolic process(GO:0018900) chlorinated hydrocarbon metabolic process(GO:0042196) halogenated hydrocarbon metabolic process(GO:0042197)
1.2 7.2 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
1.8 7.0 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
0.6 6.3 GO:0015824 proline transport(GO:0015824)
0.5 5.6 GO:0070995 NADPH oxidation(GO:0070995)
0.5 5.5 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.2 5.4 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.7 5.3 GO:0009181 purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
0.1 5.1 GO:0048709 oligodendrocyte differentiation(GO:0048709)
0.2 4.6 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.5 4.5 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.2 4.4 GO:0034340 response to type I interferon(GO:0034340)
0.7 4.2 GO:2001204 regulation of osteoclast development(GO:2001204)
0.4 4.2 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.7 4.1 GO:0002317 plasma cell differentiation(GO:0002317)
0.5 4.1 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 206 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 65.6 GO:0016021 integral component of membrane(GO:0016021)
0.0 34.3 GO:0005615 extracellular space(GO:0005615)
0.2 14.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 10.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 9.3 GO:0031225 anchored component of membrane(GO:0031225)
0.2 8.6 GO:0005604 basement membrane(GO:0005604)
0.1 8.0 GO:0005581 collagen trimer(GO:0005581)
2.6 7.8 GO:1990682 CSF1-CSF1R complex(GO:1990682)
1.4 7.2 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.4 7.1 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.1 6.0 GO:0031526 brush border membrane(GO:0031526)
0.1 5.4 GO:0060170 ciliary membrane(GO:0060170)
0.0 5.3 GO:0008021 synaptic vesicle(GO:0008021)
0.3 5.0 GO:0097449 astrocyte projection(GO:0097449)
0.1 4.5 GO:0072562 blood microparticle(GO:0072562)
0.1 4.4 GO:0055038 recycling endosome membrane(GO:0055038)
0.3 4.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.3 3.6 GO:0043203 axon hillock(GO:0043203)
0.5 3.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.4 3.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 343 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 10.6 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
3.2 9.7 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.5 8.1 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
2.5 7.4 GO:0019120 hydrolase activity, acting on acid halide bonds(GO:0016824) hydrolase activity, acting on acid halide bonds, in C-halide compounds(GO:0019120) alkylhalidase activity(GO:0047651)
1.4 7.2 GO:0097643 amylin receptor activity(GO:0097643)
0.1 6.5 GO:0005125 cytokine activity(GO:0005125)
0.3 6.4 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 5.5 GO:0005518 collagen binding(GO:0005518)
0.1 5.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.7 5.0 GO:0016160 alpha-amylase activity(GO:0004556) amylase activity(GO:0016160)
0.2 4.8 GO:0022839 ion gated channel activity(GO:0022839)
0.7 4.6 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.2 4.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 4.5 GO:0019955 cytokine binding(GO:0019955)
0.4 4.3 GO:0043262 adenosine-diphosphatase activity(GO:0043262)
0.1 4.1 GO:0005179 hormone activity(GO:0005179)
0.0 4.1 GO:0005096 GTPase activator activity(GO:0005096)
0.9 3.8 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.7 3.7 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.4 3.6 GO:1990239 steroid hormone binding(GO:1990239)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 15.2 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 14.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 10.6 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 10.4 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 10.1 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 5.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 4.7 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 4.7 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 4.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 4.3 NABA_MATRISOME_ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.1 3.4 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 3.3 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.2 3.1 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 2.9 PID_IL23_PATHWAY IL23-mediated signaling events
0.1 2.8 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.2 2.7 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 2.5 PID_ARF6_PATHWAY Arf6 signaling events
0.0 2.5 PID_MTOR_4PATHWAY mTOR signaling pathway
0.2 2.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 2.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.3 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.4 7.8 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 7.0 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.2 7.0 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 6.7 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
1.1 6.6 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 5.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 5.6 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.2 5.5 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 5.3 REACTOME_TRNA_AMINOACYLATION Genes involved in tRNA Aminoacylation
0.1 5.1 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.2 4.8 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.6 4.5 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.1 3.8 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 3.8 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.6 3.6 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.4 3.5 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 3.5 REACTOME_CELL_CELL_JUNCTION_ORGANIZATION Genes involved in Cell-cell junction organization
0.1 3.5 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.4 3.3 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases