Motif ID: Hoxa4

Z-value: 0.837


Transcription factors associated with Hoxa4:

Gene SymbolEntrez IDGene Name
Hoxa4 ENSMUSG00000000942.10 Hoxa4



Activity profile for motif Hoxa4.

activity profile for motif Hoxa4


Sorted Z-values histogram for motif Hoxa4

Sorted Z-values for motif Hoxa4



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_71528657 6.428 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr2_-_77519565 3.768 ENSMUST00000111830.2
 Zfp385b
zinc finger protein 385B
chr7_-_19699008 3.577 ENSMUST00000174355.1
ENSMUST00000172983.1
ENSMUST00000174710.1
ENSMUST00000167646.2
ENSMUST00000003066.9
ENSMUST00000174064.1
 Apoe





apolipoprotein E





chr4_+_144892813 3.450 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr2_+_170731807 2.856 ENSMUST00000029075.4
 Dok5
docking protein 5
chr4_+_144893077 2.679 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_144893127 2.387 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr3_+_86070915 2.037 ENSMUST00000182666.1
 Sh3d19
SH3 domain protein D19
chr18_+_37435602 1.888 ENSMUST00000055495.5
 Pcdhb12
protocadherin beta 12
chr14_-_79771305 1.842 ENSMUST00000039568.5
 Pcdh8
protocadherin 8
chr1_-_190170671 1.596 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr12_+_38780284 1.519 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr3_+_5218546 1.481 ENSMUST00000026284.6
 Zfhx4
zinc finger homeodomain 4
chr5_+_17574726 1.346 ENSMUST00000169603.1
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr12_+_38780817 1.281 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr15_+_32920723 1.252 ENSMUST00000022871.5
 Sdc2
syndecan 2
chr2_+_109917639 1.251 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr18_+_76059458 1.205 ENSMUST00000167921.1
 Zbtb7c
zinc finger and BTB domain containing 7C
chr5_+_137030275 1.196 ENSMUST00000041543.8
 Vgf
VGF nerve growth factor inducible
chr15_-_56694525 1.160 ENSMUST00000050544.7
 Has2
hyaluronan synthase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 8.6 GO:0042572 retinol metabolic process(GO:0042572)
2.1 6.4 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.4 4.9 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 4.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.2 3.6 GO:1903002 regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002)
0.0 3.6 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.2 2.9 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.1 2.0 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 1.8 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.1 1.8 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.5 1.6 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.0 1.6 GO:0030032 lamellipodium assembly(GO:0030032)
0.4 1.3 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.2 1.3 GO:0003350 pulmonary myocardium development(GO:0003350)
0.4 1.2 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.3 1.2 GO:1900623 positive regulation of keratinocyte proliferation(GO:0010838) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 1.2 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.1 1.2 GO:0043084 penile erection(GO:0043084)
0.4 1.1 GO:0072092 ureteric bud invasion(GO:0072092)
0.3 1.0 GO:0001543 ovarian follicle rupture(GO:0001543)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 3.6 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.0 3.3 GO:0001650 fibrillar center(GO:0001650)
0.0 1.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.7 GO:0048786 presynaptic active zone(GO:0048786)
0.0 1.2 GO:0030667 secretory granule membrane(GO:0030667)
0.1 1.1 GO:0032279 asymmetric synapse(GO:0032279)
0.0 1.1 GO:0005871 kinesin complex(GO:0005871)
0.2 1.0 GO:0044308 axonal spine(GO:0044308)
0.3 0.8 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.2 0.8 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.7 GO:0032420 stereocilium(GO:0032420)
0.0 0.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.2 0.6 GO:0044299 C-fiber(GO:0044299)
0.0 0.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.6 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.6 GO:0035371 microtubule plus-end(GO:0035371)
0.1 0.5 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.5 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 8.5 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 6.3 GO:0003682 chromatin binding(GO:0003682)
0.0 5.5 GO:0005509 calcium ion binding(GO:0005509)
0.0 4.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 3.8 GO:0002039 p53 binding(GO:0002039)
1.2 3.6 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.1 3.0 GO:0005158 insulin receptor binding(GO:0005158)
0.0 2.2 GO:0000287 magnesium ion binding(GO:0000287)
0.3 2.1 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.2 1.9 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.2 1.8 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.3 1.7 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 1.7 GO:0070064 proline-rich region binding(GO:0070064)
0.1 1.4 GO:0050693 LBD domain binding(GO:0050693)
0.1 1.3 GO:0038191 neuropilin binding(GO:0038191)
0.4 1.2 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 1.2 GO:0030275 LRR domain binding(GO:0030275)
0.1 1.2 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.1 GO:0003777 microtubule motor activity(GO:0003777)
0.1 1.0 GO:0004351 glutamate decarboxylase activity(GO:0004351)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.2 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 6.5 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 4.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 2.9 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 1.3 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 1.2 PID_FGF_PATHWAY FGF signaling pathway
0.0 1.1 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.0 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 0.8 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.8 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.8 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.7 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.6 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.5 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.5 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.5 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.3 PID_MYC_PATHWAY C-MYC pathway
0.0 0.2 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 0.2 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.6 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 2.9 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 1.8 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 1.5 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 1.2 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 1.2 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.0 1.0 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 1.0 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 0.8 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.8 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.2 0.7 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.7 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.6 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.5 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.5 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.5 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.5 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.5 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.1 0.4 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.4 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway