Motif ID: Hoxa5

Z-value: 0.716


Transcription factors associated with Hoxa5:

Gene SymbolEntrez IDGene Name
Hoxa5 ENSMUSG00000038253.6 Hoxa5



Activity profile for motif Hoxa5.

activity profile for motif Hoxa5


Sorted Z-values histogram for motif Hoxa5

Sorted Z-values for motif Hoxa5



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_17574268 4.063 ENSMUST00000030568.7
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr5_+_17574726 2.818 ENSMUST00000169603.1
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr16_+_43508118 2.611 ENSMUST00000114690.1
 Zbtb20
zinc finger and BTB domain containing 20
chrX_+_66653003 1.915 ENSMUST00000036043.4
 Slitrk2
SLIT and NTRK-like family, member 2
chr9_-_58313189 1.874 ENSMUST00000061799.8
 Loxl1
lysyl oxidase-like 1
chr16_+_43247278 1.598 ENSMUST00000114691.1
ENSMUST00000079441.6
 Zbtb20

zinc finger and BTB domain containing 20

chr5_+_3343893 1.484 ENSMUST00000165117.1
 Cdk6
cyclin-dependent kinase 6
chr3_+_62419668 1.462 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr8_-_99416397 1.398 ENSMUST00000155527.1
ENSMUST00000142129.1
ENSMUST00000093249.4
ENSMUST00000142475.2
ENSMUST00000128860.1
 Cdh8




cadherin 8




chrY_+_1010543 1.391 ENSMUST00000091197.3
 Eif2s3y
eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked
chrY_-_1286563 1.331 ENSMUST00000091190.5
 Ddx3y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr1_+_104768510 1.290 ENSMUST00000062528.8
 Cdh20
cadherin 20
chr3_-_116968969 1.269 ENSMUST00000143611.1
ENSMUST00000040097.7
 Palmd

palmdelphin

chr4_+_128846163 1.247 ENSMUST00000138291.1
 Gm12968
predicted gene 12968
chr1_+_169655493 1.227 ENSMUST00000027997.3
 Rgs5
regulator of G-protein signaling 5
chr11_+_16752203 1.195 ENSMUST00000102884.3
ENSMUST00000020329.6
 Egfr

epidermal growth factor receptor

chr5_-_62766153 1.136 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr8_+_57455898 1.050 ENSMUST00000034023.3
 Scrg1
scrapie responsive gene 1
chr6_+_17463749 1.035 ENSMUST00000115443.1
 Met
met proto-oncogene
chr17_-_31636631 0.968 ENSMUST00000135425.1
ENSMUST00000151718.1
ENSMUST00000155814.1
 Cbs


cystathionine beta-synthase



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 173 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 6.9 GO:0003350 pulmonary myocardium development(GO:0003350)
0.1 4.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 3.2 GO:0007416 synapse assembly(GO:0007416)
0.0 2.6 GO:0006413 translational initiation(GO:0006413)
0.3 2.0 GO:0044838 cell quiescence(GO:0044838)
0.0 1.9 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.2 1.6 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.1 1.5 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 1.4 GO:0009409 response to cold(GO:0009409)
0.2 1.2 GO:0070459 prolactin secretion(GO:0070459)
0.4 1.1 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344)
0.0 1.0 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 0.9 GO:0034113 heterotypic cell-cell adhesion(GO:0034113)
0.0 0.8 GO:0060134 prepulse inhibition(GO:0060134)
0.0 0.8 GO:0035640 exploration behavior(GO:0035640)
0.0 0.8 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.2 0.7 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.2 0.7 GO:0051599 response to hydrostatic pressure(GO:0051599)
0.1 0.7 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.1 0.7 GO:0006390 transcription from mitochondrial promoter(GO:0006390)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 1.4 GO:0043083 synaptic cleft(GO:0043083)
0.1 1.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.3 1.2 GO:0097487 vesicle lumen(GO:0031983) multivesicular body, internal vesicle(GO:0097487)
0.0 1.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.0 GO:0044306 neuron projection terminus(GO:0044306)
0.0 1.0 GO:0009925 basal plasma membrane(GO:0009925)
0.3 0.9 GO:0005927 muscle tendon junction(GO:0005927)
0.1 0.9 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.9 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.7 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 0.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 0.6 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.1 0.6 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.6 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.5 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.5 GO:0097542 ciliary tip(GO:0097542)
0.1 0.4 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 7.5 GO:0038191 neuropilin binding(GO:0038191)
0.0 5.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 2.5 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 1.9 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 1.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.5 1.5 GO:0098770 FBXO family protein binding(GO:0098770)
0.4 1.2 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 1.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 1.2 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.3 1.0 GO:0098809 nitrite reductase activity(GO:0098809)
0.3 1.0 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 1.0 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 1.0 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.9 GO:0043236 laminin binding(GO:0043236)
0.0 0.9 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.8 GO:0005504 fatty acid binding(GO:0005504)
0.2 0.7 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.2 0.7 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.2 0.7 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.2 0.7 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.5 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.8 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 1.3 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 0.9 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 0.6 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.5 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.5 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.4 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.4 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.4 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.3 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.3 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.3 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 0.2 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.0 0.2 PID_ATM_PATHWAY ATM pathway
0.0 0.2 PID_IL2_1PATHWAY IL2-mediated signaling events
0.0 0.2 PID_GMCSF_PATHWAY GMCSF-mediated signaling events
0.0 0.1 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.1 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 1.2 REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING Genes involved in SHC1 events in EGFR signaling
0.1 1.1 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 1.0 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 1.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.9 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 0.7 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.5 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.5 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.5 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.5 REACTOME_INWARDLY_RECTIFYING_K_CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.4 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.3 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.0 0.3 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.3 REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.0 0.3 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.0 0.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.3 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.3 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.3 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers