Motif ID: Hoxb1

Z-value: 0.722


Transcription factors associated with Hoxb1:

Gene SymbolEntrez IDGene Name
Hoxb1 ENSMUSG00000018973.2 Hoxb1



Activity profile for motif Hoxb1.

activity profile for motif Hoxb1


Sorted Z-values histogram for motif Hoxb1

Sorted Z-values for motif Hoxb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_119053339 11.442 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
Gli2


GLI-Kruppel family member GLI2


chr3_+_127633134 8.238 ENSMUST00000029587.7
Neurog2
neurogenin 2
chr1_-_119053619 7.120 ENSMUST00000062483.8
Gli2
GLI-Kruppel family member GLI2
chr9_+_65890237 4.497 ENSMUST00000045802.6
2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr1_-_135688094 4.240 ENSMUST00000112103.1
Nav1
neuron navigator 1
chr2_+_124610573 3.730 ENSMUST00000103239.3
ENSMUST00000103240.2
Sema6d

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

chr2_+_124610278 3.706 ENSMUST00000051419.8
ENSMUST00000077847.5
ENSMUST00000078621.5
ENSMUST00000076335.5
Sema6d



sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D



chr5_+_139543889 3.501 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx

UNC homeobox

chr1_+_153665274 3.498 ENSMUST00000152114.1
ENSMUST00000111812.1
Rgs8

regulator of G-protein signaling 8

chr4_-_91399984 2.970 ENSMUST00000102799.3
Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr8_-_87959560 2.612 ENSMUST00000109655.2
Zfp423
zinc finger protein 423
chr9_-_91365778 2.046 ENSMUST00000065360.3
Zic1
zinc finger protein of the cerebellum 1
chr19_-_41743665 1.996 ENSMUST00000025993.3
Slit1
slit homolog 1 (Drosophila)
chr2_+_84840612 1.888 ENSMUST00000111625.1
Slc43a1
solute carrier family 43, member 1
chr9_-_91365756 1.843 ENSMUST00000034927.6
Zic1
zinc finger protein of the cerebellum 1
chr10_-_92162753 1.837 ENSMUST00000182197.1
Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr1_+_127306706 1.561 ENSMUST00000171405.1
Mgat5
mannoside acetylglucosaminyltransferase 5
chr14_-_69284982 1.305 ENSMUST00000183882.1
ENSMUST00000037064.4
Slc25a37

solute carrier family 25, member 37

chr18_-_56562215 1.296 ENSMUST00000170309.1
Aldh7a1
aldehyde dehydrogenase family 7, member A1
chr18_-_56562261 1.232 ENSMUST00000066208.6
ENSMUST00000172734.1
Aldh7a1

aldehyde dehydrogenase family 7, member A1

chr18_-_56562187 1.147 ENSMUST00000171844.2
Aldh7a1
aldehyde dehydrogenase family 7, member A1
chr1_-_45503282 1.120 ENSMUST00000086430.4
Col5a2
collagen, type V, alpha 2
chr8_-_105471481 1.040 ENSMUST00000014990.6
Tppp3
tubulin polymerization-promoting protein family member 3
chr4_+_118428078 1.018 ENSMUST00000006557.6
ENSMUST00000167636.1
ENSMUST00000102673.4
Elovl1


elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1


chr8_+_84901928 0.940 ENSMUST00000067060.7
Klf1
Kruppel-like factor 1 (erythroid)
chr5_-_124354671 0.924 ENSMUST00000031341.4
Cdk2ap1
CDK2 (cyclin-dependent kinase 2)-associated protein 1
chr2_-_153529941 0.917 ENSMUST00000035346.7
8430427H17Rik
RIKEN cDNA 8430427H17 gene
chr8_-_8639363 0.882 ENSMUST00000152698.1
Efnb2
ephrin B2
chr10_-_63421739 0.864 ENSMUST00000054760.4
Gm7075
predicted gene 7075
chr3_-_58525867 0.835 ENSMUST00000029385.7
Serp1
stress-associated endoplasmic reticulum protein 1
chr1_-_157412576 0.832 ENSMUST00000078308.6
ENSMUST00000139470.1
Rasal2

RAS protein activator like 2

chr3_-_65958236 0.787 ENSMUST00000029416.7
Ccnl1
cyclin L1
chr14_-_69503220 0.748 ENSMUST00000180059.2
Gm21464
predicted gene, 21464
chr12_+_38780284 0.669 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
Etv1


ets variant gene 1


chr3_-_88762244 0.643 ENSMUST00000183267.1
Syt11
synaptotagmin XI
chr4_+_43669610 0.636 ENSMUST00000107866.1
Tmem8b
transmembrane protein 8B
chr4_-_103114555 0.557 ENSMUST00000106868.3
Wdr78
WD repeat domain 78
chr5_+_119834663 0.553 ENSMUST00000018407.6
Tbx5
T-box 5
chrX_+_143518671 0.552 ENSMUST00000134402.1
Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr5_-_24527276 0.534 ENSMUST00000088311.4
Gbx1
gastrulation brain homeobox 1
chr4_-_103114238 0.498 ENSMUST00000036451.8
ENSMUST00000036557.8
Wdr78

WD repeat domain 78

chr9_-_13245741 0.487 ENSMUST00000110582.2
Jrkl
jerky homolog-like (mouse)
chr17_+_29490812 0.463 ENSMUST00000024811.6
Pim1
proviral integration site 1
chr3_+_41564880 0.450 ENSMUST00000168086.1
Phf17
PHD finger protein 17
chr16_-_56024628 0.405 ENSMUST00000119981.1
ENSMUST00000096021.3
Pcnp

PEST proteolytic signal containing nuclear protein

chrX_+_110814390 0.368 ENSMUST00000078229.3
Pou3f4
POU domain, class 3, transcription factor 4
chr4_-_63662910 0.368 ENSMUST00000184252.1
Gm11214
predicted gene 11214
chr12_-_15816762 0.358 ENSMUST00000020922.7
Trib2
tribbles homolog 2 (Drosophila)
chr10_+_127677064 0.358 ENSMUST00000118612.1
ENSMUST00000048099.4
Tmem194

transmembrane protein 194

chr7_+_48789003 0.316 ENSMUST00000118927.1
ENSMUST00000125280.1
Zdhhc13

zinc finger, DHHC domain containing 13

chr10_+_4266323 0.298 ENSMUST00000045730.5
Akap12
A kinase (PRKA) anchor protein (gravin) 12
chr9_-_108083330 0.276 ENSMUST00000159372.1
ENSMUST00000160249.1
Rnf123

ring finger protein 123

chr8_-_83458386 0.225 ENSMUST00000081506.3
Scoc
short coiled-coil protein
chr2_+_119972699 0.194 ENSMUST00000066058.7
Mapkbp1
mitogen-activated protein kinase binding protein 1
chr15_+_89253035 0.168 ENSMUST00000088788.3
Ppp6r2
protein phosphatase 6, regulatory subunit 2
chrX_+_20617503 0.165 ENSMUST00000115375.1
ENSMUST00000115374.1
ENSMUST00000084383.3
Rbm10


RNA binding motif protein 10


chr4_+_103114712 0.165 ENSMUST00000143417.1
Mier1
mesoderm induction early response 1 homolog (Xenopus laevis
chr8_+_25808474 0.117 ENSMUST00000033979.4
Star
steroidogenic acute regulatory protein
chr11_+_75486813 0.106 ENSMUST00000018449.4
ENSMUST00000102510.1
ENSMUST00000131283.1
Prpf8


pre-mRNA processing factor 8


chr3_+_58526303 0.082 ENSMUST00000138848.1
Eif2a
eukaryotic translation initiation factor 2A
chr4_-_35845204 0.044 ENSMUST00000164772.1
ENSMUST00000065173.2
Lingo2

leucine rich repeat and Ig domain containing 2

chr7_+_119690026 0.027 ENSMUST00000047045.8
Acsm4
acyl-CoA synthetase medium-chain family member 4
chr17_-_85688252 0.025 ENSMUST00000024947.7
ENSMUST00000163568.2
Six2

sine oculis-related homeobox 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 18.6 GO:0060032 notochord regression(GO:0060032)
0.4 3.5 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.4 1.1 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.3 2.0 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.2 3.5 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.2 7.4 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.2 0.6 GO:1990927 negative regulation of membrane invagination(GO:1905154) calcium ion regulated lysosome exocytosis(GO:1990927)
0.1 0.5 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.1 0.6 GO:0051890 regulation of cardioblast differentiation(GO:0051890)
0.1 0.9 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.1 1.0 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 0.8 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.1 0.5 GO:2000138 positive regulation of cell proliferation involved in heart morphogenesis(GO:2000138)
0.1 0.7 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 3.9 GO:0007628 adult walking behavior(GO:0007628)
0.1 0.8 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.1 8.2 GO:0021954 central nervous system neuron development(GO:0021954)
0.1 2.3 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.1 0.9 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 5.3 GO:0001578 microtubule bundle formation(GO:0001578)
0.1 1.9 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 0.4 GO:2001053 regulation of mesenchymal cell apoptotic process(GO:2001053) negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.0 1.1 GO:0003341 cilium movement(GO:0003341)
0.0 0.2 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.3 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.4 GO:0032693 negative regulation of interleukin-10 production(GO:0032693)
0.0 1.3 GO:0006826 iron ion transport(GO:0006826)
0.0 0.1 GO:0070859 positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
0.0 0.6 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.0 0.2 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0 0.2 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.9 GO:0060325 face morphogenesis(GO:0060325)
0.0 3.0 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 1.6 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.0 GO:0097168 mesenchymal stem cell maintenance involved in nephron morphogenesis(GO:0072038) mesenchymal stem cell proliferation(GO:0097168)
0.0 0.7 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 18.6 GO:0097542 ciliary tip(GO:0097542)
0.4 1.1 GO:0005588 collagen type V trimer(GO:0005588)
0.1 4.2 GO:0043194 axon initial segment(GO:0043194)
0.1 1.0 GO:0097427 microtubule bundle(GO:0097427)
0.1 3.5 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 1.1 GO:0005858 axonemal dynein complex(GO:0005858)
0.1 0.7 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 0.6 GO:0032009 early phagosome(GO:0032009)
0.0 0.8 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.3 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.7 GO:0005881 cytoplasmic microtubule(GO:0005881)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.7 GO:0008802 betaine-aldehyde dehydrogenase activity(GO:0008802)
0.5 17.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.4 7.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.3 1.6 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.2 2.0 GO:0048495 Roundabout binding(GO:0048495)
0.2 8.2 GO:0070888 E-box binding(GO:0070888)
0.1 1.3 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.1 1.0 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 3.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 1.1 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 1.9 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.5 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.1 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.9 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.6 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.4 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.4 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.3 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 5.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.6 GO:0031369 translation initiation factor binding(GO:0031369)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 18.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 7.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.5 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.9 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 2.0 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.1 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.6 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.7 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.8 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 7.4 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.6 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 1.9 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.0 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 3.5 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 3.7 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 1.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.6 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.8 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)