Motif ID: Hoxa7_Hoxc8

Z-value: 0.398

Transcription factors associated with Hoxa7_Hoxc8:

Gene SymbolEntrez IDGene Name
Hoxa7 ENSMUSG00000038236.6 Hoxa7
Hoxc8 ENSMUSG00000001657.6 Hoxc8



Activity profile for motif Hoxa7_Hoxc8.

activity profile for motif Hoxa7_Hoxc8


Sorted Z-values histogram for motif Hoxa7_Hoxc8

Sorted Z-values for motif Hoxa7_Hoxc8



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa7_Hoxc8

PNG image of the network

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Top targets:


Showing 1 to 20 of 96 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_8710734 3.815 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710409 3.176 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr14_+_80000292 2.824 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr5_-_62766153 1.440 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr6_-_137169710 1.176 ENSMUST00000117919.1
 Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chr7_-_46667375 1.096 ENSMUST00000107669.2
 Tph1
tryptophan hydroxylase 1
chr2_+_116067213 0.928 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr9_-_90255927 0.754 ENSMUST00000144646.1
 Tbc1d2b
TBC1 domain family, member 2B
chr15_-_37458523 0.673 ENSMUST00000116445.2
 Ncald
neurocalcin delta
chr6_+_30541582 0.614 ENSMUST00000096066.4
 Cpa2
carboxypeptidase A2, pancreatic
chr5_+_66968559 0.599 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chrX_-_143933089 0.571 ENSMUST00000087313.3
 Dcx
doublecortin
chr2_+_109917639 0.566 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr8_+_45885479 0.518 ENSMUST00000034053.5
 Pdlim3
PDZ and LIM domain 3
chr17_+_88440711 0.507 ENSMUST00000112238.2
ENSMUST00000155640.1
 Foxn2

forkhead box N2

chr2_-_116067391 0.503 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr4_-_14621805 0.502 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr5_+_66968416 0.498 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr18_+_37518341 0.488 ENSMUST00000097609.1
 Pcdhb22
protocadherin beta 22
chr3_-_66296807 0.409 ENSMUST00000029419.7
 Veph1
ventricular zone expressed PH domain-containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 7.0 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 2.8 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 1.1 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.1 0.9 GO:0019532 oxalate transport(GO:0019532)
0.0 0.7 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.2 0.6 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.1 0.3 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.1 0.3 GO:2000564 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.1 0.3 GO:0097212 lysosomal membrane organization(GO:0097212)
0.1 0.3 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.3 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.0 0.3 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.0 0.3 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 0.3 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.3 GO:0098707 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.0 0.3 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 0.2 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.2 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 0.2 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.3 GO:0043197 dendritic spine(GO:0043197)
0.2 2.8 GO:0042581 specific granule(GO:0042581)
0.0 0.5 GO:0031672 A band(GO:0031672)
0.0 0.5 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.3 GO:0097433 dense body(GO:0097433)
0.0 0.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.3 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 0.2 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.2 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.1 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.1 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.1 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 7.0 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 1.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.4 1.1 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.1 0.9 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.0 0.7 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.6 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.5 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.3 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.0 0.3 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 0.2 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0 0.2 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.2 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.0 0.2 GO:0070006 metalloaminopeptidase activity(GO:0070006)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.4 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 1.1 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.9 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.7 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.3 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.3 REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS Genes involved in Prolonged ERK activation events
0.0 0.2 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.1 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease