Motif ID: Hoxa13

Z-value: 0.873


Transcription factors associated with Hoxa13:

Gene SymbolEntrez IDGene Name
Hoxa13 ENSMUSG00000038203.12 Hoxa13



Activity profile for motif Hoxa13.

activity profile for motif Hoxa13


Sorted Z-values histogram for motif Hoxa13

Sorted Z-values for motif Hoxa13



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa13

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_144893127 4.325 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr17_+_75178797 3.817 ENSMUST00000112516.1
ENSMUST00000135447.1
 Ltbp1

latent transforming growth factor beta binding protein 1

chr14_+_65805832 3.599 ENSMUST00000022612.3
 Pbk
PDZ binding kinase
chr1_-_45503282 3.576 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr11_-_84067063 3.494 ENSMUST00000108101.1
 Dusp14
dual specificity phosphatase 14
chr17_+_75178911 3.422 ENSMUST00000112514.1
 Ltbp1
latent transforming growth factor beta binding protein 1
chr14_+_65806066 3.418 ENSMUST00000139644.1
 Pbk
PDZ binding kinase
chr4_-_133967296 3.327 ENSMUST00000105893.1
 Hmgn2
high mobility group nucleosomal binding domain 2
chrY_-_1286563 3.210 ENSMUST00000091190.5
 Ddx3y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr2_-_18048784 3.158 ENSMUST00000142856.1
 Skida1
SKI/DACH domain containing 1
chr5_-_62766153 3.096 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr4_-_154636831 2.877 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
 Prdm16






PR domain containing 16






chr5_+_64812336 2.827 ENSMUST00000166409.1
 Klf3
Kruppel-like factor 3 (basic)
chr3_-_49757257 2.809 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr2_-_129297205 2.771 ENSMUST00000052708.6
 Ckap2l
cytoskeleton associated protein 2-like
chr6_-_125494754 2.633 ENSMUST00000032492.8
 Cd9
CD9 antigen
chr10_-_116972609 2.587 ENSMUST00000092165.4
 Gm10271
predicted gene 10271
chr1_-_173942445 2.583 ENSMUST00000042228.8
ENSMUST00000081216.5
ENSMUST00000129829.1
ENSMUST00000123708.1
ENSMUST00000111210.2
 Ifi203



Mndal
interferon activated gene 203



myeloid nuclear differentiation antigen like
chrX_+_106920618 2.515 ENSMUST00000060576.7
 Lpar4
lysophosphatidic acid receptor 4
chr14_+_28511344 2.486 ENSMUST00000112272.1
 Wnt5a
wingless-related MMTV integration site 5A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 148 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.5 GO:0070303 negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
0.3 7.2 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.4 6.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 5.8 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.1 3.7 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
1.2 3.6 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.2 3.5 GO:0097113 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.0 3.4 GO:0046847 filopodium assembly(GO:0046847)
0.4 2.9 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.1 2.9 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 2.8 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.4 2.6 GO:0030913 paranodal junction assembly(GO:0030913)
0.1 2.6 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.8 2.5 GO:0061349 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) hypophysis morphogenesis(GO:0048850) cervix development(GO:0060067) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354)
0.5 2.4 GO:0071879 positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.1 2.4 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.1 2.3 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 2.1 GO:0035493 SNARE complex assembly(GO:0035493)
0.4 2.0 GO:0046864 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143)
0.3 2.0 GO:0035754 B cell chemotaxis(GO:0035754)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 7.2 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.1 5.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
1.2 3.6 GO:0005588 collagen type V trimer(GO:0005588)
0.1 3.4 GO:0016459 myosin complex(GO:0016459)
0.0 3.3 GO:0045177 apical part of cell(GO:0045177)
0.6 2.5 GO:0008623 CHRAC(GO:0008623)
0.0 2.5 GO:0036064 ciliary basal body(GO:0036064)
0.5 2.4 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.1 2.4 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 2.4 GO:0043296 apical junction complex(GO:0043296)
0.0 2.3 GO:0070469 respiratory chain(GO:0070469)
0.4 2.1 GO:0070820 tertiary granule(GO:0070820)
0.0 2.0 GO:0000791 euchromatin(GO:0000791)
0.4 1.8 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.3 1.8 GO:0097513 myosin II filament(GO:0097513)
0.1 1.7 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 1.7 GO:0016235 aggresome(GO:0016235)
0.1 1.6 GO:0042788 polysomal ribosome(GO:0042788)
0.0 1.6 GO:0060077 inhibitory synapse(GO:0060077)
0.2 1.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 116 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 7.2 GO:0050436 microfibril binding(GO:0050436)
0.0 5.0 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 4.8 GO:0051015 actin filament binding(GO:0051015)
0.6 4.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 3.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.2 3.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 3.5 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.2 3.3 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 3.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 2.9 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 2.9 GO:0033613 activating transcription factor binding(GO:0033613)
0.8 2.5 GO:0005110 frizzled-2 binding(GO:0005110)
0.4 2.5 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.4 2.5 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 2.4 GO:0030507 spectrin binding(GO:0030507)
0.0 2.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 2.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 2.1 GO:0042169 SH2 domain binding(GO:0042169)
0.5 2.0 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.3 2.0 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.0 NABA_COLLAGENS Genes encoding collagen proteins
0.1 3.6 PID_ARF6_PATHWAY Arf6 signaling events
0.1 3.2 PID_ATM_PATHWAY ATM pathway
0.1 2.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.5 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 2.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 2.4 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 2.2 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 1.8 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.1 1.7 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 1.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.5 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.5 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.1 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.0 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 1.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.9 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.9 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.8 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 3.3 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 3.0 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.2 2.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.2 2.0 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 2.0 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 1.8 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 1.8 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 1.7 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.7 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.1 1.5 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 1.4 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 1.4 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 1.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 1.3 REACTOME_DNA_REPAIR Genes involved in DNA Repair
0.1 1.2 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.0 1.2 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.1 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 1.1 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.1 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP